Aliases for ANXA6 Gene
External Ids for ANXA6 Gene
Previous HGNC Symbols for ANXA6 Gene
Previous GeneCards Identifiers for ANXA6 Gene
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
GeneCards Summary for ANXA6 Gene
ANXA6 (Annexin A6) is a Protein Coding gene. Diseases associated with ANXA6 include Neonatal Lupus Erythematosus and Malignant Hyperthermia. Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTP binding. An important paralog of this gene is ANXA5.
UniProtKB/Swiss-Prot for ANXA6 Gene
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.