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Aliases for ANXA5 Gene

Aliases for ANXA5 Gene

  • Annexin A5 2 3 3 5
  • Placental Anticoagulant Protein 4 3 4
  • Placental Anticoagulant Protein I 3 4
  • Vascular Anticoagulant-Alpha 3 4
  • Thromboplastin Inhibitor 3 4
  • Calphobindin I 3 4
  • Anchorin CII 3 4
  • Endonexin II 3 4
  • Lipocortin V 3 4
  • Annexin V 3 4
  • Annexin-5 3 4
  • VAC-Alpha 3 4
  • CBP-I 3 4
  • PAP-I 3 4
  • ANX5 3 4
  • ENX2 3 4
  • PP4 3 4
  • Epididymis Secretory Protein Li 7 3
  • HEL-S-7 3
  • RPRGL3 3

External Ids for ANXA5 Gene

Previous HGNC Symbols for ANXA5 Gene

  • ENX2
  • ANX5

Previous GeneCards Identifiers for ANXA5 Gene

  • GC04M123513
  • GC04M122868
  • GC04M122982
  • GC04M123047
  • GC04M122946
  • GC04M122589
  • GC04M118316

Summaries for ANXA5 Gene

Entrez Gene Summary for ANXA5 Gene

  • The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA5 Gene

ANXA5 (Annexin A5) is a Protein Coding gene. Diseases associated with ANXA5 include Pregnancy Loss, Recurrent 3 and Antiphospholipid Syndrome. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot for ANXA5 Gene

  • This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Gene Wiki entry for ANXA5 Gene

Additional gene information for ANXA5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA5 Gene

Genomics for ANXA5 Gene

GeneHancer (GH) Regulatory Elements for ANXA5 Gene

Promoters and enhancers for ANXA5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J121694 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 676.5 +0.5 536 3.6 ATF1 SIN3A DMAP1 ZNF48 YY1 POLR2B ZNF766 GLIS2 ZNF143 ATF7 ANXA5 GC04M121668 GC04M121669
GH04J121698 Enhancer 0.4 ENCODE dbSUPER 650.7 -1.3 -1348 0.2 ANXA5 PP12613
GH04J121688 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 33.5 +6.6 6644 4.6 FOXA2 ARID4B SIN3A FEZF1 DMAP1 FOS NFKBIZ SP5 JUNB KAT8 ANXA5 GC04M121668 GC04M121669
GH04J121674 Enhancer 1 ENCODE dbSUPER 42.7 +20.6 20564 3.4 FOXA2 MLX ARID4B RARA ETS1 ZNF614 CREM MIXL1 NFKBIZ SP5 ANXA5 TMEM155 PP12613 ENSG00000237868 GC04M121668 GC04M121669
GH04J121667 Enhancer 0.7 ENCODE dbSUPER 40.3 +27.8 27824 3.5 JUND POLR2A ZNF223 FOS GC04M121669 GC04M121668 ANXA5 PP12613 TMEM155 ENSG00000237868
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANXA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANXA5 gene promoter:
  • deltaCREB
  • CREB
  • GR-alpha
  • GR
  • ATF
  • HNF-1
  • HNF-1A

Genomic Locations for ANXA5 Gene

Genomic Locations for ANXA5 Gene
29,159 bases
Minus strand
29,159 bases
Minus strand

Genomic View for ANXA5 Gene

Genes around ANXA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA5 Gene

Proteins for ANXA5 Gene

  • Protein details for ANXA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A5
    Protein Accession:
    Secondary Accessions:
    • D3DNW7
    • Q6FHB3
    • Q6FI16
    • Q8WV69
    • Q9UDH9

    Protein attributes for ANXA5 Gene

    320 amino acids
    Molecular mass:
    35937 Da
    Quaternary structure:
    • Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV).

    Three dimensional structures from OCA and Proteopedia for ANXA5 Gene

neXtProt entry for ANXA5 Gene

Post-translational modifications for ANXA5 Gene

  • S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
  • Ubiquitination at posLast=301301, posLast=290290, posLast=193193, posLast=108108, Lys79, Lys76, and posLast=2929
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA5 Gene

Antibody Products

No data available for DME Specific Peptides for ANXA5 Gene

Domains & Families for ANXA5 Gene

Gene Families for ANXA5 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Transporters

Protein Domains for ANXA5 Gene

Suggested Antigen Peptide Sequences for ANXA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • Belongs to the annexin family.
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA5: view

Function for ANXA5 Gene

Molecular function for ANXA5 Gene

UniProtKB/Swiss-Prot Function:
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
GENATLAS Biochemistry:
annexin A5,calcium and phospholipid binding protein,endonexin 2,placental protein 4,anchorin CII collagen receptor of chondrocytes,predominantly expressed in major constituent of growth plate chondrocytes,down-regulated in adult articular cartilage

Phenotypes From GWAS Catalog for ANXA5 Gene

Gene Ontology (GO) - Molecular Function for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity TAS 2967495
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21044950
GO:0005543 phospholipid binding TAS 2967291
GO:0005544 calcium-dependent phospholipid binding IEA,IDA 2138016
genes like me logo Genes that share ontologies with ANXA5: view
genes like me logo Genes that share phenotypes with ANXA5: view

Animal Models for ANXA5 Gene

MGI Knock Outs for ANXA5:

Animal Model Products

Clone Products

  • Addgene plasmids for ANXA5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA5 Gene

Localization for ANXA5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA5 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
nucleus 4
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with ANXA5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA5 Gene

Pathways & Interactions for ANXA5 Gene

genes like me logo Genes that share pathways with ANXA5: view

Gene Ontology (GO) - Biological Process for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007165 signal transduction TAS 16130169
GO:0007596 blood coagulation IEA --
GO:0007599 hemostasis IEA --
GO:0010033 response to organic substance IEA --
genes like me logo Genes that share ontologies with ANXA5: view

No data available for SIGNOR curated interactions for ANXA5 Gene

Drugs & Compounds for ANXA5 Gene

(83) Drugs for ANXA5 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Copper Approved, Investigational Pharma Target 202
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0
1,4-Dideoxy-O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0
K201 Experimental, Investigational Pharma Target 0

(75) Additional Compounds for ANXA5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA5: view

Transcripts for ANXA5 Gene

mRNA/cDNA for ANXA5 Gene

Unigene Clusters for ANXA5 Gene

Annexin A5:
Representative Sequences:

Clone Products

  • Addgene plasmids for ANXA5

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP8: - - - - - - - - - - -
SP9: - -

Relevant External Links for ANXA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA5 Gene

Protein tissue co-expression partners for ANXA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANXA5 Gene:


SOURCE GeneReport for Unigene cluster for ANXA5 Gene:


Evidence on tissue expression from TISSUES for ANXA5 Gene

  • Lung(4.9)
  • Skin(4.9)
  • Liver(4.8)
  • Nervous system(4.8)
  • Muscle(4.7)
  • Intestine(4.1)
  • Blood(3.7)
  • Heart(3.6)
  • Pancreas(3.5)
  • Bone marrow(3.3)
  • Eye(3.3)
  • Kidney(3.3)
  • Spleen(3.3)
  • Bone(3.2)
  • Stomach(3.2)
  • Adrenal gland(3.1)
  • Lymph node(3)
  • Thyroid gland(2.6)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with ANXA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA5 Gene

Orthologs for ANXA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANXA5 34 33
  • 99.79 (n)
(Canis familiaris)
Mammalia ANXA5 34 33
  • 93.44 (n)
(Bos Taurus)
Mammalia ANXA5 34 33
  • 92.08 (n)
(Ornithorhynchus anatinus)
Mammalia ANXA5 34
  • 89 (a)
(Monodelphis domestica)
Mammalia ANXA5 34
  • 89 (a)
(Mus musculus)
Mammalia Anxa5 16 34 33
  • 86.98 (n)
(Rattus norvegicus)
Mammalia Anxa5 33
  • 85.44 (n)
(Gallus gallus)
Aves ANXA5 34 33
  • 74.9 (n)
(Anolis carolinensis)
Reptilia ANXA5 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa5 33
  • 72.59 (n)
Str.8395 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398472 33
(Danio rerio)
Actinopterygii anxa5b 34 33
  • 62.19 (n)
anxa5a 34
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9774 33
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 35
  • 48 (a)
AnnX 35
  • 46 (a)
Anxb11 35
  • 43 (a)
(Caenorhabditis elegans)
Secernentea nex-2 35
  • 46 (a)
nex-1 35
  • 39 (a)
nex-3 35
  • 38 (a)
Species where no ortholog for ANXA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA5 Gene

Gene Tree for ANXA5 (if available)
Gene Tree for ANXA5 (if available)
Evolutionary constrained regions (ECRs) for ANXA5: view image

Paralogs for ANXA5 Gene

Paralogs for ANXA5 Gene

(15) SIMAP similar genes for ANXA5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ANXA5: view

Variants for ANXA5 Gene

Sequence variations from dbSNP and Humsavar for ANXA5 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000010176 -- 121,668,238(-) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000422058 -- 121,694,677(-) C/A intron_variant
rs1000502929 -- 121,697,883(-) C/T upstream_transcript_variant
rs1000510467 -- 121,680,425(-) A/G 3_prime_UTR_variant, intron_variant
rs10006900 -- 121,694,152(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA5 Gene

Variant ID Type Subtype PubMed ID
nsv999788 CNV gain 25217958
nsv997539 CNV gain 25217958
nsv595356 CNV gain 21841781
nsv473255 CNV novel sequence insertion 20440878
nsv1013073 CNV gain 25217958
esv3447335 CNV insertion 20981092

Variation tolerance for ANXA5 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA5 Gene

Disorders for ANXA5 Gene

MalaCards: The human disease database

(32) MalaCards diseases for ANXA5 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pregnancy loss, recurrent 3
  • pregnancy loss, recurrent, susceptibility to, 3
antiphospholipid syndrome
  • antiphospholipid antibody syndrome
overhydrated hereditary stomatocytosis
  • ohst
indolent myeloma
  • indolent multiple myeloma
israeli tick typhus
  • israeli spotted fever
- elite association - COSMIC cancer census association via MalaCards
Search ANXA5 in MalaCards View complete list of genes associated with diseases


  • Pregnancy loss, recurrent, 3 (RPRGL3) [MIM:614391]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. {ECO:0000269 PubMed:17339269}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for ANXA5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ANXA5: view

No data available for Genatlas for ANXA5 Gene

Publications for ANXA5 Gene

  1. A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. (PMID: 17339269) Bogdanova N … Markoff A (Human molecular genetics 2007) 3 4 44 58
  2. Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor. (PMID: 9398511) Kaneko N … Miyano M (Journal of molecular biology 1997) 3 4 22 58
  3. Organization of the human annexin V (ANX5) gene. (PMID: 8034319) Cookson BT … Tait JF (Genomics 1994) 3 4 22 58
  4. The gene encoding human annexin V has a TATA-less promoter with a high G+C content. (PMID: 7958998) Fernández MP … Carcedo MT (Gene 1994) 3 4 22 58
  5. Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. (PMID: 1311770) Huber R … Paques E (Journal of molecular biology 1992) 3 4 22 58

Products for ANXA5 Gene

  • Addgene plasmids for ANXA5

Sources for ANXA5 Gene

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