Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon... See more...

Aliases for ANXA4 Gene

Aliases for ANXA4 Gene

  • Annexin A4 2 3 4 5
  • Carbohydrate-Binding Protein P33/P41 3 4
  • Placental Anticoagulant Protein II 3 4
  • 35-Beta Calcimedin 3 4
  • Chromobindin-4 3 4
  • Lipocortin IV 3 4
  • Endonexin I 3 4
  • Protein II 3 4
  • Annexin-4 3 4
  • PAP-II 3 4
  • P32.5 3 4
  • PP4-X 3 4
  • ANX4 3 4
  • Annexin IV (Placental Anticoagulant Protein II) 3
  • Epididymis Secretory Protein Li 274 3
  • Proliferation-Inducing Protein 28 3
  • Proliferation-Inducing Gene 28 3
  • Annexin IV 4
  • HEL-S-274 3
  • PIG28 3
  • ZAP36 3

External Ids for ANXA4 Gene

Previous HGNC Symbols for ANXA4 Gene

  • ANX4

Previous GeneCards Identifiers for ANXA4 Gene

  • GC02P070018
  • GC02P070180
  • GC02P069926
  • GC02P069943
  • GC02P069880
  • GC02P069947
  • GC02P069705
  • GC02P069872

Summaries for ANXA4 Gene

Entrez Gene Summary for ANXA4 Gene

  • Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

GeneCards Summary for ANXA4 Gene

ANXA4 (Annexin A4) is a Protein Coding gene. Among its related pathways are Prostaglandin Synthesis and Regulation. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is ANXA5.

UniProtKB/Swiss-Prot Summary for ANXA4 Gene

  • Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

Gene Wiki entry for ANXA4 Gene

Additional gene information for ANXA4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANXA4 Gene

Genomics for ANXA4 Gene

GeneHancer (GH) Regulatory Elements for ANXA4 Gene

Promoters and enhancers for ANXA4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANXA4 gene promoter:
  • c-Myc
  • C/EBPalpha
  • HOXA9
  • HOXA9B
  • HSF1 (long)
  • HSF1short
  • Max1
  • Meis-1
  • Meis-1a
  • NCX

Genomic Locations for ANXA4 Gene

Genomic Locations for ANXA4 Gene
chr2:69,644,100-69,827,112
(GRCh38/hg38)
Size:
183,013 bases
Orientation:
Plus strand
chr2:69,871,557-70,053,596
(GRCh37/hg19)
Size:
182,040 bases
Orientation:
Plus strand

Genomic View for ANXA4 Gene

Genes around ANXA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA4 Gene

Proteins for ANXA4 Gene

  • Protein details for ANXA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09525-ANXA4_HUMAN
    Recommended name:
    Annexin A4
    Protein Accession:
    P09525
    Secondary Accessions:
    • B4DDF9
    • Q96F33
    • Q9BWK1

    Protein attributes for ANXA4 Gene

    Size:
    319 amino acids
    Molecular mass:
    35883 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Seems to bind one calcium ion with high affinity.
    SequenceCaution:
    • Sequence=AAC41689.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH00182.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH11659.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA11227.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANXA4 Gene

    Alternative splice isoforms for ANXA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA4 Gene

Post-translational modifications for ANXA4 Gene

  • Ubiquitination at Lys293
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANXA4 Gene

Domains & Families for ANXA4 Gene

Gene Families for ANXA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for ANXA4 Gene

Suggested Antigen Peptide Sequences for ANXA4 Gene

GenScript: Design optimal peptide antigens:
  • Protein II (ANXA4_HUMAN)
  • cDNA FLJ52218, highly similar to Annexin A4 (B4DDF9_HUMAN)
  • cDNA, FLJ96576, Homo sapiens annexin A4 (ANXA4), mRNA (Q6LES2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P09525

UniProtKB/Swiss-Prot:

ANXA4_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA4: view

Function for ANXA4 Gene

Molecular function for ANXA4 Gene

UniProtKB/Swiss-Prot Function:
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
GENATLAS Biochemistry:
annexin A4,calcium and phospholipid binding protein,calcimedin 35 beta,chromobindin 4,endonexin 1

Phenotypes From GWAS Catalog for ANXA4 Gene

Gene Ontology (GO) - Molecular Function for ANXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity NAS 2970257
GO:0005509 calcium ion binding IEA,IDA 20237821
GO:0005515 protein binding IPI,IBA 21044950
GO:0005544 calcium-dependent phospholipid binding NAS,IEA 2970257
GO:0008201 heparin binding IBA 21873635
genes like me logo Genes that share ontologies with ANXA4: view
genes like me logo Genes that share phenotypes with ANXA4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ANXA4

CRISPR Products

Clone Products

  • Addgene plasmids for ANXA4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA4 Gene

Localization for ANXA4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA4 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 16687573
GO:0005737 cytoplasm TAS,IBA 16130169
GO:0005829 cytosol IBA 21873635
GO:0005886 plasma membrane IDA 16687573
GO:0009986 cell surface IDA 22056994
genes like me logo Genes that share ontologies with ANXA4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA4 Gene

Pathways & Interactions for ANXA4 Gene

PathCards logo

SuperPathways for ANXA4 Gene

genes like me logo Genes that share pathways with ANXA4: view

Pathways by source for ANXA4 Gene

1 BioSystems pathway for ANXA4 Gene

Gene Ontology (GO) - Biological Process for ANXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IDA 20237821
GO:0007165 signal transduction TAS 16130169
GO:0007219 Notch signaling pathway IEA,IBA 21873635
GO:0030855 epithelial cell differentiation IEP,IBA 21492153
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 20237821
genes like me logo Genes that share ontologies with ANXA4: view

No data available for SIGNOR curated interactions for ANXA4 Gene

Drugs & Compounds for ANXA4 Gene

(15) Drugs for ANXA4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773
Copper Approved, Investigational Pharma Target 227
Fluocinolone Acetonide Approved, Investigational, Vet_approved Pharma Target, inducer 48

(9) Additional Compounds for ANXA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA4: view

Transcripts for ANXA4 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for ANXA4

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for ANXA4 Gene

GeneLoc Exon Structure for
ANXA4
ECgene alternative splicing isoforms for
ANXA4

Expression for ANXA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA4 Gene

This gene is overexpressed in Pancreas (x7.2).

Protein differential expression in normal tissues from HIPED for ANXA4 Gene

This gene is overexpressed in Islet of Langerhans (9.2) and Gallbladder (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA4 Gene



Protein tissue co-expression partners for ANXA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANXA4 Gene:

ANXA4

SOURCE GeneReport for Unigene cluster for ANXA4 Gene:

Hs.422986

Evidence on tissue expression from TISSUES for ANXA4 Gene

  • Liver(4.6)
  • Adrenal gland(4.3)
  • Eye(4.2)
  • Nervous system(3.8)
  • Intestine(3.7)
  • Kidney(3.4)
  • Lung(3.2)
  • Pancreas(3)
  • Gall bladder(2.6)
  • Skin(2.3)
  • Blood(2)
genes like me logo Genes that share expression patterns with ANXA4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA4 Gene

Orthologs for ANXA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANXA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA4 33 32
  • 99.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANXA4 33 32
  • 91.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA4 33 32
  • 88.61 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa4 32
  • 87.36 (n)
oppossum
(Monodelphis domestica)
Mammalia ANXA4 33
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa4 17 33 32
  • 86.52 (n)
chicken
(Gallus gallus)
Aves ANXA4 33
  • 73 (a)
OneToOne
LOC772393 32
  • 71.88 (n)
lizard
(Anolis carolinensis)
Reptilia ANXA4 33
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa4 32
  • 70.74 (n)
zebrafish
(Danio rerio)
Actinopterygii anxa4 33 32
  • 65.1 (n)
OneToOne
-- 32
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 34
  • 51 (a)
Anxb11 34
  • 49 (a)
AnnX 34
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-1 34
  • 41 (a)
nex-3 34
  • 38 (a)
nex-2 33 34
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ANN5 32
  • 48.33 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.2086 32
corn
(Zea mays)
Liliopsida Zm.13766 32
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 30 (a)
OneToMany
Species where no ortholog for ANXA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA4 Gene

ENSEMBL:
Gene Tree for ANXA4 (if available)
TreeFam:
Gene Tree for ANXA4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANXA4: view image

Paralogs for ANXA4 Gene

(15) SIMAP similar genes for ANXA4 Gene using alignment to 4 proteins:

  • ANXA4_HUMAN
  • B4DDF9_HUMAN
  • Q6LES2_HUMAN
  • Q6P452_HUMAN
genes like me logo Genes that share paralogs with ANXA4: view

Variants for ANXA4 Gene

Sequence variations from dbSNP and Humsavar for ANXA4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000016989 -- 69,813,718(+) A/G intron_variant
rs1000028386 -- 69,692,008(+) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000051225 -- 69,813,452(+) T/A intron_variant
rs1000068325 -- 69,654,586(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000071288 -- 69,726,824(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA4 Gene

Variant ID Type Subtype PubMed ID
esv2657606 CNV deletion 23128226
esv33940 CNV loss 17666407
esv3583856 CNV loss 25503493
esv3591191 CNV loss 21293372
esv7380 CNV gain 19470904
nsv582175 CNV loss 21841781
nsv834254 CNV gain 17160897

Variation tolerance for ANXA4 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.06; 84.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA4 Gene

Disorders for ANXA4 Gene

Additional Disease Information for ANXA4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANXA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA4 Gene

Publications for ANXA4 Gene

  1. Chromosomal mapping of the human annexin IV (ANX4) gene. (PMID: 1346776) Tait JF … Disteche CM (Genomics 1992) 2 3 4 23 56
  2. Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17. (PMID: 9084877) Satoh A … Matsumoto I (Biological & pharmaceutical bulletin 1997) 3 4 23 56
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  5. Annexin IV is differentially expressed in clear cell carcinoma of the ovary. (PMID: 19955935) Miao Y … Wan X (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2009) 3 23 56

Products for ANXA4 Gene

Sources for ANXA4 Gene