This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in... See more...

Aliases for ANXA3 Gene

Aliases for ANXA3 Gene

  • Annexin A3 2 3 4 5
  • Inositol 1,2-Cyclic Phosphate 2-Phosphohydrolase 3 4
  • Placental Anticoagulant Protein III 3 4
  • 35-Alpha Calcimedin 3 4
  • Lipocortin III 3 4
  • Annexin-3 3 4
  • PAP-III 3 4
  • ANX3 3 4
  • Annexin III (Lipocortin III, 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase, Placental Anticoagulant Protein III, Calcimedin 35-Alpha) 3
  • Annexin III (Lipocortin III) 3
  • Calcimedin 35-Alpha 3
  • Annexin III 4

External Ids for ANXA3 Gene

Previous HGNC Symbols for ANXA3 Gene

  • ANX3

Previous GeneCards Identifiers for ANXA3 Gene

  • GC04P079403
  • GC04P079746
  • GC04P079865
  • GC04P079933
  • GC04P079925
  • GC04P079830
  • GC04P075219
  • GC04P079472

Summaries for ANXA3 Gene

Entrez Gene Summary for ANXA3 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA3 Gene

ANXA3 (Annexin A3) is a Protein Coding gene. Diseases associated with ANXA3 include Ovarian Cancer and Prostate Cancer. Among its related pathways are Prostaglandin Synthesis and Regulation. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot Summary for ANXA3 Gene

  • Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

Gene Wiki entry for ANXA3 Gene

Additional gene information for ANXA3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANXA3 Gene

Genomics for ANXA3 Gene

GeneHancer (GH) Regulatory Elements for ANXA3 Gene

Promoters and enhancers for ANXA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J078550 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 532.1 +1.2 1162 3.8 ZBTB40 TCF12 USF1 JUND TEAD4 POLR2A ZBTB10 CLOCK ZNF623 ZBTB26 ANXA3 FRAS1 piR-35371-009
GH04J078542 Enhancer 0.9 Ensembl ENCODE dbSUPER 30.6 -7.3 -7287 4.6 FOS ZNF316 NR3C1 FOSL2 CEBPB RBM22 MAFK JUND EP300 TCF7L2 ANXA3 FRAS1 piR-55655-427 piR-50444-345
GH04J078529 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 14.7 -22.3 -22287 2.6 JUND FOS ATF2 FOXA2 FOSL2 ATF7 FRAS1 ANXA3 piR-50444-345 piR-55655-427
GH04J078555 Enhancer 1.1 Ensembl ENCODE dbSUPER 13.6 +7.7 7743 8.5 TCF12 JUND FOS EP300 CTBP1 POLR2A NR2F2 NFIC TRIM24 CEBPG ANXA3 ENSG00000200998 piR-35371-009
GH04J078563 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.9 +15.8 15787 7.2 TCF12 JUND EP300 RELA CUX1 TRIM22 MAFF BRCA1 FOS NR3C1 ANXA3 ENSG00000200998 piR-35371-009
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANXA3

Top Transcription factor binding sites by QIAGEN in the ANXA3 gene promoter:
  • AML1a
  • c-Myc
  • FOXD1
  • Lmo2
  • Max1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • RSRFC4
  • SEF-1 (1)
  • TGIF

Genomic Locations for ANXA3 Gene

Genomic Locations for ANXA3 Gene
chr4:78,551,588-78,610,451
(GRCh38/hg38)
Size:
58,864 bases
Orientation:
Plus strand
chr4:79,472,673-79,531,605
(GRCh37/hg19)
Size:
58,933 bases
Orientation:
Plus strand

Genomic View for ANXA3 Gene

Genes around ANXA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA3 Gene

Proteins for ANXA3 Gene

  • Protein details for ANXA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12429-ANXA3_HUMAN
    Recommended name:
    Annexin A3
    Protein Accession:
    P12429
    Secondary Accessions:
    • B2R9W6
    • Q6LET2

    Protein attributes for ANXA3 Gene

    Size:
    323 amino acids
    Molecular mass:
    36375 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ANXA3 Gene

neXtProt entry for ANXA3 Gene

Post-translational modifications for ANXA3 Gene

  • Ubiquitination at Lys210
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA3 Gene

No data available for DME Specific Peptides for ANXA3 Gene

Domains & Families for ANXA3 Gene

Gene Families for ANXA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ANXA3 Gene

Blocks:
  • Annexin
  • Annexin type III signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANXA3 Gene

GenScript: Design optimal peptide antigens:
  • Placental anticoagulant protein III (ANXA3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P12429

UniProtKB/Swiss-Prot:

ANXA3_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA3: view

Function for ANXA3 Gene

Molecular function for ANXA3 Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
GENATLAS Biochemistry:
annexin A3,calelectrin 32.5

Phenotypes From GWAS Catalog for ANXA3 Gene

Gene Ontology (GO) - Molecular Function for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005544 calcium-dependent phospholipid binding IDA,IEA 2138016
GO:0019834 phospholipase A2 inhibitor activity IEA,IBA 21873635
GO:0048306 calcium-dependent protein binding IBA,IPI 15226301
genes like me logo Genes that share ontologies with ANXA3: view
genes like me logo Genes that share phenotypes with ANXA3: view

Animal Models for ANXA3 Gene

MGI Knock Outs for ANXA3:
  • Anxa3 Anxa3<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for ANXA3 Gene

miRTarBase miRNAs that target ANXA3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA3 Gene

Localization for ANXA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA3 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17205602
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IBA,IDA 7526843
GO:0016020 membrane IDA 17205602
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with ANXA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA3 Gene

Pathways & Interactions for ANXA3 Gene

PathCards logo

SuperPathways for ANXA3 Gene

genes like me logo Genes that share pathways with ANXA3: view

Pathways by source for ANXA3 Gene

1 BioSystems pathway for ANXA3 Gene

Gene Ontology (GO) - Biological Process for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IBA,IDA 9497492
GO:0010595 positive regulation of endothelial cell migration IDA,IBA 16236264
GO:0021766 hippocampus development IEA --
GO:0031100 animal organ regeneration IEA --
GO:0042742 defense response to bacterium IDA 9497492
genes like me logo Genes that share ontologies with ANXA3: view

No data available for SIGNOR curated interactions for ANXA3 Gene

Drugs & Compounds for ANXA3 Gene

(8) Drugs for ANXA3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
Difluocortolone Approved, Investigational, Withdrawn Pharma Target, inducer 0
Fluocinolone Acetonide Approved, Investigational, Vet_approved Pharma Target, inducer 48
Glycerol Approved, Investigational Pharma 208
Water Approved Pharma 0

(9) Additional Compounds for ANXA3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inositol cyclic phosphate
  • D-myo-Inositol 1,2-cyclic phosphate
  • myo-Inositol 1,2-cyclic phosphate
  • D-myo-Inositol 1,2-cyclic phosphoric acid
  • Inositol cyclic phosphoric acid
  • myo-Inositol 1,2-cyclic phosphoric acid
43119-57-9
Inositol phosphate
  • D-myo-Inositol (6)-monophosphate
  • D-myo-Inositol (6)-phosphate
  • I6P
  • Ins(6)P
  • Ins6p
15421-51-9
Myo-inositol 1-phosphate
  • 1D-myo-Inositol 3-monophosphate
  • 1l-myo-Inositol 1-phosphate
  • D-myo-Inositol 3-monophosphate
  • D-myo-Inositol 3-phosphate
  • Inositol 3-phosphate
573-35-3
genes like me logo Genes that share compounds with ANXA3: view

Transcripts for ANXA3 Gene

mRNA/cDNA for ANXA3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6:

Relevant External Links for ANXA3 Gene

GeneLoc Exon Structure for
ANXA3

Expression for ANXA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANXA3 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA3 Gene

This gene is overexpressed in Whole Blood (x16.5).

Protein differential expression in normal tissues from HIPED for ANXA3 Gene

This gene is overexpressed in Neutrophil (12.0) and Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA3 Gene



Protein tissue co-expression partners for ANXA3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANXA3

SOURCE GeneReport for Unigene cluster for ANXA3 Gene:

Hs.480042

Evidence on tissue expression from TISSUES for ANXA3 Gene

  • Blood(4.5)
  • Muscle(4.2)
  • Lung(3)
  • Liver(2.5)
  • Kidney(2.4)
  • Heart(2.2)
  • Bone marrow(2.1)
  • Pancreas(2)
  • Spleen(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ANXA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA3 Gene

Orthologs for ANXA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA3 31 30
  • 98.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA3 31 30
  • 89.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANXA3 31 30
  • 88.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa3 17 31 30
  • 84.73 (n)
rat
(Rattus norvegicus)
Mammalia Anxa3 30
  • 83.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ANXA3 31
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA3 31
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3863 30
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5303 30
zebrafish
(Danio rerio)
Actinopterygii anxa3b 31 30
  • 60.08 (n)
OneToMany
anxa3a 31
  • 49 (a)
OneToMany
wufb60b03 30
fruit fly
(Drosophila melanogaster)
Insecta AnnX 32
  • 44 (a)
Anxb11 32
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-3 32
  • 35 (a)
nex-2 31 32
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
OneToMany
Species where no ortholog for ANXA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA3 Gene

ENSEMBL:
Gene Tree for ANXA3 (if available)
TreeFam:
Gene Tree for ANXA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANXA3: view image

Paralogs for ANXA3 Gene

(15) SIMAP similar genes for ANXA3 Gene using alignment to 6 proteins:

  • ANXA3_HUMAN
  • D6RA82_HUMAN
  • D6RAZ8_HUMAN
  • D6RCA8_HUMAN
  • D6RFG5_HUMAN
  • D6RFJ9_HUMAN
genes like me logo Genes that share paralogs with ANXA3: view

Variants for ANXA3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANXA3 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
724728 Likely Benign: not provided 78,610,081(+) T/C MISSENSE_VARIANT
773707 Benign: not provided 78,573,220(+) G/A MISSENSE_VARIANT
775990 Benign: not provided 78,597,340(+) T/A MISSENSE_VARIANT
rs5941 - p.Phe291Ser
rs5948 - p.Ile219Asn

Additional dbSNP identifiers (rs#s) for ANXA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANXA3 Gene

Variant ID Type Subtype PubMed ID
esv3351562 CNV insertion 20981092
esv3352391 CNV insertion 20981092
esv3601108 CNV loss 21293372
nsv1006026 CNV loss 25217958
nsv1009633 CNV gain 25217958
nsv7363 OTHER inversion 18451855

Variation tolerance for ANXA3 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA3 Gene

Disorders for ANXA3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ANXA3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search ANXA3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ANXA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ANXA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA3 Gene

Publications for ANXA3 Gene

  1. Chromosomal localization of the human annexin III (ANX3) gene. (PMID: 1830024) Tait JF … Disteche CM (Genomics 1991) 2 3 4 23 54
  2. The high-resolution crystal structure of human annexin III shows subtle differences with annexin V. (PMID: 8639653) Favier-Perron B … Russo-Marie F (Biochemistry 1996) 3 4 23 54
  3. Structure and polymorphisms of the human annexin III (ANX3) gene. (PMID: 8276419) Tait JF … Cookson BT (Genomics 1993) 3 4 23 54
  4. Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III. (PMID: 2159184) Ross TS … Majerus PW (Science (New York, N.Y.) 1990) 3 4 23 54
  5. Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules. (PMID: 2138632) Ernst JD … Jaye D (The Journal of clinical investigation 1990) 3 4 23 54

Products for ANXA3 Gene

Sources for ANXA3 Gene