Aliases for ANXA2R Gene

Aliases for ANXA2R Gene

  • Annexin A2 Receptor 2 3 5
  • AXIIR 2 3 4
  • Annexin II Receptor 3 4
  • Annexin-2 Receptor 3 4
  • C5orf39 3 4
  • AX2R 3 4
  • Chromosome 5 Open Reading Frame 39 2
  • ANXA2R 5

External Ids for ANXA2R Gene

Previous HGNC Symbols for ANXA2R Gene

  • C5orf39

Previous GeneCards Identifiers for ANXA2R Gene

  • GC05M043042
  • GC05M043045
  • GC05M043055

Summaries for ANXA2R Gene

GeneCards Summary for ANXA2R Gene

ANXA2R (Annexin A2 Receptor) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for ANXA2R Gene

  • May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANXA2R Gene

Genomics for ANXA2R Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANXA2R Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J043015 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 33.4 +24.3 24297 6.6 BCLAF1 SP1 ZNF207 ZNF600 ZNF580 ZMYM3 POLR2A CEBPA ZNF10 BRCA1 ENSG00000251131 ENSG00000272382 LOC105374748 piR-35544 piR-51211 HSALNG0041488 ZNF131 ANXA2R TMEM267 LOC153684
GH05J043006 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.8 +33.4 33447 6.4 BCLAF1 SP1 ZNF207 MYC NCOR1 IKZF1 ZNF600 SSRP1 ZNF580 ZNF592 HSALNG0041485 lnc-ZNF131-11 ZNF131 ANXA2R LOC153684 ENSG00000249492 TMEM267 ENSG00000271788 AMD1P3 GHR
GH05J043073 Enhancer 1.3 Ensembl ENCODE dbSUPER 25.8 -31.8 -31753 2.8 ZNF654 NCOR1 MYC IKZF1 ZNF592 NFIC REST CTCF SMAD5 TRIM22 piR-43644 piR-52976-002 piR-53360-008 ZNF131 LOC153684 ANXA2R TMEM267 ENSG00000249492 SERBP1P6 RPL29P12
GH05J043033 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.6 +4.2 4192 11.5 BCLAF1 ZNF207 MYC ZNF654 NCOR1 IKZF1 ZNF600 ZNF580 ZNF592 ZMYM3 ZNF131 LOC153684 ENSG00000249492 TMEM267 ENSG00000248240 EEF1A1P19 ANXA2R RPL29P12 PAIP1 ENSG00000272382
GH05J043191 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.2 -149.8 -149822 2.9 IKZF1 ZNF600 ZNF580 CEBPA ZNF223 ZIC2 ZBTB10 CEBPB ZNF639 ZNF341 NIM1K lnc-NIM1K-3 lnc-HMGCS1-3 ZNF131 TMEM267 EEF1A1P19 ENSG00000249492 RPL29P12 C5orf34 LOC153684
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA2R on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANXA2R

Genomic Locations for ANXA2R Gene

Latest Assembly
4,015 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
3,877 bases
Minus strand

(GRCh37/hg19 by Ensembl)
3,938 bases
Minus strand

Genomic View for ANXA2R Gene

Genes around ANXA2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA2R Gene

Proteins for ANXA2R Gene

  • Protein details for ANXA2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin-2 receptor
    Protein Accession:
    Secondary Accessions:
    • Q8NHX5

    Protein attributes for ANXA2R Gene

    193 amino acids
    Molecular mass:
    21682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANXA2R Gene

Post-translational modifications for ANXA2R Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA2R Gene

No data available for DME Specific Peptides for ANXA2R Gene

Domains & Families for ANXA2R Gene

Gene Families for ANXA2R Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANXA2R Gene


Suggested Antigen Peptide Sequences for ANXA2R Gene

GenScript: Design optimal peptide antigens:
  • Annexin II receptor (AX2R_HUMAN)
genes like me logo Genes that share domains with ANXA2R: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANXA2R Gene

Function for ANXA2R Gene

Molecular function for ANXA2R Gene

UniProtKB/Swiss-Prot Function:
May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

Phenotypes From GWAS Catalog for ANXA2R Gene

Gene Ontology (GO) - Molecular Function for ANXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 30833792
GO:0038023 signaling receptor activity IEA --
genes like me logo Genes that share ontologies with ANXA2R: view

Phenotypes for ANXA2R Gene

genes like me logo Genes that share phenotypes with ANXA2R: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA2R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA2R Gene

Localization for ANXA2R Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA2R gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANXA2R Gene

Pathways & Interactions for ANXA2R Gene

PathCards logo

SuperPathways for ANXA2R Gene

No Data Available

Interacting Proteins for ANXA2R Gene

Selected Interacting proteins: Q3ZCQ2-AX2R_HUMAN for ANXA2R Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for ANXA2R Gene


No data available for Pathways by source and SIGNOR curated interactions for ANXA2R Gene

Drugs & Compounds for ANXA2R Gene

No Compound Related Data Available

Transcripts for ANXA2R Gene

mRNA/cDNA for ANXA2R Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA2R

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2R Gene

No ASD Table

Relevant External Links for ANXA2R Gene

GeneLoc Exon Structure for

Expression for ANXA2R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANXA2R Gene

mRNA differential expression in normal tissues according to GTEx for ANXA2R Gene

This gene is overexpressed in Whole Blood (x7.7) and Spleen (x5.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANXA2R

SOURCE GeneReport for Unigene cluster for ANXA2R Gene:


mRNA Expression by UniProt/SwissProt for ANXA2R Gene:

Tissue specificity: Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4(+) and CD8(+) T-cells.

Evidence on tissue expression from TISSUES for ANXA2R Gene

  • Bone marrow(4.3)
genes like me logo Genes that share expression patterns with ANXA2R: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA2R Gene

Orthologs for ANXA2R Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ANXA2R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANXA2R 29 30
  • 99.48 (n)
Species where no ortholog for ANXA2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ANXA2R Gene

Gene Tree for ANXA2R (if available)
Gene Tree for ANXA2R (if available)
Evolutionary constrained regions (ECRs) for ANXA2R: view image
Alliance of Genome Resources:
Additional Orthologs for ANXA2R

Paralogs for ANXA2R Gene Pseudogenes for ANXA2R Gene

genes like me logo Genes that share paralogs with ANXA2R: view

No data available for Paralogs for ANXA2R Gene

Variants for ANXA2R Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANXA2R Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs1054428 -- p.Gln119Arg
rs10971 -- p.Arg186Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ANXA2R Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ANXA2R Gene

Variant ID Type Subtype PubMed ID
nsv1029288 CNV loss 25217958
nsv462126 CNV gain 19166990
nsv597925 CNV gain 21841781

Variation tolerance for ANXA2R Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA2R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA2R Gene

Disorders for ANXA2R Gene

Additional Disease Information for ANXA2R

No disorders were found for ANXA2R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA2R Gene

Publications for ANXA2R Gene

  1. Cloning and characterization of the annexin II receptor on human marrow stromal cells. (PMID: 16895901) Lu G … Roodman GD (The Journal of biological chemistry 2006) 2 3 4 22
  2. Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. (PMID: 18636554) Shiozawa Y … Taichman RS (Journal of cellular biochemistry 2008) 2 3 22
  3. Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures. (PMID: 10359570) Menaa C … Roodman GD (The Journal of clinical investigation 1999) 3 4
  4. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (PMID: 30833792) Hubel P … Pichlmair A (Nature immunology 2019) 3
  5. CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1. (PMID: 31067453) Douanne T … Bidère N (Cell reports 2019) 3

Products for ANXA2R Gene

Sources for ANXA2R Gene