Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANXA2R Gene

Aliases for ANXA2R Gene

  • Annexin A2 Receptor 2 3 5
  • Annexin II Receptor 3 4
  • C5orf39 3 4
  • AXIIR 3 4
  • AX2R 3 4
  • Chromosome 5 Open Reading Frame 39 2
  • Annexin-2 Receptor 3

External Ids for ANXA2R Gene

Previous HGNC Symbols for ANXA2R Gene

  • C5orf39

Summaries for ANXA2R Gene

GeneCards Summary for ANXA2R Gene

ANXA2R (Annexin A2 Receptor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANXA2R Gene

  • May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

Additional gene information for ANXA2R Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA2R Gene

Genomics for ANXA2R Gene

GeneHancer (GH) Regulatory Elements for ANXA2R Gene

Promoters and enhancers for ANXA2R Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J043044 Enhancer 0.6 ENCODE dbSUPER 650.7 -1.3 -1277 0.6 PRDM4 NCOA2 ANXA2R GC05P043043 AMD1P3 LOC153684 GC05P043054 LOC648987
GH05J043015 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 33.4 +24.2 24220 6.6 PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 GC05M043024 LOC105374748 PIR45210 ZNF131 ANXA2R TMEM267 LOC153684 RPL29P12 ENSG00000248240 ENSG00000249492
GH05J043006 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +33.6 33617 5.5 ZFP64 IRF4 YY1 ZNF213 ZNF143 MEF2D SSRP1 ZNF610 GLIS1 RCOR2 ZNF131 ANXA2R LOC153684 RPL29P12 ENSG00000249492 TMEM267 ENSG00000271788 AMD1P3 GHR PIR61621
GH05J043063 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 14.7 -23.2 -23184 5.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF131 LOC648987 LOC100506639 LOC100132356 PIR50097 SELENOP EEF1A1P19 RPL29P12 ANXA2R ENSG00000260786
GH05J043033 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.7 +4.7 4697 10.3 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZFP41 ZNF610 ZNF585B GLIS1 NBN ZNF131 ENSG00000249492 TMEM267 ENSG00000260786 ANXA2R EEF1A1P19 RPL29P12 LOC153684 ENSG00000272382 PAIP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANXA2R on UCSC Golden Path with GeneCards custom track

Genomic Locations for ANXA2R Gene

Genomic Locations for ANXA2R Gene
4,091 bases
Minus strand
4,091 bases
Minus strand

Genomic View for ANXA2R Gene

Genes around ANXA2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA2R Gene

Proteins for ANXA2R Gene

  • Protein details for ANXA2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin-2 receptor
    Protein Accession:
    Secondary Accessions:
    • Q8NHX5

    Protein attributes for ANXA2R Gene

    193 amino acids
    Molecular mass:
    21682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANXA2R Gene

Post-translational modifications for ANXA2R Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA2R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANXA2R Gene

Domains & Families for ANXA2R Gene

Gene Families for ANXA2R Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANXA2R Gene


Suggested Antigen Peptide Sequences for ANXA2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANXA2R: view

No data available for UniProtKB/Swiss-Prot for ANXA2R Gene

Function for ANXA2R Gene

Molecular function for ANXA2R Gene

UniProtKB/Swiss-Prot Function:
May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

Phenotypes From GWAS Catalog for ANXA2R Gene

Gene Ontology (GO) - Molecular Function for ANXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038023 signaling receptor activity IEA --
genes like me logo Genes that share ontologies with ANXA2R: view

Phenotypes for ANXA2R Gene

genes like me logo Genes that share phenotypes with ANXA2R: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA2R

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA2R Gene

Localization for ANXA2R Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA2R gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANXA2R Gene

Pathways & Interactions for ANXA2R Gene

SuperPathways for ANXA2R Gene

No Data Available

Interacting Proteins for ANXA2R Gene

Selected Interacting proteins: Q3ZCQ2-AX2R_HUMAN for ANXA2R Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ANXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ANXA2R: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA2R Gene

Drugs & Compounds for ANXA2R Gene

No Compound Related Data Available

Transcripts for ANXA2R Gene

mRNA/cDNA for ANXA2R Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANXA2R Gene

Annexin A2 receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA2R

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2R Gene

No ASD Table

Relevant External Links for ANXA2R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA2R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA2R Gene

mRNA differential expression in normal tissues according to GTEx for ANXA2R Gene

This gene is overexpressed in Whole Blood (x7.7) and Spleen (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of ANXA2R Gene:


SOURCE GeneReport for Unigene cluster for ANXA2R Gene:


mRNA Expression by UniProt/SwissProt for ANXA2R Gene:

Tissue specificity: Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4(+) and CD8(+) T-cells.

Evidence on tissue expression from TISSUES for ANXA2R Gene

  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with ANXA2R: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA2R Gene

Orthologs for ANXA2R Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ANXA2R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANXA2R 34 33
  • 99.48 (n)
Species where no ortholog for ANXA2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANXA2R Gene

Gene Tree for ANXA2R (if available)
Gene Tree for ANXA2R (if available)
Evolutionary constrained regions (ECRs) for ANXA2R: view image

Paralogs for ANXA2R Gene Pseudogenes for ANXA2R Gene

genes like me logo Genes that share paralogs with ANXA2R: view

No data available for Paralogs for ANXA2R Gene

Variants for ANXA2R Gene

Sequence variations from dbSNP and Humsavar for ANXA2R Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000524274 -- 43,039,957(-) T/C coding_sequence_variant, synonymous_variant
rs1001091892 -- 43,041,100(-) C/T upstream_transcript_variant
rs1002947846 -- 43,042,251(-) G/A upstream_transcript_variant
rs1003042753 -- 43,042,083(-) G/C upstream_transcript_variant
rs1004268361 -- 43,041,837(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA2R Gene

Variant ID Type Subtype PubMed ID
nsv597925 CNV gain 21841781
nsv462126 CNV gain 19166990
nsv1029288 CNV loss 25217958

Variation tolerance for ANXA2R Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA2R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA2R Gene

Disorders for ANXA2R Gene

Additional Disease Information for ANXA2R

No disorders were found for ANXA2R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA2R Gene

Publications for ANXA2R Gene

  1. Cloning and characterization of the annexin II receptor on human marrow stromal cells. (PMID: 16895901) Lu G … Roodman GD (The Journal of biological chemistry 2006) 2 3 4 22 58
  2. Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. (PMID: 18636554) Shiozawa Y … Taichman RS (Journal of cellular biochemistry 2008) 2 3 22 58
  3. Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures. (PMID: 10359570) Menaa C … Roodman GD (The Journal of clinical investigation 1999) 3 4 58
  4. hnRNPs and ELAVL1 cooperate with uORFs to inhibit protein translation. (PMID: 27789685) Zhang J … Chen M (Nucleic acids research 2016) 3 58
  5. Overexpression of Annexin II Receptor-Induced Autophagy Protects Against Apoptosis in Uveal Melanoma Cells. (PMID: 27183438) Zhang Y … Zhao S (Cancer biotherapy & radiopharmaceuticals 2016) 3 58

Products for ANXA2R Gene

Sources for ANXA2R Gene

Loading form....