Aliases for ANXA2P2 Gene

Aliases for ANXA2P2 Gene

  • Annexin A2 Pseudogene 2 2 3 4 5
  • ANX2L2 3 4
  • ANX2P2 3 4
  • LPC2B 3 4
  • Annexin II (Lipocortin II) Pseudogene 2 3
  • Putative Annexin A2-Like Protein 4
  • Lipocortin II Pseudogene 4
  • ANXA2P2 5

External Ids for ANXA2P2 Gene

Previous HGNC Symbols for ANXA2P2 Gene

  • ANX2P2
  • ANX2L2
  • LPC2B

Previous GeneCards Identifiers for ANXA2P2 Gene

  • GC09P033936
  • GC09U900026
  • GC09P033614
  • GC09P033582
  • GC09P033627
  • GC09P033632
  • GC09P033706
  • GC09P033743
  • GC09P033780
  • GC09P033819
  • GC09P033830
  • GC09P033876
  • GC09P034300
  • GC09P034412
  • GC09P034380
  • GC09P034631
  • GC09P033909
  • GC09P033949
  • GC09P033985
  • GC09P034021
  • GC09P034068
  • GC09P034105
  • GC09P034260
  • GC09P034238

Summaries for ANXA2P2 Gene

GeneCards Summary for ANXA2P2 Gene

ANXA2P2 (Annexin A2 Pseudogene 2) is a Pseudogene. Diseases associated with ANXA2P2 include Gastric Cancer. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding.

UniProtKB/Swiss-Prot Summary for ANXA2P2 Gene

  • Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Additional gene information for ANXA2P2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANXA2P2 Gene

Genomics for ANXA2P2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANXA2P2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA2P2 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the ANXA2P2 gene promoter:
  • AML1a
  • AREB6
  • c-Myc
  • E47
  • HTF
  • Max
  • Pax-2a
  • Pax-2b
  • Tal-1beta
  • Zic3

Genomic Locations for ANXA2P2 Gene

Genomic Locations for ANXA2P2 Gene
chr9:33,624,225-33,625,534
(GRCh38/hg38)
Size:
1,310 bases
Orientation:
Plus strand
chr9:33,624,223-33,625,532
(GRCh37/hg19)
Size:
1,310 bases
Orientation:
Plus strand

Genomic View for ANXA2P2 Gene

Genes around ANXA2P2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA2P2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA2P2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA2P2 Gene

Proteins for ANXA2P2 Gene

  • Protein details for ANXA2P2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMY6-AXA2L_HUMAN
    Recommended name:
    Putative annexin A2-like protein
    Protein Accession:
    A6NMY6

    Protein attributes for ANXA2P2 Gene

    Size:
    339 amino acids
    Molecular mass:
    38659 Da
    Quaternary structure:
    • Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2P2/p36.
    Miscellaneous:
    • It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

neXtProt entry for ANXA2P2 Gene

Post-translational modifications for ANXA2P2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANXA2P2 Gene

Domains & Families for ANXA2P2 Gene

Protein Domains for ANXA2P2 Gene

Suggested Antigen Peptide Sequences for ANXA2P2 Gene

GenScript: Design optimal peptide antigens:
  • Lipocortin II pseudogene (AXA2L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NMY6

UniProtKB/Swiss-Prot:

AXA2L_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA2P2: view

No data available for Gene Families for ANXA2P2 Gene

Function for ANXA2P2 Gene

Molecular function for ANXA2P2 Gene

UniProtKB/Swiss-Prot Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
GENATLAS Biochemistry:
annexin A2,pseudogene 2

Phenotypes From GWAS Catalog for ANXA2P2 Gene

Gene Ontology (GO) - Molecular Function for ANXA2P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IBA 21873635
GO:0002020 protease binding IBA 21873635
GO:0005262 calcium channel activity IBA 21873635
GO:0005509 calcium ion binding IBA 21873635
GO:0005544 calcium-dependent phospholipid binding IBA 21873635
genes like me logo Genes that share ontologies with ANXA2P2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA2P2 Gene

Localization for ANXA2P2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA2P2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. In melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ANXA2P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with ANXA2P2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ANXA2P2 Gene

Pathways & Interactions for ANXA2P2 Gene

PathCards logo

SuperPathways for ANXA2P2 Gene

No Data Available

Interacting Proteins for ANXA2P2 Gene

Selected Interacting proteins: A6NMY6-AXA2L_HUMAN for ANXA2P2 Gene via IID

Gene Ontology (GO) - Biological Process for ANXA2P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043086 negative regulation of catalytic activity IEA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ANXA2P2: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA2P2 Gene

Drugs & Compounds for ANXA2P2 Gene

(1) Drugs for ANXA2P2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with ANXA2P2: view

Transcripts for ANXA2P2 Gene

mRNA/cDNA for ANXA2P2 Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2P2 Gene

No ASD Table

Relevant External Links for ANXA2P2 Gene

GeneLoc Exon Structure for
ANXA2P2

Expression for ANXA2P2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANXA2P2 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA2P2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for ANXA2P2 Gene

This gene is overexpressed in Lavage (39.8) and Urine (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA2P2 Gene



Protein tissue co-expression partners for ANXA2P2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANXA2P2

SOURCE GeneReport for Unigene cluster for ANXA2P2 Gene:

Hs.534301
genes like me logo Genes that share expression patterns with ANXA2P2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA2P2 Gene

Orthologs for ANXA2P2 Gene

Evolution for ANXA2P2 Gene

ENSEMBL:
Gene Tree for ANXA2P2 (if available)
TreeFam:
Gene Tree for ANXA2P2 (if available)

No data available for Orthologs for ANXA2P2 Gene

Paralogs for ANXA2P2 Gene

(15) SIMAP similar genes for ANXA2P2 Gene using alignment to 1 proteins:

  • AXA2L_HUMAN
genes like me logo Genes that share paralogs with ANXA2P2: view

No data available for Paralogs for ANXA2P2 Gene

Variants for ANXA2P2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANXA2P2 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv471653 CNV gain 15918152
nsv614150 CNV gain 21841781
nsv972307 CNV duplication 23825009

Additional Variant Information for ANXA2P2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA2P2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for ANXA2P2 Gene

Disorders for ANXA2P2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANXA2P2 Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ANXA2P2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA2P2 Gene

Publications for ANXA2P2 Gene

  1. Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication. (PMID: 2174397) Spano F … Melli M (Gene 1990) 3 4
  2. Chromosomal localization of the human genes for lipocortin I and lipocortin II. (PMID: 2969496) Huebner K … Wallner BP (Oncogene research 1988) 2 3
  3. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  4. High Expression of ANXA2 Pseudogene ANXA2P2 Promotes an Aggressive Phenotype in Hepatocellular Carcinoma. (PMID: 30881525) Wang QS … Hu JL (Disease markers 2019) 3
  5. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3

Products for ANXA2P2 Gene

Sources for ANXA2P2 Gene