Aliases for ANXA2 Gene
External Ids for ANXA2 Gene
Previous HGNC Symbols for ANXA2 Gene
Previous GeneCards Identifiers for ANXA2 Gene
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. [provided by RefSeq, Dec 2019]
GeneCards Summary for ANXA2 Gene
ANXA2 (Annexin A2) is a Protein Coding gene. Diseases associated with ANXA2 include Antiphospholipid Syndrome and Acute Promyelocytic Leukemia. Among its related pathways are Dissolution of Fibrin Clot and Tyrosine Kinases / Adaptors. Gene Ontology (GO) annotations related to this gene include Rab GTPase binding. An important paralog of this gene is ANXA1.
UniProtKB/Swiss-Prot Summary for ANXA2 Gene
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).