This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, re... See more...

Aliases for ANXA2 Gene

Aliases for ANXA2 Gene

  • Annexin A2 2 3 4 5
  • Annexin II 2 3 4
  • Placental Anticoagulant Protein IV 3 4
  • Calpactin I Heavy Chain 3 4
  • Calpactin-1 Heavy Chain 3 4
  • Lipocortin II 3 4
  • Annexin-2 3 4
  • Protein I 3 4
  • ANX2L4 3 4
  • PAP-IV 3 4
  • CAL1H 3 4
  • LPC2D 3 4
  • ANX2 3 4
  • LIP2 2 3
  • P36 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Epididymis Secretory Protein Li 270 3
  • Calpactin I Heavy Polypeptide 3
  • Chromobindin 8 3
  • Chromobindin-8 4
  • HEL-S-270 3
  • ANXA2 5
  • LPC2 3

External Ids for ANXA2 Gene

Previous HGNC Symbols for ANXA2 Gene

  • ANX2
  • ANX2L4
  • CAL1H
  • LPC2D

Previous GeneCards Identifiers for ANXA2 Gene

  • GC15M056197
  • GC15M053687
  • GC15M058218
  • GC15M058355
  • GC15M058426
  • GC15M060639
  • GC15M037461

Summaries for ANXA2 Gene

Entrez Gene Summary for ANXA2 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. [provided by RefSeq, Dec 2019]

GeneCards Summary for ANXA2 Gene

ANXA2 (Annexin A2) is a Protein Coding gene. Diseases associated with ANXA2 include Antiphospholipid Syndrome and Acute Promyelocytic Leukemia. Among its related pathways are Dissolution of Fibrin Clot and Tyrosine Kinases / Adaptors. Gene Ontology (GO) annotations related to this gene include Rab GTPase binding. An important paralog of this gene is ANXA1.

UniProtKB/Swiss-Prot Summary for ANXA2 Gene

  • Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).

Gene Wiki entry for ANXA2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANXA2 Gene

Genomics for ANXA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANXA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANXA2

Top Transcription factor binding sites by QIAGEN in the ANXA2 gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3

Genomic Locations for ANXA2 Gene

Genomic Locations for ANXA2 Gene
chr15:60,347,134-60,402,883
(GRCh38/hg38)
Size:
55,750 bases
Orientation:
Minus strand
chr15:60,639,333-60,695,082
(GRCh37/hg19)
Size:
55,750 bases
Orientation:
Minus strand

Genomic View for ANXA2 Gene

Genes around ANXA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA2 Gene

Proteins for ANXA2 Gene

  • Protein details for ANXA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07355-ANXA2_HUMAN
    Recommended name:
    Annexin A2
    Protein Accession:
    P07355
    Secondary Accessions:
    • Q567R4
    • Q6N0B3
    • Q8TBV2
    • Q96DD5
    • Q9UDH8

    Protein attributes for ANXA2 Gene

    Size:
    339 amino acids
    Molecular mass:
    38604 Da
    Quaternary structure:
    • Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH (PubMed:21886777). Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR (PubMed:18799458). Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (PubMed:14522961). Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity).
    • (Microbial infection) Interacts with human cytomegalovirus (HCMV).
    SequenceCaution:
    • Sequence=AAH66955.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

    Three dimensional structures from OCA and Proteopedia for ANXA2 Gene

    Alternative splice isoforms for ANXA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA2 Gene

Post-translational modifications for ANXA2 Gene

Antibody Products

No data available for DME Specific Peptides for ANXA2 Gene

Domains & Families for ANXA2 Gene

Gene Families for ANXA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for ANXA2 Gene

InterPro:
Blocks:
  • Annexin
  • Annexin type II signature
ProtoNet:

Suggested Antigen Peptide Sequences for ANXA2 Gene

GenScript: Design optimal peptide antigens:
  • p36 (ANXA2_HUMAN)
  • cDNA FLJ34687 fis, clone MESAN2000620, highly similar to Annexin A2 (B3KRQ1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P07355

UniProtKB/Swiss-Prot:

ANXA2_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA2: view

Function for ANXA2 Gene

Molecular function for ANXA2 Gene

UniProtKB/Swiss-Prot Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).
GENATLAS Biochemistry:
annexin A2,calcium and phospholipid binding protein,calpactin 1,involved in exocytosis,overexpressed in small cell lung carcinoma

Phenotypes From GWAS Catalog for ANXA2 Gene

Gene Ontology (GO) - Molecular Function for ANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IBA 21873635
GO:0002020 protease binding IPI 22848640
GO:0003723 RNA binding IEA,HDA 22658674
GO:0004859 phospholipase inhibitor activity IEA --
GO:0004867 serine-type endopeptidase inhibitor activity IDA 22848640
genes like me logo Genes that share ontologies with ANXA2: view
genes like me logo Genes that share phenotypes with ANXA2: view

Animal Models for ANXA2 Gene

MGI Knock Outs for ANXA2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA2 Gene

Localization for ANXA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endosome 5
lysosome 5
cytosol 4
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005576 extracellular region HDA,TAS --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ANXA2: view

Pathways & Interactions for ANXA2 Gene

genes like me logo Genes that share pathways with ANXA2: view

Pathways by source for ANXA2 Gene

1 BioSystems pathway for ANXA2 Gene
1 KEGG pathway for ANXA2 Gene
1 GeneGo (Thomson Reuters) pathway for ANXA2 Gene
  • Regulation of CFTR activity (norm and CF)
2 Cell Signaling Technology pathways for ANXA2 Gene

SIGNOR curated interactions for ANXA2 Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for ANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 11866539
GO:0001765 membrane raft assembly IMP 23861394
GO:0001921 positive regulation of receptor recycling IDA 22848640
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006900 vesicle budding from membrane IMP 23861394
genes like me logo Genes that share ontologies with ANXA2: view

Drugs & Compounds for ANXA2 Gene

(32) Drugs for ANXA2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluocinolone Acetonide Approved, Investigational, Vet_approved Pharma Target, inducer 47
Tenecteplase Approved Pharma Target 51
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 115
Lanoteplase Investigational Pharma Target 0
Calcium Nutra 6556

(34) Additional Compounds for ANXA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA2: view

Transcripts for ANXA2 Gene

mRNA/cDNA for ANXA2 Gene

4 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
38 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - - - -
SP7:
SP8: - - -
SP9: - - - - - - -
SP10:

Relevant External Links for ANXA2 Gene

GeneLoc Exon Structure for
ANXA2

Expression for ANXA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANXA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for ANXA2 Gene

This gene is overexpressed in Adipocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA2 Gene



Protein tissue co-expression partners for ANXA2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANXA2

SOURCE GeneReport for Unigene cluster for ANXA2 Gene:

Hs.511605

Evidence on tissue expression from TISSUES for ANXA2 Gene

  • Liver(5)
  • Skin(5)
  • Pancreas(5)
  • Nervous system(5)
  • Intestine(5)
  • Lung(4.9)
  • Heart(4.9)
  • Kidney(4.8)
  • Blood(4.8)
  • Bone(4.8)
  • Eye(4.8)
  • Stomach(4.7)
  • Muscle(3.8)
  • Thyroid gland(3.2)
  • Lymph node(3)
  • Spleen(3)
  • Adrenal gland(2.9)
  • Bone marrow(2.8)
  • Gall bladder(2.7)
  • Urine(2)
genes like me logo Genes that share expression patterns with ANXA2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA2 Gene

Orthologs for ANXA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
OneToMany
ANXA2 30
  • 99.21 (n)
-- 31
  • 98 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ANXA2 31
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ANXA2 31
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ANXA2 30 31
  • 93.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANXA2 30 31
  • 93.02 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Anxa2 30 17 31
  • 89.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Anxa2 30
  • 89.58 (n)
Chicken
(Gallus gallus)
Aves ANXA2 30 31
  • 81.22 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANXA2 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia anxa2 30
  • 74.04 (n)
MGC76145 30
African clawed frog
(Xenopus laevis)
Amphibia LOC397754 30
Zebrafish
(Danio rerio)
Actinopterygii anxa2a 30 31
  • 67.26 (n)
OneToMany
anxa2b 31
  • 64 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8679 30
Worm
(Caenorhabditis elegans)
Secernentea nex-1 31
  • 38 (a)
ManyToMany
nex-3 31 32
  • 36 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7864 31
  • 16 (a)
ManyToMany
Species where no ortholog for ANXA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ANXA2 Gene

ENSEMBL:
Gene Tree for ANXA2 (if available)
TreeFam:
Gene Tree for ANXA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANXA2: view image

Paralogs for ANXA2 Gene

(15) SIMAP similar genes for ANXA2 Gene using alignment to 23 proteins:

  • ANXA2_HUMAN
  • H0YKL9_HUMAN
  • H0YKN4_HUMAN
  • H0YKS4_HUMAN
  • H0YKV8_HUMAN
  • H0YKX9_HUMAN
  • H0YKZ7_HUMAN
  • H0YL33_HUMAN
  • H0YLE2_HUMAN
  • H0YLV6_HUMAN
  • H0YM50_HUMAN
  • H0YMD0_HUMAN
  • H0YMD9_HUMAN
  • H0YMM1_HUMAN
  • H0YMT9_HUMAN
  • H0YMU9_HUMAN
  • H0YMW4_HUMAN
  • H0YN28_HUMAN
  • H0YN42_HUMAN
  • H0YN52_HUMAN
  • H0YNA0_HUMAN
  • H0YNB8_HUMAN
  • H0YNP5_HUMAN

Pseudogenes.org Pseudogenes for ANXA2 Gene

genes like me logo Genes that share paralogs with ANXA2: view

Variants for ANXA2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANXA2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs17845226 - p.Val98Leu

Additional dbSNP identifiers (rs#s) for ANXA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANXA2 Gene

Variant ID Type Subtype PubMed ID
esv1071950 CNV insertion 17803354
esv1613497 CNV insertion 17803354
esv2592269 CNV insertion 19546169
esv2656603 CNV deletion 23128226
esv3323259 CNV insertion 20981092
esv3326091 CNV insertion 20981092
esv3636663 CNV loss 21293372
esv3636664 CNV loss 21293372
nsv7266 OTHER inversion 18451855
nsv951969 CNV deletion 24416366

Variation tolerance for ANXA2 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA2 Gene

Disorders for ANXA2 Gene

MalaCards: The human disease database

(17) MalaCards diseases for ANXA2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
antiphospholipid syndrome
  • acromegaloid facial appearance syndrome
acute promyelocytic leukemia
  • apl
keloid formation
pancreatic cancer
  • pancreatic carcinoma
dic in newborn
  • disseminated intravascular coagulation in newborn
- elite association - COSMIC cancer census association via MalaCards
Search ANXA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ANXA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ANXA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA2 Gene

Publications for ANXA2 Gene

  1. CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis. (PMID: 14522961) Kirshner J … Shively JE (The Journal of biological chemistry 2003) 3 4 23
  2. The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein. (PMID: 8636985) Burger A … Weber K (Journal of molecular biology 1996) 3 4 23
  3. An endothelial cell-surface form of annexin II binds human cytomegalovirus. (PMID: 8117306) Wright JF … Wasi S (Biochemical and biophysical research communications 1994) 3 4 23
  4. The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha. (PMID: 1825830) Jindal HK … Vishwanatha JK (The Journal of biological chemistry 1991) 3 4 23
  5. Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9. (PMID: 24808179) Ly K … Day R (The Journal of biological chemistry 2014) 3 4

Products for ANXA2 Gene

Sources for ANXA2 Gene