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Aliases for ANXA13 Gene

Aliases for ANXA13 Gene

  • Annexin A13 2 3 3 5
  • Intestine-Specific Annexin 3 4
  • Annexin XIII 3 4
  • Annexin-13 3 4
  • ANX13 3 4
  • ISA 3 4
  • Annexin, Intestine-Specific 3

External Ids for ANXA13 Gene

Previous HGNC Symbols for ANXA13 Gene

  • ANX13

Previous GeneCards Identifiers for ANXA13 Gene

  • GC08M123834
  • GC08M124750
  • GC08M124361
  • GC08M124649
  • GC08M124762
  • GC08M120019
  • GC08M124693

Summaries for ANXA13 Gene

Entrez Gene Summary for ANXA13 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA13 Gene

ANXA13 (Annexin A13) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphatidylserine binding. An important paralog of this gene is ANXA7.

Gene Wiki entry for ANXA13 Gene

Additional gene information for ANXA13 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA13 Gene

Genomics for ANXA13 Gene

GeneHancer (GH) Regulatory Elements for ANXA13 Gene

Promoters and enhancers for ANXA13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J123733 Promoter/Enhancer 1.6 EPDnew FANTOM5 ENCODE dbSUPER 663.3 -0.3 -252 8.2 SOX13 FOXA2 MAX YY1 POLR2A ZNF207 TCF7L2 RXRA NFIA USF2 ANXA13 ENSG00000253106 GC08P123742 LOC105375739
GH08J123534 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 +198.8 198842 9 PKNOX1 ARID4B SIN3A FEZF1 ZBTB7B YY1 GLIS2 ZNF213 SP3 MXD4 FBXO32 LOC105375738 ANXA13 RNF139-AS1 WDYHV1 ATAD2 GC08M123523
GH08J123688 Enhancer 1.2 Ensembl ENCODE dbSUPER 15.9 +45.5 45456 6 FOXA2 NFRKB RAD21 RARA RFX5 ZNF143 RUNX3 DEK SMARCA5 ZNF362 ANXA13 TATDN1 KLHL38 ATAD2 WDYHV1 LOC105375738 FBXO32 DUTP2 MIR548AA1 RNU6-875P
GH08J123546 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.2 +189.7 189749 3 PKNOX1 NEUROD1 BATF IRF4 RFX5 SCRT2 FOS RCOR1 IKZF2 CREM GC08P123547 FBXO32 LOC105375738 ANXA13 KLHL38 ATAD2 WDYHV1 ENSG00000254113
GH08J123579 Enhancer 1 Ensembl ENCODE 10.8 +156.5 156529 2.1 FOXA2 ZFP64 RARA FOS CEBPB TGIF2 ZNF217 NFIL3 SMARCA4 KLF16 LOC105375738 KLHL38 ANXA13 FBXO32 ATAD2 WDYHV1 RN7SKP155 ENSG00000254113
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANXA13 gene promoter:
  • p53
  • Nkx2-5
  • Hlf
  • STAT5B
  • GATA-2
  • Lhx3a
  • LHX3b
  • MEF-2A
  • aMEF-2

Genomic Locations for ANXA13 Gene

Genomic Locations for ANXA13 Gene
56,614 bases
Minus strand
56,614 bases
Minus strand

Genomic View for ANXA13 Gene

Genes around ANXA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA13 Gene

Proteins for ANXA13 Gene

  • Protein details for ANXA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A13
    Protein Accession:
    Secondary Accessions:
    • Q9BQR5

    Protein attributes for ANXA13 Gene

    316 amino acids
    Molecular mass:
    35415 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANXA13 Gene


neXtProt entry for ANXA13 Gene

Post-translational modifications for ANXA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA13 Gene

No data available for DME Specific Peptides for ANXA13 Gene

Domains & Families for ANXA13 Gene

Gene Families for ANXA13 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ANXA13 Gene

Suggested Antigen Peptide Sequences for ANXA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA13: view

Function for ANXA13 Gene

Molecular function for ANXA13 Gene

GENATLAS Biochemistry:
annexin A13,calcium and phospholipid binding protein

Phenotypes From GWAS Catalog for ANXA13 Gene

Gene Ontology (GO) - Molecular Function for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005544 calcium-dependent phospholipid binding IEA --
genes like me logo Genes that share ontologies with ANXA13: view
genes like me logo Genes that share phenotypes with ANXA13: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA13 Gene

Localization for ANXA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA13 Gene

Cell membrane. Note=Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA13 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane NAS 1530946
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ANXA13: view

Pathways & Interactions for ANXA13 Gene

SuperPathways for ANXA13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation NAS 1530946
genes like me logo Genes that share ontologies with ANXA13: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA13 Gene

Drugs & Compounds for ANXA13 Gene

(1) Drugs for ANXA13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with ANXA13: view

Transcripts for ANXA13 Gene

mRNA/cDNA for ANXA13 Gene

Unigene Clusters for ANXA13 Gene

Annexin A13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for ANXA13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA13 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x20.6), Colon - Transverse (x8.0), and Brain - Spinal cord (cervical c-1) (x6.3).

Protein differential expression in normal tissues from HIPED for ANXA13 Gene

This gene is overexpressed in Fetal gut (56.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA13 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANXA13 Gene:


SOURCE GeneReport for Unigene cluster for ANXA13 Gene:


mRNA Expression by UniProt/SwissProt for ANXA13 Gene:

Tissue specificity: Gut specific.

Evidence on tissue expression from TISSUES for ANXA13 Gene

  • Liver(4.3)
  • Intestine(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with ANXA13: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA13 Gene

Orthologs for ANXA13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANXA13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANXA13 34 33
  • 99.44 (n)
(Canis familiaris)
Mammalia ANXA13 34 33
  • 89.54 (n)
(Mus musculus)
Mammalia Anxa13 16 34 33
  • 85.28 (n)
(Bos Taurus)
Mammalia ANXA13 34
  • 85 (a)
(Rattus norvegicus)
Mammalia Anxa13 33
  • 84.15 (n)
(Ornithorhynchus anatinus)
Mammalia ANXA13 34
  • 76 (a)
(Monodelphis domestica)
Mammalia ANXA13 34
  • 59 (a)
(Gallus gallus)
Aves ANXA13 34 33
  • 71.26 (n)
(Anolis carolinensis)
Reptilia ANXA13 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa13 33
  • 65.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25115 33
(Danio rerio)
Actinopterygii anxa13 33
  • 58.03 (n)
anxa13l 34
  • 54 (a)
Dr.16504 33
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 34 35
  • 48 (a)
AnnX 34 35
  • 41 (a)
Anxb11 34 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea nex-1 35 33
  • 49.06 (n)
nex-2 35
  • 46 (a)
nex-4 34
  • 25 (a)
(Oryza sativa)
Liliopsida Os09g0394900 33
  • 48.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4592 34
  • 43 (a)
Species where no ortholog for ANXA13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA13 Gene

Gene Tree for ANXA13 (if available)
Gene Tree for ANXA13 (if available)
Evolutionary constrained regions (ECRs) for ANXA13: view image

Paralogs for ANXA13 Gene

Paralogs for ANXA13 Gene

(15) SIMAP similar genes for ANXA13 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANXA13: view

Variants for ANXA13 Gene

Sequence variations from dbSNP and Humsavar for ANXA13 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000022725 -- 123,739,135(-) C/A upstream_transcript_variant
rs1000055906 -- 123,719,321(-) C/T intron_variant
rs1000076265 -- 123,703,757(-) A/G intron_variant
rs1000146174 -- 123,703,492(-) T/C intron_variant
rs1000153981 -- 123,692,666(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA13 Gene

Variant ID Type Subtype PubMed ID
nsv1032155 CNV loss 25217958
nsv612140 CNV loss 21841781
nsv6373 CNV deletion 18451855
nsv831451 CNV gain+loss 17160897

Variation tolerance for ANXA13 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.51; 85.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA13 Gene

Disorders for ANXA13 Gene

Additional Disease Information for ANXA13

No disorders were found for ANXA13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA13 Gene

Publications for ANXA13 Gene

  1. Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins. (PMID: 11961095) Iglesias JM … Fernandez MP (Molecular biology and evolution 2002) 3 4 22 58
  2. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. (PMID: 9503022) Morgan RO … Fernandez MP (Genomics 1998) 2 3 22 58
  3. A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin. (PMID: 1530946) Wice BM … Gordon JI (The Journal of cell biology 1992) 3 4 22 58
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 44 58
  5. Structure-function relationship in annexin A13, the founder member of the vertebrate family of annexins. (PMID: 15813707) Turnay J … Lizarbe MA (The Biochemical journal 2005) 3 22 58

Products for ANXA13 Gene

Sources for ANXA13 Gene

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