Aliases for ANXA13 Gene
External Ids for ANXA13 Gene
Previous HGNC Symbols for ANXA13 Gene
Previous GeneCards Identifiers for ANXA13 Gene
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for ANXA13 Gene
ANXA13 (Annexin A13) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphatidylserine binding. An important paralog of this gene is ANXA7.
UniProtKB/Swiss-Prot Summary for ANXA13 Gene
Isoform A: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605).
Isoform B: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.