This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and di... See more...

Aliases for ANXA13 Gene

Aliases for ANXA13 Gene

  • Annexin A13 2 3 4 5
  • Intestine-Specific Annexin 3 4
  • Annexin XIII 3 4
  • Annexin-13 3 4
  • ANX13 3 4
  • ISA 3 4
  • Annexin, Intestine-Specific 3

External Ids for ANXA13 Gene

Previous HGNC Symbols for ANXA13 Gene

  • ANX13

Previous GeneCards Identifiers for ANXA13 Gene

  • GC08M123834
  • GC08M124750
  • GC08M124361
  • GC08M124649
  • GC08M124762
  • GC08M120019
  • GC08M124693

Summaries for ANXA13 Gene

Entrez Gene Summary for ANXA13 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA13 Gene

ANXA13 (Annexin A13) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphatidylserine binding. An important paralog of this gene is ANXA7.

UniProtKB/Swiss-Prot Summary for ANXA13 Gene

  • Isoform A: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605).
  • Isoform B: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.

Gene Wiki entry for ANXA13 Gene

Additional gene information for ANXA13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANXA13 Gene

Genomics for ANXA13 Gene

GeneHancer (GH) Regulatory Elements for ANXA13 Gene

Promoters and enhancers for ANXA13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANXA13 gene promoter:
  • aMEF-2
  • GATA-2
  • Hlf
  • Lhx3a
  • LHX3b
  • MEF-2A
  • Nkx2-5
  • p53
  • STAT5B

Genomic Locations for ANXA13 Gene

Genomic Locations for ANXA13 Gene
chr8:123,680,794-123,737,407
(GRCh38/hg38)
Size:
56,614 bases
Orientation:
Minus strand
chr8:124,693,034-124,749,647
(GRCh37/hg19)
Size:
56,614 bases
Orientation:
Minus strand

Genomic View for ANXA13 Gene

Genes around ANXA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA13 Gene

Proteins for ANXA13 Gene

  • Protein details for ANXA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27216-ANX13_HUMAN
    Recommended name:
    Annexin A13
    Protein Accession:
    P27216
    Secondary Accessions:
    • Q9BQR5

    Protein attributes for ANXA13 Gene

    Size:
    316 amino acids
    Molecular mass:
    35415 Da
    Quaternary structure:
    • Isoform A: Monomer and homodimer.

    Three dimensional structures from OCA and Proteopedia for ANXA13 Gene

    Alternative splice isoforms for ANXA13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA13 Gene

Post-translational modifications for ANXA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA13 Gene

No data available for DME Specific Peptides for ANXA13 Gene

Domains & Families for ANXA13 Gene

Gene Families for ANXA13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ANXA13 Gene

Suggested Antigen Peptide Sequences for ANXA13 Gene

GenScript: Design optimal peptide antigens:
  • Intestine-specific annexin (ANX13_HUMAN)
  • Annexin A13 (Q6FHB6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P27216

UniProtKB/Swiss-Prot:

ANX13_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA13: view

Function for ANXA13 Gene

Molecular function for ANXA13 Gene

UniProtKB/Swiss-Prot Function:
Isoform A: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605).
UniProtKB/Swiss-Prot Function:
Isoform B: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.
GENATLAS Biochemistry:
annexin A13,calcium and phospholipid binding protein

Phenotypes From GWAS Catalog for ANXA13 Gene

Gene Ontology (GO) - Molecular Function for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 27676605
GO:0005509 calcium ion binding IDA,IEA 27676605
GO:0005544 calcium-dependent phospholipid binding IEA,IDA 27676605
GO:1901611 phosphatidylglycerol binding IDA,IBA 27676605
genes like me logo Genes that share ontologies with ANXA13: view
genes like me logo Genes that share phenotypes with ANXA13: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA13 Gene

Localization for ANXA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA13 Gene

Apical cell membrane. Cell membrane; Lipid-anchor. Cytoplasmic vesicle. Note=Myristoylation anchors the protein to the membrane, but the protein displays also calcium-dependent, reversible binding to lipid membranes (PubMed:30610115). Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes (PubMed:1530946). {ECO:0000269 PubMed:1530946, ECO:0000269 PubMed:30610115}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA13 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane NAS 1530946
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IDA 27676605
genes like me logo Genes that share ontologies with ANXA13: view

Pathways & Interactions for ANXA13 Gene

PathCards logo

SuperPathways for ANXA13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation NAS 1530946
GO:0042998 positive regulation of Golgi to plasma membrane protein transport IBA 21873635
genes like me logo Genes that share ontologies with ANXA13: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA13 Gene

Drugs & Compounds for ANXA13 Gene

(1) Drugs for ANXA13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773
genes like me logo Genes that share compounds with ANXA13: view

Transcripts for ANXA13 Gene

mRNA/cDNA for ANXA13 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for ANXA13 Gene

GeneLoc Exon Structure for
ANXA13
ECgene alternative splicing isoforms for
ANXA13

Expression for ANXA13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA13 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x20.6), Colon - Transverse (x8.0), and Brain - Spinal cord (cervical c-1) (x6.3).

Protein differential expression in normal tissues from HIPED for ANXA13 Gene

This gene is overexpressed in Fetal gut (56.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA13 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANXA13 Gene:

ANXA13

SOURCE GeneReport for Unigene cluster for ANXA13 Gene:

Hs.181107

mRNA Expression by UniProt/SwissProt for ANXA13 Gene:

P27216-ANX13_HUMAN
Tissue specificity: Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum.

Evidence on tissue expression from TISSUES for ANXA13 Gene

  • Liver(4.3)
  • Intestine(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with ANXA13: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA13 Gene

Orthologs for ANXA13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANXA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA13 33 32
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA13 33 32
  • 89.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa13 17 33 32
  • 85.28 (n)
cow
(Bos Taurus)
Mammalia ANXA13 33
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa13 32
  • 84.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA13 33
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANXA13 33
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANXA13 33 32
  • 71.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA13 33
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa13 32
  • 65.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25115 32
zebrafish
(Danio rerio)
Actinopterygii anxa13 32
  • 58.03 (n)
anxa13l 33
  • 54 (a)
OneToMany
Dr.16504 32
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 33 34
  • 48 (a)
OneToMany
AnnX 33 34
  • 41 (a)
OneToMany
Anxb11 33 34
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nex-1 34 32
  • 49.06 (n)
nex-2 34
  • 46 (a)
nex-4 33
  • 25 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os09g0394900 32
  • 48.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4592 33
  • 43 (a)
OneToOne
Species where no ortholog for ANXA13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA13 Gene

ENSEMBL:
Gene Tree for ANXA13 (if available)
TreeFam:
Gene Tree for ANXA13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANXA13: view image

Paralogs for ANXA13 Gene

(15) SIMAP similar genes for ANXA13 Gene using alignment to 3 proteins:

  • ANX13_HUMAN
  • E5RIN3_HUMAN
  • Q6FHB6_HUMAN
genes like me logo Genes that share paralogs with ANXA13: view

Variants for ANXA13 Gene

Sequence variations from dbSNP and Humsavar for ANXA13 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000022725 -- 123,739,135(-) C/A upstream_transcript_variant
rs1000055906 -- 123,719,321(-) C/T intron_variant
rs1000076265 -- 123,703,757(-) A/G intron_variant
rs1000146174 -- 123,703,492(-) T/C intron_variant
rs1000153981 -- 123,692,666(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA13 Gene

Variant ID Type Subtype PubMed ID
nsv1032155 CNV loss 25217958
nsv612140 CNV loss 21841781
nsv6373 CNV deletion 18451855
nsv831451 CNV gain+loss 17160897

Variation tolerance for ANXA13 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.51; 85.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA13 Gene

Disorders for ANXA13 Gene

Additional Disease Information for ANXA13

No disorders were found for ANXA13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA13 Gene

Publications for ANXA13 Gene

  1. Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins. (PMID: 11961095) Iglesias JM … Fernandez MP (Molecular biology and evolution 2002) 3 4 23 56
  2. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. (PMID: 9503022) Morgan RO … Fernandez MP (Genomics 1998) 2 3 23 56
  3. A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin. (PMID: 1530946) Wice BM … Gordon JI (The Journal of cell biology 1992) 3 4 23 56
  4. An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding. (PMID: 30610115) McCulloch KM … Iverson TM (The Journal of biological chemistry 2019) 3 4 56
  5. Structural and lipid-binding characterization of human annexin A13a reveals strong differences with its long A13b isoform. (PMID: 27676605) Fernández-Lizarbe S … Turnay J (Biological chemistry 2017) 3 4 56

Products for ANXA13 Gene

Sources for ANXA13 Gene