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Aliases for ANXA11 Gene

Aliases for ANXA11 Gene

  • Annexin A11 2 3 3 5
  • Calcyclin-Associated Annexin 50 3 4
  • 56 KDa Autoantigen 3 4
  • Annexin XI 3 4
  • Annexin-11 3 4
  • CAP-50 3 4
  • ANX11 3 4
  • ALS23 3
  • CAP50 3

External Ids for ANXA11 Gene

Previous HGNC Symbols for ANXA11 Gene

  • ANX11

Previous GeneCards Identifiers for ANXA11 Gene

  • GC10M080871
  • GC10M081136
  • GC10M082046
  • GC10M081579
  • GC10M081904
  • GC10M075758

Summaries for ANXA11 Gene

Entrez Gene Summary for ANXA11 Gene

  • This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

GeneCards Summary for ANXA11 Gene

ANXA11 (Annexin A11) is a Protein Coding gene. Diseases associated with ANXA11 include Amyotrophic Lateral Sclerosis 23 and Amyotrophic Lateral Sclerosis 1. Gene Ontology (GO) annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is ANXA7.

UniProtKB/Swiss-Prot for ANXA11 Gene

  • Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

Gene Wiki entry for ANXA11 Gene

Additional gene information for ANXA11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA11 Gene

Genomics for ANXA11 Gene

GeneHancer (GH) Regulatory Elements for ANXA11 Gene

Promoters and enhancers for ANXA11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J080192 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 659.9 +4.4 4400 16.8 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 ANXA11 MBL1P ENSG00000235858 LINC00857 ENSG00000272489 MAT1A DYDC2 PLAC9 SH2D4B LOC642361
GH10J080153 Enhancer 1.4 Ensembl ENCODE dbSUPER 20.2 +44.1 44145 15.4 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 FOS DEK REST SMARCB1 LINC00857 ENSG00000272489 MBL1P ANXA11 PLAC9 MAT1A SFTPD TSPAN14 GC10M080155 PIR39736
GH10J080077 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.2 +126.8 126774 2.6 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF143 SP3 SP5 TMEM254-AS1 TMEM254 PGGT1BP2 NPAP1P2 ZNF519P1 LOC105378386 ANXA11 LINC00857
GH10J080453 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.2 -258.7 -258690 22.7 HDGF PKNOX1 ARNT SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 ZNF207 TSPAN14 FAM213A ENSG00000272489 LOC101929574 DYDC1 DYDC2 ANXA11 PLAC9 MBL1P SH2D4B
GH10J080406 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.4 -206.1 -206069 10.7 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143 FAM213A DYDC2 LOC642361 DYDC1 MBL1P PLAC9 ANXA11 PIR57963
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANXA11 gene promoter:
  • IRF-1
  • Bach2
  • RSRFC4
  • Arnt
  • GR-alpha
  • GR
  • GR-beta

Genomic Locations for ANXA11 Gene

Genomic Locations for ANXA11 Gene
chr10:80,150,889-80,205,677
(GRCh38/hg38)
Size:
54,789 bases
Orientation:
Minus strand
chr10:81,910,645-81,965,328
(GRCh37/hg19)
Size:
54,684 bases
Orientation:
Minus strand

Genomic View for ANXA11 Gene

Genes around ANXA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA11 Gene

Proteins for ANXA11 Gene

  • Protein details for ANXA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50995-ANX11_HUMAN
    Recommended name:
    Annexin A11
    Protein Accession:
    P50995
    Secondary Accessions:
    • B4DVE7

    Protein attributes for ANXA11 Gene

    Size:
    505 amino acids
    Molecular mass:
    54390 Da
    Quaternary structure:
    • Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.

    Alternative splice isoforms for ANXA11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA11 Gene

Post-translational modifications for ANXA11 Gene

  • Ubiquitination at Lys499, posLast=378378, Lys271, Lys264, and posLast=214214
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANXA11 Gene

Domains & Families for ANXA11 Gene

Gene Families for ANXA11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for ANXA11 Gene

Graphical View of Domain Structure for InterPro Entry

P50995

UniProtKB/Swiss-Prot:

ANX11_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA11: view

Function for ANXA11 Gene

Molecular function for ANXA11 Gene

UniProtKB/Swiss-Prot Function:
Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.
GENATLAS Biochemistry:
annexin A11,calcium and phospholipid binding protein,two alternatively spliced isoforms

Phenotypes From GWAS Catalog for ANXA11 Gene

Gene Ontology (GO) - Molecular Function for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 9268363
GO:0005544 calcium-dependent phospholipid binding IEA --
GO:0008429 phosphatidylethanolamine binding IEA --
genes like me logo Genes that share ontologies with ANXA11: view
genes like me logo Genes that share phenotypes with ANXA11: view

Human Phenotype Ontology for ANXA11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA11 Gene

Localization for ANXA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA11 Gene

Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA11 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
lysosome 5
plasma membrane 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope NAS 12577318
GO:0005654 nucleoplasm NAS 12577318
GO:0005737 cytoplasm IEA,IDA 7508441
GO:0005819 spindle IDA,IEA 12805373
genes like me logo Genes that share ontologies with ANXA11: view

Pathways & Interactions for ANXA11 Gene

SuperPathways for ANXA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEP 9188810
GO:0007049 cell cycle IEA --
GO:0032506 cytokinetic process IMP 15197175
GO:0051301 cell division IEA --
GO:0051592 response to calcium ion IDA 9188810
genes like me logo Genes that share ontologies with ANXA11: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA11 Gene

Drugs & Compounds for ANXA11 Gene

(1) Drugs for ANXA11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(1) Additional Compounds for ANXA11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA11: view

Transcripts for ANXA11 Gene

Unigene Clusters for ANXA11 Gene

Annexin A11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - -
SP13: - -
SP14: - - -
SP15: - - - - - - - -
SP16:
SP17: - - - - - -
SP18: - - - - - - - - - - - -
SP19:
SP20: - - - -

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for ANXA11 Gene

GeneLoc Exon Structure for
ANXA11
ECgene alternative splicing isoforms for
ANXA11

Expression for ANXA11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA11 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA11 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for ANXA11 Gene

This gene is overexpressed in Lymph node (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA11 Gene



Protein tissue co-expression partners for ANXA11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANXA11 Gene:

ANXA11

SOURCE GeneReport for Unigene cluster for ANXA11 Gene:

Hs.530291

Evidence on tissue expression from TISSUES for ANXA11 Gene

  • Liver(4.5)
  • Spleen(4.3)
  • Nervous system(4.1)
  • Lung(3.9)
  • Intestine(3.8)
  • Skin(3.3)
  • Pancreas(2.8)
  • Kidney(2.6)
  • Blood(2.5)
  • Muscle(2.4)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with ANXA11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA11 Gene

Orthologs for ANXA11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA11 34 33
  • 95.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANXA11 34 33
  • 90.16 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA11 34 33
  • 89.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa11 16 34 33
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Anxa11 33
  • 88.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA11 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANXA11 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANXA11 34 33
  • 73.17 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA11 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa11 33
  • 67.78 (n)
Str.8682 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13331 33
zebrafish
(Danio rerio)
Actinopterygii anxa11a 34 33 33
  • 64.51 (n)
OneToMany
anxa11b 34
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1200 33
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 35 33
  • 58.58 (n)
Anxb11 35
  • 49 (a)
AnnX 35
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta ANXB9 33
  • 55.48 (n)
worm
(Caenorhabditis elegans)
Secernentea nex-2 34 35
  • 41 (a)
OneToMany
nex-1 35
  • 41 (a)
nex-3 35
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
Species where no ortholog for ANXA11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA11 Gene

ENSEMBL:
Gene Tree for ANXA11 (if available)
TreeFam:
Gene Tree for ANXA11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANXA11: view image

Paralogs for ANXA11 Gene

Paralogs for ANXA11 Gene

(15) SIMAP similar genes for ANXA11 Gene using alignment to 7 proteins:

  • ANX11_HUMAN
  • B4DVE7_HUMAN
  • H0Y6E1_HUMAN
  • Q5T0G7_HUMAN
  • Q5T0G8_HUMAN
  • Q5T0G9_HUMAN
  • Q6ICS0_HUMAN
genes like me logo Genes that share paralogs with ANXA11: view

Variants for ANXA11 Gene

Sequence variations from dbSNP and Humsavar for ANXA11 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs142083484 pathogenic, AMYOTROPHIC LATERAL SCLEROSIS 23 80,170,859(-) C/T coding_sequence_variant, missense_variant
rs754594235 pathogenic, AMYOTROPHIC LATERAL SCLEROSIS 23 80,169,007(-) C/A/T coding_sequence_variant, missense_variant
rs1000003603 -- 80,205,611(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000005841 -- 80,201,984(-) C/G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000093545 -- 80,168,909(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA11 Gene

Variant ID Type Subtype PubMed ID
esv3623946 CNV loss 21293372
esv3623947 CNV gain 21293372
nsv1141879 OTHER inversion 24896259
nsv551635 CNV loss 21841781

Variation tolerance for ANXA11 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.56; 97.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA11 Gene

Human Gene Mutation Database (HGMD)
ANXA11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA11 Gene

Disorders for ANXA11 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ANXA11 Gene - From: HGMD, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANXA11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ANXA11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA11 Gene

Publications for ANXA11 Gene

  1. The 56K autoantigen is identical to human annexin XI. (PMID: 7508441) Misaki Y … van Venrooij WJ (The Journal of biological chemistry 1994) 2 3 4 22 58
  2. Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PMID: 18256029) Shibata H … Maki M (The Journal of biological chemistry 2008) 3 4 22 58
  3. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. (PMID: 19165924) Hofmann S … Schreiber S (Nature genetics 2008) 3 22 44 58
  4. Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display. (PMID: 12805373) Farnaes L … Ditzel HJ (The Journal of biological chemistry 2003) 3 4 22 58
  5. ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. (PMID: 11883939) Satoh H … Maki M (Biochemical and biophysical research communications 2002) 3 4 22 58

Products for ANXA11 Gene

Sources for ANXA11 Gene

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