This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants en... See more...

Aliases for ANXA11 Gene

Aliases for ANXA11 Gene

  • Annexin A11 2 3 4 5
  • Calcyclin-Associated Annexin 50 3 4
  • 56 KDa Autoantigen 3 4
  • Annexin XI 3 4
  • Annexin-11 3 4
  • CAP-50 3 4
  • ANX11 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • ALS23 3
  • CAP50 3

External Ids for ANXA11 Gene

Previous HGNC Symbols for ANXA11 Gene

  • ANX11

Previous GeneCards Identifiers for ANXA11 Gene

  • GC10M080871
  • GC10M081136
  • GC10M082046
  • GC10M081579
  • GC10M081904
  • GC10M075758

Summaries for ANXA11 Gene

Entrez Gene Summary for ANXA11 Gene

  • This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

GeneCards Summary for ANXA11 Gene

ANXA11 (Annexin A11) is a Protein Coding gene. Diseases associated with ANXA11 include Amyotrophic Lateral Sclerosis 23 and Amyotrophic Lateral Sclerosis 1. Gene Ontology (GO) annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is ANXA7.

UniProtKB/Swiss-Prot Summary for ANXA11 Gene

  • Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

Gene Wiki entry for ANXA11 Gene

Additional gene information for ANXA11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANXA11 Gene

Genomics for ANXA11 Gene

GeneHancer (GH) Regulatory Elements for ANXA11 Gene

Promoters and enhancers for ANXA11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANXA11 gene promoter:
  • Arnt
  • Bach2
  • GR
  • GR-alpha
  • GR-beta
  • IRF-1
  • RSRFC4

Genomic Locations for ANXA11 Gene

Genomic Locations for ANXA11 Gene
chr10:80,150,889-80,205,677
(GRCh38/hg38)
Size:
54,789 bases
Orientation:
Minus strand
chr10:81,910,645-81,965,328
(GRCh37/hg19)
Size:
54,684 bases
Orientation:
Minus strand

Genomic View for ANXA11 Gene

Genes around ANXA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA11 Gene

Proteins for ANXA11 Gene

  • Protein details for ANXA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50995-ANX11_HUMAN
    Recommended name:
    Annexin A11
    Protein Accession:
    P50995
    Secondary Accessions:
    • B4DVE7

    Protein attributes for ANXA11 Gene

    Size:
    505 amino acids
    Molecular mass:
    54390 Da
    Quaternary structure:
    • Interacts with S100A6 (PubMed:28469040). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.

    Alternative splice isoforms for ANXA11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA11 Gene

Post-translational modifications for ANXA11 Gene

  • Ubiquitination at Lys214, Lys264, Lys271, Lys378, and Lys499
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANXA11 Gene

Domains & Families for ANXA11 Gene

Gene Families for ANXA11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for ANXA11 Gene

Suggested Antigen Peptide Sequences for ANXA11 Gene

GenScript: Design optimal peptide antigens:
  • Calcyclin-associated annexin 50 (ANX11_HUMAN)
  • cDNA FLJ58379, highly similar to Annexin A11 (B4DVE7_HUMAN)
  • Annexin A11 (Q5JTC2_HUMAN)
  • cDNA FLJ44306 fis, clone TRACH2025084, highly similar to Annexin A11 (Q5T0G8_HUMAN)
  • Annexin A11 variant (Q6ICS0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50995

UniProtKB/Swiss-Prot:

ANX11_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA11: view

Function for ANXA11 Gene

Molecular function for ANXA11 Gene

UniProtKB/Swiss-Prot Function:
Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.
GENATLAS Biochemistry:
annexin A11,calcium and phospholipid binding protein,two alternatively spliced isoforms

Phenotypes From GWAS Catalog for ANXA11 Gene

Gene Ontology (GO) - Molecular Function for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005509 calcium ion binding IBA 21873635
GO:0005515 protein binding IBA,IPI 9268363
GO:0005544 calcium-dependent phospholipid binding IBA 21873635
GO:0008429 phosphatidylethanolamine binding IBA 21873635
genes like me logo Genes that share ontologies with ANXA11: view
genes like me logo Genes that share phenotypes with ANXA11: view

Human Phenotype Ontology for ANXA11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA11 Gene

Localization for ANXA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA11 Gene

Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA11 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
lysosome 5
plasma membrane 2
extracellular 2
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope NAS 12577318
GO:0005654 nucleoplasm NAS 12577318
GO:0005737 cytoplasm IDA,IBA 7508441
GO:0005819 spindle IEA,IDA 12805373
genes like me logo Genes that share ontologies with ANXA11: view

Pathways & Interactions for ANXA11 Gene

PathCards logo

SuperPathways for ANXA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEP,IBA 9188810
GO:0007049 cell cycle IEA --
GO:0032506 cytokinetic process IBA,IMP 15197175
GO:0051301 cell division IEA --
GO:0051592 response to calcium ion IDA,IBA 9188810
genes like me logo Genes that share ontologies with ANXA11: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA11 Gene

Drugs & Compounds for ANXA11 Gene

(1) Drugs for ANXA11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773

(1) Additional Compounds for ANXA11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA11: view

Transcripts for ANXA11 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - -
SP13: - -
SP14: - - -
SP15: - - - - - - - -
SP16:
SP17: - - - - - -
SP18: - - - - - - - - - - - -
SP19:
SP20: - - - -

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for ANXA11 Gene

GeneLoc Exon Structure for
ANXA11
ECgene alternative splicing isoforms for
ANXA11

Expression for ANXA11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA11 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA11 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for ANXA11 Gene

This gene is overexpressed in Lymph node (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA11 Gene



Protein tissue co-expression partners for ANXA11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANXA11 Gene:

ANXA11

SOURCE GeneReport for Unigene cluster for ANXA11 Gene:

Hs.530291

Evidence on tissue expression from TISSUES for ANXA11 Gene

  • Liver(4.5)
  • Spleen(4.3)
  • Nervous system(4.1)
  • Lung(3.9)
  • Intestine(3.8)
  • Skin(3.3)
  • Pancreas(2.8)
  • Kidney(2.6)
  • Blood(2.5)
  • Muscle(2.4)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with ANXA11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA11 Gene

Orthologs for ANXA11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA11 33 32
  • 95.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANXA11 33 32
  • 90.16 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA11 33 32
  • 89.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa11 17 33 32
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Anxa11 32
  • 88.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA11 33
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANXA11 33
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANXA11 33 32
  • 73.17 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA11 33
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa11 32
  • 67.78 (n)
Str.8682 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.13331 32
zebrafish
(Danio rerio)
Actinopterygii anxa11a 33 32 32
  • 64.51 (n)
OneToMany
anxa11b 33
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1200 32
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 34 32
  • 58.58 (n)
Anxb11 34
  • 49 (a)
AnnX 34
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta ANXB9 32
  • 55.48 (n)
worm
(Caenorhabditis elegans)
Secernentea nex-2 33 34
  • 41 (a)
OneToMany
nex-1 34
  • 41 (a)
nex-3 34
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 44 (a)
OneToMany
Species where no ortholog for ANXA11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA11 Gene

ENSEMBL:
Gene Tree for ANXA11 (if available)
TreeFam:
Gene Tree for ANXA11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANXA11: view image

Paralogs for ANXA11 Gene

(15) SIMAP similar genes for ANXA11 Gene using alignment to 7 proteins:

  • ANX11_HUMAN
  • B4DVE7_HUMAN
  • H0Y6E1_HUMAN
  • Q5T0G7_HUMAN
  • Q5T0G8_HUMAN
  • Q5T0G9_HUMAN
  • Q6ICS0_HUMAN
genes like me logo Genes that share paralogs with ANXA11: view

Variants for ANXA11 Gene

Sequence variations from dbSNP and Humsavar for ANXA11 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1247392012 pathogenic, AMYOTROPHIC LATERAL SCLEROSIS 23, Amyotrophic lateral sclerosis 23 (ALS23) [MIM:617839] 80,170,852(-) T/C coding_sequence_variant, missense_variant
rs142083484 pathogenic, AMYOTROPHIC LATERAL SCLEROSIS 23, Amyotrophic lateral sclerosis 23 (ALS23) [MIM:617839] 80,170,859(-) C/T coding_sequence_variant, missense_variant
rs569546089 Amyotrophic lateral sclerosis 23 (ALS23) [MIM:617839] 80,167,309(-) C/T coding_sequence_variant, missense_variant
rs754594235 pathogenic, AMYOTROPHIC LATERAL SCLEROSIS 23, Amyotrophic lateral sclerosis 23 (ALS23) [MIM:617839] 80,169,007(-) C/A/T coding_sequence_variant, missense_variant
rs765489119 Amyotrophic lateral sclerosis 23 (ALS23) [MIM:617839] 80,166,930(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA11 Gene

Variant ID Type Subtype PubMed ID
esv3623946 CNV loss 21293372
esv3623947 CNV gain 21293372
nsv1141879 OTHER inversion 24896259
nsv551635 CNV loss 21841781

Variation tolerance for ANXA11 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.56; 97.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA11 Gene

Human Gene Mutation Database (HGMD)
ANXA11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA11 Gene

Disorders for ANXA11 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ANXA11 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 23
  • als23
amyotrophic lateral sclerosis 1
  • als1
papillary hidradenoma
  • tubular sweat gland adenomas
lateral sclerosis
  • adult-onset primary lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ANX11_HUMAN
  • Amyotrophic lateral sclerosis 23 (ALS23) [MIM:617839]: A form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. ALS23 is an autosomal dominant form with incomplete penetrance. {ECO:0000269 PubMed:28469040}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ANXA11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ANXA11: view

No data available for Genatlas for ANXA11 Gene

Publications for ANXA11 Gene

  1. The 56K autoantigen is identical to human annexin XI. (PMID: 7508441) Misaki Y … van Venrooij WJ (The Journal of biological chemistry 1994) 2 3 4 23 56
  2. Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PMID: 18256029) Shibata H … Maki M (The Journal of biological chemistry 2008) 3 4 23 56
  3. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. (PMID: 19165924) Hofmann S … Schreiber S (Nature genetics 2008) 3 23 43 56
  4. Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display. (PMID: 12805373) Farnaes L … Ditzel HJ (The Journal of biological chemistry 2003) 3 4 23 56
  5. ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. (PMID: 11883939) Satoh H … Maki M (Biochemical and biophysical research communications 2002) 3 4 23 56

Products for ANXA11 Gene

Sources for ANXA11 Gene