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This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]
ANXA10 (Annexin A10) is a Protein Coding gene. Diseases associated with ANXA10 include Miyoshi Muscular Dystrophy and Lynch Syndrome. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04J168165 | Promoter | 0.7 | EPDnew | 600.2 | +72.7 | 72657 | 0.1 | REST FOXA1 SP1 CEBPA SCRT2 FOXA2 YY1 TEAD1 FOXP1 HNF4A | ANXA10 ENSG00000287188 piR-34093-024 DDX60 | |
GH04J168092 | Promoter | 0.3 | EPDnew | 600.7 | 0.0 | -7 | 0.1 | ANXA10 ENSG00000248601 piR-40497-045 SPOCK3 | ||
GH04J168094 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE dbSUPER | 5.9 | +5.3 | 5272 | 5.6 | POLR2A CEBPB JUN FOS JUND EP300 FOSL2 STAT3 | ANXA10 ENSG00000248601 DDX60 | |
GH04J168136 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 7.1 | +46.1 | 46056 | 3.5 | CEBPB FOS EP300 TCF7L2 MAFK JUND NFE2L2 MAFF | ANXA10 piR-34093-024 ENSG00000287188 DDX60 | |
GH04J168123 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 7.3 | +32.1 | 32053 | 1.6 | JUND CEBPB FOS FOSL2 MAFK POLR2A | ANXA10 ENSG00000248601 piR-34093-024 DDX60 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | TAS,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 21516116 |
GO:0005544 | calcium-dependent phospholipid binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ANXA10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ANXA10 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Anxa10 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ANXA10 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Anxa10 30 |
|
||
Cow (Bos Taurus) |
Mammalia | ANXA10 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ANXA10 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ANXA10 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | anxa10 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | anxa13 31 |
|
ManyToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | nex-1 31 |
|
ManyToMany | |
nex-3 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7864 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv194e55 | CNV | loss | 17911159 |
esv2759301 | CNV | gain+loss | 17122850 |
esv3603095 | CNV | gain | 21293372 |
esv3603096 | CNV | loss | 21293372 |
nsv1073814 | CNV | deletion | 25765185 |
nsv1109652 | CNV | deletion | 24896259 |
nsv1125827 | CNV | tandem duplication | 24896259 |
nsv1136922 | CNV | deletion | 24896259 |
nsv293790 | CNV | deletion | 16902084 |
nsv428455 | CNV | gain | 18775914 |
nsv521908 | CNV | loss | 19592680 |
nsv820236 | CNV | gain | 19587683 |
nsv822825 | CNV | gain | 20364138 |
nsv830146 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
miyoshi muscular dystrophy |
|
|
lynch syndrome |
|
|