This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. [provided by RefSeq, Jul 2008] See more...

Aliases for ANXA10 Gene

Aliases for ANXA10 Gene

  • Annexin A10 2 3 4 5
  • Annexin-10 3 4
  • ANX14 3 4
  • Annexin 14 3
  • Annexin-14 4

External Ids for ANXA10 Gene

Previous GeneCards Identifiers for ANXA10 Gene

  • GC04P169783
  • GC04P169435
  • GC04P169598
  • GC04P169709
  • GC04P169388
  • GC04P169250
  • GC04P169013
  • GC04P164764

Summaries for ANXA10 Gene

Entrez Gene Summary for ANXA10 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA10 Gene

ANXA10 (Annexin A10) is a Protein Coding gene. Diseases associated with ANXA10 include Miyoshi Muscular Dystrophy and Lynch Syndrome. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA4.

Additional gene information for ANXA10 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANXA10 Gene

Genomics for ANXA10 Gene

GeneHancer (GH) Regulatory Elements for ANXA10 Gene

Promoters and enhancers for ANXA10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J168165 Promoter 0.7 EPDnew 500.2 +72.7 72656 0.1 TEAD1 FOXA2 FOXP1 HNF4A REST FOXA1 YY1 HNF4G EP300 SP1 ANXA10 ENSG00000287188 piR-34093-024
GH04J168092 Promoter 0.3 EPDnew 500.7 0.0 -8 0.1 ANXA10 ENSG00000248601 piR-40497-045
GH04J168094 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 5.9 +5.3 5271 5.6 EP300 FOS FOSL2 JUN STAT3 JUND GATA2 POLR2A CEBPB ANXA10 ENSG00000248601
GH04J168123 Enhancer 0.8 Ensembl ENCODE dbSUPER 7.3 +32.1 32052 1.6 JUND FOS FOSL2 MAFK GATA2 POLR2A CEBPB ANXA10 ENSG00000248601 piR-34093-024
GH04J168136 Enhancer 0.8 Ensembl ENCODE dbSUPER 7.1 +46.1 46055 3.5 FOS EP300 CEBPB MAFK JUND TCF7L2 NFE2L2 MAFF ANXA10 piR-34093-024 ENSG00000287188
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANXA10

Top Transcription factor binding sites by QIAGEN in the ANXA10 gene promoter:
  • Cdc5
  • FAC1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-3
  • HFH-1
  • Nkx6-1
  • Oct-B1
  • oct-B2
  • oct-B3

Genomic Locations for ANXA10 Gene

Genomic Locations for ANXA10 Gene
95,217 bases
Plus strand
95,228 bases
Plus strand

Genomic View for ANXA10 Gene

Genes around ANXA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA10 Gene

Proteins for ANXA10 Gene

  • Protein details for ANXA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A10
    Protein Accession:
    Secondary Accessions:
    • Q96IQ5
    • Q9UJV4

    Protein attributes for ANXA10 Gene

    324 amino acids
    Molecular mass:
    37278 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANXA10 Gene

Post-translational modifications for ANXA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANXA10 Gene

Domains & Families for ANXA10 Gene

Gene Families for ANXA10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANXA10 Gene

  • Annexin

Suggested Antigen Peptide Sequences for ANXA10 Gene

GenScript: Design optimal peptide antigens:
  • Annexin-14 (ANX10_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the annexin family.
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA10: view

Function for ANXA10 Gene

Molecular function for ANXA10 Gene

GENATLAS Biochemistry:
annexin A10,progenitor of annexin A6 octad formation via chromosome duplication during early chordate evolution

Phenotypes From GWAS Catalog for ANXA10 Gene

Gene Ontology (GO) - Molecular Function for ANXA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0005544 calcium-dependent phospholipid binding IEA --
genes like me logo Genes that share ontologies with ANXA10: view
genes like me logo Genes that share phenotypes with ANXA10: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA10 Gene

Localization for ANXA10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA10 gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANXA10 Gene

Pathways & Interactions for ANXA10 Gene

PathCards logo

SuperPathways for ANXA10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANXA10 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANXA10 Gene

Drugs & Compounds for ANXA10 Gene

No Compound Related Data Available

Transcripts for ANXA10 Gene

mRNA/cDNA for ANXA10 Gene

6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA10 Gene

No ASD Table

Relevant External Links for ANXA10 Gene

GeneLoc Exon Structure for

Expression for ANXA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANXA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA10 Gene

This gene is overexpressed in Stomach (x39.7) and Liver (x7.1).

Protein differential expression in normal tissues from HIPED for ANXA10 Gene

This gene is overexpressed in Cardia (30.3) and Stomach (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANXA10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANXA10

SOURCE GeneReport for Unigene cluster for ANXA10 Gene:


Evidence on tissue expression from TISSUES for ANXA10 Gene

  • Intestine(4.4)
  • Lung(4.1)
  • Stomach(3)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with ANXA10: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA10 Gene

Orthologs for ANXA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANXA10 31 30
  • 99.28 (n)
(Canis familiaris)
Mammalia ANXA10 31 30
  • 88.16 (n)
(Mus musculus)
Mammalia Anxa10 17 31 30
  • 87.45 (n)
(Monodelphis domestica)
Mammalia ANXA10 31
  • 87 (a)
(Rattus norvegicus)
Mammalia Anxa10 30
  • 85.91 (n)
(Bos Taurus)
Mammalia ANXA10 31 30
  • 84.88 (n)
(Ornithorhynchus anatinus)
Mammalia ANXA10 31
  • 76 (a)
(Gallus gallus)
Aves ANXA10 31 30
  • 79.42 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa10 30
  • 74.59 (n)
(Danio rerio)
Actinopterygii anxa13 31
  • 37 (a)
(Caenorhabditis elegans)
Secernentea nex-1 31
  • 35 (a)
nex-3 31
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7864 31
  • 13 (a)
Species where no ortholog for ANXA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA10 Gene

Gene Tree for ANXA10 (if available)
Gene Tree for ANXA10 (if available)
Evolutionary constrained regions (ECRs) for ANXA10: view image

Paralogs for ANXA10 Gene

(14) SIMAP similar genes for ANXA10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANXA10: view

Variants for ANXA10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANXA10 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs6836994 - p.Met71Leu

Additional dbSNP identifiers (rs#s) for ANXA10 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANXA10 Gene

Variant ID Type Subtype PubMed ID
dgv194e55 CNV loss 17911159
esv2759301 CNV gain+loss 17122850
esv3603095 CNV gain 21293372
esv3603096 CNV loss 21293372
nsv1073814 CNV deletion 25765185
nsv1109652 CNV deletion 24896259
nsv1125827 CNV tandem duplication 24896259
nsv1136922 CNV deletion 24896259
nsv293790 CNV deletion 16902084
nsv428455 CNV gain 18775914
nsv521908 CNV loss 19592680
nsv820236 CNV gain 19587683
nsv822825 CNV gain 20364138
nsv830146 CNV gain 17160897

Variation tolerance for ANXA10 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA10 Gene

Disorders for ANXA10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ANXA10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
miyoshi muscular dystrophy
  • miyoshi myopathy
lynch syndrome
  • colorectal cancer, hereditary nonpolyposis, type 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANXA10

genes like me logo Genes that share disorders with ANXA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA10 Gene

Publications for ANXA10 Gene

  1. Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution. (PMID: 10458909) Morgan RO … Fernandez MP (Genomics 1999) 2 3 4 23 54
  2. Reduced expression and homozygous deletion of annexin A10 in gastric carcinoma. (PMID: 19582876) Kim J … Kim WH (International journal of cancer 2009) 3 23 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation. (PMID: 12000734) Liu SH … Hsu HC (The American journal of pathology 2002) 3 23 54
  5. ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma. (PMID: 30758105) Kodaira H … Yokozaki H (Pathology international 2019) 3 54

Products for ANXA10 Gene

Sources for ANXA10 Gene