Aliases for ANXA1 Gene
Aliases for ANXA1 Gene
External Ids for ANXA1 Gene
- HGNC: 533
- Entrez Gene: 301
- Ensembl: ENSG00000135046
- OMIM: 151690
- UniProtKB: P04083
Previous HGNC Symbols for ANXA1 Gene
- ANX1
- LPC1
Previous GeneCards Identifiers for ANXA1 Gene
- GC09P066811
- GC09P067623
- GC09P069336
- GC09P071223
- GC09P072996
- GC09P074956
- GC09P075766
- GC09P045589
Summaries for ANXA1 Gene
-
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
GeneCards Summary for ANXA1 Gene
ANXA1 (Annexin A1) is a Protein Coding gene. Diseases associated with ANXA1 include Hairy Cell Leukemia and Brain Edema. Among its related pathways are Integrated Breast Cancer Pathway and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include calcium ion binding and signaling receptor binding. An important paralog of this gene is ANXA2.
UniProtKB/Swiss-Prot for ANXA1 Gene
-
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
-
Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.
Additional gene information for ANXA1 Gene
- Monarch Initiative
- Search for ANXA1 at DataMed
- Search for ANXA1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA1 Gene
Genomics for ANXA1 Gene
GeneHancer (GH) Regulatory Elements for ANXA1 Gene
Promoters and enhancers for ANXA1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09J073147 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 662.8 | +0.7 | 712 | 9.6 | PKNOX1 SMAD1 ARNT ZFP64 SIN3A FEZF1 IRF4 POLR2B ZNF766 ZNF213 | ANXA1 GC09M073159 PIR62868 GC09M073140 | |
| GH09J073117 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 16.2 | -33.0 | -32997 | 2.3 | NFIB JUN MAX CEBPG RFX5 FOSL1 FOSL2 FOS NFE2 MAFK | ANXA1 ALDH1A1 GC09P073115 GC09P073141 | |
| GH09J073115 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE dbSUPER | 15.7 | -35.5 | -35488 | 0.8 | JUNB MAFG BATF MAFF ZNF316 JUND MAFK EMSY | GC09P073115 ANXA1 ALDH1A1 GC09P073141 | |
| GH09J072359 | Promoter/Enhancer | 2.5 | EPDnew Ensembl ENCODE dbSUPER | 4.3 | -788.7 | -788656 | 7.9 | HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 | ZFAND5 TMC1 LINC01504 ANXA1 GC09P072358 | |
| GH09J073125 | Enhancer | 0.5 | ENCODE dbSUPER | 19.5 | -25.9 | -25891 | 0.2 | ZNF664 | ANXA1 GC09P073115 GC09P073141 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ANXA1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ANXA1 gene promoter:
-
- STAT3
- C/EBPalpha
- POU2F1a
- POU2F1
- C/EBPbeta
- TGIF
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- AREB6
Regulatory Element Products
Genomic Locations for ANXA1 Gene
Genomic Locations for ANXA1 Gene
- chr9:73,151,731-73,170,393
- (GRCh38/hg38)
- Size:
- 18,663 bases
- Orientation:
- Plus strand
- chr9:75,766,673-75,785,309
- (GRCh37/hg19)
- Size:
- 18,637 bases
- Orientation:
- Plus strand
Genomic View for ANXA1 Gene
Genes around ANXA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.13 by Entrez Gene
- 9q21.13 by HGNC
- 9q21.13 by Ensembl
ANXA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANXA1 Gene
Proteins for ANXA1 Gene
-
Protein details for ANXA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04083-ANXA1_HUMAN
- Recommended name:
- Annexin A1
- Protein Accession:
- P04083
Protein attributes for ANXA1 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 38714 Da
- Quaternary structure:
-
- Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation (PubMed:2532504). Homodimers linked by transglutamylation are observed in placenta, but not in other tissues (PubMed:2532504). Interacts with S100A11 (PubMed:8557678, PubMed:10673436). Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (PubMed:10673436). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).
- Miscellaneous:
-
- Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro) (PubMed:2936963, PubMed:8425544). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.
Protein Expression for ANXA1 Gene
Post-translational modifications for ANXA1 Gene
- Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504).
- Sumoylated.
- Ubiquitination at posLast=274274, Lys166, and Lys58
- Modification sites at PhosphoSitePlus
Other Protein References for ANXA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ANXA1 (Annexin A1)
- Novus Biologicals Antibodies for ANXA1
-
Abcam antibodies for ANXA1
- Invitrogen Antibodies for ANXA1
- antibodies-online: Search results for 379 available Annexin a1 Antibodies ranked by validation data
- Compare Top Annexin a1 Antibodies
-
Recommended
- 249 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 92 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 71 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex ANXA1 Antibody for ANXA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ANXA1
Protein Products
- R&D Systems Proteins and Enzymes for ANXA1 (Annexin A1)
-
OriGene Purified Proteins for ANXA1
- Search Origene for MassSpec and Protein Over-expression Lysates for ANXA1
- Origene Custom Protein Services for ANXA1
- ProSpec Recombinant Proteins for ANXA1
- Search GeneTex for Proteins for ANXA1
-
ProSci Proteins for ANXA1
-
Abcam proteins for ANXA1
No data available for DME Specific Peptides for ANXA1 Gene
Domains & Families for ANXA1 Gene
Gene Families for ANXA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Transporters
Protein Domains for ANXA1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANXA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P04083UniProtKB/Swiss-Prot:
ANXA1_HUMAN :- The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
- Belongs to the annexin family.
- Domain:
-
- The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
- The N-terminal 26 amino acids are sufficient for its extracellular functions in the regulation of inflammation and wound healing (PubMed:25664854). Acylated peptides that contain the first 26 amino acids of the mature protein can activate signaling via the formyl peptide receptors (PubMed:15187149, PubMed:25664854).
- Family:
-
- Belongs to the annexin family.
Function for ANXA1 Gene
Molecular function for ANXA1 Gene
- UniProtKB/Swiss-Prot Function:
- Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
- GENATLAS Biochemistry:
- annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid feadback action in the hypothalamo-hypophysial system
Phenotypes From GWAS Catalog for ANXA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003697 | single-stranded DNA binding | IEA | -- |
| GO:0003727 | single-stranded RNA binding | IEA | -- |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0004859 | phospholipase inhibitor activity | IEA | -- |
| GO:0005102 | signaling receptor binding | TAS | 10882119 |
Phenotypes for ANXA1 Gene
- MGI mutant phenotypes for ANXA1:
-
inferred from 1 alleles
- cardiovascular system phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- skeleton phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for ANXA1:
Animal Models for ANXA1 Gene
- MGI Knock Outs for ANXA1:
-
- Anxa1 Anxa1<tm1Rjf>
Animal Model Products
-
Taconic Biosciences Mouse Models for ANXA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANXA1
-
CRISPR Products
-
OriGene CRISPR knockouts for ANXA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANXA1
- genomics-online: gRNA clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
- Applied Biological Materials CRISPR for ANXA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANXA1
- GenScript: Design CRISPR guide RNA sequences for ANXA1
miRNA for ANXA1 Gene
- miRTarBase miRNAs that target ANXA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANXA1
- Browse OriGene Inhibitory RNA Products For ANXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA1
- genomics-online: shRNA clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ANXA1
- VectorBuilder custom plasmid, inducible vectors for ANXA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANXA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANXA1
- Applied Biological Materials Clones for ANXA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ANXA1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA1 Gene
Localization for ANXA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANXA1 Gene
- Nucleus. Cytoplasm. Cell projection, cilium. Cell membrane. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Basolateral cell membrane. Apical cell membrane. Lateral cell membrane. Secreted. Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted, exosome. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, phagocytic cup. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). {ECO:0000250 UniProtKB:P10107, ECO:0000269 PubMed:10772777, ECO:0000269 PubMed:17008549, ECO:0000269 PubMed:2532504, ECO:0000269 PubMed:25664854, ECO:0000269 PubMed:8557678}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| endosome | 5 |
| mitochondrion | 3 |
| lysosome | 3 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 1 |
- Cytosol (4)
- Nucleoplasm (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001533 | cornified envelope | IDA | 10908733 |
| GO:0001891 | phagocytic cup | IEA | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA,IEA | 17008549 |
| GO:0005634 | nucleus | IDA | 22056994 |
Pathways & Interactions for ANXA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Cytokine Signaling in Immune system | ||
| 4 | RET signaling | ||
| 5 | Ca, cAMP and Lipid Signaling | ||
Pathways by source for ANXA1 Gene
3 BioSystems pathways for ANXA1 Gene
1 Cell Signaling Technology pathway for ANXA1 Gene
Interacting Proteins for ANXA1 Gene
Selected Interacting proteins:
P04083-ANXA1_HUMAN
ENSP00000257497
for ANXA1 Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for ANXA1
SIGNOR curated interactions for ANXA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000733 | DNA strand renaturation | IEA | -- |
| GO:0001780 | neutrophil homeostasis | IMP | 21957127 |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002548 | monocyte chemotaxis | IDA | 15187149 |
Drugs & Compounds for ANXA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist, agonist, Target | Anti-inflammatory glucocorticoid | 2314 | |
| Amcinonide | Approved | Pharma | agonist, Target | 0 | ||
| Hydrocortisone | Approved, Vet_approved | Pharma | Agonist, Target, agonist | 713 | ||
| Prednisolone | Approved, Vet_approved | Pharma | Agonist, binder | 1277 | ||
| calcium | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Ac2-12 |
|
256447-08-2 |
|
|
||
| Ac2-26 |
|
151988-33-9 |
|
|
||
| Heparin sodium salt |
|
9041-08-1 |
|
|
||
| KF 38789 |
|
257292-29-8 |
|
|
||
| PM 102 |
|
1234564-95-4 |
|
|
(5) Tocris Compounds for ANXA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ac2-12 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 256447-08-2 |
| Ac2-26 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 151988-33-9 |
| Heparin sodium salt | Anticoagulant | 9041-08-1 |
| KF 38789 | Selective inhibitor of P-selectin-mediated cell adhesion | 257292-29-8 |
| PM 102 | Antagonist of heparin (Cat. No. 2812) | 1234564-95-4 |
(1) ApexBio Compounds for ANXA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Thiolutin | RNA polymerase inhibitor,antibiotic | 1987-11-6 |
Transcripts for ANXA1 Gene
mRNA/cDNA for ANXA1 Gene
- (3) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (1569) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000257497 1509 bps (uc004ajf.2)
- ENST00000468639 800 bps (uc064ttf.1)
- ENST00000456643 799 bps (uc064ttg.1)
- ENST00000415424 526 bps (uc064tth.1)
- ENST00000376911 2209 bps (uc004ajg.2)
CRISPR Products
-
OriGene CRISPR knockouts for ANXA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANXA1
- genomics-online: gRNA clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
- Applied Biological Materials CRISPR for ANXA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANXA1
- GenScript: Design CRISPR guide RNA sequences for ANXA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANXA1
- Browse OriGene Inhibitory RNA Products For ANXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA1
- genomics-online: shRNA clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ANXA1
- VectorBuilder custom plasmid, inducible vectors for ANXA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANXA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANXA1
- Applied Biological Materials Clones for ANXA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
Expression for ANXA1 Gene
mRNA differential expression in normal tissues according to GTEx for ANXA1 Gene
This gene is overexpressed in Esophagus - Mucosa (x19.5) and Minor Salivary Gland (x6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ANXA1 Gene:
ANXA1SOURCE GeneReport for Unigene cluster for ANXA1 Gene:
Hs.494173mRNA Expression by UniProt/SwissProt for ANXA1 Gene:
P04083-ANXA1_HUMAN
Tissue specificity:
Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.
Evidence on tissue expression from TISSUES for ANXA1 Gene
- Liver(4.9)
- Lung(4.9)
- Nervous system(4.4)
- Bone(4)
- Skin(3.6)
- Stomach(3.6)
- Blood(3.4)
- Thyroid gland(3.4)
- Bone marrow(3.3)
- Intestine(3.3)
- Heart(3.2)
- Spleen(2.8)
- Kidney(2.6)
- Muscle(2.5)
- Adrenal gland(2.4)
- Gall bladder(2.4)
- Lymph node(2.4)
- Pancreas(2.2)
- Eye(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ANXA1
-
OriGene qPCR primer pairs for ANXA1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA1 Gene
Orthologs for ANXA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANXA1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANXA1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ANXA1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Anxa1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Anxa1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANXA1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANXA1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANXA1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ANXA1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | anxa1 33 |
|
||
| MGC76270 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | anxa1-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | anxa1a 34 33 33 |
|
OneToMany | |
| anxa1b 34 |
|
OneToMany | |||
| ANXA1 (4 of 4) 34 |
|
OneToMany | |||
| anxa1c 34 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8605 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | AnnIX 35 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | nex-2 35 |
|
|
|
| nex-1 34 35 |
|
ManyToMany | |||
| nex-3 34 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany |
- Species where no ortholog for ANXA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ANXA1 Gene
- ENSEMBL:
- Gene Tree for ANXA1 (if available)
- TreeFam:
- Gene Tree for ANXA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ANXA1: view image
Paralogs for ANXA1 Gene
Paralogs for ANXA1 Gene
(15) SIMAP similar genes for ANXA1 Gene using alignment to 6 proteins:
- ANXA1_HUMAN
- B5BU38_HUMAN
- Q05BR2_HUMAN
- Q5T3N0_HUMAN
- Q5T3N1_HUMAN
- Q5TZZ9_HUMAN
Variants for ANXA1 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000241754 | -- | 73,170,167(+) | A/G | 3_prime_UTR_variant | |
| rs1000266047 | -- | 73,154,568(+) | A/G | 5_prime_UTR_variant, intron_variant | |
| rs1000373649 | -- | 73,153,274(+) | A/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000594415 | -- | 73,153,045(+) | A/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000754947 | -- | 73,166,252(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv951528 | CNV | duplication | 24416366 |
| nsv6561 | CNV | insertion | 18451855 |
| nsv614612 | CNV | gain | 21841781 |
| nsv526225 | CNV | gain | 19592680 |
| esv3620662 | CNV | gain | 21293372 |
| esv3620661 | CNV | gain | 21293372 |
| esv3620660 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.38;
27.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ANXA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA1 Gene
Disorders for ANXA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hairy cell leukemia |
|
|
| brain edema |
|
|
| rheumatoid arthritis |
|
|
| breast cancer |
|
|
| esophageal cancer |
|
|
Search ANXA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ANXA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA1 Gene
Publications for ANXA1 Gene
- Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PMID: 16883066) Morand EF … Yang YH (Mediators of inflammation 2006) 3 22 25 58
- Calcium-dependent binding of S100C to the N-terminal domain of annexin I. (PMID: 8557678) Mailliard WS … Schlaepfer DD (The Journal of biological chemistry 1996) 3 4 22 58
- Crystal structure of human annexin I at 2.5 A resolution. (PMID: 8453382) Weng X … Huber R (Protein science : a publication of the Protein Society 1993) 3 4 22 58
- Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PMID: 2936963) Wallner BP … Ramachandran KL (Nature 1986) 2 3 4 58
- Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. (PMID: 25664854) Leoni G … Nusrat A (The Journal of clinical investigation 2015) 3 4 58
Products for ANXA1 Gene
- R&D Systems Antibodies for ANXA1 (Annexin A1)
- R&D Systems Proteins and Enzymes for ANXA1 (Annexin A1)
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ANXA1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ANXA1
- Search Origene for MassSpec and Protein Over-expression Lysates for ANXA1
- Origene Custom Protein Services for ANXA1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANXA1
- Browse OriGene Inhibitory RNA Products For ANXA1
- OriGene qPCR primer pairs and template standards for ANXA1
- OriGene qPCR primer pairs for ANXA1
- OriGene CRISPR knockouts for ANXA1
- OriGene ORF clones in human for ANXA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ANXA1
- GenScript: Next-day shipping of latest version cDNA ORF clones for ANXA1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ANXA1
- GenScript Custom Assay Services for ANXA1
- GenScript Custom overexpressing Cell Line Services for ANXA1
- GenScript: Design CRISPR guide RNA sequences for ANXA1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ANXA1
- Sino Biological Human cDNA Clone for ANXA1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ANXA1
- Novus Biologicals lysates and proteins for ANXA1
- Novus Biologicals ELISA Kits for ANXA1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ANXA1
- Abcam proteins for ANXA1
- Abcam assays for ANXA1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for ANXA1
- Taconic Biosciences Mouse Models for ANXA1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ANXA1
- ApexBio compounds for ANXA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANXA1
- VectorBuilder custom plasmid, inducible vectors for ANXA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANXA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANXA1
- antibodies-online: Search results for 379 available Annexin a1 Antibodies ranked by validation data
- Compare Top Annexin a1 Antibodies
- Recommended
- 249 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 92 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 71 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 46 available Annexin a1 Elisa Kits ranked by validation data
- Compare Top Annexin a1 Elisa Kits
- antibodies-online: Search results for 56 available Annexin a1 Proteins ranked by validation data
- Compare Top Annexin a1 Proteins
- GeneTex ANXA1 Antibody for ANXA1
- Search GeneTex for Proteins for ANXA1
- Santa Cruz Biotechnology (SCBT) Antibodies for ANXA1
- Search Santa Cruz Biotechnology (SCBT) for ANXA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ANXA1
- Search for ANXA1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ANXA1
- Horizon Cell Lines for ANXA1
- genomics-online: cdna clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
- orf clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
- genomics-online: gRNA clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
- genomics-online: primer clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
- genomics-online: shRNA clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANXA1
- GeneCopoeia miRNA 3'UTR Target clone products for ANXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA1
Sources for ANXA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt