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This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
ANXA1 (Annexin A1) is a Protein Coding gene. Diseases associated with ANXA1 include Hairy Cell Leukemia and Brain Edema. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and signaling receptor binding. An important paralog of this gene is ANXA2.
Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003697 | single-stranded DNA binding | IEA | -- |
GO:0003727 | single-stranded RNA binding | IEA | -- |
GO:0004859 | phospholipase inhibitor activity | IEA | -- |
GO:0005102 | signaling receptor binding | TAS | 10882119 |
GO:0005509 | calcium ion binding | TAS,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001533 | cornified envelope | IDA | 10908733 |
GO:0001891 | phagocytic cup | IEA | -- |
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA,IDA | 17008549 |
GO:0005634 | nucleus | IEA,IDA | 22056994 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Cytokine Signaling in Immune system | ||
4 | RET signaling | ||
5 | Ca, cAMP and Lipid Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001780 | neutrophil homeostasis | IMP | 21957127 |
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002548 | monocyte chemotaxis | IDA | 15187149 |
GO:0002685 | regulation of leukocyte migration | IBA,ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist, Target, agonist | Anti-inflammatory glucocorticoid | 2886 | |
Amcinonide | Approved | Pharma | Target, agonist | 0 | ||
Hydrocortisone | Approved, Vet_approved | Pharma | Agonist, Target, agonist | 897 | ||
Clobetasol | Approved, Experimental, Investigational | Pharma | Target, inducer, inhibitor | 102 | ||
Methylprednisolone | Approved, Vet_approved | Pharma | Target, agonist | Apoptosis inducer,GR agonist, Glucocorticoid receptor agonist | 1553 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Ac2-12 |
|
256447-08-2 |
|
|
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Ac2-26 |
|
151988-33-9 |
|
|
||
Heparin sodium salt |
|
9041-08-1 |
|
|
||
KF 38789 |
|
257292-29-8 |
|
|
||
PM 102 |
|
1234564-95-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
Ac2-12 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 256447-08-2 |
Ac2-26 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 151988-33-9 |
Heparin sodium salt | Anticoagulant | 9041-08-1 |
KF 38789 | Selective inhibitor of P-selectin-mediated cell adhesion | 257292-29-8 |
PM 102 | Antagonist of heparin (Cat. No. 2812) | 1234564-95-4 |
Compound | Action | Cas Number |
---|---|---|
Thiolutin | RNA polymerase inhibitor,antibiotic | 1987-11-6 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ANXA1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ANXA1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ANXA1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Anxa1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Anxa1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ANXA1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ANXA1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ANXA1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ANXA1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | anxa1 30 |
|
||
MGC76270 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | anxa1-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | anxa1a 30 31 |
|
OneToMany | |
anxa1b 31 |
|
OneToMany | |||
ANXA1 (4 of 4) 31 |
|
OneToMany | |||
anxa1c 31 |
|
OneToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8605 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | AnnIX 32 |
|
|
|
Worm (Caenorhabditis elegans) |
Secernentea | nex-2 32 |
|
|
|
nex-1 31 32 |
|
ManyToMany | |||
nex-3 31 32 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
738641 | Likely Benign: not provided | 73,167,565(+) | A/G | INTRON_VARIANT | |
748693 | Likely Benign: not provided | 73,165,111(+) | G/T | INTRON_VARIANT | |
768303 | Benign: not provided | 73,163,535(+) | A/G | INTRON_VARIANT | |
774466 | Benign: not provided | 73,165,139(+) | G/A | SYNONYMOUS_VARIANT | |
774674 | Likely Benign: not provided | 73,160,259(+) | G/T | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3620660 | CNV | loss | 21293372 |
esv3620661 | CNV | gain | 21293372 |
esv3620662 | CNV | gain | 21293372 |
nsv526225 | CNV | gain | 19592680 |
nsv614612 | CNV | gain | 21841781 |
nsv6561 | CNV | insertion | 18451855 |
nsv951528 | CNV | duplication | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hairy cell leukemia |
|
|
brain edema |
|
|
rheumatoid arthritis |
|
|
penis squamous cell carcinoma |
|
|
colon adenocarcinoma |
|