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This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014] See more...
Aliases for ANXA1 Gene
Aliases for ANXA1 Gene
External Ids for ANXA1 Gene
- HGNC: 533
- Entrez Gene: 301
- Ensembl: ENSG00000135046
- OMIM: 151690
- UniProtKB: P04083
Previous HGNC Symbols for ANXA1 Gene
- ANX1
- LPC1
Previous GeneCards Identifiers for ANXA1 Gene
- GC09P066811
- GC09P067623
- GC09P069336
- GC09P071223
- GC09P072996
- GC09P074956
- GC09P075766
- GC09P045589
Summaries for ANXA1 Gene
-
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
GeneCards Summary for ANXA1 Gene
ANXA1 (Annexin A1) is a Protein Coding gene. Diseases associated with ANXA1 include Hairy Cell Leukemia and Brain Edema. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and signaling receptor binding. An important paralog of this gene is ANXA2.
UniProtKB/Swiss-Prot Summary for ANXA1 Gene
-
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
-
Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.
Additional gene information for ANXA1 Gene
- HGNC(533)
- Entrez Gene(301)
- Ensembl(ENSG00000135046)
- OMIM(151690)
- UniProtKB(P04083)
- Open Targets Platform(ENSG00000135046)
- Monarch Initiative
- Search for ANXA1 at DataMed
- Search for ANXA1 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANXA1 Gene
Genomics for ANXA1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ANXA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ANXA1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANXA1
- Top Transcription factor binding sites by QIAGEN in the ANXA1 gene promoter:
-
- AREB6
- C/EBPalpha
- C/EBPbeta
- POU2F1
- POU2F1a
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- STAT3
- TGIF
Genomic Locations for ANXA1 Gene
Genomic Locations for ANXA1 Gene
- chr9:73,151,865-73,170,393
- (GRCh38/hg38)
- Size:
- 18,529 bases
- Orientation:
- Plus strand
- chr9:75,766,673-75,785,309
- (GRCh37/hg19)
- Size:
- 18,637 bases
- Orientation:
- Plus strand
Genomic View for ANXA1 Gene
Genes around ANXA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.13 by HGNC
- 9q21.13 by Entrez Gene
- 9q21.13 by Ensembl
ANXA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANXA1 Gene
Proteins for ANXA1 Gene
-
Protein details for ANXA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04083-ANXA1_HUMAN
- Recommended name:
- Annexin A1
- Protein Accession:
- P04083
- B5BU38
Protein attributes for ANXA1 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 38714 Da
- Quaternary structure:
-
- Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation (PubMed:2532504). Homodimers linked by transglutamylation are observed in placenta, but not in other tissues (PubMed:2532504). Interacts with S100A11 (PubMed:8557678, PubMed:10673436). Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (PubMed:10673436). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).
- Miscellaneous:
-
- Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro) (PubMed:2936963, PubMed:8425544). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.
Protein Expression for ANXA1 Gene
Post-translational modifications for ANXA1 Gene
- Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504).
- Sumoylated.
-
Glycosylation at Ser37
- NX_P04083 (NX_P04083-1)
-
Ubiquitination at Lys58, Lys166, and Lys274
- NX_P04083 (NX_P04083-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ANXA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ANXA1 / Annexin A1 Antibody (LS-B3028) and ANXA1 / Annexin A1 Antibody (LS-B3363)
- NSJ Bioreagents Annexin A1 Antibody (Protein Microarray-Validated Monoclonal)
- Creative Diagnostics Anti-ANXA1 monoclonal antibody, clone 4B9
- Novus Biologicals Antibodies for ANXA1
-
Abcam antibodies for ANXA1
- Invitrogen Antibodies for ANXA1 (AFLGC-ANXA1)
- antibodies-online: Show 103 available Annexin a1 Antibodies ranked by validation data
- Compare Top Annexin a1 Antibodies
-
Recommended
- 239 WB Antibodies (anti-human)
- 13 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 104 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 75 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ANXA1
- Sino Biological Antibodies for ANXA1
Protein Products
- G Biosciences Human Annexin A1/ANXA1, Lyophilized
- Creative Biomart Recombinant Human annexin A1
- Search Origene for MassSpec and Protein Over-expression Lysates for ANXA1
- Origene Custom Protein Services for ANXA1
- ProSpec Recombinant Proteins for ANXA1
-
ProSci Proteins for ANXA1
-
Abcam proteins for ANXA1
Assay Products
- G Biosciences Immunotag™ Human ANXA1 (Annexin A1) ELISA and Immunotag™ Annexin A1 ELISA Kit
- RayBiotech Human Annexin A1 ELISA
- Creative Diagnostics Human ANXA1 ELISA Matched Antibody Pair (ABPR-0057) and Human ANXA1 ELISA Matched Antibody Pair (ABPR-0056)
-
Custom Assay ServicesOriGene ELISA Kits for ANXA1
- Novus Biologicals ELISA Kits for ANXA1
- antibodies-online: Show 58 available Annexin a1 Elisa Kits ranked by validation data
- Compare Top Annexin a1 Elisa Kits
-
Quality Products:
- ABIN6574319
- ABIN415284
- ABIN365069
- ABIN1568401
- ABIN5519870
- ABIN5519157
- ABIN1081225
- ABIN512788
- ABIN6384251
- ABIN5651824
- ABIN427785
- ABIN827983
- ABIN1568402
- ABIN511903
- ABIN5651826
- ABIN2541390
- ABIN4967170
- ABIN6201661
- ABIN1121982
- ABIN2112097
- ABIN434737
- ABIN5591645
- ABIN509720
- ABIN5651829
- ABIN2945276
- ABIN6201663
- ABIN6201664
- ABIN1121984
- ABIN988941
- ABIN1121980
-
Boster Bio ELISA Kits for ANXA1
-
Abcam assays for ANXA1
No data available for DME Specific Peptides for ANXA1 Gene
Domains & Families for ANXA1 Gene
Gene Families for ANXA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
- Transporters
Protein Domains for ANXA1 Gene
- InterPro:
- Blocks:
-
- Annexin
- Annexin type I signature
- ProtoNet:
Suggested Antigen Peptide Sequences for ANXA1 Gene
- GenScript: Design optimal peptide antigens:
-
- p35 (ANXA1_HUMAN)
- Annexin I (B5BU38_HUMAN)
- ANXA1 protein (Q05BR2_HUMAN)
- Annexin A1, isoform CRA_a (Q5TZZ9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P04083UniProtKB/Swiss-Prot:
ANXA1_HUMAN :- The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
- Belongs to the annexin family.
- Domain:
-
- The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
- The N-terminal 26 amino acids are sufficient for its extracellular functions in the regulation of inflammation and wound healing (PubMed:25664854). Acylated peptides that contain the first 26 amino acids of the mature protein can activate signaling via the formyl peptide receptors (PubMed:15187149, PubMed:25664854).
- Family:
-
- Belongs to the annexin family.
Function for ANXA1 Gene
Molecular function for ANXA1 Gene
- UniProtKB/Swiss-Prot Function:
- Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
- GENATLAS Biochemistry:
- annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid feadback action in the hypothalamo-hypophysial system
Phenotypes From GWAS Catalog for ANXA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003697 | single-stranded DNA binding | IEA | -- |
| GO:0003727 | single-stranded RNA binding | IEA | -- |
| GO:0004859 | phospholipase inhibitor activity | IEA | -- |
| GO:0005102 | signaling receptor binding | TAS | 10882119 |
| GO:0005509 | calcium ion binding | TAS,ISS | -- |
Phenotypes for ANXA1 Gene
- MGI mutant phenotypes for ANXA1:
-
inferred from 1 alleles
- nervous system phenotype
- immune system phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- skeleton phenotype
- hematopoietic system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for ANXA1:
Animal Models for ANXA1 Gene
- MGI Knock Outs for ANXA1:
-
- Anxa1 Anxa1<tm1Rjf>
Animal Model Products
-
Taconic Biosciences Mouse Models for ANXA1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ANXA1 - Select products 50% OFF >
- * ANXA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ANXA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANXA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANXA1
miRNA for ANXA1 Gene
- miRTarBase miRNAs that target ANXA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANXA1
- Browse OriGene Inhibitory RNA Products For ANXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA1
Clone Products
- Applied Biological Materials (abm): Clones for ANXA1 - Select products 50% OFF >
- * ANXA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205210
- MR205210
- MR205210L1
- MR205210L2
- MR205210L3
- MR205210L4
- RC201569
- RC201569L1
- RC201569L2
- RC201569L3
- RC201569L4
- RG201569
- RR204988
- RR204988L1
- RR204988L2
- RR204988L3
- RR204988L4
- MR205210L1V
- MR205210L2V
- MR205210L3V
- MR205210L4V
- RC201569L1V
- RC201569L2V
- RC201569L3V
- RC201569L4V
- RR204988L1V
- RR204988L2V
- RR204988L3V
- RR204988L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANXA1
- Addgene plasmids for ANXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANXA1
Cell Line Products
-
Horizon Cell Lines for ANXA1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA1 Gene
Localization for ANXA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANXA1 Gene
- Nucleus. Cytoplasm. Cell projection, cilium. Cell membrane. Membrane. Peripheral membrane protein. Endosome membrane. Peripheral membrane protein. Basolateral cell membrane. Apical cell membrane. Lateral cell membrane. Secreted. Secreted, extracellular space. Cell membrane. Peripheral membrane protein. Extracellular side. Secreted, extracellular exosome. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, phagocytic cup. Early endosome. Cytoplasmic vesicle membrane. Peripheral membrane protein. Note=Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). {ECO:0000250 UniProtKB:P10107, ECO:0000269 PubMed:10772777, ECO:0000269 PubMed:17008549, ECO:0000269 PubMed:2532504, ECO:0000269 PubMed:25664854, ECO:0000269 PubMed:8557678}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| endosome | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| lysosome | 3 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Cytosol (4)
- Nucleoplasm (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001533 | cornified envelope | IDA | 10908733 |
| GO:0001891 | phagocytic cup | IEA | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA,IDA | 17008549 |
| GO:0005634 | nucleus | IEA,IDA | 22056994 |
Pathways & Interactions for ANXA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Cytokine Signaling in Immune system | ||
| 4 | RET signaling | ||
| 5 | Ca, cAMP and Lipid Signaling | ||
Pathways by source for ANXA1 Gene
3 BioSystems pathways for ANXA1 Gene
1 Cell Signaling Technology pathway for ANXA1 Gene
Interacting Proteins for ANXA1 Gene
Selected Interacting proteins:
P04083-ANXA1_HUMAN
ENSP00000366109
for ANXA1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ANXA1
SIGNOR curated interactions for ANXA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001780 | neutrophil homeostasis | IMP | 21957127 |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002548 | monocyte chemotaxis | IDA | 15187149 |
| GO:0002685 | regulation of leukocyte migration | IBA,ISS | -- |
Drugs & Compounds for ANXA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist, Target, agonist | Anti-inflammatory glucocorticoid | 2886 | |
| Amcinonide | Approved | Pharma | Target, agonist | 0 | ||
| Hydrocortisone | Approved, Vet_approved | Pharma | Agonist, Target, agonist | 897 | ||
| Clobetasol | Approved, Experimental, Investigational | Pharma | Target, inducer, inhibitor | 102 | ||
| Methylprednisolone | Approved, Vet_approved | Pharma | Target, agonist | Apoptosis inducer,GR agonist, Glucocorticoid receptor agonist | 1553 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Ac2-12 |
|
256447-08-2 |
|
|
||
| Ac2-26 |
|
151988-33-9 |
|
|
||
| Heparin sodium salt |
|
9041-08-1 |
|
|
||
| KF 38789 |
|
257292-29-8 |
|
|
||
| PM 102 |
|
1234564-95-4 |
|
|
(5) Tocris Compounds for ANXA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ac2-12 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 256447-08-2 |
| Ac2-26 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 151988-33-9 |
| Heparin sodium salt | Anticoagulant | 9041-08-1 |
| KF 38789 | Selective inhibitor of P-selectin-mediated cell adhesion | 257292-29-8 |
| PM 102 | Antagonist of heparin (Cat. No. 2812) | 1234564-95-4 |
(1) ApexBio Compounds for ANXA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Thiolutin | RNA polymerase inhibitor,antibiotic | 1987-11-6 |
Drug Products
- G Biosciences Human Annexin A1/ANXA1, Lyophilized
- Creative Biomart Recombinant Human annexin A1
- ApexBio compounds for ANXA1
Transcripts for ANXA1 Gene
mRNA/cDNA for ANXA1 Gene
- 1 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000257497 1401 nts (view in UCSC)
- ENST00000468639 800 nts (view in UCSC)
- ENST00000456643 799 nts (view in UCSC)
- ENST00000415424 526 nts (view in UCSC)
- ENST00000376911 2209 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ANXA1 - Select products 50% OFF >
- * ANXA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ANXA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANXA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANXA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANXA1
- Browse OriGene Inhibitory RNA Products For ANXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA1
Clone Products
- Applied Biological Materials (abm): Clones for ANXA1 - Select products 50% OFF >
- * ANXA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205210
- MR205210
- MR205210L1
- MR205210L2
- MR205210L3
- MR205210L4
- RC201569
- RC201569L1
- RC201569L2
- RC201569L3
- RC201569L4
- RG201569
- RR204988
- RR204988L1
- RR204988L2
- RR204988L3
- RR204988L4
- MR205210L1V
- MR205210L2V
- MR205210L3V
- MR205210L4V
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- RR204988L2V
- RR204988L3V
- RR204988L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANXA1
- Addgene plasmids for ANXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANXA1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
Relevant External Links for ANXA1 Gene
- GeneLoc Exon Structure for
- ANXA1
Expression for ANXA1 Gene
mRNA differential expression in normal tissues according to GTEx for ANXA1 Gene
This gene is overexpressed in Esophagus - Mucosa (x19.5) and Minor Salivary Gland (x6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANXA1
SOURCE GeneReport for Unigene cluster for ANXA1 Gene:
Hs.494173mRNA Expression by UniProt/SwissProt for ANXA1 Gene:
P04083-ANXA1_HUMAN
Tissue specificity:
Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.
Evidence on tissue expression from TISSUES for ANXA1 Gene
- Liver(5)
- Lung(4.9)
- Nervous system(4.6)
- Bone(4.4)
- Skin(4)
- Stomach(3.9)
- Intestine(3.8)
- Bone marrow(3.7)
- Blood(3.7)
- Thyroid gland(3.7)
- Heart(3.7)
- Spleen(3.4)
- Muscle(3.3)
- Kidney(3.2)
- Lymph node(3.2)
- Adrenal gland(2.9)
- Pancreas(2.8)
- Eye(2.7)
- Gall bladder(2.7)
- Saliva(2)
Primer Products
-
OriGene qPCR primer pairs for ANXA1
-
OriGene qPCR primer pairs and template standards for ANXA1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA1 Gene
Orthologs for ANXA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ANXA1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ANXA1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ANXA1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Anxa1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Anxa1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | ANXA1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ANXA1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ANXA1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ANXA1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | anxa1 30 |
|
||
| MGC76270 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | anxa1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | anxa1a 30 31 |
|
OneToMany | |
| anxa1b 31 |
|
OneToMany | |||
| ANXA1 (4 of 4) 31 |
|
OneToMany | |||
| anxa1c 31 |
|
OneToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8605 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | AnnIX 32 |
|
|
|
| Worm (Caenorhabditis elegans) |
Secernentea | nex-2 32 |
|
|
|
| nex-1 31 32 |
|
ManyToMany | |||
| nex-3 31 32 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
- Species where no ortholog for ANXA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ANXA1 Gene
- ENSEMBL:
- Gene Tree for ANXA1 (if available)
- TreeFam:
- Gene Tree for ANXA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ANXA1: view image
Paralogs for ANXA1 Gene
Paralogs for ANXA1 Gene
(15) SIMAP similar genes for ANXA1 Gene using alignment to 6 proteins:
- ANXA1_HUMAN
- B5BU38_HUMAN
- Q05BR2_HUMAN
- Q5T3N0_HUMAN
- Q5T3N1_HUMAN
- Q5TZZ9_HUMAN
Variants for ANXA1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANXA1 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 738641 | Likely Benign: not provided | 73,167,565(+) | A/G | INTRON_VARIANT | |
| 748693 | Likely Benign: not provided | 73,165,111(+) | G/T | INTRON_VARIANT | |
| 768303 | Benign: not provided | 73,163,535(+) | A/G | INTRON_VARIANT | |
| 774466 | Benign: not provided | 73,165,139(+) | G/A | SYNONYMOUS_VARIANT | |
| 774674 | Likely Benign: not provided | 73,160,259(+) | G/T | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3620660 | CNV | loss | 21293372 |
| esv3620661 | CNV | gain | 21293372 |
| esv3620662 | CNV | gain | 21293372 |
| nsv526225 | CNV | gain | 19592680 |
| nsv614612 | CNV | gain | 21841781 |
| nsv6561 | CNV | insertion | 18451855 |
| nsv951528 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.38;
27.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ANXA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA1 Gene
Disorders for ANXA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hairy cell leukemia |
|
|
| brain edema |
|
|
| rheumatoid arthritis |
|
|
| penis squamous cell carcinoma |
|
|
| colon adenocarcinoma |
|
Search ANXA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ANXA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA1 Gene
Publications for ANXA1 Gene
- Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PMID: 16883066) Morand EF … Yang YH (Mediators of inflammation 2006) 3 23 26
- Calcium-dependent binding of S100C to the N-terminal domain of annexin I. (PMID: 8557678) Mailliard WS … Schlaepfer DD (The Journal of biological chemistry 1996) 3 4 23
- Crystal structure of human annexin I at 2.5 A resolution. (PMID: 8453382) Weng X … Huber R (Protein science : a publication of the Protein Society 1993) 3 4 23
- Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PMID: 2936963) Wallner BP … Ramachandran KL (Nature 1986) 2 3 4
- Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. (PMID: 25664854) Leoni G … Nusrat A (The Journal of clinical investigation 2015) 3 4
ExternalLinks
Products for ANXA1 Gene
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- Humanized Mice
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- antibodies-online: Show 103 available Annexin a1 Antibodies ranked by validation data
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- 239 WB Antibodies (anti-human)
- 13 IHC Antibodies (anti-human)
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- 8 IHC (p) Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 104 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
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- 75 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
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- antibodies-online: Show 48 available Annexin a1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for ANXA1
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Sources for ANXA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB