ANXA1 Gene (Protein Coding)

Annexin A1

GC09P073151
GIFtS:
50
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014] See more...

Aliases for ANXA1 Gene

Aliases for ANXA1 Gene

  • Annexin A1 2 3 4 5
  • Phospholipase A2 Inhibitory Protein 3 4
  • Chromobindin-9 3 4
  • Calpactin II 3 4
  • Calpactin-2 3 4
  • Annexin-1 3 4
  • ANX1 3 4
  • LPC1 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Annexin I (Lipocortin I) 3
  • Lipocortin I 4
  • Annexin I 4
  • ANXA1 5
  • P35 4

External Ids for ANXA1 Gene

Previous HGNC Symbols for ANXA1 Gene

  • ANX1
  • LPC1

Previous GeneCards Identifiers for ANXA1 Gene

  • GC09P066811
  • GC09P067623
  • GC09P069336
  • GC09P071223
  • GC09P072996
  • GC09P074956
  • GC09P075766
  • GC09P045589

Summaries for ANXA1 Gene

Entrez Gene Summary for ANXA1 Gene

  • This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]

GeneCards Summary for ANXA1 Gene

ANXA1 (Annexin A1) is a Protein Coding gene. Diseases associated with ANXA1 include Hairy Cell Leukemia and Brain Edema. Among its related pathways are Signaling by GPCR and Spinal Cord Injury. Gene Ontology (GO) annotations related to this gene include calcium ion binding and signaling receptor binding. An important paralog of this gene is ANXA2.

UniProtKB/Swiss-Prot Summary for ANXA1 Gene

  • Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).

Tocris Summary for ANXA1 Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for ANXA1 Gene

Additional gene information for ANXA1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANXA1 Gene

Genomics for ANXA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ANXA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J073147 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 262.7 +0.6 578 9.6 NCOR1 IKZF1 JUND ZNF580 ZNF592 NFIC BCL11A CEBPB SMAD5 BHLHE40 ANXA1 NONHSAG052568.2 lnc-ALDH1A1-3
GH09J073115 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 20.4 -36.5 -36464 3.6 MAFF ZNF316 MAFK BATF MAFG JUND JUNB EP300 EMSY LOC105376081 ANXA1 ALDH1A1 lnc-ANXA1-6 lnc-ALDH1A1-3
GH09J073117 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 16.2 -33.1 -33131 2.3 NFIC CEBPB MAX EP300 RFX5 STAT3 TBP NFE2 JUND ZBTB33 ANXA1 ALDH1A1 LOC105376081 lnc-ANXA1-6 lnc-ALDH1A1-3
GH09J073270 Enhancer 1.2 FANTOM5 Ensembl ENCODE 13.3 +118.6 118636 2.6 ZNF654 JUND CEBPA NFIC REST CEBPB HOMEZ CTCF EP300 RAD21 ANXA1 HSALNG0071903 lnc-ANXA1-1 LOC101927281
GH09J073203 Enhancer 0.8 FANTOM5 Ensembl 16.8 +51.2 51235 5 ZNF654 REST CTCF RAD21 SMC3 SPI1 POLR2A ZNF384 ZNF362 HLF ANXA1 lnc-ALDH1A1-11 HSALNG0071893 lnc-ALDH1A1-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANXA1

Top Transcription factor binding sites by QIAGEN in the ANXA1 gene promoter:
  • AREB6
  • C/EBPalpha
  • C/EBPbeta
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • STAT3
  • TGIF

Genomic Locations for ANXA1 Gene

Latest Assembly
chr9:73,151,865-73,170,393
(GRCh38/hg38)
Size:
18,529 bases
Orientation:
Plus strand

Previous Assembly
chr9:75,766,781-75,785,309
(GRCh37/hg19 by Entrez Gene)
Size:
18,529 bases
Orientation:
Plus strand

chr9:75,766,673-75,785,309
(GRCh37/hg19 by Ensembl)
Size:
18,637 bases
Orientation:
Plus strand

Genomic View for ANXA1 Gene

Genes around ANXA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ANXA1 Gene

Proteins for ANXA1 Gene

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  • Protein details for ANXA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04083-ANXA1_HUMAN
    Recommended name:
    Annexin A1
    Protein Accession:
    P04083
    Secondary Accessions:
    • B5BU38

    Protein attributes for ANXA1 Gene

    Size:
    346 amino acids
    Molecular mass:
    38714 Da
    Quaternary structure:
    • Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation (PubMed:2532504). Homodimers linked by transglutamylation are observed in placenta, but not in other tissues (PubMed:2532504). Interacts with S100A11 (PubMed:8557678, PubMed:10673436). Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (PubMed:10673436). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).
    Miscellaneous:
    • Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro) (PubMed:2936963, PubMed:8425544). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.

    Three dimensional structures from OCA and Proteopedia for ANXA1 Gene

neXtProt entry for ANXA1 Gene

Protein Expression for ANXA1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ANXA1 Gene

  • Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504).
  • Sumoylated.
  • Glycosylation at Ser37
  • Ubiquitination at Lys58, Lys166, and Lys274
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for ANXA1 Gene

Domains & Families for ANXA1 Gene

Gene Families for ANXA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for ANXA1 Gene

InterPro:
Blocks:
  • Annexin
  • Annexin type I signature

Suggested Antigen Peptide Sequences for ANXA1 Gene

GenScript: Design optimal peptide antigens:
  • p35 (ANXA1_HUMAN)
  • Annexin I (B5BU38_HUMAN)
  • ANXA1 protein (Q05BR2_HUMAN)
  • Annexin A1, isoform CRA_a (Q5TZZ9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04083

UniProtKB/Swiss-Prot:

ANXA1_HUMAN :
  • The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
  • Belongs to the annexin family.
Domain:
  • The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
  • The N-terminal 26 amino acids are sufficient for its extracellular functions in the regulation of inflammation and wound healing (PubMed:25664854). Acylated peptides that contain the first 26 amino acids of the mature protein can activate signaling via the formyl peptide receptors (PubMed:15187149, PubMed:25664854).
Family:
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA1: view

Function for ANXA1 Gene

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Molecular function for ANXA1 Gene

UniProtKB/Swiss-Prot Function:
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
GENATLAS Biochemistry:
annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid feadback action in the hypothalamo-hypophysial system

Phenotypes From GWAS Catalog for ANXA1 Gene

Gene Ontology (GO) - Molecular Function for ANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IEA --
GO:0003727 single-stranded RNA binding IEA --
GO:0004859 phospholipase inhibitor activity IEA --
GO:0005102 signaling receptor binding TAS 10882119
GO:0005509 calcium ion binding TAS,ISS --
genes like me logo Genes that share ontologies with ANXA1: view
genes like me logo Genes that share phenotypes with ANXA1: view

Animal Models for ANXA1 Gene

MGI Knock Outs for ANXA1:

Animal Models for research

  • Taconic Biosciences Mouse Models for ANXA1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA1 Gene

Localization for ANXA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA1 Gene

Nucleus. Cytoplasm. Cell projection, cilium. Cell membrane. Membrane. Peripheral membrane protein. Endosome membrane. Peripheral membrane protein. Basolateral cell membrane. Apical cell membrane. Lateral cell membrane. Secreted. Secreted, extracellular space. Cell membrane. Peripheral membrane protein. Extracellular side. Secreted, extracellular exosome. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, phagocytic cup. Early endosome. Cytoplasmic vesicle membrane. Peripheral membrane protein. Note=Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in the protein translocation from the cytoplasm into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). {ECO:0000250 UniProtKB:P10107, ECO:0000269 PubMed:10772777, ECO:0000269 PubMed:17008549, ECO:0000269 PubMed:2532504, ECO:0000269 PubMed:25664854, ECO:0000269 PubMed:32272059, ECO:0000269 PubMed:8557678}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endosome 5
cytosol 5
cytoskeleton 3
mitochondrion 3
lysosome 3
endoplasmic reticulum 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IDA 10908733
GO:0001891 phagocytic cup IEA --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,IDA 17008549
GO:0005634 nucleus IEA,IDA 22056994
genes like me logo Genes that share ontologies with ANXA1: view

Pathways & Interactions for ANXA1 Gene

genes like me logo Genes that share pathways with ANXA1: view

SIGNOR curated interactions for ANXA1 Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for ANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001780 neutrophil homeostasis IMP 21957127
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002548 monocyte chemotaxis IDA 15187149
GO:0002685 regulation of leukocyte migration IBA,ISS --
genes like me logo Genes that share ontologies with ANXA1: view

Drugs & Compounds for ANXA1 Gene

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(61) Drugs for ANXA1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational, Vet_approved Pharma Target, agonist Anti-inflammatory glucocorticoid 3149
Amcinonide Approved Pharma Target, agonist 0
Hydrocortisone Approved, Vet_approved Pharma Target, agonist 949
Clobetasol Approved, Experimental, Investigational Pharma Target, inducer, inhibitor 110
Methylprednisolone Approved, Vet_approved Pharma Target, agonist Apoptosis inducer,GR agonist, Glucocorticoid receptor agonist 1686

(32) Additional Compounds for ANXA1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ac2-12
256447-08-2
Ac2-26
151988-33-9
Heparin sodium salt
9041-08-1
KF 38789
257292-29-8
PM 102
1234564-95-4

(5) Tocris Compounds for ANXA1 Gene

Compound Action Cas Number
Ac2-12 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 256447-08-2
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 151988-33-9
Heparin sodium salt Anticoagulant 9041-08-1
KF 38789 Selective inhibitor of P-selectin-mediated cell adhesion 257292-29-8
PM 102 Antagonist of heparin (Cat. No. 2812) 1234564-95-4

(1) ApexBio Compounds for ANXA1 Gene

Compound Action Cas Number
Thiolutin RNA polymerase inhibitor,antibiotic 1987-11-6
genes like me logo Genes that share compounds with ANXA1: view

Transcripts for ANXA1 Gene

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mRNA/cDNA for ANXA1 Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANXA1

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - - -
SP10: - - -
SP11:
SP12: -
SP13:

Relevant External Links for ANXA1 Gene

GeneLoc Exon Structure for
ANXA1

Expression for ANXA1 Gene

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  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANXA1 Gene

mRNA expression in normal human tissues for ANXA1 Gene
mRNA expression by BioGPS for ANXA1 GenemRNA expression by GTEx for ANXA1 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA1 Gene

This gene is overexpressed in Esophagus - Mucosa (x19.5) and Minor Salivary Gland (x6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA1 Gene



Protein tissue co-expression partners for ANXA1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANXA1

SOURCE GeneReport for Unigene cluster for ANXA1 Gene:

Hs.494173

mRNA Expression by UniProt/SwissProt for ANXA1 Gene:

P04083-ANXA1_HUMAN
Tissue specificity: Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.

Evidence on tissue expression from TISSUES for ANXA1 Gene

  • Liver(5)
  • Lung(4.9)
  • Nervous system(4.5)
  • Bone(4.3)
  • Skin(3.9)
  • Stomach(3.8)
  • Intestine(3.7)
  • Bone marrow(3.6)
  • Thyroid gland(3.6)
  • Blood(3.5)
  • Heart(3.5)
  • Spleen(3.3)
  • Muscle(3.1)
  • Kidney(3)
  • Lymph node(3)
  • Adrenal gland(2.7)
  • Pancreas(2.7)
  • Gall bladder(2.7)
  • Eye(2.6)
genes like me logo Genes that share expression patterns with ANXA1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA1 Gene

Orthologs for ANXA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ANXA1 29 30
  • 99.42 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ANXA1 29 30
  • 89.53 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ANXA1 29 30
  • 88.57 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Anxa1 29 16 30
  • 86.61 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Anxa1 29
  • 86.13 (n)
Oppossum
(Monodelphis domestica)
 Mammalia ANXA1 30
  • 86 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia ANXA1 30
  • 81 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves ANXA1 29 30
  • 75.07 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ANXA1 30
  • 76 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia anxa1 29
  • 69.73 (n)
MGC76270 29
African clawed frog
(Xenopus laevis)
 Amphibia anxa1-prov 29
Zebrafish
(Danio rerio)
 Actinopterygii anxa1a 29 30
  • 65.49 (n)
 OneToMany
anxa1b 30
  • 52 (a)
 OneToMany
ANXA1 (4 of 4) 30
  • 52 (a)
 OneToMany
anxa1c 30
  • 51 (a)
 OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8605 29
Fruit Fly
(Drosophila melanogaster)
 Insecta AnnIX 31
  • 45 (a)
Worm
(Caenorhabditis elegans)
 Secernentea nex-2 31
  • 42 (a)
nex-1 30 31
  • 36 (a)
 ManyToMany
nex-3 30 31
  • 34 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 36 (a)
 ManyToMany
Species where no ortholog for ANXA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ANXA1 Gene

ENSEMBL:
Gene Tree for ANXA1 (if available)
TreeFam:
Gene Tree for ANXA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANXA1: view image
Alliance of Genome Resources:
Additional Orthologs for ANXA1

Paralogs for ANXA1 Gene

Paralogs for ANXA1 Gene

(15) SIMAP similar genes for ANXA1 Gene using alignment to 6 proteins:

  • ANXA1_HUMAN
  • B5BU38_HUMAN
  • Q05BR2_HUMAN
  • Q5T3N0_HUMAN
  • Q5T3N1_HUMAN
  • Q5TZZ9_HUMAN
genes like me logo Genes that share paralogs with ANXA1: view

Variants for ANXA1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANXA1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs115362505 Benign: not provided 73,163,535(+) A/G
NM_000700.3(ANXA1):c.612+3A>G 		INTRON
rs1269877580 Likely Benign: not provided 73,160,259(+) G/T
NM_000700.3(ANXA1):c.271-4G>T 		INTRON
rs149033255 Benign: not provided 73,165,139(+) G/A
NM_000700.3(ANXA1):c.636G>A (p.Arg212=) 		SYNONYMOUS
rs1563961902 Uncertain Significance: not provided 73,159,357(+) TCTAA/T
NM_000700.3(ANXA1):c.205_208CTAA[1] (p.Thr70fs) 		FRAMESHIFT
rs181802457 Likely Benign: not provided 73,167,565(+) A/G
NM_000700.3(ANXA1):c.861+10A>G 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ANXA1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ANXA1 Gene

Variant ID Type Subtype PubMed ID
esv3620660 CNV loss 21293372
esv3620661 CNV gain 21293372
esv3620662 CNV gain 21293372
nsv526225 CNV gain 19592680
nsv614612 CNV gain 21841781
nsv6561 CNV insertion 18451855
nsv951528 CNV duplication 24416366

Variation tolerance for ANXA1 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA1 Gene

Human Gene Mutation Database (HGMD)
ANXA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA1
Leiden Open Variation Database (LOVD)
ANXA1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA1 Gene

Disorders for ANXA1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for ANXA1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hairy cell leukemia
  • hcl-v
brain edema
  • intracranial swelling
rheumatoid arthritis
  • ra
colon adenocarcinoma
  • adenocarcinoma of colon
penis squamous cell carcinoma
  • epidermoid cell carcinoma of penis
- elite association - COSMIC cancer census association via MalaCards
Search ANXA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ANXA1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ANXA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA1 Gene

Publications for ANXA1 Gene

  1. Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PMID: 16883066) Morand EF … Yang YH (Mediators of inflammation 2006) 3 22 25
  2. Calcium-dependent binding of S100C to the N-terminal domain of annexin I. (PMID: 8557678) Mailliard WS … Schlaepfer DD (The Journal of biological chemistry 1996) 3 4 22
  3. Crystal structure of human annexin I at 2.5 A resolution. (PMID: 8453382) Weng X … Huber R (Protein science : a publication of the Protein Society 1993) 3 4 22
  4. Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PMID: 2936963) Wallner BP … Ramachandran KL (Nature 1986) 2 3 4
  5. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. (PMID: 25664854) Leoni G … Nusrat A (The Journal of clinical investigation 2015) 3 4

ExternalLinks

View latest publications for ANXA1 gene in Mastermind

Products for ANXA1 Gene

  • Addgene plasmids for ANXA1

Sources for ANXA1 Gene