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Aliases for ANTXRL Gene

Aliases for ANTXRL Gene

  • Anthrax Toxin Receptor Like 2 3 5

External Ids for ANTXRL Gene

Previous GeneCards Identifiers for ANTXRL Gene

  • GC10U900624
  • GC10P047130
  • GC10P047658
  • GC10M045383

Summaries for ANTXRL Gene

GeneCards Summary for ANTXRL Gene

ANTXRL (Anthrax Toxin Receptor Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include receptor activity. An important paralog of this gene is ANTXR1.

Additional gene information for ANTXRL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANTXRL Gene

Genomics for ANTXRL Gene

GeneHancer (GH) Regulatory Elements for ANTXRL Gene

Promoters and enhancers for ANTXRL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I046287 Promoter 0.5 EPDnew 556.3 +0.7 690 0.1 ANTXRL PIR43906
GH10I046298 Enhancer 0.9 Ensembl ENCODE 34.2 +13.2 13242 1.9 HDGF ZSCAN4 MAX TSC22D4 GLI4 CDC5L MCM2 ZIC2 ZFHX2 POLR2A ANTXRL WASHC2C PARGP1 PIR43906
GH10I046282 Enhancer 1.4 Ensembl ENCODE dbSUPER 6.8 -2.3 -2344 3.2 ATF1 SIN3A ZNF2 GLIS2 E2F8 KLF7 ATF7 RUNX3 ZNF202 SP3 GC10P046284 LOC105378577 PARGP1 BMS1P1 WASHC2C ANTXRLP1 AGAP4 AGAP10P ANTXRL HNRNPA1P33
GH10I046265 Enhancer 1.2 Ensembl ENCODE dbSUPER 6.5 -17.7 -17693 5.4 HDGF PKNOX1 ZNF473 ZSCAN4 TCF12 EGR1 ATF7 BCLAF1 IKZF2 RUNX3 ANTXRLP1 AGAP10P ZFAND4 AGAP4 ANTXRL ANXA8L1 PIR53286
GH10I046294 Enhancer 0.6 Ensembl 12.3 +8.5 8456 0.4 CTCF L3MBTL2 ETV1 MAX ZBTB40 SMARCA4 GABPB1 MYC MGA ANTXRL PIR43906
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANTXRL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANTXRL gene promoter:

Genomic Locations for ANTXRL Gene

Genomic Locations for ANTXRL Gene
chr10:46,286,345-46,330,419
(GRCh38/hg38)
Size:
44,075 bases
Orientation:
Plus strand
chr10:47,657,581-47,701,446
(GRCh37/hg19)

Genomic View for ANTXRL Gene

Genes around ANTXRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANTXRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANTXRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANTXRL Gene

Proteins for ANTXRL Gene

  • Protein details for ANTXRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NF34-ANTRL_HUMAN
    Recommended name:
    Anthrax toxin receptor-like
    Protein Accession:
    A6NF34
    Secondary Accessions:
    • H3BPS2

    Protein attributes for ANTXRL Gene

    Size:
    631 amino acids
    Molecular mass:
    70629 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANTXRL Gene

Post-translational modifications for ANTXRL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANTXRL Gene

Domains & Families for ANTXRL Gene

Gene Families for ANTXRL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ANTXRL Gene

Suggested Antigen Peptide Sequences for ANTXRL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NF34

UniProtKB/Swiss-Prot:

ANTRL_HUMAN :
  • Belongs to the ATR family.
Family:
  • Belongs to the ATR family.
genes like me logo Genes that share domains with ANTXRL: view

Function for ANTXRL Gene

Phenotypes From GWAS Catalog for ANTXRL Gene

Gene Ontology (GO) - Molecular Function for ANTXRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ANTXRL: view

Phenotypes for ANTXRL Gene

genes like me logo Genes that share phenotypes with ANTXRL: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANTXRL Gene

Localization for ANTXRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANTXRL Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for ANTXRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANTXRL: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ANTXRL Gene

Pathways & Interactions for ANTXRL Gene

SuperPathways for ANTXRL Gene

No Data Available

Interacting Proteins for ANTXRL Gene

Gene Ontology (GO) - Biological Process for ANTXRL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANTXRL Gene

Drugs & Compounds for ANTXRL Gene

No Compound Related Data Available

Transcripts for ANTXRL Gene

mRNA/cDNA for ANTXRL Gene

(16) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANTXRL Gene

Anthrax toxin receptor-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANTXRL Gene

No ASD Table

Relevant External Links for ANTXRL Gene

GeneLoc Exon Structure for
ANTXRL
ECgene alternative splicing isoforms for
ANTXRL

Expression for ANTXRL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANTXRL Gene

mRNA differential expression in normal tissues according to GTEx for ANTXRL Gene

This gene is overexpressed in Testis (x36.5).

NURSA nuclear receptor signaling pathways regulating expression of ANTXRL Gene:

ANTXRL

SOURCE GeneReport for Unigene cluster for ANTXRL Gene:

Hs.538515
genes like me logo Genes that share expression patterns with ANTXRL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANTXRL Gene

Orthologs for ANTXRL Gene

This gene was present in the common ancestor of mammals.

Orthologs for ANTXRL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC782834 33
  • 67.57 (n)
dog
(Canis familiaris)
Mammalia LOC611121 33
  • 63.48 (n)
mouse
(Mus musculus)
Mammalia Antxrl 33 16
  • 62.86 (n)
rat
(Rattus norvegicus)
Mammalia Antxrl 33
  • 59.7 (n)
Species where no ortholog for ANTXRL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANTXRL Gene

ENSEMBL:
Gene Tree for ANTXRL (if available)
TreeFam:
Gene Tree for ANTXRL (if available)

Paralogs for ANTXRL Gene

Paralogs for ANTXRL Gene

(3) SIMAP similar genes for ANTXRL Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ANTXRL Gene

genes like me logo Genes that share paralogs with ANTXRL: view

Variants for ANTXRL Gene

Sequence variations from dbSNP and Humsavar for ANTXRL Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000356057 -- 46,325,507(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000414541 -- 46,318,888(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000742492 -- 46,323,894(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000812060 -- 46,325,117(+) C/T genic_downstream_transcript_variant, intron_variant
rs1002423765 -- 46,285,518(+) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ANTXRL Gene

Variant ID Type Subtype PubMed ID
dgv1108n54 CNV loss 21841781
dgv1109n54 CNV gain 21841781
dgv1110n54 CNV gain 21841781
dgv1112n54 CNV gain+loss 21841781
dgv1113n54 CNV loss 21841781
dgv1115n54 CNV gain 21841781
dgv1116n54 CNV gain 21841781
dgv1117n54 CNV loss 21841781
dgv1118n54 CNV gain 21841781
dgv1119n54 CNV loss 21841781
dgv122e214 CNV gain 21293372
dgv229e212 CNV loss 25503493
dgv27e55 CNV gain 17911159
dgv28e55 CNV gain 17911159
dgv32n111 CNV duplication 26073780
dgv831n100 CNV loss 25217958
dgv832n100 CNV gain+loss 25217958
dgv833n100 CNV gain 25217958
dgv834n100 CNV loss 25217958
dgv835n100 CNV gain 25217958
dgv836n100 CNV gain+loss 25217958
dgv837n100 CNV gain 25217958
dgv83n27 CNV loss 19166990
dgv842n100 CNV gain 25217958
dgv843n100 CNV gain 25217958
dgv844n100 CNV gain 25217958
dgv845n100 CNV gain 25217958
dgv847n100 CNV loss 25217958
dgv84n27 CNV loss 19166990
dgv85n27 CNV gain 19166990
dgv88n27 CNV gain 19166990
dgv89n27 CNV loss 19166990
dgv90n27 CNV gain 19166990
esv2475335 OTHER inversion 19546169
esv2736152 CNV deletion 23290073
esv2736351 CNV deletion 23290073
esv2736363 CNV deletion 23290073
esv2750959 CNV loss 17911159
esv28391 CNV loss 19812545
esv3332605 CNV duplication 20981092
esv3435780 CNV duplication 20981092
esv3439446 CNV duplication 20981092
esv3584554 CNV gain 24956385
esv3623133 CNV loss 21293372
esv3623136 CNV loss 21293372
esv3891801 CNV gain+loss 25118596
esv3891802 CNV gain 25118596
esv5777 OTHER inversion 19470904
nsv1037635 CNV gain 25217958
nsv1050382 CNV gain 25217958
nsv1051404 CNV loss 25217958
nsv1051450 CNV gain+loss 25217958
nsv1110173 CNV duplication 24896259
nsv1145763 CNV duplication 26484159
nsv1150234 OTHER inversion 26484159
nsv1161949 CNV duplication 26073780
nsv1161950 CNV duplication 26073780
nsv24140 CNV deletion 16902084
nsv437116 CNV loss 16327808
nsv438173 CNV loss 16468122
nsv442574 CNV gain+loss 18776908
nsv469676 CNV gain+loss 16826518
nsv470935 CNV loss 18288195
nsv471667 CNV gain 15918152
nsv478470 CNV novel sequence insertion 20440878
nsv480982 CNV novel sequence insertion 20440878
nsv550758 CNV loss 21841781
nsv550795 CNV gain 21841781
nsv6543 CNV insertion 18451855
nsv818760 CNV gain 17921354
nsv820578 CNV duplication 20802225
nsv831857 CNV gain 17160897
nsv831859 CNV gain+loss 17160897
nsv947948 CNV duplication 23825009
nsv947949 CNV duplication 23825009

Variation tolerance for ANTXRL Gene

Gene Damage Index Score: 13.05; 95.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANTXRL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANTXRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANTXRL Gene

Disorders for ANTXRL Gene

Additional Disease Information for ANTXRL

No disorders were found for ANTXRL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANTXRL Gene

Publications for ANTXRL Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for ANTXRL Gene

Sources for ANTXRL Gene

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