Aliases for ANTXR1 Gene
External Ids for ANTXR1 Gene
Previous GeneCards Identifiers for ANTXR1 Gene
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
GeneCards Summary for ANTXR1 Gene
ANTXR1 (ANTXR Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ANTXR1 include Gapo Syndrome and Tetramelic Deficiencies, Ectodermal Dysplasia, Deformed Ears, And Other Abnormalities. Among its related pathways are Cellular roles of Anthrax toxin and Uptake and actions of bacterial toxins. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is ANTXR2.
UniProtKB/Swiss-Prot Summary for ANTXR1 Gene
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.