Aliases for ANPEP Gene
Aliases for ANPEP Gene
External Ids for ANPEP Gene
- HGNC: 500
- Entrez Gene: 290
- Ensembl: ENSG00000166825
- OMIM: 151530
- UniProtKB: P15144
Previous HGNC Symbols for ANPEP Gene
- CD13
- PEPN
Previous GeneCards Identifiers for ANPEP Gene
- GC15M086732
- GC15M083693
- GC15M087915
- GC15M088057
- GC15M088129
- GC15M090328
- GC15M066440
Summaries for ANPEP Gene
-
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
GeneCards Summary for ANPEP Gene
ANPEP (Alanyl Aminopeptidase, Membrane) is a Protein Coding gene. Diseases associated with ANPEP include Gastroenteritis and Tetrasomy 21. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and C-MYB transcription factor network. Gene Ontology (GO) annotations related to this gene include virus receptor activity. An important paralog of this gene is LVRN.
UniProtKB/Swiss-Prot for ANPEP Gene
-
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization.
-
(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.
-
(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.
-
Aminopeptidases catalyze the removal of amino acids from the amino terminus of proteins and peptides. They express different substrate specificities - for example, leucyl aminopeptidase preferentially cleaves leucine residues.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANPEP Gene
Genomics for ANPEP Gene
GeneHancer (GH) Regulatory Elements for ANPEP Gene
Promoters and enhancers for ANPEP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ANPEP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ANPEP gene promoter:
-
- C/EBPalpha
- N-Myc
- Nkx2-5
- Elk-1
- PPAR-gamma2
- PPAR-gamma1
- FOXD1
- HFH-3
- FOXI1
Regulatory Element Products
Genomic Locations for ANPEP Gene
Genomic Locations for ANPEP Gene
- chr15:89,784,889-89,815,401
- (GRCh38/hg38)
- Size:
- 30,513 bases
- Orientation:
- Minus strand
- chr15:90,328,120-90,358,633
- (GRCh37/hg19)
- Size:
- 30,514 bases
- Orientation:
- Minus strand
Genomic View for ANPEP Gene
Genes around ANPEP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q26.1 by Entrez Gene
- 15q26.1 by HGNC
- 15q26.1 by Ensembl
ANPEP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANPEP Gene
Proteins for ANPEP Gene
-
Protein details for ANPEP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15144-AMPN_HUMAN
- Recommended name:
- Aminopeptidase N
- Protein Accession:
- P15144
- Q16728
- Q6GT90
- Q8IUK3
- Q8IVH3
- Q9UCE0
Protein attributes for ANPEP Gene
- Size:
- 967 amino acids
- Molecular mass:
- 109540 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer.
- (Microbial infection) Interacts with the S1 domain of human coronavirus 229E/HCoV-229E spike protein.
- Miscellaneous:
-
- Found to serve as a receptor for tumor-homing peptides, more specifically NGR peptides. It could serve thus as a target for delivering drugs into tumors. Concentration in human hepatic bile, varies from 17.3 to 57.6 micrograms/ml.
Protein Expression for ANPEP Gene
Post-translational modifications for ANPEP Gene
- Sulfated.
- N- and O-glycosylated.
- May undergo proteolysis and give rise to a soluble form.
- Glycosylation at Asn818, posLast=735735, posLast=681681, posLast=625625, Asn573, Asn527, Asn319, posLast=265265, Asn234, and posLast=128128
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- AMPN_HUMAN (815)
Other Protein References for ANPEP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ANPEP (Aminopeptidase N/CD13)
-
Custom Antibody ServicesOriGene Antibodies for ANPEP
- AM00642BT-N
- AM01047FC-N
- AM01047PU-S
- AM05175FC-N
- AM05175PU-N
- AM05175RP-N
- AM31221AF-N
- AM31221FC-N
- AM31221PU-N
- AM31221RP-N
- AM32324FC-N
- AM32324RP-N
- AP20647PU-N
- SM1070AC
- SM1070APC
- SM1070APCT
- SM1070BT
- SM1070FC
- SM1070FT
- SM1070P
- SM1070PP
- SM1070PS
- SM1070PT
- SM1070R
- SM1070RP
- SM1070RT
- SM1856F
- SM1856FS
- SM1856FT
- SM1856FX
- SM1856P
- SM1856PS
- SM1856PT
- SM1856R
- SM1856RT
- SM2263P
- SM2298P
- SM2298PS
- TA307568
- TA320221
- TA329672
- TA329673
- TA332824
- TA343101
- TA350805
- TA353652
- TA353653
- TA807395
- CF807395
- TA807396
- CF807396
- TA807397
- CF807397
- Novus Biologicals Antibodies for ANPEP
-
Abcam antibodies for ANPEP
- Invitrogen Antibodies for ANPEP
- antibodies-online: Search results for 543 available CD13 Antibodies ranked by validation data
- Compare Top CD13 Antibodies
-
Recommended
- 132 WB Antibodies (anti-human)
- 94 FACS Antibodies (anti-human)
- 35 IHC (fro) Antibodies (anti-human)
- 34 IHC (p) Antibodies (anti-human)
- 29 IHC Antibodies (anti-human)
- 29 IP Antibodies (anti-human)
- 18 IF Antibodies (anti-human)
- 8 IF/ICC Antibodies (anti-human)
- 1 MA Antibody (anti-human)
- 34 FACS Antibodies (anti-mouse)
- 25 IHC (p) Antibodies (anti-mouse)
- 24 IHC (fro) Antibodies (anti-mouse)
- 19 WB Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 14 WB Antibodies (anti-rat)
- GeneTex ANPEP Antibody for ANPEP
-
Boster Bio Antibodies for ANPEP
-
Santa Cruz Biotechnology (SCBT) Antibodies for ANPEP
- Sino Biological Antibodies for ANPEP
Protein Products
- R&D Systems Proteins and Enzymes for ANPEP (Aminopeptidase N/CD13)
-
OriGene Purified Proteins for ANPEP
- Search Origene for MassSpec and Protein Over-expression Lysates for ANPEP
- Origene Custom Protein Services for ANPEP
- Sino Biological Recombinant Proteins for ANPEP
- Sino Biological Cell Lysates for ANPEP
- Search GeneTex for Proteins for ANPEP
-
Abcam proteins for ANPEP
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for ANPEP (Aminopeptidase N/CD13)
No data available for DME Specific Peptides for ANPEP Gene
Domains & Families for ANPEP Gene
Gene Families for ANPEP Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- Enzymes
- Plasma proteins
- Predicted membrane proteins
Protein Domains for ANPEP Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANPEP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P15144- Family:
-
- Belongs to the peptidase M1 family.
Function for ANPEP Gene
Molecular function for ANPEP Gene
- UniProtKB/Swiss-Prot Function:
- Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Release of an N-terminal amino acid, Xaa- -Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
- UniProtKB/Swiss-Prot Induction:
- Estradiol and IL8/interleukin-8 decrease enzymatic activity in vitro in endometrial stromal cells by 40% and 30%, respectively.
- GENATLAS Biochemistry:
- membrane leucyl aminopeptidase N,p150
Enzyme Numbers (IUBMB) for ANPEP Gene
Phenotypes From GWAS Catalog for ANPEP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0004177 | aminopeptidase activity | TAS | 10734069 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | TAS,IEA | 2564851 |
| GO:0008270 | zinc ion binding | IBA,IEA | -- |
Phenotypes for ANPEP Gene
- MGI mutant phenotypes for ANPEP:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ANPEP:
Animal Models for ANPEP Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ANPEP
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANPEP
-
CRISPR Products
-
OriGene CRISPR knockouts for ANPEP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANPEP
- genomics-online: gRNA clones - Search results for 101 available CD13 gene related products
- Overview of 101 available CD13 gene related products
- Applied Biological Materials CRISPR for ANPEP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANPEP
- GenScript: Design CRISPR guide RNA sequences for ANPEP
miRNA for ANPEP Gene
- miRTarBase miRNAs that target ANPEP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANPEP
- Browse OriGene Inhibitory RNA Products For ANPEP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANPEP
- genomics-online: shRNA clones - Search results for 101 available CD13 gene related products
- Overview of 101 available CD13 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ANPEP
- VectorBuilder custom plasmid, inducible vectors for ANPEP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANPEP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANPEP
- Applied Biological Materials Clones for ANPEP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ANPEP
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANPEP Gene
Localization for ANPEP Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANPEP Gene
- Cell membrane; Single-pass type II membrane protein. Note=Also found as a soluble form. {ECO:0000269 PubMed:7902291}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| lysosome | 5 |
| endoplasmic reticulum | 3 |
| cytoskeleton | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| endosome | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 25645918 |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005765 | lysosomal membrane | HDA | 17897319 |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | IDA | 15308636 |
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for ANPEP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glutathione metabolism | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Peptide hormone metabolism | ||
| 4 | Hematopoietic cell lineage | ||
| 5 | Metabolism | ||
Pathways by source for ANPEP Gene
4 BioSystems pathways for ANPEP Gene
6 Reactome pathways for ANPEP Gene
4 KEGG pathways for ANPEP Gene
1 GeneGo (Thomson Reuters) pathway for ANPEP Gene
1 R&D Systems pathway for ANPEP Gene
1 Cell Signaling Technology pathway for ANPEP Gene
Interacting Proteins for ANPEP Gene
GPS-Prot Interaction Network for ANPEP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0007165 | signal transduction | IBA | -- |
| GO:0007267 | cell-cell signaling | IBA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for SIGNOR curated interactions for ANPEP Gene
Drugs & Compounds for ANPEP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ezetimibe | Approved | Pharma | Target, other | Cholesterol transport inhibitor | 286 | |
| Icatibant | Approved, Investigational | Pharma | Antagonist, Target, inhibitor | 18 | ||
| Zinc | Approved, Investigational | Pharma | 2430 | |||
| Human calcitonin | Approved, Investigational | Pharma | Enzyme, substrate | 0 | ||
| Oxidized glutathione | Approved, Experimental, Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| cysteinylglycine |
|
19246-18-5 |
|
|||
| CHR 2797 |
|
238750-77-1 |
|
|
||
| HFI 142 |
|
332164-34-8 |
|
|
(4) Tocris Compounds for ANPEP Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bestatin | Aminopeptidase inhibitor | 58970-76-6 |
| CHR 2797 | Aminopeptidase inhibitor | 238750-77-1 |
| Fumagillin | Methionine aminopeptidase-2 inhibitor; antiangiogenic | 23110-15-8 |
| HFI 142 | Insulin-regulated aminopeptidase (IRAP) inhibitor | 332164-34-8 |
(4) ApexBio Compounds for ANPEP Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bestatin | Aminopeptidase inhibitor | 58970-76-6 |
| Bestatin hydrochloride | 65391-42-6 | |
| Bestatin trifluoroacetate | 223763-80-2 | |
| Tosedostat (CHR2797) | Aminopeptidase inhibitor | 238750-77-1 |
Transcripts for ANPEP Gene
mRNA/cDNA for ANPEP Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (341) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000300060 3678 bps (uc002bop.5)
- ENST00000560137 638 bps (uc059nce.1)
- ENST00000559874 663 bps (uc059ncd.1)
- ENST00000560028 582 bps (uc059ncc.1)
- ENST00000559887 534 bps (uc059ncb.1)
Unigene Clusters for ANPEP Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANPEP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANPEP
- genomics-online: gRNA clones - Search results for 101 available CD13 gene related products
- Overview of 101 available CD13 gene related products
- Applied Biological Materials CRISPR for ANPEP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANPEP
- GenScript: Design CRISPR guide RNA sequences for ANPEP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANPEP
- Browse OriGene Inhibitory RNA Products For ANPEP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANPEP
- genomics-online: shRNA clones - Search results for 101 available CD13 gene related products
- Overview of 101 available CD13 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ANPEP
- VectorBuilder custom plasmid, inducible vectors for ANPEP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANPEP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANPEP
- Applied Biological Materials Clones for ANPEP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
| ExUns: | 21 |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: |
Expression for ANPEP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Zeugopod Periosteum
- Mesenchymal Stem Cells Cord Blood
- Bone Marrow Stromal Cells Pelvic Girdle
- Adventitial Reticular Cells Bone Marrow
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
- Mesenchymal Stem Cells Subcutaneous White Adipose
- Adipose-derived stem cells (Adipoplus)
- Adipose-derived stromal cells
- Adipose-derived mesenchymal stromal cells
-
Blood (Hematopoietic System)
- Mesenchymal Stem Cells Cord Blood
- Granulocytes Peripheral Blood
- Basophils Peripheral Blood
- Mast cell progenitor cells Hematopoietic Bone Marrow
- Granulocyte-Monocyte Progenitor Cells Hematopoietic Bone Marrow
- Umbilical Cord (Extraembryonic Tissues)
-
Bone (Muscoskeletal System)
- Mesenchymal Stem Cells Zeugopod Periosteum
- Adventitial Reticular Cells Bone Marrow
- Membranous Facial Bones
- Bone Marrow
- Bone marrow-derived adherent progenitor cells (MultiStem)
- Tooth (Integumentary System)
- Kidney (Urinary System)
- Placenta (Extraembryonic Tissues)
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Mature Granulosa Cells Antral Follicle
- Epithelial Cells
-
Brain (Nervous System)
- Pericytes Blood Brain Barrier
- Pituitary Gland
- Gut Tube (Gastrointestinal Tract)
- Endothelium (Cardiovascular System)
- NULL (Uncategorized)
-
Cartilage (Muscoskeletal System)
- Mesenchymal Stem Cells Zeugopod Periosteum
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Chorion (Extraembryonic Tissues)
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Pericytes Splanchnic Mesoderm
- Intestine (Gastrointestinal Tract)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
- Heart (Cardiovascular System)
- Epiblast (Early Embryonic Tissues)
- Neural Tube (Nervous System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for ANPEP Gene
This gene is overexpressed in Small Intestine - Terminal Ileum (x11.3), Pancreas (x10.0), Whole Blood (x5.6), and Liver (x4.2).
This gene is overexpressed in Pancreatic juice (20.1), Urine (13.5), Fetal gut (9.5), and Nasal epithelium (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANPEP Gene
NURSA nuclear receptor signaling pathways regulating expression of ANPEP Gene:
ANPEPSOURCE GeneReport for Unigene cluster for ANPEP Gene:
Hs.1239mRNA Expression by UniProt/SwissProt for ANPEP Gene:
P15144-AMPN_HUMAN
Tissue specificity:
Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
Evidence on tissue expression from TISSUES for ANPEP Gene
- Intestine(4.8)
- Liver(4.8)
- Blood(4.7)
- Bone marrow(4.7)
- Pancreas(4.6)
- Kidney(4)
- Gall bladder(2.7)
- Heart(2.4)
- Lung(2.4)
- Skin(2.4)
- Spleen(2.4)
- Lymph node(2.3)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ANPEP
-
OriGene qPCR primer pairs for ANPEP
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANPEP Gene
Orthologs for ANPEP Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANPEP 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ANPEP 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANPEP 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Anpep 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Anpep 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANPEP 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANPEP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANPEP 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ANPEP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | anpep 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12671 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100535773 33 |
|
||
| BX572619.7 34 |
|
OneToMany | |||
| anpepb 34 |
|
OneToMany | |||
| ANPEP (6 of 6) 34 |
|
OneToMany | |||
| BX005410.1 34 |
|
OneToMany | |||
| BX005410.2 34 |
|
OneToMany | |||
| ANPEP (3 of 6) 34 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9152 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP013001 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG14516 34 35 33 |
|
ManyToMany | |
| CG8773 35 |
|
|
|||
| CG31445 34 |
|
ManyToMany | |||
| SP1029 34 35 |
|
ManyToMany | |||
| CG11951 34 35 |
|
ManyToMany | |||
| BG:DS00365.1 35 |
|
|
|||
| CG7653 34 |
|
ManyToMany | |||
| CG31198 34 |
|
ManyToMany | |||
| CG31233 34 |
|
ManyToMany | |||
| CG3502 34 35 |
|
ManyToMany | |||
| CG31343 34 |
|
ManyToMany | |||
| CG2111 34 35 |
|
ManyToMany | |||
| CG42335 34 |
|
ManyToMany | |||
| CG9806 34 35 |
|
ManyToMany | |||
| sda 34 35 |
|
ManyToMany | |||
| CG5849 34 35 |
|
ManyToMany | |||
| CG6071 34 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | Y67D8C.9 35 |
|
|
|
| Y42A5A.1 35 |
|
|
|||
| R03G8.6 35 |
|
|
|||
| T12E12.6 35 |
|
|
|||
| T07F10.1 34 35 |
|
ManyToMany | |||
| R03G8.4 35 |
|
|
|||
| T16G12.1 35 |
|
|
|||
| AC3.5 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AAP1 34 |
|
ManyToMany | |
| APE2 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for ANPEP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ANPEP Gene
- ENSEMBL:
- Gene Tree for ANPEP (if available)
- TreeFam:
- Gene Tree for ANPEP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ANPEP: view image
Paralogs for ANPEP Gene
(9) SIMAP similar genes for ANPEP Gene using alignment to 5 proteins:
- AMPN_HUMAN
- H0YKT6_HUMAN
- H0YLZ8_HUMAN
- H0YM04_HUMAN
- H0YMC1_HUMAN
Variants for ANPEP Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000043327 | -- | 89,795,588(-) | C/T | intron_variant | |
| rs1000152961 | -- | 89,808,772(-) | C/A/T | intron_variant | |
| rs1000169670 | -- | 89,791,593(-) | A/G | intron_variant | |
| rs1000211512 | -- | 89,793,189(-) | G/A | intron_variant | |
| rs1000574488 | -- | 89,789,212(-) | T/C | intron_variant |
Residual Variation Intolerance Score:
35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.20;
62.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ANPEP Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANPEP Gene
Disorders for ANPEP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastroenteritis |
|
|
| tetrasomy 21 |
|
|
| mast-cell sarcoma |
|
|
| myelophthisic anemia |
|
|
| myeloid sarcoma |
|
Search ANPEP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ANPEP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ANPEP Gene
Publications for ANPEP Gene
- Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. (PMID: 11384645) Seli E … Arici A (Fertility and sterility 2001) 3 4 22 58
- Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation. (PMID: 11559807) Wentworth DE … Holmes KV (Journal of virology 2001) 3 4 22 58
- Modification of the amino terminus of a class II epitope confers resistance to degradation by CD13 on dendritic cells and enhances presentation to T cells. (PMID: 10605003) Dong X … Salter RD (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 58
- Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. (PMID: 10676659) Pasqualini R … Ruoslahti E (Cancer research 2000) 3 4 22 58
- Defectively N-glycosylated and non-O-glycosylated aminopeptidase N (CD13) is normally expressed at the cell surface and has full enzymatic activity. (PMID: 9056417) Norén K … Vogel LK (Experimental cell research 1997) 3 4 22 58
Products for ANPEP Gene
- R&D Systems Antibodies for ANPEP (Aminopeptidase N/CD13)
- R&D Systems Proteins and Enzymes for ANPEP (Aminopeptidase N/CD13)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for ANPEP (Aminopeptidase N/CD13)
- Browse Human Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for ANPEP
- AM00642BT-N
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- AM05175FC-N
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- AM31221AF-N
- AM31221FC-N
- AM31221PU-N
- AM31221RP-N
- AM32324FC-N
- AM32324RP-N
- AP20647PU-N
- SM1070AC
- SM1070APC
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- SM1070FC
- SM1070FT
- SM1070P
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- SM1070R
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- SM1856F
- SM1856FS
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- SM1856P
- SM1856PS
- SM1856PT
- SM1856R
- SM1856RT
- SM2263P
- SM2298P
- SM2298PS
- TA307568
- TA320221
- TA329672
- TA329673
- TA332824
- TA343101
- TA350805
- TA353652
- TA353653
- TA807395
- CF807395
- TA807396
- CF807396
- TA807397
- CF807397
- Custom Assay Services
- OriGene Purified Proteins for ANPEP
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- Origene Custom Protein Services for ANPEP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANPEP
- Browse OriGene Inhibitory RNA Products For ANPEP
- OriGene qPCR primer pairs and template standards for ANPEP
- OriGene qPCR primer pairs for ANPEP
- OriGene CRISPR knockouts for ANPEP
- OriGene ORF clones in human for ANPEP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ANPEP
- GenScript: Next-day shipping of latest version cDNA ORF clones for ANPEP in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ANPEP
- GenScript Custom Assay Services for ANPEP
- GenScript Custom overexpressing Cell Line Services for ANPEP
- GenScript: Design CRISPR guide RNA sequences for ANPEP
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- Plasmid Preparation
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- Sino Biological Human cDNA Clone for ANPEP
- Sino Biological Recombinant Proteins for ANPEP
- Sino Biological Cell Lysates for ANPEP
- Sino Biological Antibodies for ANPEP
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ANPEP
- Novus Biologicals lysates and proteins for ANPEP
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ANPEP
- Abcam proteins for ANPEP
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for ANPEP
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ANPEP
- ApexBio compounds for ANPEP
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANPEP
- VectorBuilder custom plasmid, inducible vectors for ANPEP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANPEP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 543 available CD13 Antibodies ranked by validation data
- Compare Top CD13 Antibodies
- Recommended
- 132 WB Antibodies (anti-human)
- 94 FACS Antibodies (anti-human)
- 35 IHC (fro) Antibodies (anti-human)
- 34 IHC (p) Antibodies (anti-human)
- 29 IHC Antibodies (anti-human)
- 29 IP Antibodies (anti-human)
- 18 IF Antibodies (anti-human)
- 8 IF/ICC Antibodies (anti-human)
- 1 MA Antibody (anti-human)
- 34 FACS Antibodies (anti-mouse)
- 25 IHC (p) Antibodies (anti-mouse)
- 24 IHC (fro) Antibodies (anti-mouse)
- 19 WB Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 14 WB Antibodies (anti-rat)
- antibodies-online: Search results for 29 available CD13 Elisa Kits ranked by validation data
- Compare Top CD13 Elisa Kits
- antibodies-online: Search results for 14 available CD13 Proteins ranked by validation data
- Compare Top CD13 Proteins
- GeneTex ANPEP Antibody for ANPEP
- Search GeneTex for Proteins for ANPEP
- Santa Cruz Biotechnology (SCBT) Antibodies for ANPEP
- Search Santa Cruz Biotechnology (SCBT) for ANPEP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ANPEP
- Horizon Cell Lines for ANPEP
- genomics-online: cdna clones - Search results for 101 available CD13 gene related products
- Overview of 101 available CD13 gene related products
- orf clones - Search results for 101 available CD13 gene related products
- Overview of 101 available CD13 gene related products
- genomics-online: gRNA clones - Search results for 101 available CD13 gene related products
- Overview of 101 available CD13 gene related products
- genomics-online: primer clones - Search results for 101 available CD13 gene related products
- Overview of 101 available CD13 gene related products
- genomics-online: shRNA clones - Search results for 101 available CD13 gene related products
- Overview of 101 available CD13 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANPEP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANPEP
- GeneCopoeia miRNA 3'UTR Target clone products for ANPEP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANPEP
- Boster Bio Antibodies for ANPEP
Sources for ANPEP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt