Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large e... See more...

Aliases for ANPEP Gene

Aliases for ANPEP Gene

  • Alanyl Aminopeptidase, Membrane 2 3 5
  • Microsomal Aminopeptidase 2 3 4
  • Aminopeptidase N 2 3 4
  • Aminopeptidase M 2 3 4
  • Myeloid Plasma Membrane Glycoprotein CD13 3 4
  • Alanyl (Membrane) Aminopeptidase 2 3
  • Membrane Alanyl Aminopeptidase 2 3
  • EC 3.4.11.2 4 51
  • Gp150 2 4
  • CD13 3 4
  • LAP1 2 3
  • P150 2 3
  • PEPN 3 4
  • AP-M 3 4
  • AP-N 3 4
  • HAPN 3 4
  • APN 3 4
  • Alanyl Aminopeptidase 4
  • CD13 Antigen 4
  • EC 3.4.11 51
  • GP150 3
  • ANPEP 5

External Ids for ANPEP Gene

Previous HGNC Symbols for ANPEP Gene

  • CD13
  • PEPN

Previous GeneCards Identifiers for ANPEP Gene

  • GC15M086732
  • GC15M083693
  • GC15M087915
  • GC15M088057
  • GC15M088129
  • GC15M090328
  • GC15M066440

Summaries for ANPEP Gene

Entrez Gene Summary for ANPEP Gene

  • Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020]

GeneCards Summary for ANPEP Gene

ANPEP (Alanyl Aminopeptidase, Membrane) is a Protein Coding gene. Diseases associated with ANPEP include Gastroenteritis and Tetrasomy 21. Among its related pathways are Neuroscience and Peptide hormone metabolism. Gene Ontology (GO) annotations related to this gene include virus receptor activity. An important paralog of this gene is LVRN.

UniProtKB/Swiss-Prot Summary for ANPEP Gene

  • Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
  • (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.
  • (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.

Tocris Summary for ANPEP Gene

  • Aminopeptidases catalyze the removal of amino acids from the amino terminus of proteins and peptides. They express different substrate specificities - for example, leucyl aminopeptidase preferentially cleaves leucine residues.

Gene Wiki entry for ANPEP Gene

Additional gene information for ANPEP Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANPEP Gene

Genomics for ANPEP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANPEP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J089811 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 628.5 +1.6 1632 4.2 HNRNPL GATAD2A PRDM10 ZNF512 JUND MTA2 PHF21A ZIC2 RBFOX2 ZNF24 ANPEP HMGB1P8 ENSG00000259314 ZNF710 AP3S2 SEMA4B POLG lnc-AP3S2-1 MESP2
GH15J089801 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 618.9 +9.6 9638 8.4 HNRNPL GATAD2A PRDM10 TFE3 SOX13 NFKBIZ RCOR2 ZIC2 RBFOX2 PKNOX1 ANPEP lnc-AP3S2-1 ENSG00000228998 MESP2
GH15J089820 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 25.3 -6.2 -6180 2.7 LEF1 IKZF1 DPF2 HDAC1 SOX6 SP1 CEBPB NFE2 NR3C1 ZNF316 LOC105370965 ANPEP AP3S2 FANCI MESP1 ZNF710 CIB1 POLG SEMA4B MIR5094
GH15J089834 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 16.5 -21.5 -21472 4 FOXA1 CEBPB RFX1 JUND CTBP1 NR3C1 FOS ZNF217 ESR1 GATA3 AP3S2 ANPEP MESP2 MESP1 MIR5094 LOC105370965 lnc-ANPEP-1 ARPIN-AP3S2
GH15J089827 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.1 -13.1 -13063 1.7 HNRNPL REST SP1 ESR1 FOXA2 USF1 ESRRA YY1 GABPA ZBTB33 AP3S2 ANPEP MESP1 ZNF710 CIB1 LOC105370965 MIR5094
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANPEP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANPEP

Top Transcription factor binding sites by QIAGEN in the ANPEP gene promoter:
  • C/EBPalpha
  • Elk-1
  • FOXD1
  • FOXI1
  • HFH-3
  • N-Myc
  • Nkx2-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ANPEP Gene

Genomic Locations for ANPEP Gene
chr15:89,784,895-89,815,401
(GRCh38/hg38)
Size:
30,507 bases
Orientation:
Minus strand
chr15:90,328,120-90,358,633
(GRCh37/hg19)
Size:
30,514 bases
Orientation:
Minus strand

Genomic View for ANPEP Gene

Genes around ANPEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANPEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANPEP Gene

Proteins for ANPEP Gene

  • Protein details for ANPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15144-AMPN_HUMAN
    Recommended name:
    Aminopeptidase N
    Protein Accession:
    P15144
    Secondary Accessions:
    • Q16728
    • Q6GT90
    • Q8IUK3
    • Q8IVH3
    • Q9UCE0

    Protein attributes for ANPEP Gene

    Size:
    967 amino acids
    Molecular mass:
    109540 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer. Interacts with SLC6A19 (By similarity).
    • (Microbial infection) Interacts with the S1 domain of human coronavirus 229E/HCoV-229E spike protein.
    Miscellaneous:
    • Found to serve as a receptor for tumor-homing peptides, more specifically NGR peptides. It could serve thus as a target for delivering drugs into tumors. Concentration in human hepatic bile, varies from 17.3 to 57.6 micrograms/ml.

    Three dimensional structures from OCA and Proteopedia for ANPEP Gene

neXtProt entry for ANPEP Gene

Selected DME Specific Peptides for ANPEP Gene

P15144:
  • VIIIHSKKLNYT
  • TEYLVVHL
  • LNRYLSYTLNPD
  • WWNDLWLNE
  • ELQQLEQF
  • GAMENWG
  • NNPIHPNLR
  • SNWKKLF
  • STVRFTC
  • VTGPILNFFA
  • WWNDLWLNEGFASYVE
  • AEPTWNLKDL
  • NTPAQISE
  • LVNEADKLR
  • LPDFNAGAMENWGLVTYRE
  • IPVINRAQ
  • WNRYRLP
  • LGILGILLGVAA
  • WFGNLVT
  • DVYRVMAVDALASSHPL
  • HELAHQWFG
  • ARKSFPCFDEP
  • WLNEGFA
  • LMFDRSEVYGPMK

Post-translational modifications for ANPEP Gene

  • Sulfated.
  • N- and O-glycosylated.
  • May undergo proteolysis and give rise to a soluble form.
  • Glycosylation at Asn42, Asn128, Asn234, Asn265, Asn319, Asn527, Asn573, Asn625, Asn681, Asn735, and Asn818
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • AMPN_HUMAN (815)

Other Protein References for ANPEP Gene

Antibody Products

  • Abcam antibodies for ANPEP

Domains & Families for ANPEP Gene

Gene Families for ANPEP Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ANPEP Gene

InterPro:
Blocks:
  • Membrane alanyl dipeptidase (M1) family signature
ProtoNet:

Suggested Antigen Peptide Sequences for ANPEP Gene

GenScript: Design optimal peptide antigens:
  • gp150 (AMPN_HUMAN)
  • cDNA FLJ51269, highly similar to Aminopeptidase N (EC 3.4.11.2) (B4DP96_HUMAN)
  • Aminopeptidase N (Q8IVL7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15144

UniProtKB/Swiss-Prot:

AMPN_HUMAN :
  • Belongs to the peptidase M1 family.
Family:
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with ANPEP: view

Function for ANPEP Gene

Molecular function for ANPEP Gene

UniProtKB/Swiss-Prot Function:
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.; EC=3.4.11.2; Evidence={ECO:0000269|PubMed:22932899, ECO:0000269|PubMed:6149934, ECO:0000269|PubMed:7576235, ECO:0000269|PubMed:8887485};.
UniProtKB/Swiss-Prot Induction:
Estradiol and IL8/interleukin-8 decrease enzymatic activity in vitro in endometrial stromal cells by 40% and 30%, respectively.
GENATLAS Biochemistry:
membrane leucyl aminopeptidase N,p150

Enzyme Numbers (IUBMB) for ANPEP Gene

Phenotypes From GWAS Catalog for ANPEP Gene

Gene Ontology (GO) - Molecular Function for ANPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004177 aminopeptidase activity TAS 10734069
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA,TAS 2564851
GO:0008270 zinc ion binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with ANPEP: view
genes like me logo Genes that share phenotypes with ANPEP: view

Animal Models for ANPEP Gene

MGI Knock Outs for ANPEP:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANPEP

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANPEP

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANPEP Gene

Localization for ANPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANPEP Gene

Cell membrane. Single-pass type II membrane protein. Note=Also found as a soluble form. {ECO:0000269 PubMed:7902291}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANPEP gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 4
endoplasmic reticulum 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25645918
GO:0005737 cytoplasm IBA 21873635
GO:0005765 lysosomal membrane HDA 17897319
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ANPEP: view

Pathways & Interactions for ANPEP Gene

genes like me logo Genes that share pathways with ANPEP: view

Pathways by source for ANPEP Gene

1 GeneGo (Thomson Reuters) pathway for ANPEP Gene
  • Glutathione metabolism
1 R&D Systems pathway for ANPEP Gene
1 Cell Signaling Technology pathway for ANPEP Gene

Gene Ontology (GO) - Biological Process for ANPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006508 proteolysis IEA,IBA 21873635
GO:0007275 multicellular organism development IEA --
GO:0016032 viral process IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ANPEP: view

No data available for SIGNOR curated interactions for ANPEP Gene

Drugs & Compounds for ANPEP Gene

(57) Drugs for ANPEP Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ezetimibe Approved Pharma Target, other Cholesterol transport inhibitor 333
Icatibant Approved, Investigational Pharma Antagonist, Target, inhibitor 21
Zinc Approved, Investigational Pharma 1594
Cysteine Approved Nutra 250
Human calcitonin Approved, Investigational Pharma Enzyme, substrate 0

(47) Additional Compounds for ANPEP Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cysteinylglycine
  • CG
  • Cys-gly
  • N-L-Cysteinylglycine
  • L-Cysteinylglycine
  • N-Cysteinyl glycine
19246-18-5
CHR 2797
238750-77-1
HFI 142
332164-34-8

(4) Tocris Compounds for ANPEP Gene

Compound Action Cas Number
Bestatin Aminopeptidase inhibitor 58970-76-6
CHR 2797 Aminopeptidase inhibitor 238750-77-1
Fumagillin Methionine aminopeptidase-2 inhibitor; antiangiogenic 23110-15-8
HFI 142 Insulin-regulated aminopeptidase (IRAP) inhibitor 332164-34-8

(3) ApexBio Compounds for ANPEP Gene

Compound Action Cas Number
Bestatin Aminopeptidase inhibitor 58970-76-6
Bestatin hydrochloride 65391-42-6
Tosedostat (CHR2797) Aminopeptidase inhibitor 238750-77-1
genes like me logo Genes that share compounds with ANPEP: view

Drug Products

Transcripts for ANPEP Gene

mRNA/cDNA for ANPEP Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANPEP

Alternative Splicing Database (ASD) splice patterns (SP) for ANPEP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2: -
SP3:
SP4:
SP5:

ExUns: 21
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ANPEP Gene

GeneLoc Exon Structure for
ANPEP

Expression for ANPEP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANPEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANPEP Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x11.3), Pancreas (x10.0), Whole Blood (x5.6), and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for ANPEP Gene

This gene is overexpressed in Pancreatic juice (20.1), Urine (13.5), Fetal gut (9.5), and Nasal epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANPEP Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANPEP

SOURCE GeneReport for Unigene cluster for ANPEP Gene:

Hs.1239

mRNA Expression by UniProt/SwissProt for ANPEP Gene:

P15144-AMPN_HUMAN
Tissue specificity: Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.

Evidence on tissue expression from TISSUES for ANPEP Gene

  • Intestine(4.8)
  • Liver(4.8)
  • Bone marrow(4.8)
  • Blood(4.7)
  • Pancreas(4.7)
  • Kidney(4.1)
  • Skin(3)
  • Gall bladder(3)
  • Heart(3)
  • Spleen(2.9)
  • Lymph node(2.8)
  • Lung(2.8)
  • Nervous system(2.8)
  • Muscle(2.4)
  • Bone(2.4)
  • Stomach(2.3)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with ANPEP: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANPEP Gene

Orthologs for ANPEP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANPEP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANPEP 30 31
  • 98.97 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANPEP 30 31
  • 81.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANPEP 30 31
  • 81.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Anpep 30
  • 79.15 (n)
Mouse
(Mus musculus)
Mammalia Anpep 30 17 31
  • 78.22 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANPEP 31
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ANPEP 31
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ANPEP 30 31
  • 71.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANPEP 31
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia anpep 30
  • 61.53 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12671 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100535773 30
  • 61.7 (n)
BX572619.7 31
  • 60 (a)
OneToMany
anpepb 31
  • 59 (a)
OneToMany
ANPEP (6 of 6) 31
  • 57 (a)
OneToMany
BX005410.1 31
  • 56 (a)
OneToMany
BX005410.2 31
  • 53 (a)
OneToMany
ANPEP (3 of 6) 31
  • 53 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9152 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013001 30
  • 53.38 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG14516 30 31 32
  • 51.06 (n)
ManyToMany
CG8773 32
  • 36 (a)
CG31445 31
  • 33 (a)
ManyToMany
SP1029 31 32
  • 33 (a)
ManyToMany
CG11951 31 32
  • 33 (a)
ManyToMany
BG:DS00365.1 32
  • 32 (a)
CG7653 31
  • 29 (a)
ManyToMany
CG31198 31
  • 29 (a)
ManyToMany
CG31233 31
  • 29 (a)
ManyToMany
CG3502 31 32
  • 28 (a)
ManyToMany
CG31343 31
  • 27 (a)
ManyToMany
CG2111 31 32
  • 27 (a)
ManyToMany
CG42335 31
  • 26 (a)
ManyToMany
CG9806 31 32
  • 26 (a)
ManyToMany
sda 31 32
  • 24 (a)
ManyToMany
CG5849 31 32
  • 22 (a)
ManyToMany
CG6071 31 32
  • 20 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea Y67D8C.9 32
  • 33 (a)
R03G8.6 32
  • 30 (a)
Y42A5A.1 32
  • 30 (a)
T12E12.6 32
  • 28 (a)
T07F10.1 31 32
  • 27 (a)
ManyToMany
R03G8.4 32
  • 27 (a)
T16G12.1 32
  • 27 (a)
AC3.5 32
  • 22 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAP1 31
  • 30 (a)
ManyToMany
APE2 31
  • 28 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
Species where no ortholog for ANPEP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ANPEP Gene

ENSEMBL:
Gene Tree for ANPEP (if available)
TreeFam:
Gene Tree for ANPEP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANPEP: view image

Paralogs for ANPEP Gene

Paralogs for ANPEP Gene

(9) SIMAP similar genes for ANPEP Gene using alignment to 5 proteins:

  • AMPN_HUMAN
  • H0YKT6_HUMAN
  • H0YLZ8_HUMAN
  • H0YM04_HUMAN
  • H0YMC1_HUMAN
genes like me logo Genes that share paralogs with ANPEP: view

Variants for ANPEP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANPEP Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
716129 Likely Benign: not provided 89,803,917(-) G/C MISSENSE_VARIANT
716130 Likely Benign: not provided 89,805,203(-) G/T MISSENSE_VARIANT
720704 Benign: not provided 89,797,719(-) G/C SYNONYMOUS_VARIANT
720834 Benign: not provided 89,792,255(-) G/A SYNONYMOUS_VARIANT
741271 Likely Benign: not provided 89,803,653(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ANPEP Gene

Structural Variations from Database of Genomic Variants (DGV) for ANPEP Gene

Variant ID Type Subtype PubMed ID
nsv1126406 CNV deletion 24896259
nsv1661 CNV insertion 18451855
nsv519689 CNV loss 19592680
nsv570388 CNV loss 21841781
nsv819621 CNV gain 19587683

Variation tolerance for ANPEP Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 62.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANPEP Gene

Human Gene Mutation Database (HGMD)
ANPEP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANPEP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANPEP Gene

Disorders for ANPEP Gene

MalaCards: The human disease database

(35) MalaCards diseases for ANPEP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastroenteritis
  • cholera morbus
tetrasomy 21
  • isochromosome 21
lactose intolerance
  • lm - lactose malabsorption
mast-cell sarcoma
  • mast cell sarcoma
myeloid sarcoma
  • chloroma
- elite association - COSMIC cancer census association via MalaCards
Search ANPEP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ANPEP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ANPEP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANPEP Gene

Publications for ANPEP Gene

  1. Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation. (PMID: 11559807) Wentworth DE … Holmes KV (Journal of virology 2001) 3 4 23
  2. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. (PMID: 11384645) Seli E … Arici A (Fertility and sterility 2001) 3 4 23
  3. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. (PMID: 10676659) Pasqualini R … Ruoslahti E (Cancer research 2000) 3 4 23
  4. Modification of the amino terminus of a class II epitope confers resistance to degradation by CD13 on dendritic cells and enhances presentation to T cells. (PMID: 10605003) Dong X … Salter RD (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 23
  5. Identification of residues critical for the human coronavirus 229E receptor function of human aminopeptidase N. (PMID: 9367365) Kolb AF … Siddell SG (The Journal of general virology 1997) 3 4 23

Products for ANPEP Gene

Sources for ANPEP Gene