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Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020]
ANPEP (Alanyl Aminopeptidase, Membrane) is a Protein Coding gene. Diseases associated with ANPEP include Gastroenteritis and Tetrasomy 21. Among its related pathways are Neuroscience and Peptide hormone metabolism. Gene Ontology (GO) annotations related to this gene include virus receptor activity. An important paralog of this gene is LVRN.
Aminopeptidases catalyze the removal of amino acids from the amino terminus of proteins and peptides. They express different substrate specificities - for example, leucyl aminopeptidase preferentially cleaves leucine residues.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001618 | virus receptor activity | IEA | -- |
GO:0004177 | aminopeptidase activity | TAS | 10734069 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008237 | metallopeptidase activity | IEA,TAS | 2564851 |
GO:0008270 | zinc ion binding | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 25645918 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005765 | lysosomal membrane | HDA | 17897319 |
GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | IDA | 15308636 |
GO:0005886 | plasma membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glutathione metabolism |
Glutathione metabolism
.60
|
|
2 | Innate Immune System |
.61
|
|
3 | Peptide hormone metabolism | ||
4 | Neuroscience | ||
5 | Hematopoietic cell lineage |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IEA | -- |
GO:0006508 | proteolysis | IEA,IBA | 21873635 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0016032 | viral process | IEA | -- |
GO:0030154 | cell differentiation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ezetimibe | Approved | Pharma | Target, other | Cholesterol transport inhibitor | 333 | |
Icatibant | Approved, Investigational | Pharma | Antagonist, Target, inhibitor | 21 | ||
Zinc | Approved, Investigational | Pharma | 1594 | |||
Cysteine | Approved | Nutra | 250 | |||
Human calcitonin | Approved, Investigational | Pharma | Enzyme, substrate | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
cysteinylglycine |
|
19246-18-5 |
|
|||
CHR 2797 |
|
238750-77-1 |
|
|
||
HFI 142 |
|
332164-34-8 |
|
|
Compound | Action | Cas Number |
---|---|---|
Bestatin | Aminopeptidase inhibitor | 58970-76-6 |
CHR 2797 | Aminopeptidase inhibitor | 238750-77-1 |
Fumagillin | Methionine aminopeptidase-2 inhibitor; antiangiogenic | 23110-15-8 |
HFI 142 | Insulin-regulated aminopeptidase (IRAP) inhibitor | 332164-34-8 |
Compound | Action | Cas Number |
---|---|---|
Bestatin | Aminopeptidase inhibitor | 58970-76-6 |
Bestatin hydrochloride | 65391-42-6 | |
Tosedostat (CHR2797) | Aminopeptidase inhibitor | 238750-77-1 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: |
ExUns: | 21 |
---|---|
SP1: | |
SP2: | |
SP3: | |
SP4: | |
SP5: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ANPEP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ANPEP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ANPEP 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Anpep 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Anpep 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ANPEP 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ANPEP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ANPEP 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ANPEP 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | anpep 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.12671 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100535773 30 |
|
||
BX572619.7 31 |
|
OneToMany | |||
anpepb 31 |
|
OneToMany | |||
ANPEP (6 of 6) 31 |
|
OneToMany | |||
BX005410.1 31 |
|
OneToMany | |||
BX005410.2 31 |
|
OneToMany | |||
ANPEP (3 of 6) 31 |
|
OneToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9152 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP013001 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG14516 30 31 32 |
|
ManyToMany | |
CG8773 32 |
|
|
|||
CG31445 31 |
|
ManyToMany | |||
SP1029 31 32 |
|
ManyToMany | |||
CG11951 31 32 |
|
ManyToMany | |||
BG:DS00365.1 32 |
|
|
|||
CG7653 31 |
|
ManyToMany | |||
CG31198 31 |
|
ManyToMany | |||
CG31233 31 |
|
ManyToMany | |||
CG3502 31 32 |
|
ManyToMany | |||
CG31343 31 |
|
ManyToMany | |||
CG2111 31 32 |
|
ManyToMany | |||
CG42335 31 |
|
ManyToMany | |||
CG9806 31 32 |
|
ManyToMany | |||
sda 31 32 |
|
ManyToMany | |||
CG5849 31 32 |
|
ManyToMany | |||
CG6071 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | Y67D8C.9 32 |
|
|
|
R03G8.6 32 |
|
|
|||
Y42A5A.1 32 |
|
|
|||
T12E12.6 32 |
|
|
|||
T07F10.1 31 32 |
|
ManyToMany | |||
R03G8.4 32 |
|
|
|||
T16G12.1 32 |
|
|
|||
AC3.5 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AAP1 31 |
|
ManyToMany | |
APE2 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
716129 | Likely Benign: not provided | 89,803,917(-) | G/C | MISSENSE_VARIANT | |
716130 | Likely Benign: not provided | 89,805,203(-) | G/T | MISSENSE_VARIANT | |
720704 | Benign: not provided | 89,797,719(-) | G/C | SYNONYMOUS_VARIANT | |
720834 | Benign: not provided | 89,792,255(-) | G/A | SYNONYMOUS_VARIANT | |
741271 | Likely Benign: not provided | 89,803,653(-) | G/A | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
gastroenteritis |
|
|
tetrasomy 21 |
|
|
lactose intolerance |
|
|
mast-cell sarcoma |
|
|
myeloid sarcoma |
|