Aliases for ANP32E Gene

Aliases for ANP32E Gene

  • Acidic Nuclear Phosphoprotein 32 Family Member E 2 3 5
  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member E 2 3
  • Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member E 3 4
  • LANP-Like Protein 3 4
  • LANP-L 3 4
  • Leucine-Rich Acidic Nuclear Protein Like 3
  • LANPL 3

External Ids for ANP32E Gene

Previous GeneCards Identifiers for ANP32E Gene

  • GC01M146965
  • GC01M147407
  • GC01M147003
  • GC01M148457
  • GC01M121570

Summaries for ANP32E Gene

GeneCards Summary for ANP32E Gene

ANP32E (Acidic Nuclear Phosphoprotein 32 Family Member E) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include histone binding and phosphatase inhibitor activity. An important paralog of this gene is ANP32A.

UniProtKB/Swiss-Prot Summary for ANP32E Gene

  • Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.

Gene Wiki entry for ANP32E Gene

Additional gene information for ANP32E Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANP32E Gene

Genomics for ANP32E Gene

GeneHancer (GH) Regulatory Elements for ANP32E Gene

Promoters and enhancers for ANP32E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANP32E on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANP32E gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • Evi-1
  • MyoD
  • ZID

Genomic Locations for ANP32E Gene

Genomic Locations for ANP32E Gene
chr1:150,218,417-150,236,156
(GRCh38/hg38)
Size:
17,740 bases
Orientation:
Minus strand
chr1:150,190,717-150,208,504
(GRCh37/hg19)
Size:
17,788 bases
Orientation:
Minus strand

Genomic View for ANP32E Gene

Genes around ANP32E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANP32E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANP32E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32E Gene

Proteins for ANP32E Gene

  • Protein details for ANP32E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTT0-AN32E_HUMAN
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member E
    Protein Accession:
    Q9BTT0
    Secondary Accessions:
    • B4E0I6
    • E9PEA6
    • Q5TB18
    • Q5TB20
    • Q8N1S4
    • Q8WWW9

    Protein attributes for ANP32E Gene

    Size:
    268 amino acids
    Molecular mass:
    30692 Da
    Quaternary structure:
    • Interacts with the importin alpha KPNA1 and KPNA2 (By similarity). Component of a SWR1-like complex, composed of EP400, KAT5/TIP60, TRRAP, BRD8, RUVBL1, RUVBL2, ING3 and ANP32E; the complex does not contain SRCAP. Interacts with H2A.Z/H2AFZ.

    Three dimensional structures from OCA and Proteopedia for ANP32E Gene

    Alternative splice isoforms for ANP32E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANP32E Gene

Post-translational modifications for ANP32E Gene

  • Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity).
  • Ubiquitination at Lys65, Lys86, Lys99, Lys101, and Lys113
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANP32E Gene

Domains & Families for ANP32E Gene

Gene Families for ANP32E Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANP32E Gene

Suggested Antigen Peptide Sequences for ANP32E Gene

GenScript: Design optimal peptide antigens:
  • LANP-like protein (AN32E_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BTT0

UniProtKB/Swiss-Prot:

AN32E_HUMAN :
  • The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AFZ.
  • Belongs to the ANP32 family.
Domain:
  • The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AFZ.
Family:
  • Belongs to the ANP32 family.
genes like me logo Genes that share domains with ANP32E: view

Function for ANP32E Gene

Molecular function for ANP32E Gene

UniProtKB/Swiss-Prot Function:
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.

Phenotypes From GWAS Catalog for ANP32E Gene

Gene Ontology (GO) - Molecular Function for ANP32E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0019212 phosphatase inhibitor activity ISS,IBA --
GO:0042393 histone binding IDA 24463511
genes like me logo Genes that share ontologies with ANP32E: view
genes like me logo Genes that share phenotypes with ANP32E: view

Animal Model Products

CRISPR Products

miRNA for ANP32E Gene

miRTarBase miRNAs that target ANP32E

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANP32E

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANP32E Gene

Localization for ANP32E Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANP32E Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANP32E gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANP32E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus ISS,IDA --
GO:0005737 cytoplasm IEA --
GO:0031410 cytoplasmic vesicle ISS --
genes like me logo Genes that share ontologies with ANP32E: view

Pathways & Interactions for ANP32E Gene

PathCards logo

SuperPathways for ANP32E Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANP32E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0043086 negative regulation of catalytic activity IEA --
GO:0043486 histone exchange IDA 24463511
genes like me logo Genes that share ontologies with ANP32E: view

No data available for Pathways by source and SIGNOR curated interactions for ANP32E Gene

Drugs & Compounds for ANP32E Gene

No Compound Related Data Available

Transcripts for ANP32E Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANP32E

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32E Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5: -

Relevant External Links for ANP32E Gene

GeneLoc Exon Structure for
ANP32E
ECgene alternative splicing isoforms for
ANP32E

Expression for ANP32E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANP32E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANP32E Gene

This gene is overexpressed in Lymph node (8.8) and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANP32E Gene



Protein tissue co-expression partners for ANP32E Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANP32E Gene:

ANP32E

SOURCE GeneReport for Unigene cluster for ANP32E Gene:

Hs.656466

mRNA Expression by UniProt/SwissProt for ANP32E Gene:

Q9BTT0-AN32E_HUMAN
Tissue specificity: Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney.

Evidence on tissue expression from TISSUES for ANP32E Gene

  • Nervous system(4.6)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with ANP32E: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANP32E Gene

Orthologs for ANP32E Gene

This gene was present in the common ancestor of animals.

Orthologs for ANP32E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANP32E 33 32
  • 99.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANP32E 33
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANP32E 33
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anp32e 33
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANP32E 33
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANP32E 33
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANP32E 33
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANP32E 33
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia anp32e-prov 32
zebrafish
(Danio rerio)
Actinopterygii anp32e 33
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mapmodulin 33
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T19H12.2 33
  • 38 (a)
ManyToMany
F33H2.3 33
  • 37 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11188 33
  • 44 (a)
OneToMany
Species where no ortholog for ANP32E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ANP32E Gene

ENSEMBL:
Gene Tree for ANP32E (if available)
TreeFam:
Gene Tree for ANP32E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANP32E: view image

Paralogs for ANP32E Gene

Paralogs for ANP32E Gene

(4) SIMAP similar genes for ANP32E Gene using alignment to 7 proteins:

  • AN32E_HUMAN
  • E9PI45_HUMAN
  • E9PLC4_HUMAN
  • E9PPH5_HUMAN
  • H0YCE2_HUMAN
  • Q5TB19_HUMAN
  • Q5TB25_HUMAN
genes like me logo Genes that share paralogs with ANP32E: view

Variants for ANP32E Gene

Sequence variations from dbSNP and Humsavar for ANP32E Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000137629 -- 150,235,405(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000421211 -- 150,228,125(-) T/C intron_variant
rs1000646120 -- 150,227,969(-) A/G intron_variant
rs1001538834 -- 150,234,323(-) C/G intron_variant
rs1001855552 -- 150,219,510(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ANP32E Gene

Variant ID Type Subtype PubMed ID
esv3377218 CNV insertion 20981092
esv3389799 CNV insertion 20981092
esv3395116 CNV insertion 20981092
nsv1078948 CNV deletion 25765185

Variation tolerance for ANP32E Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.84; 93.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANP32E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANP32E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANP32E Gene

Disorders for ANP32E Gene

Additional Disease Information for ANP32E

No disorders were found for ANP32E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANP32E Gene

Publications for ANP32E Gene

  1. Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain. (PMID: 12438741) Jiang M … Mao Y (Cytogenetic and genome research 2002) 2 3 4 23 56
  2. ANP32E is a histone chaperone that removes H2A.Z from chromatin. (PMID: 24463511) Obri A … Hamiche A (Nature 2014) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. (PMID: 30890647) Viita T … Vartiainen MK (Journal of cell science 2019) 3 56

Products for ANP32E Gene

Sources for ANP32E Gene