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Aliases for ANP32C Gene

Aliases for ANP32C Gene

  • Acidic Nuclear Phosphoprotein 32 Family Member C 2 3 5
  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member C 2 3
  • Phosphoprotein 32-Related Protein 1 3 4
  • Tumorigenic Protein Pp32r1 3 4
  • PP32R1 3 4
  • Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member C 3
  • Pp32 Related 1 3

External Ids for ANP32C Gene

Previous GeneCards Identifiers for ANP32C Gene

  • GC04M165967
  • GC04M165546
  • GC04M165695
  • GC04M165475
  • GC04M165337
  • GC04M165118
  • GC04M160872

Summaries for ANP32C Gene

Entrez Gene Summary for ANP32C Gene

  • Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANP32C Gene

ANP32C (Acidic Nuclear Phosphoprotein 32 Family Member C) is a Protein Coding gene.

Gene Wiki entry for ANP32C Gene

Additional gene information for ANP32C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANP32C Gene

Genomics for ANP32C Gene

GeneHancer (GH) Regulatory Elements for ANP32C Gene

Promoters and enhancers for ANP32C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J164197 Promoter 0.5 EPDnew 650.7 +0.2 203 0.1 ANP32C MARCH1 LOC100288073 GC04M163839
GH04J164203 Enhancer 0.8 Ensembl ENCODE 0.4 -6.7 -6742 2.1 NANOG JUN TEAD3 GATA3 JUND POLR2A STAT3 POU5F1 ANP32C MARCH1 GC04M163839
GH04J164383 Promoter/Enhancer 1.1 EPDnew ENCODE 0.1 -186.1 -186056 1.3 CTCF MXI1 SUZ12 SIN3A ZNF398 ATF2 ZIC2 ZNF335 ZNF692 POLR2A MARCH1 GC04M163839 ANP32C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANP32C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANP32C gene promoter:
  • Nkx2-5
  • Pax-2a
  • Pax-2
  • LHX3b
  • Lhx3a
  • TBP
  • NF-1/L
  • NF-1
  • HSF2
  • Pax-4a

Genomic Locations for ANP32C Gene

Genomic Locations for ANP32C Gene
705 bases
Minus strand
705 bases
Minus strand

Genomic View for ANP32C Gene

Genes around ANP32C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANP32C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANP32C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32C Gene

Proteins for ANP32C Gene

  • Protein details for ANP32C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member C
    Protein Accession:
    Secondary Accessions:
    • Q4W5F9

    Protein attributes for ANP32C Gene

    234 amino acids
    Molecular mass:
    26762 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANP32C Gene

Post-translational modifications for ANP32C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANP32C Gene

REFSEQ proteins:

No data available for DME Specific Peptides for ANP32C Gene

Domains & Families for ANP32C Gene

Gene Families for ANP32C Gene

Protein Domains for ANP32C Gene


Suggested Antigen Peptide Sequences for ANP32C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ANP32 family.
  • Belongs to the ANP32 family.
genes like me logo Genes that share domains with ANP32C: view

Function for ANP32C Gene

Gene Ontology (GO) - Molecular Function for ANP32C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with ANP32C: view
genes like me logo Genes that share phenotypes with ANP32C: view

Animal Model Products

miRNA for ANP32C Gene

miRTarBase miRNAs that target ANP32C

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANP32C Gene

Localization for ANP32C Gene

Gene Ontology (GO) - Cellular Components for ANP32C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0048471 perinuclear region of cytoplasm IBA --
genes like me logo Genes that share ontologies with ANP32C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ANP32C Gene

Pathways & Interactions for ANP32C Gene

SuperPathways for ANP32C Gene

No Data Available

Interacting Proteins for ANP32C Gene

Gene Ontology (GO) - Biological Process for ANP32C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 NOT nucleosome assembly IBA --
GO:0006338 chromatin remodeling IBA --
GO:0006913 nucleocytoplasmic transport IBA --
GO:0042981 regulation of apoptotic process IBA --
GO:0043486 NOT histone exchange IBA --
genes like me logo Genes that share ontologies with ANP32C: view

No data available for Pathways by source and SIGNOR curated interactions for ANP32C Gene

Drugs & Compounds for ANP32C Gene

No Compound Related Data Available

Transcripts for ANP32C Gene

mRNA/cDNA for ANP32C Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANP32C Gene

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32C Gene

No ASD Table

Relevant External Links for ANP32C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANP32C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANP32C Gene

Protein differential expression in normal tissues from HIPED for ANP32C Gene

This gene is overexpressed in Heart (59.2) and Brain (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANP32C Gene

Protein tissue co-expression partners for ANP32C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANP32C Gene:


SOURCE GeneReport for Unigene cluster for ANP32C Gene:


mRNA Expression by UniProt/SwissProt for ANP32C Gene:

Tissue specificity: Expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, but not in resting bone marrow CD34+ cells. Expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines. Not expressed in normal prostatic tissue.
genes like me logo Genes that share expression patterns with ANP32C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANP32C Gene

Orthologs for ANP32C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ANP32C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANP32C 33
  • 97.29 (n)
Species where no ortholog for ANP32C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANP32C Gene

Gene Tree for ANP32C (if available)
Gene Tree for ANP32C (if available)

Paralogs for ANP32C Gene

(4) SIMAP similar genes for ANP32C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANP32C: view

No data available for Paralogs for ANP32C Gene

Variants for ANP32C Gene

Sequence variations from dbSNP and Humsavar for ANP32C Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1001716197 -- 164,199,322(-) A/G upstream_transcript_variant
rs1004077345 -- 164,199,338(-) T/A/C upstream_transcript_variant
rs1005617162 -- 164,199,709(-) G/C upstream_transcript_variant
rs1007858568 -- 164,196,676(-) G/T downstream_transcript_variant
rs1010700599 -- 164,197,693(-) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ANP32C Gene

Variant ID Type Subtype PubMed ID
nsv966335 CNV duplication 23825009
nsv1030184 CNV loss 25217958
esv2762472 CNV loss 21179565

Additional Variant Information for ANP32C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ANP32C Gene

Disorders for ANP32C Gene

Additional Disease Information for ANP32C

No disorders were found for ANP32C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANP32C Gene

Publications for ANP32C Gene

  1. Modulation of oncogenic potential by alternative gene use in human prostate cancer. (PMID: 10086381) Kadkol SS … Pasternack GR (Nature medicine 1999) 2 3 4 22 58
  2. Identification of a functional mutation in pp32r1 (ANP32C). (PMID: 15146458) Kochevar GJ … Pasternack GR (Human mutation 2004) 3 4 22 58
  3. The Anp32 family of proteins containing leucine-rich repeats. (PMID: 15895553) Matilla A … Radrizzani M (Cerebellum (London, England) 2005) 3 4 58
  4. Identification of sequences required for inhibition of oncogene-mediated transformation by pp32. (PMID: 10400610) Brody JR … Pasternack GR (The Journal of biological chemistry 1999) 2 3 58
  5. Correction to "Modulation of oncogenic potential by alternative gene use in human prostate cancer" (PMID: 10471270) Kadkol SS … Pasternack GR (Nature medicine 1999) 3 4 58

Products for ANP32C Gene

Sources for ANP32C Gene

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