Aliases for ANP32B Gene

Aliases for ANP32B Gene

  • Acidic Nuclear Phosphoprotein 32 Family Member B 2 3 5
  • Acidic Protein Rich In Leucines 2 3 4
  • PHAPI2 2 3 4
  • APRIL 2 3 4
  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member B 2 3
  • Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B 3 4
  • Putative HLA-DR-Associated Protein I-2 3 4
  • Silver-Stainable Protein SSP29 3 4
  • SSP29 2 3
  • ANP32B 5

External Ids for ANP32B Gene

Previous GeneCards Identifiers for ANP32B Gene

  • GC09P091570
  • GC09P092489
  • GC09P094202
  • GC09P096125
  • GC09P097825
  • GC09P099785
  • GC09P100745

Summaries for ANP32B Gene

GeneCards Summary for ANP32B Gene

ANP32B (Acidic Nuclear Phosphoprotein 32 Family Member B) is a Protein Coding gene. Diseases associated with ANP32B include Myopathy, Congenital, Compton-North. Gene Ontology (GO) annotations related to this gene include histone binding and RNA polymerase binding. An important paralog of this gene is ANP32A.

UniProtKB/Swiss-Prot Summary for ANP32B Gene

  • Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.

Gene Wiki entry for ANP32B Gene

Additional gene information for ANP32B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANP32B Gene

Genomics for ANP32B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANP32B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANP32B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANP32B

Top Transcription factor binding sites by QIAGEN in the ANP32B gene promoter:
  • MIF-1
  • Nkx6-1
  • RFX1
  • TBP
  • TFIID

Genomic Locations for ANP32B Gene

Genomic Locations for ANP32B Gene
chr9:97,983,341-98,015,943
(GRCh38/hg38)
Size:
32,603 bases
Orientation:
Plus strand
chr9:100,745,489-100,778,225
(GRCh37/hg19)
Size:
32,737 bases
Orientation:
Plus strand

Genomic View for ANP32B Gene

Genes around ANP32B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANP32B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANP32B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32B Gene

Proteins for ANP32B Gene

  • Protein details for ANP32B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92688-AN32B_HUMAN
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member B
    Protein Accession:
    Q92688
    Secondary Accessions:
    • B2R9C7
    • O00655
    • P78458
    • P78459

    Protein attributes for ANP32B Gene

    Size:
    251 amino acids
    Molecular mass:
    28788 Da
    Quaternary structure:
    • Monomer. Interacts with histones H3 and H4.
    Miscellaneous:
    • [Isoform 2]: No canonical donor splice site.

    Three dimensional structures from OCA and Proteopedia for ANP32B Gene

    Alternative splice isoforms for ANP32B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANP32B Gene

Post-translational modifications for ANP32B Gene

  • Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
  • Ubiquitination at Lys86 and Lys99
  • Modification sites at PhosphoSitePlus

Other Protein References for ANP32B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for ANP32B

No data available for DME Specific Peptides for ANP32B Gene

Domains & Families for ANP32B Gene

Gene Families for ANP32B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ANP32B Gene

InterPro:
Blocks:
  • Leucine-rich-associated
ProtoNet:

Suggested Antigen Peptide Sequences for ANP32B Gene

GenScript: Design optimal peptide antigens:
  • Silver-stainable protein SSP29 (AN32B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92688

UniProtKB/Swiss-Prot:

AN32B_HUMAN :
  • Histone binding is mediated by the concave surface of the LRR region.
  • Belongs to the ANP32 family.
Domain:
  • Histone binding is mediated by the concave surface of the LRR region.
Family:
  • Belongs to the ANP32 family.
genes like me logo Genes that share domains with ANP32B: view

Function for ANP32B Gene

Molecular function for ANP32B Gene

UniProtKB/Swiss-Prot Function:
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.

Phenotypes From GWAS Catalog for ANP32B Gene

Gene Ontology (GO) - Molecular Function for ANP32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0042393 histone binding IDA 20538007
GO:0070063 RNA polymerase binding IDA 9285060
genes like me logo Genes that share ontologies with ANP32B: view
genes like me logo Genes that share phenotypes with ANP32B: view

Animal Model Products

CRISPR Products

miRNA for ANP32B Gene

miRTarBase miRNAs that target ANP32B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANP32B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANP32B Gene

Localization for ANP32B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANP32B Gene

[Isoform 1]: Nucleus. Note=Accumulates in the nuclei at the S phase. {ECO:0000250}.
[Isoform 2]: Cytoplasm. Note=Lacks a nuclear localization signal.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANP32B gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 3
mitochondrion 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (4)
  • Nucleoplasm (4)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANP32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9285060
GO:0005654 nucleoplasm IDA --
GO:0005730 colocalizes_with nucleolus IDA 9285060
GO:0005737 cytoplasm IEA,IDA 17178712
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with ANP32B: view

Pathways & Interactions for ANP32B Gene

PathCards logo

SuperPathways for ANP32B Gene

No Data Available

SIGNOR curated interactions for ANP32B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ANP32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001944 vasculature development IEA --
GO:0006334 nucleosome assembly IDA 20538007
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP 20015864
GO:0021591 ventricular system development IEA --
GO:0042981 regulation of apoptotic process IBA 21873635
genes like me logo Genes that share ontologies with ANP32B: view

No data available for Pathways by source for ANP32B Gene

Drugs & Compounds for ANP32B Gene

No Compound Related Data Available

Transcripts for ANP32B Gene

mRNA/cDNA for ANP32B Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANP32B

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: -
SP3:

Relevant External Links for ANP32B Gene

GeneLoc Exon Structure for
ANP32B

Expression for ANP32B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANP32B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Tonsil (Hematopoietic System)

Protein differential expression in normal tissues from HIPED for ANP32B Gene

This gene is overexpressed in Lymph node (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANP32B Gene



Protein tissue co-expression partners for ANP32B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANP32B

SOURCE GeneReport for Unigene cluster for ANP32B Gene:

Hs.730654

mRNA Expression by UniProt/SwissProt for ANP32B Gene:

Q92688-AN32B_HUMAN
Tissue specificity: Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.

Evidence on tissue expression from TISSUES for ANP32B Gene

  • Liver(4.6)
  • Blood(4.5)
  • Muscle(4.5)
  • Pancreas(4.3)
  • Nervous system(3.5)
  • Skin(3.3)
  • Lung(3.2)
  • Spleen(3)
  • Intestine(2.9)
  • Kidney(2.8)
  • Lymph node(2.4)
  • Heart(2.3)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with ANP32B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANP32B Gene

Orthologs for ANP32B Gene

This gene was present in the common ancestor of animals.

Orthologs for ANP32B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANP32B 30 31
  • 99.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANP32B 30 31
  • 94.17 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANP32B 30 31
  • 84.27 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANP32B 31
  • 80 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Anp32b 31
  • 80 (a)
OneToMany
Gm5263 31
  • 79 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia ANP32B 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ANP32B 31
  • 60 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia ANP32B 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia anp32b 30
  • 78.54 (n)
Str.20236 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6758 30
Zebrafish
(Danio rerio)
Actinopterygii anp32b 30 31
  • 77.92 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5197 30
Fruit Fly
(Drosophila melanogaster)
Insecta Mapmodulin 31 32
  • 31 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F33H2.3 31
  • 35 (a)
ManyToMany
T19H12.2 31
  • 32 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11188 31
  • 43 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.12721 30
Species where no ortholog for ANP32B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ANP32B Gene

ENSEMBL:
Gene Tree for ANP32B (if available)
TreeFam:
Gene Tree for ANP32B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANP32B: view image

Paralogs for ANP32B Gene

Paralogs for ANP32B Gene

(4) SIMAP similar genes for ANP32B Gene using alignment to 2 proteins:

  • AN32B_HUMAN
  • Q5T6W8_HUMAN

Pseudogenes.org Pseudogenes for ANP32B Gene

genes like me logo Genes that share paralogs with ANP32B: view

Variants for ANP32B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANP32B Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
733735 Likely Benign: not provided 98,011,293(+) G/A SYNONYMOUS_VARIANT
746323 Benign: not provided 98,011,296(+) C/T SYNONYMOUS_VARIANT
788592 Benign: not provided 98,005,025(+) A/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ANP32B Gene

Structural Variations from Database of Genomic Variants (DGV) for ANP32B Gene

Variant ID Type Subtype PubMed ID
dgv4102n106 CNV deletion 24896259
dgv491e215 CNV deletion 23714750
esv1007178 CNV deletion 20482838
esv1721459 CNV deletion 17803354
esv2540773 CNV deletion 19546169
esv2738816 CNV deletion 23290073
esv4458 CNV loss 18987735
esv7209 CNV loss 19470904
nsv1075258 CNV deletion 25765185
nsv1077165 CNV deletion 25765185
nsv1137664 CNV deletion 24896259
nsv1153519 CNV deletion 26484159
nsv416479 CNV deletion 16902084

Variation tolerance for ANP32B Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANP32B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANP32B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANP32B Gene

Disorders for ANP32B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANP32B Gene - From: DISEASES

Disorder Aliases PubMed IDs
myopathy, congenital, compton-north
  • mypcn
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANP32B

genes like me logo Genes that share disorders with ANP32B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANP32B Gene

Publications for ANP32B Gene

  1. Expression analysis and chromosomal mapping of a novel human gene, APRIL, encoding an acidic protein rich in leucines. (PMID: 9473664) Mencinger M … Aman P (Biochimica et biophysica acta 1998) 2 3 4 23
  2. Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family. (PMID: 9285060) Zhu L … Valdez BC (Biochemistry and molecular biology international 1997) 2 3 23
  3. Solution structure of histone chaperone ANP32B: interaction with core histones H3-H4 through its acidic concave domain. (PMID: 20538007) Tochio N … Yokoyama S (Journal of molecular biology 2010) 3 4
  4. Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression. (PMID: 19130553) Chemnitz J … Hauber J (European journal of immunology 2009) 3 23
  5. Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression. (PMID: 17178712) Fries B … Chemnitz J (The Journal of biological chemistry 2007) 3 23

Products for ANP32B Gene

Sources for ANP32B Gene