Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANO8 Gene

Aliases for ANO8 Gene

  • Anoctamin 8 2 3 5
  • Transmembrane Protein 16H 2 3 4
  • KIAA1623 2 3 4
  • TMEM16H 3 4
  • Anoctamin-8 3
  • EC 56
  • EC 6.1.1 56

External Ids for ANO8 Gene

Previous HGNC Symbols for ANO8 Gene

  • KIAA1623
  • TMEM16H

Previous GeneCards Identifiers for ANO8 Gene

  • GC19M017299
  • GC19M017434
  • GC19M017000

Summaries for ANO8 Gene

GeneCards Summary for ANO8 Gene

ANO8 (Anoctamin 8) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO10.

UniProtKB/Swiss-Prot for ANO8 Gene

  • Does not exhibit calcium-activated chloride channel (CaCC) activity.

Additional gene information for ANO8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO8 Gene

Genomics for ANO8 Gene

GeneHancer (GH) Regulatory Elements for ANO8 Gene

Promoters and enhancers for ANO8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I017333 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.6 573 2.4 FEZF1 IRF4 YY1 ZNF213 ZNF416 ZNF143 SP3 NFYC MEF2D ZNF610 GTPBP3 ANO8 CHERP IQCN C19orf44 ENSG00000267904 ENSG00000268743 ENSG00000268087 MRPL34 ENSG00000269578
GH19I017332 Enhancer 0.8 ENCODE 0.8 +2.0 2037 0.2 HDGF HDAC1 PKNOX1 ATF1 ARNT SIN3A ZNF143 KLF7 FOS ATF7 ABHD8 MRPL34 DDA1 MVB12A BST2 ANO8 PIR41076
GH19I017326 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +6.3 6347 4.7 ZNF76 SIN3A ZNF335 GLIS2 ZNF366 EGR1 ZNF143 EGR2 ZNF263 SP3 MRPL34 ABHD8 MVB12A BST2 PLVAP ANO8 PIR41076
GH19I017321 Enhancer 0.8 Ensembl dbSUPER 0.4 +11.3 11347 3.9 NR2F1 ELF1 GLIS2 POLR2A SCRT2 NR2C1 ZBTB33 SPI1 NR2C2 PIR41076 MRPL34 ABHD8 MVB12A BST2 DDA1 ANO8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANO8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANO8 gene promoter:

Genomic Locations for ANO8 Gene

Genomic Locations for ANO8 Gene
11,612 bases
Minus strand

Genomic View for ANO8 Gene

Genes around ANO8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANO8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANO8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO8 Gene

Proteins for ANO8 Gene

  • Protein details for ANO8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NIJ0

    Protein attributes for ANO8 Gene

    1232 amino acids
    Molecular mass:
    136034 Da
    Quaternary structure:
    No Data Available
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
    • Sequence=BAB13449.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANO8 Gene


neXtProt entry for ANO8 Gene

Selected DME Specific Peptides for ANO8 Gene


Post-translational modifications for ANO8 Gene

No Post-translational modifications

Other Protein References for ANO8 Gene

Domains & Families for ANO8 Gene

Gene Families for ANO8 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ANO8 Gene


Suggested Antigen Peptide Sequences for ANO8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the anoctamin family.
  • Belongs to the anoctamin family.
genes like me logo Genes that share domains with ANO8: view

Function for ANO8 Gene

Molecular function for ANO8 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit calcium-activated chloride channel (CaCC) activity.

Enzyme Numbers (IUBMB) for ANO8 Gene

Phenotypes From GWAS Catalog for ANO8 Gene

Gene Ontology (GO) - Molecular Function for ANO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity TAS --
genes like me logo Genes that share ontologies with ANO8: view
genes like me logo Genes that share phenotypes with ANO8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANO8 Gene

Localization for ANO8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO8 Gene

Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANO8 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANO8: view

Pathways & Interactions for ANO8 Gene

genes like me logo Genes that share pathways with ANO8: view

Pathways by source for ANO8 Gene

Interacting Proteins for ANO8 Gene

Gene Ontology (GO) - Biological Process for ANO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport IMP 22946059
GO:0034220 ion transmembrane transport TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with ANO8: view

No data available for SIGNOR curated interactions for ANO8 Gene

Drugs & Compounds for ANO8 Gene

(1) Drugs for ANO8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(1) Additional Compounds for ANO8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
genes like me logo Genes that share compounds with ANO8: view

Transcripts for ANO8 Gene

mRNA/cDNA for ANO8 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANO8 Gene

Anoctamin 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANO8 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: -

Relevant External Links for ANO8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANO8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANO8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANO8 Gene

This gene is overexpressed in Pancreas (58.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANO8 Gene

Protein tissue co-expression partners for ANO8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANO8 Gene:


SOURCE GeneReport for Unigene cluster for ANO8 Gene:


mRNA Expression by UniProt/SwissProt for ANO8 Gene:

Tissue specificity: Expressed in embryonic stem cells, fetal brain and neural tissues.

Evidence on tissue expression from TISSUES for ANO8 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ANO8: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANO8 Gene

Orthologs for ANO8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANO8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANO8 33 34
  • 97.48 (n)
(Canis familiaris)
Mammalia ANO8 33 34
  • 89.09 (n)
(Bos Taurus)
Mammalia ANO8 33 34
  • 85.04 (n)
(Mus musculus)
Mammalia Ano8 33 16 34
  • 82.08 (n)
(Rattus norvegicus)
Mammalia Ano8 33
  • 81.61 (n)
(Monodelphis domestica)
Mammalia ANO8 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ANO8 34
  • 71 (a)
(Gallus gallus)
Aves -- 34
  • 84 (a)
ANO8 33
  • 73.64 (n)
-- 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ano8 33
  • 64.58 (n)
(Danio rerio)
Actinopterygii ano8 33
  • 66.67 (n)
ANO8 34
  • 62 (a)
ano8a 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15270 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea anoh-2 33 34
  • 48.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
Species where no ortholog for ANO8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANO8 Gene

Gene Tree for ANO8 (if available)
Gene Tree for ANO8 (if available)

Paralogs for ANO8 Gene

Paralogs for ANO8 Gene

genes like me logo Genes that share paralogs with ANO8: view

Variants for ANO8 Gene

Sequence variations from dbSNP and Humsavar for ANO8 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000200183 -- 17,334,532(-) C/A/T intron_variant
rs1000485306 -- 17,328,549(-) C/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000530852 -- 17,333,122(-) C/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000705150 -- 17,327,787(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1001070672 -- 17,324,615(-) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ANO8 Gene

Variant ID Type Subtype PubMed ID
esv21604 CNV gain 19812545
esv3643817 CNV loss 21293372
esv3643818 CNV gain 21293372
nsv470129 CNV loss 18288195

Variation tolerance for ANO8 Gene

Residual Variation Intolerance Score: 5.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANO8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANO8 Gene

Disorders for ANO8 Gene

Additional Disease Information for ANO8

No disorders were found for ANO8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANO8 Gene

Publications for ANO8 Gene

  1. Identification and characterization of TMEM16H gene in silico. (PMID: 15647853) Katoh M … Katoh M (International journal of molecular medicine 2005) 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N … Galietta LJ (Physiological reviews 2014) 2 3 58
  4. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PMID: 21984732) Scudieri P … Galietta LJ (Experimental physiology 2012) 3 4 58
  5. Anoctamins are a family of Ca2+-activated Cl- channels. (PMID: 22946059) Tian Y … Kunzelmann K (Journal of cell science 2012) 3 4 58

Products for ANO8 Gene

Sources for ANO8 Gene

Loading form....