This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011] See more...

Aliases for ANO7 Gene

Aliases for ANO7 Gene

  • Anoctamin 7 2 3 5
  • Transmembrane Protein 16G 2 3 4
  • Anoctamin-7 3 4
  • PCANAP5 3 4
  • TMEM16G 3 4
  • D-TMPP 3 4
  • IPCA-5 3 4
  • NGEP 3 4
  • Dresden-Transmembrane Protein Of The Prostate 3
  • Dresden Transmembrane Protein Of The Prostate 4
  • Prostate Cancer Associated Protein 5 3
  • Prostate Cancer-Associated Protein 5 4
  • New Gene Expressed In Prostate 4
  • PCANAP5L 3
  • DTMPP 3
  • IPCA5 3

External Ids for ANO7 Gene

Previous HGNC Symbols for ANO7 Gene

  • PCANAP5
  • TMEM16G

Previous GeneCards Identifiers for ANO7 Gene

  • GC02P241776
  • GC02P242127
  • GC02P233884

Summaries for ANO7 Gene

Entrez Gene Summary for ANO7 Gene

  • This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]

GeneCards Summary for ANO7 Gene

ANO7 (Anoctamin 7) is a Protein Coding gene. Diseases associated with ANO7 include Prostate Cancer. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. Gene Ontology (GO) annotations related to this gene include intracellular calcium activated chloride channel activity and phospholipid scramblase activity. An important paralog of this gene is ANO3.

UniProtKB/Swiss-Prot Summary for ANO7 Gene

  • Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693). May play a role in cell-cell interactions (PubMed:17308099).

Additional gene information for ANO7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANO7 Gene

Genomics for ANO7 Gene

GeneHancer (GH) Regulatory Elements for ANO7 Gene

Promoters and enhancers for ANO7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J241217 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 769.2 +29.9 29892 3.2 CTCF MLX RBPJ NR2F1 NFYC L3MBTL2 RAD21 ZNF121 POLR2A ZNF652 ANO7 SEPTIN2 FARP2 lnc-HDLBP-3 lnc-PASK-1
GH02J241188 Enhancer 0.5 CraniofacialAtlas 750.6 -0.3 -323 0.8 PRDM1 POLR2A PRDM10 ZNF512B KLF4 NONO ZNF366 SP3 KLF1 ANO7 LOC105373971 PASK ENSG00000223374 ING5 LOC100422094 D2HGDH SNED1 piR-61945-295
GH02J241189 Promoter 0.5 Ensembl 750.6 +0.4 391 0.2 POLR2A KLF4 ANO7 LOC105373971 lnc-HDLBP-3
GH02J241186 Enhancer 0.2 Ensembl 750.6 -1.6 -1608 0.2 ANO7 LOC105373971 piR-61945-295
GH02J241354 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.7 +168.9 168861 6 SP1 MLX RBPJ POLR2A CREB1 NFYC ETV6 RELA HLF L3MBTL2 FARP2 SEPTIN2 HDLBP ANO7 ANKMY1 ENSG00000261186 hsa-miR-566-003
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANO7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANO7 gene promoter:
  • aMEF-2
  • CREB
  • CUTL1
  • deltaCREB
  • E2F
  • MEF-2A
  • NF-1
  • Pax-5
  • POU2F1
  • POU2F1a

Genomic Locations for ANO7 Gene

Genomic Locations for ANO7 Gene
chr2:241,188,509-241,239,595
(GRCh38/hg38)
Size:
51,087 bases
Orientation:
Plus strand
chr2:242,127,924-242,164,792
(GRCh37/hg19)
Size:
36,869 bases
Orientation:
Plus strand

Genomic View for ANO7 Gene

Genes around ANO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO7 Gene

Proteins for ANO7 Gene

  • Protein details for ANO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IWH7-ANO7_HUMAN
    Recommended name:
    Anoctamin-7
    Protein Accession:
    Q6IWH7
    Secondary Accessions:
    • Q6IWH6

    Protein attributes for ANO7 Gene

    Size:
    933 amino acids
    Molecular mass:
    105532 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

    Alternative splice isoforms for ANO7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANO7 Gene

Post-translational modifications for ANO7 Gene

  • Glycosylation at Asn809 and Asn824
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANO7 Gene

Domains & Families for ANO7 Gene

Gene Families for ANO7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ANO7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANO7 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 16G (ANO7_HUMAN)
  • ANO7 protein (Q8N348_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IWH7

UniProtKB/Swiss-Prot:

ANO7_HUMAN :
  • Belongs to the anoctamin family.
Family:
  • Belongs to the anoctamin family.
genes like me logo Genes that share domains with ANO7: view

Function for ANO7 Gene

Molecular function for ANO7 Gene

UniProtKB/Swiss-Prot Function:
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693). May play a role in cell-cell interactions (PubMed:17308099).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = 1,2-diacyl-sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38664; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in); Xref=Rhea:RHEA:38899, ChEBI:CHEBI:18390; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38900; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence=. ; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38573; Evidence=. ;.
UniProtKB/Swiss-Prot Induction:
Up-regulated by androgen.

Phenotypes From GWAS Catalog for ANO7 Gene

Gene Ontology (GO) - Molecular Function for ANO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 NOT intracellular calcium activated chloride channel activity IDA 21984732
GO:0017128 phospholipid scramblase activity IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ANO7: view
genes like me logo Genes that share phenotypes with ANO7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANO7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANO7 Gene

Localization for ANO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO7 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein. Cell junction. Endoplasmic reticulum. Note=Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604. {ECO:0000269 PubMed:17308099, ECO:0000269 PubMed:20056604, ECO:0000269 PubMed:22075693}.
Isoform 2: Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANO7 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ANO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA,IEA 22075693
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ANO7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANO7 Gene

Pathways & Interactions for ANO7 Gene

genes like me logo Genes that share pathways with ANO7: view

Pathways by source for ANO7 Gene

Interacting Proteins for ANO7 Gene

Selected Interacting proteins: Q6IWH7-ANO7_HUMAN for ANO7 Gene via IID

Symbol External ID(s) Details
ACPP

Gene Ontology (GO) - Biological Process for ANO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport IDA 22946059
GO:0006869 lipid transport IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0061588 calcium activated phospholipid scrambling IEA --
GO:0061589 calcium activated phosphatidylserine scrambling IEA --
genes like me logo Genes that share ontologies with ANO7: view

No data available for SIGNOR curated interactions for ANO7 Gene

Drugs & Compounds for ANO7 Gene

(2) Drugs for ANO7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773
Chloride ion Experimental Pharma 0
genes like me logo Genes that share compounds with ANO7: view

Transcripts for ANO7 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANO7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANO7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for ANO7 Gene

GeneLoc Exon Structure for
ANO7
ECgene alternative splicing isoforms for
ANO7

Expression for ANO7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANO7 Gene

mRNA differential expression in normal tissues according to GTEx for ANO7 Gene

This gene is overexpressed in Prostate (x22.2), Colon - Transverse (x11.2), Stomach (x4.8), and Small Intestine - Terminal Ileum (x4.6).

Protein differential expression in normal tissues from HIPED for ANO7 Gene

This gene is overexpressed in Prostate (37.8) and Brain (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANO7 Gene



Protein tissue co-expression partners for ANO7 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANO7 Gene:

ANO7

SOURCE GeneReport for Unigene cluster for ANO7 Gene:

Hs.163909

mRNA Expression by UniProt/SwissProt for ANO7 Gene:

Q6IWH7-ANO7_HUMAN
Tissue specificity: Specifically expressed in epithelial cells of the prostate (at protein level).
genes like me logo Genes that share expression patterns with ANO7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANO7 Gene

Orthologs for ANO7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANO7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANO7 33
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANO7 33 32
  • 83.87 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ano7 17 33 32
  • 83.61 (n)
rat
(Rattus norvegicus)
Mammalia Ano7 32
  • 83.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANO7 33
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANO7 33
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANO7 33
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ano7 32
  • 62.26 (n)
ANO7 33
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea anoh-1 33
  • 25 (a)
OneToOne
Species where no ortholog for ANO7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ANO7 Gene

ENSEMBL:
Gene Tree for ANO7 (if available)
TreeFam:
Gene Tree for ANO7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANO7: view image

Paralogs for ANO7 Gene

Paralogs for ANO7 Gene

(7) SIMAP similar genes for ANO7 Gene using alignment to 3 proteins:

  • ANO7_HUMAN
  • H7C220_HUMAN
  • Q8N348_HUMAN

Pseudogenes.org Pseudogenes for ANO7 Gene

genes like me logo Genes that share paralogs with ANO7: view

Variants for ANO7 Gene

Sequence variations from dbSNP and Humsavar for ANO7 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000109921 -- 241,221,546(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000255005 -- 241,215,967(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000273750 -- 241,233,637(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000314930 -- 241,225,806(+) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000395223 -- 241,235,668(+) T/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANO7 Gene

Variant ID Type Subtype PubMed ID
esv1000552 CNV deletion 20482838
esv1026368 CNV deletion 17803354
esv1409539 CNV deletion 17803354
esv1480304 CNV deletion 17803354
esv26159 CNV loss 19812545
esv2647088 CNV deletion 19546169
esv2674511 CNV deletion 23128226
esv2721986 CNV deletion 23290073
esv2721987 CNV deletion 23290073
esv2721988 CNV deletion 23290073
esv2721989 CNV deletion 23290073
esv2721990 CNV deletion 23290073
esv2721991 CNV deletion 23290073
esv2721992 CNV deletion 23290073
esv3594821 CNV loss 21293372
esv995493 CNV deletion 20482838
nsv1072090 CNV deletion 25765185
nsv1115592 CNV duplication 24896259
nsv214015 CNV deletion 16902084
nsv3241 CNV insertion 18451855
nsv3242 CNV insertion 18451855
nsv470532 CNV loss 18288195
nsv508900 CNV insertion 20534489
nsv513025 CNV loss 21212237
nsv521716 CNV loss 19592680
nsv524008 CNV gain 19592680
nsv527790 CNV loss 19592680
nsv584955 CNV loss 21841781

Variation tolerance for ANO7 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.47; 92.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANO7 Gene

Human Gene Mutation Database (HGMD)
ANO7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANO7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANO7 Gene

Disorders for ANO7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANO7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search ANO7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ANO7

genes like me logo Genes that share disorders with ANO7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANO7 Gene

Publications for ANO7 Gene

  1. Characterization of human TMEM16G gene in silico. (PMID: 15375614) Katoh M … Katoh M (International journal of molecular medicine 2004) 2 3 4 23 56
  2. NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. (PMID: 14981236) Bera TK … Pastan I (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 4 23 56
  3. Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. (PMID: 18676855) Das S … Pastan I (Cancer research 2008) 3 4 23 56
  4. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N … Galietta LJ (Physiological reviews 2014) 2 3 56
  5. ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. (PMID: 22075693) Duran C … Hartzell HC (American journal of physiology. Cell physiology 2012) 3 4 56

Products for ANO7 Gene

Sources for ANO7 Gene