Aliases for ANO2 Gene
External Ids for ANO2 Gene
Previous HGNC Symbols for ANO2 Gene
Previous GeneCards Identifiers for ANO2 Gene
ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]
GeneCards Summary for ANO2 Gene
ANO2 (Anoctamin 2) is a Protein Coding gene. Diseases associated with ANO2 include Von Willebrand Disease, Type 3 and Scrotal Carcinoma. Among its related pathways are Olfactory Signaling Pathway and Ion channel transport. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO1.
UniProtKB/Swiss-Prot for ANO2 Gene
Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.