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Aliases for ANO10 Gene

Aliases for ANO10 Gene

  • Anoctamin 10 2 3 5
  • Transmembrane Protein 16K 2 3 4
  • TMEM16K 3 4
  • Anoctamin-10 3
  • SCAR10 3

External Ids for ANO10 Gene

Previous HGNC Symbols for ANO10 Gene

  • TMEM16K

Previous GeneCards Identifiers for ANO10 Gene

  • GC03M043385

Summaries for ANO10 Gene

Entrez Gene Summary for ANO10 Gene

  • The transmembrane protein encoded by this gene belongs to the anoctamin family of calcium-activated chloride channels, also known as the transmembrane 16 family. The encoded protein contains eight transmembrane domains with cytosolic N- and C-termini. Defects in this gene may cause autosomal recessive spinocerebellar ataxia-10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

GeneCards Summary for ANO10 Gene

ANO10 (Anoctamin 10) is a Protein Coding gene. Diseases associated with ANO10 include Spinocerebellar Ataxia, Autosomal Recessive 10 and Autosomal Recessive Cerebellar Ataxia. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include intracellular calcium activated chloride channel activity and calcium activated cation channel activity. An important paralog of this gene is ANO8.

UniProtKB/Swiss-Prot for ANO10 Gene

  • Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

Additional gene information for ANO10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO10 Gene

Genomics for ANO10 Gene

GeneHancer (GH) Regulatory Elements for ANO10 Gene

Promoters and enhancers for ANO10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I043620 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.1 +69.5 69541 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B E2F8 ANO10 TUBAP3 RPL18AP9 GC03M043165
GH03I043476 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 7.1 +214.0 213999 2.8 BCOR POLR2A JUN ZMYM3 EZH2 ANO10 SNRK ENSG00000271941 ENSG00000251811 RPL18AP9 GC03M043165
GH03I043392 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 6.3 +297.6 297558 2.5 RXRA JUN ETV1 MAX REST MYC RAD21 NR2F2 SNRK SNRK-AS1 ABHD5 ANO10 ENSG00000251811 GC03M043165
GH03I043387 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +301.6 301635 4.4 HDAC1 FOXA2 RAD21 ZBTB40 YY1 ETV6 ATF7 RXRA ZBTB11 CEBPB SNRK ABHD5 SNRK-AS1 ENSG00000271941 ANO10 ENSG00000251811 GC03M043165
GH03I043325 Enhancer 1 Ensembl ENCODE dbSUPER 5.8 +364.2 364210 3.2 HDAC1 MEIS2 HLF CEBPB CEBPG MITF PRDM6 ZNF766 NFE2 SNRK-AS1 SNRK ANO10 RN7SL517P ENSG00000271941 GC03M043165
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANO10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANO10 gene promoter:

Genomic Locations for ANO10 Gene

Genomic Locations for ANO10 Gene
336,736 bases
Minus strand

Genomic View for ANO10 Gene

Genes around ANO10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANO10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANO10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO10 Gene

Proteins for ANO10 Gene

  • Protein details for ANO10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K8K3
    • A8MV74
    • B3KTZ1
    • B3KY93
    • B4DJ83
    • B4DNK2
    • B7WP12
    • C9JHS1
    • Q8IXX9

    Protein attributes for ANO10 Gene

    660 amino acids
    Molecular mass:
    76329 Da
    Quaternary structure:
    No Data Available
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
    • Sequence=BAA91573.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BC038855; Type=Frameshift; Positions=42; Evidence={ECO:0000305};

    Alternative splice isoforms for ANO10 Gene


neXtProt entry for ANO10 Gene

Post-translational modifications for ANO10 Gene

No data available for DME Specific Peptides for ANO10 Gene

Domains & Families for ANO10 Gene

Gene Families for ANO10 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ANO10 Gene


Suggested Antigen Peptide Sequences for ANO10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the anoctamin family.
  • Belongs to the anoctamin family.
genes like me logo Genes that share domains with ANO10: view

Function for ANO10 Gene

Molecular function for ANO10 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

Phenotypes From GWAS Catalog for ANO10 Gene

Gene Ontology (GO) - Molecular Function for ANO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005227 calcium activated cation channel activity IDA 22946059
GO:0005229 intracellular calcium activated chloride channel activity TAS --
genes like me logo Genes that share ontologies with ANO10: view
genes like me logo Genes that share phenotypes with ANO10: view

Human Phenotype Ontology for ANO10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ANO10 Gene

MGI Knock Outs for ANO10:

Animal Model Products

CRISPR Products

miRNA for ANO10 Gene

miRTarBase miRNAs that target ANO10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ANO10 Gene

Localization for ANO10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO10 Gene

Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANO10 gene
Compartment Confidence
plasma membrane 5
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ANO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 22075693
GO:0005886 plasma membrane TAS --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANO10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANO10 Gene

Pathways & Interactions for ANO10 Gene

genes like me logo Genes that share pathways with ANO10: view

Pathways by source for ANO10 Gene

Interacting Proteins for ANO10 Gene

Gene Ontology (GO) - Biological Process for ANO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport IDA 22946059
GO:0006821 chloride transport IDA 22946059
GO:0034220 ion transmembrane transport TAS --
GO:0098655 cation transmembrane transport IEA --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with ANO10: view

No data available for SIGNOR curated interactions for ANO10 Gene

Drugs & Compounds for ANO10 Gene

(1) Drugs for ANO10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(1) Additional Compounds for ANO10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
genes like me logo Genes that share compounds with ANO10: view

Transcripts for ANO10 Gene

Unigene Clusters for ANO10 Gene

Anoctamin 10:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANO10 Gene

No ASD Table

Relevant External Links for ANO10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANO10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANO10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANO10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.2) and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANO10 Gene

Protein tissue co-expression partners for ANO10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANO10 Gene:


SOURCE GeneReport for Unigene cluster for ANO10 Gene:


mRNA Expression by UniProt/SwissProt for ANO10 Gene:

Tissue specificity: Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.

Evidence on tissue expression from TISSUES for ANO10 Gene

  • Nervous system(4.8)
  • Blood(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ANO10 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • nervous
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • head
  • foot
  • lower limb
  • upper limb
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with ANO10: view

Primer Products

No data available for mRNA differential expression in normal tissues for ANO10 Gene

Orthologs for ANO10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANO10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANO10 33 34
  • 99.34 (n)
(Canis familiaris)
Mammalia ANO10 33 34
  • 91.15 (n)
(Bos Taurus)
Mammalia ANO10 33 34
  • 90.09 (n)
(Rattus norvegicus)
Mammalia Ano10 33
  • 85.2 (n)
(Mus musculus)
Mammalia Ano10 33 16 34
  • 85.19 (n)
(Monodelphis domestica)
Mammalia ANO10 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia ANO10 34
  • 78 (a)
(Gallus gallus)
Aves ANO10 33 34
  • 74.28 (n)
(Anolis carolinensis)
Reptilia ANO10 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ano10 33
  • 68.88 (n)
(Danio rerio)
Actinopterygii ano10a 33 34
  • 65.79 (n)
wufc37b04 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009776 33
  • 49.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta Axs 33 34
  • 48.54 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IST2 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73020 33
  • 44.85 (n)
(Oryza sativa)
Liliopsida Os01g0706700 33
  • 44.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for ANO10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANO10 Gene

Gene Tree for ANO10 (if available)
Gene Tree for ANO10 (if available)

Paralogs for ANO10 Gene

Paralogs for ANO10 Gene Pseudogenes for ANO10 Gene

genes like me logo Genes that share paralogs with ANO10: view

Variants for ANO10 Gene

Sequence variations from dbSNP and Humsavar for ANO10 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1046324794 uncertain-significance, Triglyceride storage disease with ichthyosis 43,690,902(-) C/G genic_upstream_transcript_variant, intron_variant
rs104893676 pathogenic, Triglyceride storage disease with ichthyosis 43,691,011(-) G/A genic_upstream_transcript_variant, intron_variant
rs111871863 uncertain-significance, Spinocerebellar Ataxia, Recessive 43,366,727(-) G/A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs112040665 likely-benign, Spinocerebellar Ataxia, Recessive 43,605,779(-) T/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs112787589 uncertain-significance, Spinocerebellar Ataxia, Recessive 43,366,459(-) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ANO10 Gene

Variant ID Type Subtype PubMed ID
nsv963314 CNV duplication 23825009
nsv834673 CNV gain 17160897
nsv822070 CNV loss 20364138
nsv820135 CNV loss 19587683
esv5543 OTHER inversion 19470904
esv3596018 CNV loss 21293372
esv3596016 CNV gain 21293372
esv3596015 CNV loss 21293372
esv3596014 CNV loss 21293372
esv3596013 CNV loss 21293372
esv3596012 CNV loss 21293372
esv3568715 CNV loss 25503493
esv3434287 CNV insertion 20981092
esv3374423 CNV insertion 20981092
esv2763720 CNV loss 21179565
esv2525562 CNV insertion 19546169
esv1480257 CNV insertion 17803354
esv1011105 CNV insertion 20482838
dgv804n67 CNV loss 20364138

Variation tolerance for ANO10 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANO10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANO10 Gene

Disorders for ANO10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANO10 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ANO10 in MalaCards View complete list of genes associated with diseases


  • Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10) [MIM:613728]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. {ECO:0000269 PubMed:21092923}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ANO10

genes like me logo Genes that share disorders with ANO10: view

No data available for Genatlas for ANO10 Gene

Publications for ANO10 Gene

  1. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N … Galietta LJ (Physiological reviews 2014) 2 3 58
  2. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PMID: 21984732) Scudieri P … Galietta LJ (Experimental physiology 2012) 3 4 58
  3. Anoctamins are a family of Ca2+-activated Cl- channels. (PMID: 22946059) Tian Y … Kunzelmann K (Journal of cell science 2012) 3 4 58
  4. ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. (PMID: 22075693) Duran C … Hartzell HC (American journal of physiology. Cell physiology 2012) 3 4 58
  5. Anoctamins. (PMID: 21607626) Kunzelmann K … Schreiber R (Pflugers Archiv : European journal of physiology 2011) 3 4 58

Products for ANO10 Gene

Sources for ANO10 Gene

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