Aliases for ANO10 Gene
External Ids for ANO10 Gene
Previous HGNC Symbols for ANO10 Gene
Previous GeneCards Identifiers for ANO10 Gene
The transmembrane protein encoded by this gene belongs to the anoctamin family of calcium-activated chloride channels, also known as the transmembrane 16 family. The encoded protein contains eight transmembrane domains with cytosolic N- and C-termini. Defects in this gene may cause autosomal recessive spinocerebellar ataxia-10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
GeneCards Summary for ANO10 Gene
ANO10 (Anoctamin 10) is a Protein Coding gene. Diseases associated with ANO10 include Spinocerebellar Ataxia, Autosomal Recessive 10 and Autosomal Recessive Cerebellar Ataxia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. Gene Ontology (GO) annotations related to this gene include intracellular calcium activated chloride channel activity and calcium activated cation channel activity. An important paralog of this gene is ANO8.
UniProtKB/Swiss-Prot for ANO10 Gene
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.