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Aliases for ANLN Gene

Aliases for ANLN Gene

  • Anillin Actin Binding Protein 2 3 5
  • Anillin, Actin Binding Protein (Scraps Homolog, Drosophila) 2
  • Anillin (Drosophila Scraps Homolog), Actin Binding Protein 2
  • Anillin 3
  • Scraps 3
  • FSGS8 3
  • Scra 3

External Ids for ANLN Gene

Previous GeneCards Identifiers for ANLN Gene

  • GC07P036076
  • GC07P036170
  • GC07P036202
  • GC07P036395
  • GC07P036309

Summaries for ANLN Gene

Entrez Gene Summary for ANLN Gene

  • This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GeneCards Summary for ANLN Gene

ANLN (Anillin Actin Binding Protein) is a Protein Coding gene. Diseases associated with ANLN include Focal Segmental Glomerulosclerosis 8 and Focal Segmental Glomerulosclerosis 1. Among its related pathways are Retinoblastoma (RB) in Cancer. Gene Ontology (GO) annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for ANLN Gene

  • Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636).

Gene Wiki entry for ANLN Gene

Additional gene information for ANLN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANLN Gene

Genomics for ANLN Gene

GeneHancer (GH) Regulatory Elements for ANLN Gene

Promoters and enhancers for ANLN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J036386 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.1 2077 10.4 HDGF CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 IRF4 KIAA0895 ANLN HERPUD2 ENSG00000237400 GC07P036215
GH07J035799 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650 -588.5 -588515 4.5 HDGF FOXA2 PKNOX1 CLOCK SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 HERPUD2 SEPT7 SEPT7-AS1 ANLN LOC101930085 SEPT7P3 ENSG00000274328
GH07J036366 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.1 -22.8 -22762 1.7 ARID4B SIN3A YY1 ZNF207 ZNF143 DEK SP3 ZHX2 MXD4 SMARCB1 KIAA0895 ANLN GC07M036337 ENSG00000201432 GC07P036215
GH07J036458 Enhancer 0.5 ENCODE 10.2 +69.6 69575 1.1 NRF1 HMBOX1 CBFA2T3 CBFA2T2 ANLN KIAA0895 ENSG00000237400 GC07P036215
GH07J036347 Enhancer 0.3 ENCODE 10.8 -41.9 -41886 1.2 PRDM6 KIAA0895 ANLN ENSG00000201432 GC07M036337 GC07P036215
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANLN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANLN gene promoter:
  • GATA-1
  • MIF-1
  • POU3F2
  • Max1
  • c-Myc
  • AP-1
  • Sp1
  • Max
  • FOXD1

Genomic Locations for ANLN Gene

Genomic Locations for ANLN Gene
63,989 bases
Plus strand
63,986 bases
Plus strand

Genomic View for ANLN Gene

Genes around ANLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANLN Gene

Proteins for ANLN Gene

  • Protein details for ANLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5CZ78
    • Q6NSK5
    • Q9H8Y4
    • Q9NVN9
    • Q9NVP0

    Protein attributes for ANLN Gene

    1124 amino acids
    Molecular mass:
    124199 Da
    Quaternary structure:
    • Interacts with F-actin (PubMed:10931866). Interacts with CD2AP (PubMed:15800069). May interact with RHOA (PubMed:16357138). Interacts with FZR1/CDH1 during mitotic exit (PubMed:16040610).
    • Sequence=AAH34692.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91710.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91711.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANLN Gene

    Alternative splice isoforms for ANLN Gene


neXtProt entry for ANLN Gene

Post-translational modifications for ANLN Gene

No data available for DME Specific Peptides for ANLN Gene

Domains & Families for ANLN Gene

Gene Families for ANLN Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for ANLN Gene

Suggested Antigen Peptide Sequences for ANLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANLN: view

No data available for UniProtKB/Swiss-Prot for ANLN Gene

Function for ANLN Gene

Molecular function for ANLN Gene

UniProtKB/Swiss-Prot Function:
Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636).

Phenotypes From GWAS Catalog for ANLN Gene

Gene Ontology (GO) - Molecular Function for ANLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 10931866
GO:0017049 GTP-Rho binding IBA --
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with ANLN: view
genes like me logo Genes that share phenotypes with ANLN: view

Human Phenotype Ontology for ANLN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

  • Addgene plasmids for ANLN

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANLN Gene

Localization for ANLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANLN Gene

Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell projection, bleb. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANLN gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Midbody (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005826 actomyosin contractile ring IDA 10931866
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ANLN: view

Pathways & Interactions for ANLN Gene

genes like me logo Genes that share pathways with ANLN: view

Pathways by source for ANLN Gene

1 BioSystems pathway for ANLN Gene

Gene Ontology (GO) - Biological Process for ANLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IDA 10931866
GO:0000915 actomyosin contractile ring assembly IBA --
GO:0000921 septin ring assembly TAS 10931866
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with ANLN: view

No data available for SIGNOR curated interactions for ANLN Gene

Drugs & Compounds for ANLN Gene

No Compound Related Data Available

Transcripts for ANLN Gene

Unigene Clusters for ANLN Gene

Anillin, actin binding protein:
Representative Sequences:

Clone Products

  • Addgene plasmids for ANLN

Alternative Splicing Database (ASD) splice patterns (SP) for ANLN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
SP1: -
SP4: - -
SP7: -
SP8: -
SP10: - - -
SP11: - -
SP12: - -
SP14: - -
SP15: -
SP16: - -
SP17: - -
SP18: -

ExUns: 12c · 12d ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP3: -
SP4: - -
SP5: -
SP6: -
SP12: - -

Relevant External Links for ANLN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANLN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANLN Gene

mRNA differential expression in normal tissues according to GTEx for ANLN Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x14.7), Brain - Substantia nigra (x8.0), and Brain - Hippocampus (x5.4).

Protein differential expression in normal tissues from HIPED for ANLN Gene

This gene is overexpressed in Blymphocyte (44.4) and Platelet (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANLN Gene

NURSA nuclear receptor signaling pathways regulating expression of ANLN Gene:


SOURCE GeneReport for Unigene cluster for ANLN Gene:


mRNA Expression by UniProt/SwissProt for ANLN Gene:

Tissue specificity: Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.

Evidence on tissue expression from TISSUES for ANLN Gene

  • Nervous system(4.9)
  • Liver(4.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ANLN Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • immune
  • integumentary
  • respiratory
  • urinary
  • lung
  • kidney
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with ANLN: view

No data available for Protein tissue co-expression partners for ANLN Gene

Orthologs for ANLN Gene

This gene was present in the common ancestor of animals.

Orthologs for ANLN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANLN 34 33
  • 99.32 (n)
(Canis familiaris)
Mammalia ANLN 34 33
  • 89.93 (n)
(Bos Taurus)
Mammalia ANLN 34 33
  • 89.39 (n)
(Mus musculus)
Mammalia Anln 16 34 33
  • 83.15 (n)
(Rattus norvegicus)
Mammalia Anln 33
  • 81.26 (n)
(Ornithorhynchus anatinus)
Mammalia ANLN 34
  • 59 (a)
(Monodelphis domestica)
Mammalia ANLN 34
  • 58 (a)
(Gallus gallus)
Aves ANLN 34 33
  • 69.76 (n)
(Anolis carolinensis)
Reptilia ANLN 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491625 33
  • 64.36 (n)
Str.7526 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398569 33
(Danio rerio)
Actinopterygii anln 34 33
  • 57.9 (n)
wufa12d06 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1959 33
fruit fly
(Drosophila melanogaster)
Insecta scra 34 35
  • 21 (a)
(Caenorhabditis elegans)
Secernentea ani-3 34
  • 21 (a)
ani-2 34
  • 17 (a)
ani-1 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10671 34
  • 39 (a)
Cin.4355 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4355 33
Species where no ortholog for ANLN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANLN Gene

Gene Tree for ANLN (if available)
Gene Tree for ANLN (if available)
Evolutionary constrained regions (ECRs) for ANLN: view image

Paralogs for ANLN Gene

(1) SIMAP similar genes for ANLN Gene using alignment to 9 proteins:

  • C9J0G4_HUMAN
  • H7C0Y6_HUMAN
  • H7C167_HUMAN
  • H7C1C2_HUMAN
  • H7C1K5_HUMAN
  • H7C3R2_HUMAN
  • H7C3S1_HUMAN
genes like me logo Genes that share paralogs with ANLN: view

No data available for Paralogs for ANLN Gene

Variants for ANLN Gene

Sequence variations from dbSNP and Humsavar for ANLN Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs201613256 uncertain-significance, Focal segmental glomerulosclerosis 8 36,410,555(+) C/T coding_sequence_variant, missense_variant
rs587777741 pathogenic, Focal segmental glomerulosclerosis 8, Focal segmental glomerulosclerosis 8 (FSGS8) [MIM:616032] 36,411,062(+) C/T coding_sequence_variant, missense_variant
VAR_072419 Focal segmental glomerulosclerosis 8 (FSGS8) [MIM:616032] p.Gly618Cys
rs197367 benign, not specified 36,406,247(+) G/A coding_sequence_variant, missense_variant
rs3815484 benign, not specified 36,427,046(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANLN Gene

Variant ID Type Subtype PubMed ID
dgv189n73 CNV deletion 24416366
esv2657144 CNV deletion 23128226
esv2734254 CNV deletion 23290073
esv3280385 CNV deletion 24192839
esv3306077 CNV mobile element insertion 20981092
esv3410200 CNV insertion 20981092
esv3541483 CNV deletion 23714750
esv3612834 CNV loss 21293372
nsv1143343 CNV deletion 24896259
nsv511959 CNV loss 21212237
nsv521965 CNV loss 19592680

Variation tolerance for ANLN Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.14; 96.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANLN Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANLN Gene

Disorders for ANLN Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANLN Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ANLN in MalaCards View complete list of genes associated with diseases


  • Focal segmental glomerulosclerosis 8 (FSGS8) [MIM:616032]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. {ECO:0000269 PubMed:24676636}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ANLN

genes like me logo Genes that share disorders with ANLN: view

No data available for Genatlas for ANLN Gene

Publications for ANLN Gene

  1. Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis. (PMID: 10931866) Oegema K … Field CM (The Journal of cell biology 2000) 2 3 4 22 58
  2. ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. (PMID: 16357138) Suzuki C … Nakamura Y (Cancer research 2005) 3 4 22 58
  3. The septin-binding protein anillin is overexpressed in diverse human tumors. (PMID: 16203764) Hall PA … Russell SE (Clinical cancer research : an official journal of the American Association for Cancer Research 2005) 3 4 22 58
  4. MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. (PMID: 16129829) Zhao WM … Fang G (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22 58
  5. Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis. (PMID: 16040610) Zhao WM … Fang G (The Journal of biological chemistry 2005) 3 4 22 58

Products for ANLN Gene

Sources for ANLN Gene

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