Aliases for ANLN Gene
External Ids for ANLN Gene
Previous GeneCards Identifiers for ANLN Gene
This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
GeneCards Summary for ANLN Gene
ANLN (Anillin Actin Binding Protein) is a Protein Coding gene. Diseases associated with ANLN include Focal Segmental Glomerulosclerosis 8 and Familial Idiopathic Steroid-Resistant Nephrotic Syndrome With Focal Segmental Hyalinosis. Among its related pathways are Retinoblastoma (RB) in Cancer. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is RTKN.
UniProtKB/Swiss-Prot Summary for ANLN Gene
Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636).