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Aliases for ANKUB1 Gene

Aliases for ANKUB1 Gene

  • Ankyrin Repeat And Ubiquitin Domain Containing 1 2 3 5
  • C3orf16 3 4
  • Ankyrin Repeat And Ubiquitin Domain-Containing 1 4
  • Chromosome 3 Open Reading Frame 16 2
  • Protein ANKUB1 3

External Ids for ANKUB1 Gene

Previous HGNC Symbols for ANKUB1 Gene

  • C3orf16

Previous GeneCards Identifiers for ANKUB1 Gene

  • GC03M149479

Summaries for ANKUB1 Gene

GeneCards Summary for ANKUB1 Gene

ANKUB1 (Ankyrin Repeat And Ubiquitin Domain Containing 1) is a Protein Coding gene.

Additional gene information for ANKUB1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKUB1 Gene

Genomics for ANKUB1 Gene

GeneHancer (GH) Regulatory Elements for ANKUB1 Gene

Promoters and enhancers for ANKUB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I149968 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -1.8 -1779 4.9 CLOCK FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ETS1 PFN2 ANKUB1 GC03P149970 LOC646903
GH03I149967 Enhancer 0.7 ENCODE 550.8 +1.1 1116 0.2 CTCF SIN3A CEBPG RAD21 ZNF143 SMC3 ZNF654 CEBPB REST ZEB2 ANKUB1 LOC105374152 PFN2
GH03I149792 Promoter 0.6 EPDnew 550.1 +175.5 175500 0.1 FOXA2 ANKUB1 WWTR1 RNU6-507P RNF13
GH03I149793 Promoter 0.5 EPDnew 550.1 +175.8 175811 0.1 ANKUB1 COMMD2 RNU6-507P RNF13
GH03I150183 Enhancer 1.1 Ensembl ENCODE 11.7 -216.0 -215963 1.3 FOXA2 ARID4B ZNF48 RAD21 ETS1 SLC30A9 ZNF335 EGR1 ZNF366 ZNF143 PFN2 ENSG00000242791 ANKUB1 GC03P150194 RPL32P9 ENSG00000243944
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANKUB1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ANKUB1 Gene

Genomic Locations for ANKUB1 Gene
chr3:149,760,648-149,968,385
(GRCh38/hg38)
Size:
207,738 bases
Orientation:
Minus strand
chr3:149,478,887-149,686,172
(GRCh37/hg19)

Genomic View for ANKUB1 Gene

Genes around ANKUB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKUB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKUB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKUB1 Gene

Proteins for ANKUB1 Gene

  • Protein details for ANKUB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFN9-ANKUB_HUMAN
    Recommended name:
    Protein ANKUB1
    Protein Accession:
    A6NFN9
    Secondary Accessions:
    • B4E2N8

    Protein attributes for ANKUB1 Gene

    Size:
    424 amino acids
    Molecular mass:
    47648 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKUB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKUB1 Gene

Post-translational modifications for ANKUB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKUB1 Gene

Domains & Families for ANKUB1 Gene

Gene Families for ANKUB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ANKUB1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKUB1: view

No data available for UniProtKB/Swiss-Prot for ANKUB1 Gene

Function for ANKUB1 Gene

miRNA for ANKUB1 Gene

miRTarBase miRNAs that target ANKUB1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKUB1 Gene

Localization for ANKUB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKUB1 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
peroxisome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKUB1 Gene

Pathways & Interactions for ANKUB1 Gene

SuperPathways for ANKUB1 Gene

No Data Available

Interacting Proteins for ANKUB1 Gene

Gene Ontology (GO) - Biological Process for ANKUB1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKUB1 Gene

Drugs & Compounds for ANKUB1 Gene

No Compound Related Data Available

Transcripts for ANKUB1 Gene

mRNA/cDNA for ANKUB1 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKUB1 Gene

Ankyrin repeat and ubiquitin domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKUB1 Gene

No ASD Table

Relevant External Links for ANKUB1 Gene

GeneLoc Exon Structure for
ANKUB1
ECgene alternative splicing isoforms for
ANKUB1

Expression for ANKUB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKUB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKUB1 Gene

This gene is overexpressed in Cervix - Endocervix (x10.3), Testis (x10.0), and Lung (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of ANKUB1 Gene:

ANKUB1

SOURCE GeneReport for Unigene cluster for ANKUB1 Gene:

Hs.665988
genes like me logo Genes that share expression patterns with ANKUB1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKUB1 Gene

Orthologs for ANKUB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKUB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKUB1 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia ANKUB1 33
  • 88.77 (n)
cow
(Bos Taurus)
Mammalia ANKUB1 33 34
  • 87.48 (n)
mouse
(Mus musculus)
Mammalia Gm410 33 34
  • 86.32 (n)
Ankub1 16
rat
(Rattus norvegicus)
Mammalia Ankub1 33
  • 82.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKUB1 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKUB1 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKUB1 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankub1 33
  • 59.85 (n)
Str.19383 33
Species where no ortholog for ANKUB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKUB1 Gene

ENSEMBL:
Gene Tree for ANKUB1 (if available)
TreeFam:
Gene Tree for ANKUB1 (if available)

Paralogs for ANKUB1 Gene

No data available for Paralogs for ANKUB1 Gene

Variants for ANKUB1 Gene

Sequence variations from dbSNP and Humsavar for ANKUB1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000165825 -- 149,765,497(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000179838 -- 149,761,212(-) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000413547 -- 149,794,081(-) C/G upstream_transcript_variant
rs1000493144 -- 149,766,970(-) G/C 3_prime_UTR_variant, intron_variant
rs1000529793 -- 149,771,214(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKUB1 Gene

Variant ID Type Subtype PubMed ID
esv1145264 CNV insertion 17803354
esv34142 CNV loss 18971310
esv3598148 CNV loss 21293372
nsv829754 CNV gain 17160897

Variation tolerance for ANKUB1 Gene

Gene Damage Index Score: 4.99; 68.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKUB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKUB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKUB1 Gene

Disorders for ANKUB1 Gene

Additional Disease Information for ANKUB1

No disorders were found for ANKUB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKUB1 Gene

Publications for ANKUB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for ANKUB1 Gene

Sources for ANKUB1 Gene

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