Aliases for ANKRD7 Gene

Aliases for ANKRD7 Gene

  • Ankyrin Repeat Domain 7 2 3 5
  • Testis-Specific Ankyrin Motif Containing Protein 2 3
  • Ankyrin Repeat Domain-Containing Protein 7 3 4
  • Testis-Specific Protein TSA806 3 4
  • Testicular Tissue Protein Li 19 3
  • TSA806 3

External Ids for ANKRD7 Gene

Previous GeneCards Identifiers for ANKRD7 Gene

  • GC07P116342
  • GC07P117405
  • GC07P117419
  • GC07P117458
  • GC07P117652
  • GC07P117854
  • GC07P112230

Summaries for ANKRD7 Gene

GeneCards Summary for ANKRD7 Gene

ANKRD7 (Ankyrin Repeat Domain 7) is a Protein Coding gene. An important paralog of this gene is MTPN.

Additional gene information for ANKRD7 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD7 Gene

Genomics for ANKRD7 Gene

GeneHancer (GH) Regulatory Elements for ANKRD7 Gene

Promoters and enhancers for ANKRD7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J118214 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 505.8 -0.2 -195 1.5 NRF1 PHF8 ZBTB26 POLR2A MXI1 KLF9 SP2 ZBTB17 SRF ZNF335 ANKRD7 LSM8 piR-38605-011
GH07J118182 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 7.5 -30.1 -30100 4.5 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G GTF2E2 PHF8 PHB2 ZFX LSM8 LOC105375470 lnc-CTTNBP2-3 ANKRD7 HSALNG0060821
GH07J118311 Enhancer 1 FANTOM5 ENCODE 4.9 +97.0 97006 1.2 EP300 OSR2 GABPA CEBPG FOS SRF CEBPB MEF2B POLR2H CHD2 LSM8 ANKRD7 piR-61240-272 piR-32023-228 LOC102724495 NONHSAG048632.2
GH07J118223 Enhancer 0.2 FANTOM5 16.3 +9.2 9206 0.2 piR-37425 piR-40335 piR-38151 piR-49868 piR-59117 ANKRD7
GH07J118245 Enhancer 0.5 Ensembl 5.3 +30.8 30832 1 EP300 ZIC2 SPI1 BATF NR2F1 MAX GATA2 JUND RUNX3 LSM8 ANKRD7 NONHSAG048632.2 LOC102724495
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD7

Top Transcription factor binding sites by QIAGEN in the ANKRD7 gene promoter:
  • aMEF-2
  • C/EBPalpha
  • CUTL1
  • FOXO1
  • FOXO1a
  • GATA-2
  • MEF-2A
  • Nkx2-5
  • POU2F1a
  • Sox9

Genomic Locations for ANKRD7 Gene

Genomic Locations for ANKRD7 Gene
chr7:118,214,669-118,496,171
(GRCh38/hg38)
Size:
281,503 bases
Orientation:
Plus strand
chr7:117,854,727-117,882,785
(GRCh37/hg19)
Size:
28,059 bases
Orientation:
Plus strand

Genomic View for ANKRD7 Gene

Genes around ANKRD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD7 Gene

Proteins for ANKRD7 Gene

  • Protein details for ANKRD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92527-ANKR7_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 7
    Protein Accession:
    Q92527
    Secondary Accessions:
    • B4DYF5
    • Q96QN1
    • Q9UDM3

    Protein attributes for ANKRD7 Gene

    Size:
    254 amino acids
    Molecular mass:
    29029 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH32799.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD7 Gene

Post-translational modifications for ANKRD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD7 Gene

No data available for DME Specific Peptides for ANKRD7 Gene

Domains & Families for ANKRD7 Gene

Gene Families for ANKRD7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD7 Gene

Blocks:
  • Ankyrin repeat signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANKRD7 Gene

GenScript: Design optimal peptide antigens:
  • Testis-specific protein TSA806 (ANKR7_HUMAN)
genes like me logo Genes that share domains with ANKRD7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD7 Gene

Function for ANKRD7 Gene

Phenotypes From GWAS Catalog for ANKRD7 Gene

Phenotypes for ANKRD7 Gene

genes like me logo Genes that share phenotypes with ANKRD7: view

Animal Models for ANKRD7 Gene

MGI Knock Outs for ANKRD7:
  • Ankrd7 Ankrd7<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD7 Gene

Localization for ANKRD7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD7 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANKRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with ANKRD7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKRD7 Gene

Pathways & Interactions for ANKRD7 Gene

PathCards logo

SuperPathways for ANKRD7 Gene

No Data Available

Interacting Proteins for ANKRD7 Gene

;

Gene Ontology (GO) - Biological Process for ANKRD7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD7 Gene

Drugs & Compounds for ANKRD7 Gene

No Compound Related Data Available

Transcripts for ANKRD7 Gene

mRNA/cDNA for ANKRD7 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: -
SP7: -

Relevant External Links for ANKRD7 Gene

GeneLoc Exon Structure for
ANKRD7

Expression for ANKRD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD7 Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for ANKRD7 Gene

This gene is overexpressed in Liver, secretome (37.2), Testis (12.3), CD4 Tcells (10.2), and Adipocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD7 Gene



Protein tissue co-expression partners for ANKRD7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD7

SOURCE GeneReport for Unigene cluster for ANKRD7 Gene:

Hs.729340

mRNA Expression by UniProt/SwissProt for ANKRD7 Gene:

Q92527-ANKR7_HUMAN
Tissue specificity: Testis specific.

Evidence on tissue expression from TISSUES for ANKRD7 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ANKRD7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD7 Gene

Orthologs for ANKRD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD7 31 30
  • 99.87 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd7 17 31 30
  • 77.4 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd7 30
  • 73.96 (n)
dog
(Canis familiaris)
Mammalia ANKRD7 31
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 46 (a)
OneToMany
-- 31
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 3 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 7 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 35 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 31
  • 4 (a)
OneToMany
Species where no ortholog for ANKRD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD7 Gene

ENSEMBL:
Gene Tree for ANKRD7 (if available)
TreeFam:
Gene Tree for ANKRD7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD7: view image

Paralogs for ANKRD7 Gene

Paralogs for ANKRD7 Gene

(25) SIMAP similar genes for ANKRD7 Gene using alignment to 3 proteins:

  • ANKR7_HUMAN
  • C9J2M7_HUMAN
  • C9JIJ7_HUMAN
genes like me logo Genes that share paralogs with ANKRD7: view

Variants for ANKRD7 Gene

Additional dbSNP identifiers (rs#s) for ANKRD7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD7 Gene

Variant ID Type Subtype PubMed ID
esv3614730 CNV loss 21293372
nsv5920 CNV insertion 18451855
nsv608259 CNV gain 21841781
nsv7405 OTHER inversion 18451855

Variation tolerance for ANKRD7 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD7 Gene

Disorders for ANKRD7 Gene

Additional Disease Information for ANKRD7

No disorders were found for ANKRD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD7 Gene

Publications for ANKRD7 Gene

  1. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PMID: 8812458) Ozaki K … Nakamura Y (Genomics 1996) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 54
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 54
  5. ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. (PMID: 22613542) Chen XD … Deng HW (Chinese medical journal 2012) 3 54

Products for ANKRD7 Gene

Sources for ANKRD7 Gene