Aliases for ANKRD66 Gene

Aliases for ANKRD66 Gene

  • Ankyrin Repeat Domain 66 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 66 3 4
  • ANKRD66 5

External Ids for ANKRD66 Gene

Previous GeneCards Identifiers for ANKRD66 Gene

  • GC06P046716

Summaries for ANKRD66 Gene

GeneCards Summary for ANKRD66 Gene

ANKRD66 (Ankyrin Repeat Domain 66) is a Protein Coding gene.

Additional gene information for ANKRD66 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD66 Gene

Genomics for ANKRD66 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD66 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J046745 Enhancer 0.3 Ensembl 600.7 0.0 -16 2.6 PRDM1 ANKRD66 TDRD6 MEP1A ADGRF5 SLC25A27 PLA2G7
GH06J046749 Enhancer 0.6 Ensembl ENCODE 0.7 +2.7 2697 1.2 USF1 YY1 TAF1 TDRD6 MEP1A CYP39A1 ANKRD66 ENSG00000236164
GH06J046757 Enhancer 0.8 Ensembl 0.4 +10.0 9984 4.6 PRDM10 ZNF629 ZNF692 PATZ1 ZNF501 ZNF600 SCRT2 ZNF639 SMARCC1 ZNF10 TDRD6 SLC25A27 CYP39A1 ENSG00000236164 ANKRD66 MEP1A
GH06J046761 Enhancer 0.8 Ensembl ENCODE 0.4 +14.1 14084 1.2 PRDM10 ZNF629 ZNF239 ZNF639 ZNF10 CEBPB OSR2 RCOR1 ZBTB17 ATF2 ENSG00000236164 CYP39A1 ANKRD66 MEP1A
GH06J046770 Enhancer 1 FANTOM5 ENCODE 0.3 +25.5 25522 3.7 GATAD2A PKNOX1 PBX2 SOX6 CEBPA TCF7 HES1 CEBPB TEAD1 HHEX lnc-ANKRD66-1 PLA2G7 MEP1A TDRD6 ENSG00000236164 ANKRD66
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD66 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD66

Genomic Locations for ANKRD66 Gene

Genomic Locations for ANKRD66 Gene
chr6:46,746,917-46,759,506
(GRCh38/hg38)
Size:
12,590 bases
Orientation:
Plus strand
chr6:46,714,654-46,727,243
(GRCh37/hg19)
Size:
12,590 bases
Orientation:
Plus strand

Genomic View for ANKRD66 Gene

Genes around ANKRD66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD66 Gene

Proteins for ANKRD66 Gene

  • Protein details for ANKRD66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4E2M5-ANR66_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 66
    Protein Accession:
    B4E2M5

    Protein attributes for ANKRD66 Gene

    Size:
    251 amino acids
    Molecular mass:
    27916 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG65187.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ANKRD66 Gene

Post-translational modifications for ANKRD66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD66 Gene

Domains & Families for ANKRD66 Gene

Gene Families for ANKRD66 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD66 Gene

genes like me logo Genes that share domains with ANKRD66: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD66 Gene

Function for ANKRD66 Gene

Gene Ontology (GO) - Molecular Function for ANKRD66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD66: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD66

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD66 Gene

Localization for ANKRD66 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKRD66 Gene

Pathways & Interactions for ANKRD66 Gene

PathCards logo

SuperPathways for ANKRD66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD66 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD66 Gene

Drugs & Compounds for ANKRD66 Gene

No Compound Related Data Available

Transcripts for ANKRD66 Gene

mRNA/cDNA for ANKRD66 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD66

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD66 Gene

No ASD Table

Relevant External Links for ANKRD66 Gene

GeneLoc Exon Structure for
ANKRD66

Expression for ANKRD66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD66 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD66 Gene

This gene is overexpressed in Fallopian Tube (x8.1), Brain - Hypothalamus (x7.5), Cervix - Endocervix (x7.5), Brain - Caudate (basal ganglia) (x7.0), Brain - Hippocampus (x5.3), Brain - Amygdala (x4.9), and Lung (x4.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD66

SOURCE GeneReport for Unigene cluster for ANKRD66 Gene:

Hs.736491
genes like me logo Genes that share expression patterns with ANKRD66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD66 Gene

Orthologs for ANKRD66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD66 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100614902 30
  • 99.07 (n)
Dog
(Canis familiaris)
Mammalia ANKRD66 30 31
  • 86.39 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANKRD66 30 31
  • 84.36 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ankrd66 30
  • 82.3 (n)
Mouse
(Mus musculus)
Mammalia Ankrd66 30 17 31
  • 80.56 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD66 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101733445 30
  • 69.23 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101886816 30
  • 59.92 (n)
ANKRD66 31
  • 52 (a)
OneToOne
Species where no ortholog for ANKRD66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD66 Gene

ENSEMBL:
Gene Tree for ANKRD66 (if available)
TreeFam:
Gene Tree for ANKRD66 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD66: view image

Paralogs for ANKRD66 Gene

(2) SIMAP similar genes for ANKRD66 Gene using alignment to 2 proteins:

  • ANR66_HUMAN
  • H3BTF0_HUMAN
genes like me logo Genes that share paralogs with ANKRD66: view

No data available for Paralogs for ANKRD66 Gene

Variants for ANKRD66 Gene

Additional dbSNP identifiers (rs#s) for ANKRD66 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD66 Gene

Variant ID Type Subtype PubMed ID
esv2759425 CNV gain+loss 17122850
nsv428147 CNV gain 18775914
nsv830654 CNV gain 17160897

Variation tolerance for ANKRD66 Gene

Gene Damage Index Score: 5.82; 73.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD66 Gene

Disorders for ANKRD66 Gene

No disorders were found for ANKRD66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD66 Gene

Publications for ANKRD66 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3

Products for ANKRD66 Gene

Sources for ANKRD66 Gene