Aliases for ANKRD65 Gene

Aliases for ANKRD65 Gene

  • Ankyrin Repeat Domain 65 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 65 3 4

External Ids for ANKRD65 Gene

Previous GeneCards Identifiers for ANKRD65 Gene

  • GC01M001355
  • GC01M001358

Summaries for ANKRD65 Gene

GeneCards Summary for ANKRD65 Gene

ANKRD65 (Ankyrin Repeat Domain 65) is a Protein Coding gene. An important paralog of this gene is CTTNBP2.

Additional gene information for ANKRD65 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD65 Gene

Genomics for ANKRD65 Gene

GeneHancer (GH) Regulatory Elements for ANKRD65 Gene

Promoters and enhancers for ANKRD65 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD65 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ANKRD65 Gene

Genomic Locations for ANKRD65 Gene
3,401 bases
Minus strand
3,350 bases
Minus strand

Genomic View for ANKRD65 Gene

Genes around ANKRD65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD65 Gene

Proteins for ANKRD65 Gene

  • Protein details for ANKRD65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 65
    Protein Accession:
    Secondary Accessions:
    • J3KR93

    Protein attributes for ANKRD65 Gene

    399 amino acids
    Molecular mass:
    41497 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD65 Gene


neXtProt entry for ANKRD65 Gene

Post-translational modifications for ANKRD65 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD65 Gene

Domains & Families for ANKRD65 Gene

Gene Families for ANKRD65 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD65 Gene

genes like me logo Genes that share domains with ANKRD65: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD65 Gene

Function for ANKRD65 Gene

Phenotypes From GWAS Catalog for ANKRD65 Gene

Phenotypes for ANKRD65 Gene

genes like me logo Genes that share phenotypes with ANKRD65: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD65

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD65 Gene

Localization for ANKRD65 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ANKRD65 Gene

Pathways & Interactions for ANKRD65 Gene

PathCards logo

SuperPathways for ANKRD65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD65 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD65 Gene

Drugs & Compounds for ANKRD65 Gene

No Compound Related Data Available

Transcripts for ANKRD65 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD65

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD65 Gene

No ASD Table

Relevant External Links for ANKRD65 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD65 Gene

Protein differential expression in normal tissues from HIPED for ANKRD65 Gene

This gene is overexpressed in Pancreatic juice (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD65 Gene

Protein tissue co-expression partners for ANKRD65 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD65 Gene:


SOURCE GeneReport for Unigene cluster for ANKRD65 Gene:

genes like me logo Genes that share expression patterns with ANKRD65: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD65 Gene

Orthologs for ANKRD65 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD65 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC457197 32
  • 97.49 (n)
(Canis familiaris)
Mammalia ANKRD65 33 32
  • 79.67 (n)
(Bos Taurus)
Mammalia ANKRD65 33 32
  • 79.22 (n)
(Rattus norvegicus)
Mammalia Ankrd65 32
  • 71.47 (n)
(Mus musculus)
Mammalia Ankrd65 17 32
  • 69.96 (n)
(Anolis carolinensis)
Reptilia ANKRD65 33
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd65 32
  • 49 (n)
(Danio rerio)
Actinopterygii ANKRD65 33
  • 34 (a)
(Caenorhabditis elegans)
Secernentea trp-4 33
  • 8 (a)
Species where no ortholog for ANKRD65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKRD65 Gene

Gene Tree for ANKRD65 (if available)
Gene Tree for ANKRD65 (if available)
Evolutionary constrained regions (ECRs) for ANKRD65: view image

Paralogs for ANKRD65 Gene

Paralogs for ANKRD65 Gene

(24) SIMAP similar genes for ANKRD65 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD65: view

Variants for ANKRD65 Gene

Sequence variations from dbSNP and Humsavar for ANKRD65 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000010885 -- 1,422,375(-) G/A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000146004 -- 1,422,527(-) A/G upstream_transcript_variant
rs1000538355 -- 1,422,481(-) G/C upstream_transcript_variant
rs1000624828 -- 1,423,506(-) C/G/T upstream_transcript_variant
rs1000843734 -- 1,418,001(-) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD65 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
esv2758913 CNV gain+loss 17122850
esv3577672 CNV loss 25503493
nsv1009541 CNV gain 25217958
nsv1011818 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1074445 CNV deletion 25765185
nsv1143428 CNV deletion 24896259
nsv482937 CNV loss 15286789
nsv545000 CNV loss 21841781
nsv950452 CNV deletion 24416366

Variation tolerance for ANKRD65 Gene

Gene Damage Index Score: 9.12; 87.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD65 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD65 Gene

Disorders for ANKRD65 Gene

Additional Disease Information for ANKRD65

No disorders were found for ANKRD65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD65 Gene

Publications for ANKRD65 Gene

  1. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56
  2. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L … Zhang L (The Journal of biological chemistry 2013) 3 56
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for ANKRD65 Gene

Sources for ANKRD65 Gene