Aliases for ANKRD62 Gene

Aliases for ANKRD62 Gene

  • Ankyrin Repeat Domain 62 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 62 3 4
  • DKFZp779B1634 2 3
  • ANKRD62 5

External Ids for ANKRD62 Gene

Previous GeneCards Identifiers for ANKRD62 Gene

  • GC18P012091
  • GC18P012094
  • GC18P012149
  • GC18P012787
  • GC18P012843
  • GC18P012869
  • GC18P013059
  • GC18P012206
  • GC18P012261
  • GC18P012334
  • GC18P012417
  • GC18P012495
  • GC18P012565
  • GC18P012631
  • GC18P012712

Summaries for ANKRD62 Gene

GeneCards Summary for ANKRD62 Gene

ANKRD62 (Ankyrin Repeat Domain 62) is a Protein Coding gene. Diseases associated with ANKRD62 include Lung Carcinoma In Situ. An important paralog of this gene is ANKRD26.

Additional gene information for ANKRD62 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD62 Gene

Genomics for ANKRD62 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD62 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J012092 Enhancer 0.7 Ensembl 600.7 -0.8 -826 0.5 HNRNPL CREB1 CTCF NFKBIZ JUND PKNOX1 REST RAD21 PBX2 ZFX ANKRD62 ENSG00000267478 LOC100533852 ENSG00000267722 IMPA2
GH18J012091 Enhancer 0.2 Ensembl 600.7 -1.8 -1797 0.4 ANKRD62 ENSG00000267478 LOC100533852 ENSG00000267733 ENSG00000267722 IMPA2
GH18J012076 Promoter 1.1 Ensembl CraniofacialAtlas 0.4 -17.1 -17095 1 ZNF512 ZFX UBTF ZBTB48 YY1 POLR2A ZNF335 ZNF18 NRF1 ZNF664 ENSG00000256616 LOC100996333 ENSG00000267733 ANKRD62 IMPA2
GH18J012039 Promoter/Enhancer 1.4 ENCODE CraniofacialAtlas dbSUPER 0.2 -54.7 -54739 1.3 HNRNPL GATAD2A CTCF PRDM10 TFE3 ZNF692 JUND LARP7 ZNF143 ZIC2 ENSG00000266995 IMPA2 ENSG00000267733 MPPE1 CHMP1B ENSG00000267247 ENSG00000267480 ANKRD62
GH18J012085 Enhancer 0.7 Ensembl ENCODE 0.4 -7.3 -7321 1.1 HNRNPL SMARCC1 CEBPB SMAD4 RARA KLF1 RAD21 ENSG00000267733 ENSG00000267722 ANKRD62 LOC100533852 IMPA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD62 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD62

Top Transcription factor binding sites by QIAGEN in the ANKRD62 gene promoter:
  • C/EBPbeta
  • CBF(2)
  • CBF-A
  • CBF-B
  • E47
  • FOXL1
  • HEN1
  • NF-Y
  • Nkx2-2
  • Nkx2-5

Genomic Locations for ANKRD62 Gene

Genomic Locations for ANKRD62 Gene
chr18:12,093,796-12,181,684
(GRCh38/hg38)
Size:
87,889 bases
Orientation:
Plus strand
chr18:12,093,848-12,129,763
(GRCh37/hg19)
Size:
35,916 bases
Orientation:
Plus strand

Genomic View for ANKRD62 Gene

Genes around ANKRD62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD62 Gene

Proteins for ANKRD62 Gene

  • Protein details for ANKRD62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NC57-ANR62_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 62
    Protein Accession:
    A6NC57

    Protein attributes for ANKRD62 Gene

    Size:
    917 amino acids
    Molecular mass:
    106446 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BX649021; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD62 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD62 Gene

Post-translational modifications for ANKRD62 Gene

  • Glycosylation at Asn99
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ANR62_HUMAN (2020)

Other Protein References for ANKRD62 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD62 Gene

Domains & Families for ANKRD62 Gene

Gene Families for ANKRD62 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD62 Gene

Suggested Antigen Peptide Sequences for ANKRD62 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 62 (ANR62_HUMAN)
genes like me logo Genes that share domains with ANKRD62: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD62 Gene

Function for ANKRD62 Gene

Phenotypes From GWAS Catalog for ANKRD62 Gene

Gene Ontology (GO) - Molecular Function for ANKRD62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD62: view
genes like me logo Genes that share phenotypes with ANKRD62: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD62

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD62 Gene

Localization for ANKRD62 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD62 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKRD62 Gene

Pathways & Interactions for ANKRD62 Gene

PathCards logo

SuperPathways for ANKRD62 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD62 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD62 Gene

Drugs & Compounds for ANKRD62 Gene

No Compound Related Data Available

Transcripts for ANKRD62 Gene

mRNA/cDNA for ANKRD62 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD62

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD62 Gene

No ASD Table

Relevant External Links for ANKRD62 Gene

GeneLoc Exon Structure for
ANKRD62

Expression for ANKRD62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD62 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD62 Gene

This gene is overexpressed in Testis (x23.1) and Pancreas (x17.4).

Protein differential expression in normal tissues from HIPED for ANKRD62 Gene

This gene is overexpressed in Urinary Bladder (33.5) and Bone marrow mesenchymal stem cell (28.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD62 Gene



Protein tissue co-expression partners for ANKRD62 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD62

SOURCE GeneReport for Unigene cluster for ANKRD62 Gene:

Hs.448906
genes like me logo Genes that share expression patterns with ANKRD62: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD62 Gene

Orthologs for ANKRD62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD62 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD62 30 31
  • 99.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 47 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
-- 31
  • 18 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 41 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gm1758 31
  • 34 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 15 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 24 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 40 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii ANKRD7 31
  • 11 (a)
OneToMany
Species where no ortholog for ANKRD62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD62 Gene

ENSEMBL:
Gene Tree for ANKRD62 (if available)
TreeFam:
Gene Tree for ANKRD62 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD62: view image

Paralogs for ANKRD62 Gene

(28) SIMAP similar genes for ANKRD62 Gene using alignment to 3 proteins:

  • ANR62_HUMAN
  • J3QTZ2_HUMAN
  • L0R816_HUMAN

Pseudogenes.org Pseudogenes for ANKRD62 Gene

genes like me logo Genes that share paralogs with ANKRD62: view

Variants for ANKRD62 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD62 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs1986751 - p.Ala188Ser
rs4519391 - p.Glu406Lys
rs6505715 - p.Cys265Arg
rs7243248 - p.Ala613Thr

Additional dbSNP identifiers (rs#s) for ANKRD62 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD62 Gene

Variant ID Type Subtype PubMed ID
dgv1553n106 CNV deletion 24896259
esv3893075 CNV gain 25118596
nsv1055343 CNV gain 25217958
nsv1063125 CNV loss 25217958
nsv1129331 OTHER inversion 24896259
nsv1153637 OTHER inversion 26484159
nsv952413 CNV deletion 24416366
nsv960655 CNV duplication 23825009
nsv960656 CNV duplication 23825009
nsv978605 CNV duplication 23825009

Variation tolerance for ANKRD62 Gene

Gene Damage Index Score: 1.96; 36.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD62 Gene

Disorders for ANKRD62 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANKRD62 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lung carcinoma in situ
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ANKRD62: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD62 Gene

Publications for ANKRD62 Gene

  1. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4
  2. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 4

Products for ANKRD62 Gene

Sources for ANKRD62 Gene