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Aliases for ANKRD61 Gene

Aliases for ANKRD61 Gene

  • Ankyrin Repeat Domain 61 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 61 3

External Ids for ANKRD61 Gene

Previous GeneCards Identifiers for ANKRD61 Gene

  • GC00U923118
  • GC07P006071

Summaries for ANKRD61 Gene

GeneCards Summary for ANKRD61 Gene

ANKRD61 (Ankyrin Repeat Domain 61) is a Protein Coding gene.

Additional gene information for ANKRD61 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD61 Gene

Genomics for ANKRD61 Gene

GeneHancer (GH) Regulatory Elements for ANKRD61 Gene

Promoters and enhancers for ANKRD61 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J006031 Enhancer 0.6 ENCODE 650.7 +1.0 1028 1.1 TEAD4 BHLHE40 TAL1 CBFA2T3 ZNF121 TCF12 NFIC NCOR1 KLF16 MYNN ANKRD61 EIF2AK1 RNU6-218P CCZ1 RN7SL851P
GH07J005523 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 49.4 -501.9 -501878 11.1 MLX FEZF1 DMAP1 E2F8 ZNF143 NFYC GLIS1 RCOR2 NBN KDM1A ACTB GC07M005528 GC07M005529 GC07M005530 PIR61399 USP42 ANKRD61 AP5Z1 RNF216 CCZ1
GH07J006007 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.7 -20.8 -20750 6.3 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC PPARGC1A PMS2 AIMP2 USP42 ANKRD61 RNF216 C7orf26 EIF2AK1 ZNF316 ZNF12 PMS2CL
GH07J005416 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 34.7 -607.4 -607395 15.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 TNRC18 ENSG00000272953 GC07P005425 USP42 RNF216P1 AP5Z1 ANKRD61 RNF216 RBAK RPL22P16
GH07J006446 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 29.2 +417.4 417408 4.4 CLOCK MLX ZFP64 FEZF1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZC3H11A DAGLB ZNF316 C7orf26 ZNF12 USP42 ANKRD61 ENSG00000198580 ENSG00000228010 KDELR2 PMS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANKRD61 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ANKRD61 Gene

Genomic Locations for ANKRD61 Gene
chr7:6,031,376-6,036,552
(GRCh38/hg38)
Size:
5,177 bases
Orientation:
Plus strand
chr7:6,071,007-6,076,017
(GRCh37/hg19)

Genomic View for ANKRD61 Gene

Genes around ANKRD61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD61 Gene

Proteins for ANKRD61 Gene

  • Protein details for ANKRD61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGH8-ANR61_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 61
    Protein Accession:
    A6NGH8

    Protein attributes for ANKRD61 Gene

    Size:
    418 amino acids
    Molecular mass:
    46141 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD61 Gene

Post-translational modifications for ANKRD61 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD61 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD61 Gene

Domains & Families for ANKRD61 Gene

Gene Families for ANKRD61 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD61 Gene

Suggested Antigen Peptide Sequences for ANKRD61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD61: view

No data available for UniProtKB/Swiss-Prot for ANKRD61 Gene

Function for ANKRD61 Gene

Phenotypes From GWAS Catalog for ANKRD61 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD61 Gene

Localization for ANKRD61 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD61 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKRD61 Gene

Pathways & Interactions for ANKRD61 Gene

SuperPathways for ANKRD61 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD61 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD61 Gene

Drugs & Compounds for ANKRD61 Gene

No Compound Related Data Available

Transcripts for ANKRD61 Gene

mRNA/cDNA for ANKRD61 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD61 Gene

Ankyrin repeat domain 61:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD61 Gene

No ASD Table

Relevant External Links for ANKRD61 Gene

GeneLoc Exon Structure for
ANKRD61
ECgene alternative splicing isoforms for
ANKRD61

Expression for ANKRD61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD61 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD61 Gene

This gene is overexpressed in Testis (x9.9).

Protein differential expression in normal tissues from HIPED for ANKRD61 Gene

This gene is overexpressed in Heart (60.8) and Blymphocyte (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD61 Gene



Protein tissue co-expression partners for ANKRD61 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD61 Gene:

ANKRD61

SOURCE GeneReport for Unigene cluster for ANKRD61 Gene:

Hs.744468
genes like me logo Genes that share expression patterns with ANKRD61: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD61 Gene

Orthologs for ANKRD61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD61 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD61 34 33
  • 81.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd61 16 34 33
  • 77.59 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd61 33
  • 77.19 (n)
cow
(Bos Taurus)
Mammalia ANKRD61 34 33
  • 73.48 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD61 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD61 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101752127 33
  • 58.87 (n)
Species where no ortholog for ANKRD61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD61 Gene

ENSEMBL:
Gene Tree for ANKRD61 (if available)
TreeFam:
Gene Tree for ANKRD61 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD61: view image

Paralogs for ANKRD61 Gene

(2) SIMAP similar genes for ANKRD61 Gene using alignment to 1 proteins:

  • ANR61_HUMAN
genes like me logo Genes that share paralogs with ANKRD61: view

No data available for Paralogs for ANKRD61 Gene

Variants for ANKRD61 Gene

Sequence variations from dbSNP and Humsavar for ANKRD61 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000480877 -- 6,030,727(+) G/C upstream_transcript_variant
rs1000966395 -- 6,033,220(+) C/T intron_variant
rs1001190267 -- 6,033,331(+) A/C intron_variant
rs1001223422 -- 6,030,472(+) G/A upstream_transcript_variant
rs1001275845 -- 6,030,671(+) G/A/C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD61 Gene

Variant ID Type Subtype PubMed ID
esv1385792 CNV deletion 17803354
esv1914954 OTHER inversion 16254605
esv3891031 CNV loss 25118596
esv988101 CNV deletion 20482838
nsv1018388 CNV gain 25217958
nsv1034916 CNV gain 25217958
nsv1114913 CNV deletion 24896259
nsv436904 CNV insertion 17901297
nsv471823 CNV novel sequence insertion 20440878
nsv605998 CNV loss 21841781
nsv7392 OTHER inversion 18451855
nsv830894 CNV loss 17160897

Variation tolerance for ANKRD61 Gene

Gene Damage Index Score: 11.01; 92.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD61 Gene

Disorders for ANKRD61 Gene

Additional Disease Information for ANKRD61

No disorders were found for ANKRD61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD61 Gene

Publications for ANKRD61 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  2. Ankyrin repeat: a unique motif mediating protein-protein interactions. (PMID: 17176038) Li J … Tsai MD (Biochemistry 2006) 3 58
  3. The ankyrin repeat as molecular architecture for protein recognition. (PMID: 15152081) Mosavi LK … Peng ZY (Protein science : a publication of the Protein Society 2004) 3 58
  4. Ankyrins, multifunctional proteins involved in many cellular pathways. (PMID: 12219834) Hryniewicz-Jankowska A … Sikorsk AF (Folia histochemica et cytobiologica 2002) 3 58
  5. The ankyrin repeat: a diversity of interactions on a common structural framework. (PMID: 10431175) Sedgwick SG … Smerdon SJ (Trends in biochemical sciences 1999) 3 58

Products for ANKRD61 Gene

Sources for ANKRD61 Gene

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