Aliases for ANKRD60 Gene

Aliases for ANKRD60 Gene

  • Ankyrin Repeat Domain 60 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 60 3 4
  • BA196N14.3 2 3
  • C20orf86 3 4
  • Chromosome 20 Open Reading Frame 86 2
  • ANKRD60 5

External Ids for ANKRD60 Gene

Previous HGNC Symbols for ANKRD60 Gene

  • C20orf86

Previous GeneCards Identifiers for ANKRD60 Gene

  • GC20M056227
  • GC20M056793
  • GC20M053576

Summaries for ANKRD60 Gene

GeneCards Summary for ANKRD60 Gene

ANKRD60 (Ankyrin Repeat Domain 60) is a Protein Coding gene. Diseases associated with ANKRD60 include Mental Retardation, Autosomal Dominant 21.

Additional gene information for ANKRD60 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD60 Gene

Genomics for ANKRD60 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD60 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J058228 Promoter/Enhancer 1 Ensembl ENCODE 608.8 -0.2 -232 1.8 RNF2 POLR2A EZH2 BMI1 YY1 ZNF335 ETS1 SIN3A VEZF1 SMARCA4 ANKRD60 lnc-C20orf85-3 PPP4R1L RAB22A
GH20J058250 Enhancer 1.2 Ensembl ENCODE 16.2 -23.5 -23548 2.8 CEBPG CREB1 GATAD2A ZBTB33 YBX1 ZNF629 TFE3 LEF1 IKZF1 TARDBP ANKRD60 ENSG00000225806 NELFCD PPP4R1L lnc-RAB22A-1 RAB22A lnc-ANKRD60-4
GH20J058456 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.3 -230.0 -230047 4.6 SP1 KDM1A BACH1 STAT3 ZNF143 RELA ZIC2 TCF12 IKZF2 TRIM22 VAPB ANKRD60 lnc-ANKRD60-5 lnc-RAB22A-2 APCDD1L
GH20J057627 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 9.8 +599.8 599752 3.5 POLR2A MTA3 CEBPB USF1 SPI1 SIX4 GABPA VEZF1 NFATC3 MAX piR-39098-129 piR-58297-279 ZBP1 ANKRD60 RBM38 PMEPA1
GH20J058372 Enhancer 1.1 ENCODE CraniofacialAtlas 10.3 -145.8 -145833 4.2 GATAD2A TEAD4 PRDM10 REST TFE3 ZNF512 IKZF1 KDM1A TARDBP RXRB RAB22A PPP4R1L ANKRD60 APCDD1L APCDD1L-DT VAPB piR-50444-283 RF00017-3655
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD60 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD60

Top Transcription factor binding sites by QIAGEN in the ANKRD60 gene promoter:
  • Bach2
  • FAC1
  • GCNF
  • GCNF-1
  • GCNF-2
  • Nkx2-5
  • POU2F1
  • POU2F1a

Genomic Locations for ANKRD60 Gene

Genomic Locations for ANKRD60 Gene
chr20:58,216,126-58,228,653
(GRCh38/hg38)
Size:
12,528 bases
Orientation:
Minus strand
chr20:56,793,551-56,803,709
(GRCh37/hg19)
Size:
10,159 bases
Orientation:
Minus strand

Genomic View for ANKRD60 Gene

Genes around ANKRD60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD60 Gene

Proteins for ANKRD60 Gene

  • Protein details for ANKRD60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ19-ANR60_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 60
    Protein Accession:
    Q9BZ19
    Secondary Accessions:
    • Q4VXE6

    Protein attributes for ANKRD60 Gene

    Size:
    345 amino acids
    Molecular mass:
    37630 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD60 Gene

Post-translational modifications for ANKRD60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD60 Gene

Domains & Families for ANKRD60 Gene

Gene Families for ANKRD60 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD60 Gene

Suggested Antigen Peptide Sequences for ANKRD60 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 60 (ANR60_HUMAN)
genes like me logo Genes that share domains with ANKRD60: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD60 Gene

Function for ANKRD60 Gene

Phenotypes From GWAS Catalog for ANKRD60 Gene

Gene Ontology (GO) - Molecular Function for ANKRD60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD60: view
genes like me logo Genes that share phenotypes with ANKRD60: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD60

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD60 Gene

Localization for ANKRD60 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD60 gene
Compartment Confidence
mitochondrion 2
cytosol 2
peroxisome 0
nucleus 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKRD60 Gene

Pathways & Interactions for ANKRD60 Gene

PathCards logo

SuperPathways for ANKRD60 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD60 Gene

Drugs & Compounds for ANKRD60 Gene

No Compound Related Data Available

Transcripts for ANKRD60 Gene

mRNA/cDNA for ANKRD60 Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD60

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD60 Gene

No ASD Table

Relevant External Links for ANKRD60 Gene

GeneLoc Exon Structure for
ANKRD60

Expression for ANKRD60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD60 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD60 Gene

This gene is overexpressed in Testis (x52.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD60 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD60

genes like me logo Genes that share expression patterns with ANKRD60: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD60 Gene

Orthologs for ANKRD60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD60 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD60 30 31
  • 99.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANKRD60 30 31
  • 79.19 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANKRD60 30 31
  • 78.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ankrd60 30 17 31
  • 73.16 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ankrd60 30
  • 72.65 (n)
Oppossum
(Monodelphis domestica)
Mammalia ANKRD60 31
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ANKRD60 30 31
  • 56.65 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANKRD60 31
  • 40 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ankrd60 30
  • 51.44 (n)
Species where no ortholog for ANKRD60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ANKRD60 Gene

ENSEMBL:
Gene Tree for ANKRD60 (if available)
TreeFam:
Gene Tree for ANKRD60 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD60: view image

Paralogs for ANKRD60 Gene

(2) SIMAP similar genes for ANKRD60 Gene using alignment to 2 proteins:

  • ANR60_HUMAN
  • H7BY81_HUMAN
genes like me logo Genes that share paralogs with ANKRD60: view

No data available for Paralogs for ANKRD60 Gene

Variants for ANKRD60 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD60 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs584855 - p.Arg295Cys

Additional dbSNP identifiers (rs#s) for ANKRD60 Gene

Variation tolerance for ANKRD60 Gene

Gene Damage Index Score: 7.62; 82.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD60 Gene

Disorders for ANKRD60 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANKRD60 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 21
  • mrd21
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANKRD60

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ANKRD60: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD60 Gene

Publications for ANKRD60 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  2. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 41
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3

Products for ANKRD60 Gene

Sources for ANKRD60 Gene