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Aliases for ANKRD60 Gene

Aliases for ANKRD60 Gene

  • Ankyrin Repeat Domain 60 2 3 5
  • C20orf86 3 4
  • Ankyrin Repeat Domain-Containing Protein 60 3
  • Chromosome 20 Open Reading Frame 86 2
  • BA196N14.3 3

External Ids for ANKRD60 Gene

Previous HGNC Symbols for ANKRD60 Gene

  • C20orf86

Previous GeneCards Identifiers for ANKRD60 Gene

  • GC20M056227
  • GC20M056793
  • GC20M053576

Summaries for ANKRD60 Gene

GeneCards Summary for ANKRD60 Gene

ANKRD60 (Ankyrin Repeat Domain 60) is a Protein Coding gene.

Additional gene information for ANKRD60 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD60 Gene

Genomics for ANKRD60 Gene

GeneHancer (GH) Regulatory Elements for ANKRD60 Gene

Promoters and enhancers for ANKRD60 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I058228 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 -0.4 -397 1.4 RNF2 REST BMI1 ETS1 SP1 POLR2A SMARCA4 VEZF1 EZH2 ANKRD60 PPP4R1L
GH20I057627 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +599.8 599752 3.5 SIX4 USF1 NFATC3 L3MBTL2 CEBPB MAX USF2 E4F1 GABPA MTA3 ZBP1 ANKRD60 RBM38 GC20P057650
GH20I058372 Enhancer 1.2 Ensembl ENCODE 10.3 -145.8 -145833 4.2 HDGF ATF1 SIN3A ZNF48 ETS1 TCF12 ZNF207 ZNF143 RXRA MIER2 PPP4R1L RAB22A ANKRD60 APCDD1L-AS1 APCDD1L ENSG00000254419 VAPB PIR40663
GH20I058456 Enhancer 1.1 FANTOM5 ENCODE 10.3 -229.4 -229403 2.8 PKNOX1 NFIB BMI1 BATF IRF4 ZNF207 ZNF143 ATF7 ETV6 FOS VAPB ANKRD60 APCDD1L APCDD1L-AS1
GH20I058179 Enhancer 1 Ensembl ENCODE 10.3 +49.0 48979 1.1 RB1 NFIB SIN3A ZNF2 ZBTB7B ZNF48 RAD21 GLIS2 EGR1 ZNF143 LOC105372694 PCK1 ANKRD60 CTCFL C20orf85
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANKRD60 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD60 gene promoter:

Genomic Locations for ANKRD60 Gene

Genomic Locations for ANKRD60 Gene
chr20:58,216,126-58,228,653
(GRCh38/hg38)
Size:
12,528 bases
Orientation:
Minus strand
chr20:56,793,551-56,803,709
(GRCh37/hg19)

Genomic View for ANKRD60 Gene

Genes around ANKRD60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD60 Gene

Proteins for ANKRD60 Gene

  • Protein details for ANKRD60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ19-ANR60_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 60
    Protein Accession:
    Q9BZ19
    Secondary Accessions:
    • Q4VXE6

    Protein attributes for ANKRD60 Gene

    Size:
    345 amino acids
    Molecular mass:
    37630 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI94996.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ANKRD60 Gene

Post-translational modifications for ANKRD60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD60 Gene

Domains & Families for ANKRD60 Gene

Gene Families for ANKRD60 Gene

Suggested Antigen Peptide Sequences for ANKRD60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD60: view

No data available for UniProtKB/Swiss-Prot for ANKRD60 Gene

Function for ANKRD60 Gene

Phenotypes From GWAS Catalog for ANKRD60 Gene

Phenotypes for ANKRD60 Gene

GenomeRNAi human phenotypes for ANKRD60:
genes like me logo Genes that share phenotypes with ANKRD60: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD60 Gene

Localization for ANKRD60 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD60 gene
Compartment Confidence
mitochondrion 3
cytosol 3
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKRD60 Gene

Pathways & Interactions for ANKRD60 Gene

SuperPathways for ANKRD60 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD60 Gene

Drugs & Compounds for ANKRD60 Gene

No Compound Related Data Available

Transcripts for ANKRD60 Gene

mRNA/cDNA for ANKRD60 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD60 Gene

No ASD Table

Relevant External Links for ANKRD60 Gene

GeneLoc Exon Structure for
ANKRD60
ECgene alternative splicing isoforms for
ANKRD60

Expression for ANKRD60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD60 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD60 Gene

This gene is overexpressed in Testis (x52.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD60 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKRD60 Gene:

ANKRD60
genes like me logo Genes that share expression patterns with ANKRD60: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD60 Gene

Orthologs for ANKRD60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD60 33 34
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia ANKRD60 33 34
  • 79.19 (n)
dog
(Canis familiaris)
Mammalia ANKRD60 33 34
  • 78.07 (n)
mouse
(Mus musculus)
Mammalia Ankrd60 33 16 34
  • 73.16 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd60 33
  • 72.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD60 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD60 33 34
  • 56.65 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD60 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd60 33
  • 51.44 (n)
Species where no ortholog for ANKRD60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD60 Gene

ENSEMBL:
Gene Tree for ANKRD60 (if available)
TreeFam:
Gene Tree for ANKRD60 (if available)

Paralogs for ANKRD60 Gene

(2) SIMAP similar genes for ANKRD60 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD60: view

No data available for Paralogs for ANKRD60 Gene

Variants for ANKRD60 Gene

Sequence variations from dbSNP and Humsavar for ANKRD60 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000549632 -- 58,228,722(-) C/A/G upstream_transcript_variant
rs1000813832 -- 58,215,745(-) G/T downstream_transcript_variant
rs1000951879 -- 58,217,173(-) G/A 3_prime_UTR_variant
rs1001097610 -- 58,222,667(-) C/A intron_variant
rs1001263498 -- 58,222,462(-) A/G intron_variant

Variation tolerance for ANKRD60 Gene

Gene Damage Index Score: 7.62; 82.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD60 Gene

Disorders for ANKRD60 Gene

Additional Disease Information for ANKRD60

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANKRD60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD60 Gene

Publications for ANKRD60 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 44 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 58

Products for ANKRD60 Gene

Sources for ANKRD60 Gene

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