Aliases for ANKRD60 Gene

Aliases for ANKRD60 Gene

  • Ankyrin Repeat Domain 60 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 60 3 4
  • C20orf86 3 4
  • Chromosome 20 Open Reading Frame 86 2
  • BA196N14.3 3

External Ids for ANKRD60 Gene

Previous HGNC Symbols for ANKRD60 Gene

  • C20orf86

Previous GeneCards Identifiers for ANKRD60 Gene

  • GC20M056227
  • GC20M056793
  • GC20M053576

Summaries for ANKRD60 Gene

GeneCards Summary for ANKRD60 Gene

ANKRD60 (Ankyrin Repeat Domain 60) is a Protein Coding gene.

Additional gene information for ANKRD60 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD60 Gene

Genomics for ANKRD60 Gene

GeneHancer (GH) Regulatory Elements for ANKRD60 Gene

Promoters and enhancers for ANKRD60 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD60 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD60 gene promoter:
  • Bach2
  • FAC1
  • GCNF
  • GCNF-1
  • GCNF-2
  • Nkx2-5
  • POU2F1
  • POU2F1a

Genomic Locations for ANKRD60 Gene

Genomic Locations for ANKRD60 Gene
chr20:58,216,126-58,228,653
(GRCh38/hg38)
Size:
12,528 bases
Orientation:
Minus strand
chr20:56,793,551-56,803,709
(GRCh37/hg19)
Size:
10,159 bases
Orientation:
Minus strand

Genomic View for ANKRD60 Gene

Genes around ANKRD60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD60 Gene

Proteins for ANKRD60 Gene

  • Protein details for ANKRD60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ19-ANR60_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 60
    Protein Accession:
    Q9BZ19
    Secondary Accessions:
    • Q4VXE6

    Protein attributes for ANKRD60 Gene

    Size:
    345 amino acids
    Molecular mass:
    37630 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD60 Gene

Post-translational modifications for ANKRD60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD60 Gene

Domains & Families for ANKRD60 Gene

Gene Families for ANKRD60 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ANKRD60 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 60 (ANR60_HUMAN)
genes like me logo Genes that share domains with ANKRD60: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD60 Gene

Function for ANKRD60 Gene

Phenotypes From GWAS Catalog for ANKRD60 Gene

genes like me logo Genes that share phenotypes with ANKRD60: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD60 Gene

Localization for ANKRD60 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD60 gene
Compartment Confidence
mitochondrion 2
cytosol 2
peroxisome 0
nucleus 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKRD60 Gene

Pathways & Interactions for ANKRD60 Gene

PathCards logo

SuperPathways for ANKRD60 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD60 Gene

Drugs & Compounds for ANKRD60 Gene

No Compound Related Data Available

Transcripts for ANKRD60 Gene

mRNA/cDNA for ANKRD60 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD60 Gene

No ASD Table

Relevant External Links for ANKRD60 Gene

GeneLoc Exon Structure for
ANKRD60
ECgene alternative splicing isoforms for
ANKRD60

Expression for ANKRD60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD60 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD60 Gene

This gene is overexpressed in Testis (x52.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD60 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKRD60 Gene:

ANKRD60
genes like me logo Genes that share expression patterns with ANKRD60: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD60 Gene

Orthologs for ANKRD60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD60 33 32
  • 99.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD60 33 32
  • 79.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD60 33 32
  • 78.07 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd60 17 33 32
  • 73.16 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd60 32
  • 72.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD60 33
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD60 33 32
  • 56.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD60 33
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd60 32
  • 51.44 (n)
Species where no ortholog for ANKRD60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD60 Gene

ENSEMBL:
Gene Tree for ANKRD60 (if available)
TreeFam:
Gene Tree for ANKRD60 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD60: view image

Paralogs for ANKRD60 Gene

(2) SIMAP similar genes for ANKRD60 Gene using alignment to 2 proteins:

  • ANR60_HUMAN
  • H7BY81_HUMAN
genes like me logo Genes that share paralogs with ANKRD60: view

No data available for Paralogs for ANKRD60 Gene

Variants for ANKRD60 Gene

Sequence variations from dbSNP and Humsavar for ANKRD60 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000549632 -- 58,228,722(-) C/A/G upstream_transcript_variant
rs1000813832 -- 58,215,745(-) G/T downstream_transcript_variant
rs1000951879 -- 58,217,173(-) G/A 3_prime_UTR_variant
rs1001097610 -- 58,222,667(-) C/A intron_variant
rs1001263498 -- 58,222,462(-) A/G intron_variant

Variation tolerance for ANKRD60 Gene

Gene Damage Index Score: 7.62; 82.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD60 Gene

Disorders for ANKRD60 Gene

Additional Disease Information for ANKRD60

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANKRD60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD60 Gene

Publications for ANKRD60 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  2. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 43 56
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 56
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 56

Products for ANKRD60 Gene

Sources for ANKRD60 Gene