Aliases for ANKRD6 Gene

Aliases for ANKRD6 Gene

  • Ankyrin Repeat Domain 6 2 3 5
  • Diversin 2 3 4
  • Ankyrin Repeat Domain-Containing Protein 6 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Diego Homolog (Drosophila) 2
  • Diego Homolog 3
  • KIAA0957 4

External Ids for ANKRD6 Gene

Previous GeneCards Identifiers for ANKRD6 Gene

  • GC06P090222
  • GC06P090093
  • GC06P090138
  • GC06P090199
  • GC06P090142
  • GC06P087360

Summaries for ANKRD6 Gene

GeneCards Summary for ANKRD6 Gene

ANKRD6 (Ankyrin Repeat Domain 6) is a Protein Coding gene. An important paralog of this gene is ANKRD10.

UniProtKB/Swiss-Prot Summary for ANKRD6 Gene

  • Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.

Additional gene information for ANKRD6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD6 Gene

Genomics for ANKRD6 Gene

GeneHancer (GH) Regulatory Elements for ANKRD6 Gene

Promoters and enhancers for ANKRD6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J089432 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.1 149 2.2 ZNF785 ZNF24 ZBTB40 CTCF RAD21 ZNF548 KLF14 GLIS2 ZIC2 REST ANKRD6 LYRM2 CASP8AP2 ENSG00000237027 PM20D2 MDN1 piR-41195-031
GH06J089536 Promoter/Enhancer 0.7 EPDnew Ensembl 761.5 +103.2 103248 0.4 ZSCAN4 CTCF ANKRD6 ENSG00000237027 RF00994-924 piR-50391-015
GH06J089345 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 -82.9 -82896 8.6 ZNF24 ZBTB40 LCORL POLR2A RUNX1 ZNF362 ZNF133 MYC NFYC ETV6 UBE2J1 CASP8AP2 MDN1 SRSF12 RRAGD GABRR2 TUBB3P1 PNRC1 ANKRD6 RNGTT
GH06J089409 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 10.7 -21.8 -21751 4.4 ZNF24 SREBF1 HDAC2 ZNF362 MAX ZNF121 MNT NKRF POLR2A SP7 RRAGD CASP8AP2 LYRM2 ANKRD6 PM20D2 SRSF12 ENSG00000237027 piR-30306-015
GH06J089828 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.7 +396.6 396649 3.2 E2F8 ZBTB40 SP1 SMARCE1 POLR2A ATF1 FOS CREB1 ZNF362 NFYC MDN1 CASP8AP2 NONHSAG044346.2 MAP3K7 SRSF12 ENSG00000237027 ANKRD6 LYRM2 RF00017-5674 L13712-025
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD6 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for ANKRD6 Gene

Genomic Locations for ANKRD6 Gene
200,683 bases
Plus strand
200,665 bases
Plus strand

Genomic View for ANKRD6 Gene

Genes around ANKRD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD6 Gene

Proteins for ANKRD6 Gene

  • Protein details for ANKRD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • B3KUC3
    • Q5JUJ4
    • Q5JUJ5
    • Q8IUQ8
    • Q9NU24
    • Q9UFQ9

    Protein attributes for ANKRD6 Gene

    727 amino acids
    Molecular mass:
    79971 Da
    Quaternary structure:
    • Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon.
    • Sequence=BAA76801.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD6 Gene


neXtProt entry for ANKRD6 Gene

Post-translational modifications for ANKRD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD6 Gene

Domains & Families for ANKRD6 Gene

Gene Families for ANKRD6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD6 Gene

Suggested Antigen Peptide Sequences for ANKRD6 Gene

GenScript: Design optimal peptide antigens:
  • Diversin (ANKR6_HUMAN)
  • cDNA FLJ39548 fis, clone PUAEN2010824, highly similar to Ankyrin repeat domain-containing protein 6 (B3KUC3_HUMAN)
  • ANKRD6 protein (Q9BVM3_HUMAN)
genes like me logo Genes that share domains with ANKRD6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD6 Gene

Function for ANKRD6 Gene

Molecular function for ANKRD6 Gene

UniProtKB/Swiss-Prot Function:
Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.

Phenotypes From GWAS Catalog for ANKRD6 Gene

genes like me logo Genes that share phenotypes with ANKRD6: view

Animal Models for ANKRD6 Gene

MGI Knock Outs for ANKRD6:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD6 Gene

Localization for ANKRD6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD6 gene
Compartment Confidence
nucleus 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANKRD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ANKRD6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKRD6 Gene

Pathways & Interactions for ANKRD6 Gene

PathCards logo

SuperPathways for ANKRD6 Gene

No Data Available

SIGNOR curated interactions for ANKRD6 Gene


Gene Ontology (GO) - Biological Process for ANKRD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046330 positive regulation of JNK cascade IBA 21873635
GO:0090090 negative regulation of canonical Wnt signaling pathway IBA 21873635
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA --
genes like me logo Genes that share ontologies with ANKRD6: view

No data available for Pathways by source for ANKRD6 Gene

Drugs & Compounds for ANKRD6 Gene

No Compound Related Data Available

Transcripts for ANKRD6 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP7: -
SP8: - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - -
SP13: - - -
SP14: -
SP15: - - - - - -

ExUns: 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b · 22c
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: - -
SP10: - -
SP11: -
SP12: -

Relevant External Links for ANKRD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.5) and Brain - Cerebellum (x4.5).

Protein differential expression in normal tissues from HIPED for ANKRD6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD6 Gene

Protein tissue co-expression partners for ANKRD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD6 Gene:


SOURCE GeneReport for Unigene cluster for ANKRD6 Gene:


Evidence on tissue expression from TISSUES for ANKRD6 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ANKRD6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD6 Gene

Orthologs for ANKRD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKRD6 33 32
  • 99.54 (n)
(Canis familiaris)
Mammalia ANKRD6 33 32
  • 90.92 (n)
(Bos Taurus)
Mammalia ANKRD6 33 32
  • 89.43 (n)
(Mus musculus)
Mammalia Ankrd6 17 33 32
  • 84.93 (n)
(Rattus norvegicus)
Mammalia Ankrd6 32
  • 84.43 (n)
(Ornithorhynchus anatinus)
Mammalia ANKRD6 33
  • 80 (a)
(Monodelphis domestica)
Mammalia ANKRD6 33
  • 74 (a)
(Gallus gallus)
Aves ANKRD6 33 32
  • 73.34 (n)
(Anolis carolinensis)
Reptilia ANKRD6 33
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd6 32
  • 66.53 (n)
(Danio rerio)
Actinopterygii ankrd6b 33 32
  • 60.23 (n)
ankrd6a 33
  • 40 (a)
ankrd6 32
fruit fly
(Drosophila melanogaster)
Insecta dgo 33
  • 17 (a)
Species where no ortholog for ANKRD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD6 Gene

Gene Tree for ANKRD6 (if available)
Gene Tree for ANKRD6 (if available)
Evolutionary constrained regions (ECRs) for ANKRD6: view image

Paralogs for ANKRD6 Gene

Paralogs for ANKRD6 Gene

(36) SIMAP similar genes for ANKRD6 Gene using alignment to 12 proteins:

  • E5RH98_HUMAN
  • E5RJ05_HUMAN
  • E5RJ45_HUMAN
genes like me logo Genes that share paralogs with ANKRD6: view

Variants for ANKRD6 Gene

Sequence variations from dbSNP and Humsavar for ANKRD6 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000005008 -- 89,606,412(+) G/C intron_variant
rs1000013792 -- 89,564,067(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000025754 -- 89,498,620(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000042547 -- 89,503,732(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000045113 -- 89,597,282(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD6 Gene

Variant ID Type Subtype PubMed ID
dgv6089n100 CNV gain 25217958
esv2667529 CNV deletion 23128226
esv2732410 CNV deletion 23290073
esv2732411 CNV deletion 23290073
esv3609900 CNV loss 21293372
esv3609901 CNV gain 21293372
esv3609902 CNV gain 21293372
esv3609903 CNV gain 21293372
esv3609904 CNV gain 21293372
esv3609906 CNV loss 21293372
esv3890901 CNV gain 25118596
esv3890902 CNV loss 25118596
esv3890903 CNV gain 25118596
nsv1027007 CNV gain 25217958
nsv1073997 CNV deletion 25765185
nsv604124 CNV loss 21841781
nsv965747 CNV duplication 23825009

Variation tolerance for ANKRD6 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD6 Gene

Disorders for ANKRD6 Gene

Additional Disease Information for ANKRD6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANKRD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD6 Gene

Publications for ANKRD6 Gene

  1. Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear. (PMID: 25218921) Jones C … Chen P (Developmental biology 2014) 2 3 56
  2. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. (PMID: 21810271) Antoni G … Tregouet DA (BMC medical genetics 2011) 3 43 56
  3. The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. (PMID: 19591803) Haribaskar R … Schäfer T (Biochemical and biophysical research communications 2009) 3 23 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56

Products for ANKRD6 Gene

Sources for ANKRD6 Gene