Aliases for ANKRD55 Gene

Aliases for ANKRD55 Gene

  • Ankyrin Repeat Domain 55 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 55 3 4
  • FLJ11795 2
  • ANKRD55 5

External Ids for ANKRD55 Gene

Previous GeneCards Identifiers for ANKRD55 Gene

  • GC05M055432
  • GC05M052368
  • GC05M055395

Summaries for ANKRD55 Gene

GeneCards Summary for ANKRD55 Gene

ANKRD55 (Ankyrin Repeat Domain 55) is a Protein Coding gene. Diseases associated with ANKRD55 include Oligoarticular Juvenile Idiopathic Arthritis and Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis. An important paralog of this gene is ANKRD52.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD55 Gene

Genomics for ANKRD55 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD55 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J056116 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 600.1 +116.1 116129 2 GATAD2A REST TFE3 LEF1 IKZF1 NFKBIZ MTA2 RXRB NR2C1 IRF2 ANKRD55 ENSG00000238326 lnc-IL31RA-5 piR-61945-404 lnc-IL6ST-2 IL6ST RF00017-4627
GH05J056232 Enhancer 0.3 Ensembl 600.7 -0.1 -71 0.4 POLR2A NRF1 ANKRD55 lnc-IL6ST-3 piR-31199-291 LOC105378979
GH05J056235 Enhancer 0.2 Ensembl 600.7 -2.0 -1971 0.6 ANKRD55 lnc-IL6ST-3 piR-31199-291 LOC105378979
GH05J056174 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +56.9 56903 3 ZNF692 JUND SOX6 HMBOX1 SMARCC1 CEBPB ESR1 NFE2 FOS JUN ANKRD55 RNU6-299P ENSG00000238326 IL6ST FJ601678-029 lnc-IL6ST-2 lnc-IL6ST-3 RF00017-4627
GH05J056258 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -25.9 -25871 2.4 JUND RELA IKZF2 DPF2 RELB CEBPB RUNX3 FOS FOSL1 BCL11A RF00001-254 RNA5SP185 piR-43099-479 piR-50308-518 piR-54764-517 ANKRD55 ENSG00000237705 LINC01948 SETD9 LOC105378979
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD55 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD55

Top Transcription factor binding sites by QIAGEN in the ANKRD55 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • NF-Y
  • NF-YB
  • Pax-3
  • Pbx1a

Genomic Locations for ANKRD55 Gene

Genomic Locations for ANKRD55 Gene
chr5:56,099,680-56,233,330
(GRCh38/hg38)
Size:
133,651 bases
Orientation:
Minus strand
chr5:55,395,507-55,529,186
(GRCh37/hg19)
Size:
133,680 bases
Orientation:
Minus strand

Genomic View for ANKRD55 Gene

Genes around ANKRD55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD55 Gene

Proteins for ANKRD55 Gene

  • Protein details for ANKRD55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KP44-ANR55_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 55
    Protein Accession:
    Q3KP44
    Secondary Accessions:
    • B3KVT8
    • Q3KP45
    • Q9HAD3

    Protein attributes for ANKRD55 Gene

    Size:
    614 amino acids
    Molecular mass:
    68414 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD55 Gene

Post-translational modifications for ANKRD55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD55 Gene

No data available for DME Specific Peptides for ANKRD55 Gene

Domains & Families for ANKRD55 Gene

Gene Families for ANKRD55 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD55 Gene

Suggested Antigen Peptide Sequences for ANKRD55 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 55 (ANR55_HUMAN)
  • cDNA FLJ41395 fis, clone BRCOC2016525, weakly similar to Inversin (B3KVT8_HUMAN)
genes like me logo Genes that share domains with ANKRD55: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD55 Gene

Function for ANKRD55 Gene

Phenotypes From GWAS Catalog for ANKRD55 Gene

Gene Ontology (GO) - Molecular Function for ANKRD55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD55: view
genes like me logo Genes that share phenotypes with ANKRD55: view

Human Phenotype Ontology for ANKRD55 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD55

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD55 Gene

Localization for ANKRD55 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD55 gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD55 Gene

Pathways & Interactions for ANKRD55 Gene

PathCards logo

SuperPathways for ANKRD55 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD55 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD55 Gene

Drugs & Compounds for ANKRD55 Gene

No Compound Related Data Available

Transcripts for ANKRD55 Gene

mRNA/cDNA for ANKRD55 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD55

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD55 Gene

No ASD Table

Relevant External Links for ANKRD55 Gene

GeneLoc Exon Structure for
ANKRD55

Expression for ANKRD55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD55 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD55 Gene

This gene is overexpressed in Whole Blood (x16.4), Brain - Hypothalamus (x5.3), and Testis (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD55

SOURCE GeneReport for Unigene cluster for ANKRD55 Gene:

Hs.436214

Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD55 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • nervous
  • skeleton
Regions:
Head and neck:
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • skull
  • tooth
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with ANKRD55: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for ANKRD55 Gene

Orthologs for ANKRD55 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANKRD55 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD55 30 31
  • 99.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANKRD55 30 31
  • 88.91 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANKRD55 30 31
  • 88.64 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ankrd55 30 17 31
  • 84.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ankrd55 30
  • 84.5 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD55 31
  • 82 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANKRD55 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ANKRD55 30 31
  • 70.08 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANKRD55 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ankrd55 30
  • 67.69 (n)
Zebrafish
(Danio rerio)
Actinopterygii ankrd55 30 31
  • 63.9 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVO2 31
  • 22 (a)
OneToOne
Species where no ortholog for ANKRD55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD55 Gene

ENSEMBL:
Gene Tree for ANKRD55 (if available)
TreeFam:
Gene Tree for ANKRD55 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD55: view image

Paralogs for ANKRD55 Gene

Paralogs for ANKRD55 Gene

(6) SIMAP similar genes for ANKRD55 Gene using alignment to 3 proteins:

  • ANR55_HUMAN
  • D6R9N4_HUMAN
  • D6RBD3_HUMAN
genes like me logo Genes that share paralogs with ANKRD55: view

Variants for ANKRD55 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD55 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
719615 Likely Benign: not provided 56,111,622(-) A/G MISSENSE_VARIANT
741976 Likely Benign: not provided 56,111,696(-) C/T MISSENSE_VARIANT
743566 Likely Benign: not provided 56,159,842(-) C/T SYNONYMOUS_VARIANT
785800 Benign: not provided 56,116,745(-) C/T MISSENSE_VARIANT
787817 Benign: not provided 56,126,996(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ANKRD55 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD55 Gene

Variant ID Type Subtype PubMed ID
dgv1607e212 CNV loss 25503493
dgv164n73 CNV deletion 24416366
dgv9787n54 CNV loss 21841781
esv1152739 CNV deletion 17803354
esv1539040 CNV insertion 17803354
esv23752 CNV loss 19812545
esv2667446 CNV deletion 23128226
esv2677484 CNV deletion 23128226
esv2730194 CNV deletion 23290073
esv274955 CNV loss 21479260
esv29252 CNV loss 19812545
esv3293385 CNV deletion 24192839
esv3331343 CNV insertion 20981092
esv3337539 CNV insertion 20981092
esv3357462 CNV insertion 20981092
esv3416017 CNV duplication 20981092
esv3565940 CNV deletion 23714750
esv3605111 CNV loss 21293372
esv3605112 CNV loss 21293372
esv3605115 CNV loss 21293372
esv993277 CNV deletion 20482838
nsv1024291 CNV gain 25217958
nsv1074831 CNV deletion 25765185
nsv1112420 CNV deletion 24896259
nsv1136997 CNV deletion 24896259
nsv1143135 CNV tandem duplication 24896259
nsv329245 CNV deletion 16902084
nsv513238 CNV loss 21212237
nsv519960 CNV loss 19592680
nsv598186 CNV loss 21841781
nsv980644 CNV duplication 23825009

Variation tolerance for ANKRD55 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD55 Gene

Disorders for ANKRD55 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANKRD55 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
oligoarticular juvenile idiopathic arthritis
  • pauciarticular chronic arthritis
rheumatoid factor-negative polyarticular juvenile idiopathic arthritis
  • juvenile rheumatoid factor-negative polyarthritis
celiac disease 1
  • celiac disease, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANKRD55

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ANKRD55: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD55 Gene

Publications for ANKRD55 Gene

  1. Interactome of the Autoimmune Risk Protein ANKRD55. (PMID: 31620119) Ugidos N … Vandenbroeck K (Frontiers in immunology 2019) 2 3
  2. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl EA … Plenge RM (Nature genetics 2010) 3 41
  3. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ANKRD55 Gene

  • Biorbyt antibodies for ANKRD55

Sources for ANKRD55 Gene