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Aliases for ANKRD53 Gene

Aliases for ANKRD53 Gene

  • Ankyrin Repeat Domain 53 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 53 3

External Ids for ANKRD53 Gene

Previous GeneCards Identifiers for ANKRD53 Gene

  • GC02P071059
  • GC02P071205
  • GC02P070942

Summaries for ANKRD53 Gene

GeneCards Summary for ANKRD53 Gene

ANKRD53 (Ankyrin Repeat Domain 53) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANKRD53 Gene

  • Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.

Additional gene information for ANKRD53 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD53 Gene

Genomics for ANKRD53 Gene

GeneHancer (GH) Regulatory Elements for ANKRD53 Gene

Promoters and enhancers for ANKRD53 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J070976 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 656.7 +0.7 716 3.8 PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 FOS ANKRD53 ZNF638 TEX261 ATP6V1B1-AS1 VAX2 NAGK OR7E62P CLEC4F LOC105374795 ENSG00000258881
GH02J071226 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.4 +249.8 249824 1.9 HDGF PKNOX1 ATF1 FOXA2 SIN3A FEZF1 GLI4 ZNF2 ZBTB7B IRF4 PAIP2B TEX261 TIA1 ANKRD53 MPHOSPH10 CLEC4F ZNF638 ENSG00000233870
GH02J070246 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.1 -728.9 -728949 3.3 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 TIA1 C2orf42 TRG-CCC2-1 PCBP1-AS1 TEX261 GMCL1 CLEC4F ANKRD53 MPHOSPH10 CD207
GH02J070080 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 20.7 -890.8 -890819 11.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 MEF2D PCBP1 TIA1 PCBP1-AS1 TEX261 C2orf42 CLEC4F GMCL1 ANKRD53 MXD1 SNRNP27
GH02J070139 Enhancer 1.6 Ensembl ENCODE dbSUPER 20.3 -835.3 -835344 5.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 TIA1 TEX261 PCBP1-AS1 CLEC4F ANKRD53 MPHOSPH10 FAM136A C2orf42 GMCL1 ASPRV1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD53 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD53 gene promoter:
  • STAT5A
  • Arnt
  • AhR
  • Pax-3
  • NF-kappaB
  • NF-kappaB1
  • FOXD1
  • MyoD
  • FOXO3
  • FOXO4

Genomic Locations for ANKRD53 Gene

Genomic Locations for ANKRD53 Gene
9,465 bases
Plus strand
7,120 bases
Plus strand

Genomic View for ANKRD53 Gene

Genes around ANKRD53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD53 Gene

Proteins for ANKRD53 Gene

  • Protein details for ANKRD53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 53
    Protein Accession:
    Secondary Accessions:
    • Q8IYP8

    Protein attributes for ANKRD53 Gene

    530 amino acids
    Molecular mass:
    59571 Da
    Quaternary structure:
    • Interacts with PSRC1; recruited by PSRC1 to the spindle during mitosis (PubMed:26820536).

    Alternative splice isoforms for ANKRD53 Gene


neXtProt entry for ANKRD53 Gene

Post-translational modifications for ANKRD53 Gene

Other Protein References for ANKRD53 Gene

No data available for DME Specific Peptides for ANKRD53 Gene

Domains & Families for ANKRD53 Gene

Gene Families for ANKRD53 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD53 Gene

Suggested Antigen Peptide Sequences for ANKRD53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD53: view

No data available for UniProtKB/Swiss-Prot for ANKRD53 Gene

Function for ANKRD53 Gene

Molecular function for ANKRD53 Gene

UniProtKB/Swiss-Prot Function:
Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.

Phenotypes From GWAS Catalog for ANKRD53 Gene

Gene Ontology (GO) - Molecular Function for ANKRD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26820536
genes like me logo Genes that share ontologies with ANKRD53: view
genes like me logo Genes that share phenotypes with ANKRD53: view

Animal Models for ANKRD53 Gene

MGI Knock Outs for ANKRD53:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD53 Gene

Localization for ANKRD53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD53 Gene

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at the spindle around the centrosome at prophase and prometaphase and at the spindle poles at metaphase and anaphase (PubMed:26820536). {ECO:0000269 PubMed:26820536}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD53 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for ANKRD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 26820536
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IDA,IEA 26820536
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ANKRD53: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANKRD53 Gene

Pathways & Interactions for ANKRD53 Gene

SuperPathways for ANKRD53 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007080 mitotic metaphase plate congression IMP 26820536
GO:0031116 positive regulation of microtubule polymerization IMP 26820536
GO:0051301 cell division IEA --
GO:0060236 regulation of mitotic spindle organization IMP 26820536
genes like me logo Genes that share ontologies with ANKRD53: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD53 Gene

Drugs & Compounds for ANKRD53 Gene

No Compound Related Data Available

Transcripts for ANKRD53 Gene

mRNA/cDNA for ANKRD53 Gene

Unigene Clusters for ANKRD53 Gene

Ankyrin repeat domain 53:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD53 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - -
SP2: - - - -
SP3: - - - - -
SP5: - - - -

Relevant External Links for ANKRD53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD53 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD53 Gene

This gene is overexpressed in Testis (x12.2).

Protein differential expression in normal tissues from HIPED for ANKRD53 Gene

This gene is overexpressed in Plasma (59.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD53 Gene

Protein tissue co-expression partners for ANKRD53 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD53 Gene:


SOURCE GeneReport for Unigene cluster for ANKRD53 Gene:


Evidence on tissue expression from TISSUES for ANKRD53 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ANKRD53: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD53 Gene

Orthologs for ANKRD53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD53 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKRD53 34 33
  • 99.12 (n)
(Bos Taurus)
Mammalia ANKRD53 34 33
  • 80.13 (n)
(Canis familiaris)
Mammalia ANKRD53 34 33
  • 77.73 (n)
(Mus musculus)
Mammalia Ankrd53 16 34 33
  • 70.06 (n)
(Ornithorhynchus anatinus)
Mammalia ANKRD53 34
  • 50 (a)
(Anolis carolinensis)
Reptilia ANKRD53 34
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732970 33
  • 48.64 (n)
(Danio rerio)
Actinopterygii LOC567792 33
  • 48.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
Species where no ortholog for ANKRD53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD53 Gene

Gene Tree for ANKRD53 (if available)
Gene Tree for ANKRD53 (if available)
Evolutionary constrained regions (ECRs) for ANKRD53: view image

Paralogs for ANKRD53 Gene

(2) SIMAP similar genes for ANKRD53 Gene using alignment to 3 proteins:

  • C9JZ61_HUMAN
genes like me logo Genes that share paralogs with ANKRD53: view

No data available for Paralogs for ANKRD53 Gene

Variants for ANKRD53 Gene

Sequence variations from dbSNP and Humsavar for ANKRD53 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000188860 -- 70,985,812(+) G/A downstream_transcript_variant
rs1000461676 -- 70,980,354(+) G/C intron_variant
rs1001736976 -- 70,979,145(+) C/T coding_sequence_variant, intron_variant, synonymous_variant
rs1002104412 -- 70,979,342(+) A/T coding_sequence_variant, missense_variant
rs1002120408 -- 70,983,933(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD53 Gene

Variant ID Type Subtype PubMed ID
nsv1013232 CNV gain 25217958
nsv1146915 OTHER inversion 26484159
nsv517881 CNV loss 19592680

Variation tolerance for ANKRD53 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD53 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD53 Gene

Disorders for ANKRD53 Gene

Additional Disease Information for ANKRD53

No disorders were found for ANKRD53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD53 Gene

Publications for ANKRD53 Gene

  1. ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis. (PMID: 26820536) Kim S … Jang CY (Biochemical and biophysical research communications 2016) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T … Hayashizaki Y (Cell 2010) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ANKRD53 Gene

Sources for ANKRD53 Gene

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