Aliases for ANKRD52 Gene

Aliases for ANKRD52 Gene

  • Ankyrin Repeat Domain 52 2 3 5
  • PP6-ARS-C 2 3 4
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit C 3 4
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-C 3 4
  • Protein Phosphatase 6 Ankyrin Repeat Subunit C 2 3
  • Ankyrin Repeat Domain-Containing Protein 52 3 4
  • Ankyrin Repeat Domain 33 3
  • CVWG5837 3
  • FLJ34236 2
  • ANKRD33 3
  • ANKRD52 5

External Ids for ANKRD52 Gene

Previous GeneCards Identifiers for ANKRD52 Gene

  • GC12M054920
  • GC12U900660
  • GC12M056631
  • GC12M053670

Summaries for ANKRD52 Gene

GeneCards Summary for ANKRD52 Gene

ANKRD52 (Ankyrin Repeat Domain 52) is a Protein Coding gene. An important paralog of this gene is ANKRD28.

UniProtKB/Swiss-Prot Summary for ANKRD52 Gene

  • Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Additional gene information for ANKRD52 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD52 Gene

Genomics for ANKRD52 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD52 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD52 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD52

Top Transcription factor binding sites by QIAGEN in the ANKRD52 gene promoter:
  • ER-alpha
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB1
  • Sox9
  • TBP

Genomic Locations for ANKRD52 Gene

Genomic Locations for ANKRD52 Gene
20,585 bases
Minus strand
20,585 bases
Minus strand

Genomic View for ANKRD52 Gene

Genes around ANKRD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD52 Gene

Proteins for ANKRD52 Gene

  • Protein details for ANKRD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
    Protein Accession:
    Secondary Accessions:
    • A6NE79
    • B1Q2K2

    Protein attributes for ANKRD52 Gene

    1076 amino acids
    Molecular mass:
    115077 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.

neXtProt entry for ANKRD52 Gene

Post-translational modifications for ANKRD52 Gene

  • Ubiquitination at Lys337
  • Modification sites at PhosphoSitePlus

Other Protein References for ANKRD52 Gene

Antibody Products

  • Boster Bio Antibodies for ANKRD52

No data available for DME Specific Peptides for ANKRD52 Gene

Domains & Families for ANKRD52 Gene

Gene Families for ANKRD52 Gene

Protein Domains for ANKRD52 Gene

Suggested Antigen Peptide Sequences for ANKRD52 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 52 (ANR52_HUMAN)
genes like me logo Genes that share domains with ANKRD52: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD52 Gene

Function for ANKRD52 Gene

Molecular function for ANKRD52 Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Phenotypes From GWAS Catalog for ANKRD52 Gene

Gene Ontology (GO) - Molecular Function for ANKRD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18186651
genes like me logo Genes that share ontologies with ANKRD52: view

Phenotypes for ANKRD52 Gene

MGI mutant phenotypes for ANKRD52:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ANKRD52: view

Animal Model Products

CRISPR Products

miRNA for ANKRD52 Gene

miRTarBase miRNAs that target ANKRD52

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD52

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD52 Gene

Localization for ANKRD52 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD52 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD52 Gene

Pathways & Interactions for ANKRD52 Gene

PathCards logo

SuperPathways for ANKRD52 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD52 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD52 Gene

Drugs & Compounds for ANKRD52 Gene

No Compound Related Data Available

Transcripts for ANKRD52 Gene

mRNA/cDNA for ANKRD52 Gene

8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD52

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD52 Gene

No ASD Table

Relevant External Links for ANKRD52 Gene

GeneLoc Exon Structure for

Expression for ANKRD52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD52 Gene

This gene is overexpressed in Lung (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD52 Gene

Protein tissue co-expression partners for ANKRD52 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD52

SOURCE GeneReport for Unigene cluster for ANKRD52 Gene:


Evidence on tissue expression from TISSUES for ANKRD52 Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ANKRD52: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD52 Gene

Orthologs for ANKRD52 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKRD52 30 31
  • 99.75 (n)
(Canis familiaris)
Mammalia ANKRD52 30 31
  • 94.73 (n)
(Bos Taurus)
Mammalia ANKRD52 30 31
  • 94.64 (n)
(Mus musculus)
Mammalia Ankrd52 30 17 31
  • 93.18 (n)
(Rattus norvegicus)
Mammalia Ankrd52 30
  • 93.06 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 18 (a)
(Gallus gallus)
Aves ANKRD52 30 31
  • 79.93 (n)
(Anolis carolinensis)
Reptilia ANKRD52 31
  • 90 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ankrd52 30
  • 75.17 (n)
(Danio rerio)
Actinopterygii ankrd52a 30 31
  • 67.76 (n)
ANKRD52 (2 of 2) 31
  • 61 (a)
Dr.18831 30
Fruit Fly
(Drosophila melanogaster)
Insecta nompC 31
  • 13 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
Species where no ortholog for ANKRD52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD52 Gene

Gene Tree for ANKRD52 (if available)
Gene Tree for ANKRD52 (if available)
Evolutionary constrained regions (ECRs) for ANKRD52: view image

Paralogs for ANKRD52 Gene

Paralogs for ANKRD52 Gene

(12) SIMAP similar genes for ANKRD52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD52: view

Variants for ANKRD52 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD52 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
785412 Benign: not provided 56,252,288(-) G/A SYNONYMOUS_VARIANT
785413 Benign: not provided 56,254,282(-) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ANKRD52 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD52 Gene

Variant ID Type Subtype PubMed ID
esv3381217 CNV duplication 20981092
nsv482992 CNV gain+loss 15286789
nsv952186 CNV deletion 24416366

Variation tolerance for ANKRD52 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD52 Gene

Disorders for ANKRD52 Gene

Additional Disease Information for ANKRD52

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ANKRD52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD52 Gene

Publications for ANKRD52 Gene

  1. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B … Brautigan DL (Biochemistry 2008) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for ANKRD52 Gene

Sources for ANKRD52 Gene