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Aliases for ANKRD52 Gene

Aliases for ANKRD52 Gene

  • Ankyrin Repeat Domain 52 2 3 5
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit ARS-C 3 4
  • Protein Phosphatase 6 Ankyrin Repeat Subunit C 2 3
  • Ankyrin Repeat Domain-Containing Protein 52 3 4
  • PP6-ARS-C 3 4
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Ankyrin Repeat Subunit C 3
  • Ankyrin Repeat Domain 33 3
  • CVWG5837 3
  • ANKRD33 3

External Ids for ANKRD52 Gene

Previous GeneCards Identifiers for ANKRD52 Gene

  • GC12M054920
  • GC12U900660
  • GC12M056631
  • GC12M053670

Summaries for ANKRD52 Gene

GeneCards Summary for ANKRD52 Gene

ANKRD52 (Ankyrin Repeat Domain 52) is a Protein Coding gene. An important paralog of this gene is ANKRD28.

UniProtKB/Swiss-Prot for ANKRD52 Gene

  • Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Additional gene information for ANKRD52 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD52 Gene

Genomics for ANKRD52 Gene

GeneHancer (GH) Regulatory Elements for ANKRD52 Gene

Promoters and enhancers for ANKRD52 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J056255 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 660.6 +0.7 688 4 HDGF ATF1 ZNF133 ARID4B SIN3A DMAP1 GLI4 ZNF48 YY1 ZNF121 ANKRD52 NEMP1 ENSG00000257303 SMARCC2 PA2G4 PHC1P1 DNAJC14 NAB2 ZC3H10 PRIM1
GH12J057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 96 -852.9 -852863 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 CDK4 ANKRD52 DTX3
GH12J056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 64.8 +35.5 35509 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 NABP2 RNF41 NEMP1 BAZ2A PAN2 DNAJC14 ZBTB39 RN7SL809P ZC3H10 PHC1P1
GH12J056266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 55.9 -8.8 -8803 2 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC COQ10A GC12M056238 NEMP1 PAN2 BAZ2A ANKRD52 PHC1P1 DNAJC14 ZBTB39 TMEM198B
GH12J056187 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.3 +68.9 68935 3.5 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 ZNF610 ENSG00000258199 SMARCC2 GC12P056192 TRS-CGA4-1 NEMP1 BAZ2A ZC3H10 ENSG00000257740 ANKRD52 PHC1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD52 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD52 gene promoter:
  • GR
  • NF-kappaB1
  • ER-alpha
  • TBP
  • GR-alpha
  • GR-beta
  • Sox9

Genomic Locations for ANKRD52 Gene

Genomic Locations for ANKRD52 Gene
20,585 bases
Minus strand
20,585 bases
Minus strand

Genomic View for ANKRD52 Gene

Genes around ANKRD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD52 Gene

Proteins for ANKRD52 Gene

  • Protein details for ANKRD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
    Protein Accession:
    Secondary Accessions:
    • A6NE79
    • B1Q2K2

    Protein attributes for ANKRD52 Gene

    1076 amino acids
    Molecular mass:
    115077 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.

neXtProt entry for ANKRD52 Gene

Post-translational modifications for ANKRD52 Gene

  • Ubiquitination at posLast=337337
  • Modification sites at PhosphoSitePlus

Other Protein References for ANKRD52 Gene

No data available for DME Specific Peptides for ANKRD52 Gene

Domains & Families for ANKRD52 Gene

Gene Families for ANKRD52 Gene

Protein Domains for ANKRD52 Gene

Suggested Antigen Peptide Sequences for ANKRD52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD52: view

No data available for UniProtKB/Swiss-Prot for ANKRD52 Gene

Function for ANKRD52 Gene

Molecular function for ANKRD52 Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Phenotypes From GWAS Catalog for ANKRD52 Gene

Gene Ontology (GO) - Molecular Function for ANKRD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18186651
genes like me logo Genes that share ontologies with ANKRD52: view

Animal Model Products

miRNA for ANKRD52 Gene

miRTarBase miRNAs that target ANKRD52

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD52 Gene

Localization for ANKRD52 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD52 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD52 Gene

Pathways & Interactions for ANKRD52 Gene

SuperPathways for ANKRD52 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD52 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD52 Gene

Drugs & Compounds for ANKRD52 Gene

No Compound Related Data Available

Transcripts for ANKRD52 Gene

mRNA/cDNA for ANKRD52 Gene

Unigene Clusters for ANKRD52 Gene

Ankyrin repeat domain 52:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD52 Gene

No ASD Table

Relevant External Links for ANKRD52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD52 Gene

This gene is overexpressed in Lung (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD52 Gene

Protein tissue co-expression partners for ANKRD52 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD52 Gene:


SOURCE GeneReport for Unigene cluster for ANKRD52 Gene:


Evidence on tissue expression from TISSUES for ANKRD52 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ANKRD52: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD52 Gene

Orthologs for ANKRD52 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKRD52 34 33
  • 99.75 (n)
(Canis familiaris)
Mammalia ANKRD52 34 33
  • 94.73 (n)
(Bos Taurus)
Mammalia ANKRD52 34 33
  • 94.64 (n)
(Mus musculus)
Mammalia Ankrd52 16 34 33
  • 93.18 (n)
(Rattus norvegicus)
Mammalia Ankrd52 33
  • 93.06 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 18 (a)
(Gallus gallus)
Aves ANKRD52 34 33
  • 79.93 (n)
(Anolis carolinensis)
Reptilia ANKRD52 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd52 33
  • 75.17 (n)
(Danio rerio)
Actinopterygii ankrd52a 34 33
  • 67.76 (n)
ANKRD52 (2 of 2) 34
  • 61 (a)
Dr.18831 33
fruit fly
(Drosophila melanogaster)
Insecta nompC 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
Species where no ortholog for ANKRD52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD52 Gene

Gene Tree for ANKRD52 (if available)
Gene Tree for ANKRD52 (if available)
Evolutionary constrained regions (ECRs) for ANKRD52: view image

Paralogs for ANKRD52 Gene

Paralogs for ANKRD52 Gene

(12) SIMAP similar genes for ANKRD52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD52: view

Variants for ANKRD52 Gene

Sequence variations from dbSNP and Humsavar for ANKRD52 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000156605 -- 56,249,079(-) C/G intron_variant
rs1000393735 -- 56,245,525(-) A/G coding_sequence_variant, synonymous_variant
rs1000789373 -- 56,240,517(-) C/T 3_prime_UTR_variant
rs1000827861 -- 56,245,915(-) C/G intron_variant
rs1000883162 -- 56,244,632(-) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD52 Gene

Variant ID Type Subtype PubMed ID
esv3381217 CNV duplication 20981092
nsv482992 CNV gain+loss 15286789
nsv952186 CNV deletion 24416366

Variation tolerance for ANKRD52 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD52 Gene

Disorders for ANKRD52 Gene

Additional Disease Information for ANKRD52

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANKRD52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD52 Gene

Publications for ANKRD52 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B … Brautigan DL (Biochemistry 2008) 3 4 58
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ANKRD52 Gene

Sources for ANKRD52 Gene

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