This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] See more...

Aliases for ANKRD46 Gene

Aliases for ANKRD46 Gene

  • Ankyrin Repeat Domain 46 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 46 3 4
  • Ankyrin Repeat Small Protein 3 4
  • ANK-S 3 4
  • GENX-115279 3
  • ANKRD46 5

External Ids for ANKRD46 Gene

Previous GeneCards Identifiers for ANKRD46 Gene

  • GC08M101592
  • GC08M101602
  • GC08M101522
  • GC08M096732

Summaries for ANKRD46 Gene

Entrez Gene Summary for ANKRD46 Gene

  • This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for ANKRD46 Gene

ANKRD46 (Ankyrin Repeat Domain 46) is a Protein Coding gene. Diseases associated with ANKRD46 include Epidemic Typhus and Human Monocytic Ehrlichiosis.

Additional gene information for ANKRD46 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD46 Gene

Genomics for ANKRD46 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD46 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD46 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD46

Top Transcription factor binding sites by QIAGEN in the ANKRD46 gene promoter:
  • AML1a
  • AP-1
  • c-Myb
  • E4BP4
  • FOXO1
  • FOXO1a
  • NF-kappaB
  • NF-kappaB1
  • p300
  • RelA

Genomic Locations for ANKRD46 Gene

Genomic Locations for ANKRD46 Gene
chr8:100,509,752-100,559,784
(GRCh38/hg38)
Size:
50,033 bases
Orientation:
Minus strand
chr8:101,521,980-101,572,012
(GRCh37/hg19)
Size:
50,033 bases
Orientation:
Minus strand

Genomic View for ANKRD46 Gene

Genes around ANKRD46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD46 Gene

Proteins for ANKRD46 Gene

  • Protein details for ANKRD46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W74-ANR46_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 46
    Protein Accession:
    Q86W74
    Secondary Accessions:
    • Q6P9B7

    Protein attributes for ANKRD46 Gene

    Size:
    232 amino acids
    Molecular mass:
    25967 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD46 Gene

Post-translational modifications for ANKRD46 Gene

  • Ubiquitination at Lys137
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANKRD46 Gene

Domains & Families for ANKRD46 Gene

Gene Families for ANKRD46 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ANKRD46 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for ANKRD46 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat small protein (ANR46_HUMAN)
genes like me logo Genes that share domains with ANKRD46: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD46 Gene

Function for ANKRD46 Gene

Phenotypes From GWAS Catalog for ANKRD46 Gene

Gene Ontology (GO) - Molecular Function for ANKRD46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD46: view
genes like me logo Genes that share phenotypes with ANKRD46: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD46

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD46 Gene

Localization for ANKRD46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD46 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD46 gene
Compartment Confidence
plasma membrane 2
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANKRD46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANKRD46: view

Pathways & Interactions for ANKRD46 Gene

PathCards logo

SuperPathways for ANKRD46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD46 Gene

Drugs & Compounds for ANKRD46 Gene

No Compound Related Data Available

Transcripts for ANKRD46 Gene

mRNA/cDNA for ANKRD46 Gene

4 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD46

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD46 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7:

Relevant External Links for ANKRD46 Gene

GeneLoc Exon Structure for
ANKRD46

Expression for ANKRD46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD46 Gene

This gene is overexpressed in CD4 Tcells (31.2), Retina (14.8), Fetal testis (8.2), and Frontal cortex (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD46 Gene



Protein tissue co-expression partners for ANKRD46 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD46

SOURCE GeneReport for Unigene cluster for ANKRD46 Gene:

Hs.530199

Evidence on tissue expression from TISSUES for ANKRD46 Gene

  • Nervous system(4.6)
  • Skin(4.4)
  • Lymph node(4.3)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with ANKRD46: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD46 Gene

Orthologs for ANKRD46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD46 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD46 30 31
  • 99.85 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANKRD46 31
  • 93 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ANKRD46 30 31
  • 92.69 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD46 31
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ANKRD46 30 31
  • 91.08 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ankrd46 30 17 31
  • 87.72 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ankrd46 30
  • 87.28 (n)
Chicken
(Gallus gallus)
Aves ANKRD46 30 31
  • 82.89 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANKRD46 31
  • 92 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ankrd46 30
  • 78.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8886 30
Zebrafish
(Danio rerio)
Actinopterygii ankrd46b 30 31
  • 74.56 (n)
OneToMany
ankrd46a 31
  • 71 (a)
OneToMany
Dr.18723 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9304 30
Species where no ortholog for ANKRD46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD46 Gene

ENSEMBL:
Gene Tree for ANKRD46 (if available)
TreeFam:
Gene Tree for ANKRD46 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD46: view image

Paralogs for ANKRD46 Gene

(16) SIMAP similar genes for ANKRD46 Gene using alignment to 6 proteins:

  • ANR46_HUMAN
  • E5RFM7_HUMAN
  • E5RHV2_HUMAN
  • E5RI04_HUMAN
  • E5RI20_HUMAN
  • J3KP26_HUMAN
genes like me logo Genes that share paralogs with ANKRD46: view

No data available for Paralogs for ANKRD46 Gene

Variants for ANKRD46 Gene

Additional dbSNP identifiers (rs#s) for ANKRD46 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD46 Gene

Variant ID Type Subtype PubMed ID
esv2761451 CNV gain 21179565
esv3618190 CNV loss 21293372
esv3618191 CNV loss 21293372
esv3891450 CNV loss 25118596
nsv971689 CNV duplication 23825009

Variation tolerance for ANKRD46 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD46 Gene

Disorders for ANKRD46 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANKRD46 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epidemic typhus
  • sylvatic typhus
human monocytic ehrlichiosis
  • ehrlichiosis chafeensis
ehrlichiosis
  • human ehrlichiosis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ANKRD46: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD46 Gene

Publications for ANKRD46 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane. (PMID: 31056421) Ceccarelli DF … Sicheri F (Structure (London, England : 1993) 2019) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. (PMID: 28986522) Antoniali G … Tell G (Nature communications 2017) 3

Products for ANKRD46 Gene

Sources for ANKRD46 Gene