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Aliases for ANKRD46 Gene

Aliases for ANKRD46 Gene

  • Ankyrin Repeat Domain 46 2 3 5
  • Ankyrin Repeat Small Protein 3 4
  • ANK-S 3 4
  • Ankyrin Repeat Domain-Containing Protein 46 3
  • GENX-115279 3

External Ids for ANKRD46 Gene

Previous GeneCards Identifiers for ANKRD46 Gene

  • GC08M101592
  • GC08M101602
  • GC08M101522
  • GC08M096732

Summaries for ANKRD46 Gene

Entrez Gene Summary for ANKRD46 Gene

  • This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for ANKRD46 Gene

ANKRD46 (Ankyrin Repeat Domain 46) is a Protein Coding gene. An important paralog of this gene is ANKRD63.

Additional gene information for ANKRD46 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD46 Gene

Genomics for ANKRD46 Gene

GeneHancer (GH) Regulatory Elements for ANKRD46 Gene

Promoters and enhancers for ANKRD46 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J100558 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.3 285 1.8 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ANKRD46 RNF19A PABPC1 LOC105375674 GAPDHP62
GH08J100525 Enhancer 1.4 Ensembl ENCODE dbSUPER 15.2 +31.9 31860 4.5 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B IRF4 ETS1 YY1 ZNF207 ANKRD46 FBXO43 POLR2K ENSG00000253666 SPAG1 ENSG00000202310 ENSG00000253217 RNF19A RGS22 LOC105375674
GH08J100487 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +64.4 64414 16.6 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 YBX1 IRF4 RNF19A SPAG1 PABPC1 ENSG00000202310 ANKRD46 ENSG00000253217 RGS22 ENSG00000254364 YWHAZ ENSG00000253666
GH08J100905 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -348.0 -347965 4.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A BRCA1 YY1 POLR2B GLIS2 FOS YWHAZ ANKRD46 FLJ42969 ZNF706 PABPC1 ENSG00000275041 ENSG00000260368 GC08P100637
GH08J100471 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.1 +85.4 85416 6 PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 IRF4 ENSG00000253666 SPAG1 ENSG00000202310 ANKRD46 FLJ42969 RNF19A GC08M100448 LOC105375670
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANKRD46 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD46 gene promoter:
  • FOXO1a
  • FOXO1
  • RelA
  • NF-kappaB1
  • NF-kappaB
  • AML1a
  • AP-1
  • p300
  • E4BP4
  • c-Myb

Genomic Locations for ANKRD46 Gene

Genomic Locations for ANKRD46 Gene
50,035 bases
Minus strand
50,033 bases
Minus strand

Genomic View for ANKRD46 Gene

Genes around ANKRD46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD46 Gene

Proteins for ANKRD46 Gene

  • Protein details for ANKRD46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 46
    Protein Accession:
    Secondary Accessions:
    • Q6P9B7

    Protein attributes for ANKRD46 Gene

    232 amino acids
    Molecular mass:
    25967 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD46 Gene


neXtProt entry for ANKRD46 Gene

Post-translational modifications for ANKRD46 Gene

  • Ubiquitination at posLast=137137
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANKRD46 Gene

Domains & Families for ANKRD46 Gene

Gene Families for ANKRD46 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ANKRD46 Gene

Suggested Antigen Peptide Sequences for ANKRD46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD46: view

No data available for UniProtKB/Swiss-Prot for ANKRD46 Gene

Function for ANKRD46 Gene

Phenotypes From GWAS Catalog for ANKRD46 Gene

genes like me logo Genes that share phenotypes with ANKRD46: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD46

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD46 Gene

Localization for ANKRD46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD46 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD46 gene
Compartment Confidence
plasma membrane 2
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANKRD46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANKRD46: view

Pathways & Interactions for ANKRD46 Gene

SuperPathways for ANKRD46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD46 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD46 Gene

Drugs & Compounds for ANKRD46 Gene

No Compound Related Data Available

Transcripts for ANKRD46 Gene

Unigene Clusters for ANKRD46 Gene

Ankyrin repeat domain 46:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD46

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD46 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -

Relevant External Links for ANKRD46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD46 Gene

Protein differential expression in normal tissues from HIPED for ANKRD46 Gene

This gene is overexpressed in CD4 Tcells (31.2), Retina (14.8), Fetal testis (8.2), and Frontal cortex (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD46 Gene

Protein tissue co-expression partners for ANKRD46 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRD46 Gene:


SOURCE GeneReport for Unigene cluster for ANKRD46 Gene:


Evidence on tissue expression from TISSUES for ANKRD46 Gene

  • Nervous system(4.5)
  • Lymph node(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ANKRD46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD46 Gene

Orthologs for ANKRD46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD46 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKRD46 34 33
  • 99.85 (n)
(Monodelphis domestica)
Mammalia ANKRD46 34
  • 93 (a)
(Canis familiaris)
Mammalia ANKRD46 34 33
  • 92.69 (n)
(Ornithorhynchus anatinus)
Mammalia ANKRD46 34
  • 92 (a)
(Bos Taurus)
Mammalia ANKRD46 34 33
  • 91.08 (n)
(Mus musculus)
Mammalia Ankrd46 16 34 33
  • 87.72 (n)
(Rattus norvegicus)
Mammalia Ankrd46 33
  • 87.28 (n)
(Gallus gallus)
Aves ANKRD46 34 33
  • 82.89 (n)
(Anolis carolinensis)
Reptilia ANKRD46 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd46 33
  • 78.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8886 33
(Danio rerio)
Actinopterygii ankrd46b 34 33
  • 74.56 (n)
ankrd46a 34
  • 71 (a)
Dr.18723 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9304 33
Species where no ortholog for ANKRD46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD46 Gene

Gene Tree for ANKRD46 (if available)
Gene Tree for ANKRD46 (if available)
Evolutionary constrained regions (ECRs) for ANKRD46: view image

Paralogs for ANKRD46 Gene

Paralogs for ANKRD46 Gene

(16) SIMAP similar genes for ANKRD46 Gene using alignment to 6 proteins:

  • E5RI04_HUMAN
  • E5RI20_HUMAN
  • J3KP26_HUMAN
genes like me logo Genes that share paralogs with ANKRD46: view

Variants for ANKRD46 Gene

Sequence variations from dbSNP and Humsavar for ANKRD46 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000060293 -- 100,550,583(-) C/T intron_variant
rs1000075664 -- 100,514,538(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000106208 -- 100,531,172(-) G/A intron_variant
rs1000157863 -- 100,536,217(-) C/G/T intron_variant
rs1000242277 -- 100,530,026(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD46 Gene

Variant ID Type Subtype PubMed ID
nsv971689 CNV duplication 23825009
esv3891450 CNV loss 25118596
esv3618191 CNV loss 21293372
esv3618190 CNV loss 21293372
esv2761451 CNV gain 21179565

Variation tolerance for ANKRD46 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD46 Gene

Disorders for ANKRD46 Gene

Additional Disease Information for ANKRD46

No disorders were found for ANKRD46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD46 Gene

Publications for ANKRD46 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58
  5. Identification of genes with a correlation between copy number and expression in gastric cancer. (PMID: 22559327) Cheng L … Zhang Q (BMC medical genomics 2012) 3 58

Products for ANKRD46 Gene

Sources for ANKRD46 Gene

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