Aliases for ANKRD37 Gene

Aliases for ANKRD37 Gene

  • Ankyrin Repeat Domain 37 2 3 5
  • Low-Density Lipoprotein Receptor-Related Protein 2-Binding Protein 3 4
  • Ankyrin Repeat Domain-Containing Protein 37 3 4
  • Low Density Lipoprotein Receptor-Related Protein Binding Protein 3
  • HLrp2bp 4
  • Lrp2bp 3
  • LPR2BP 4

External Ids for ANKRD37 Gene

Previous GeneCards Identifiers for ANKRD37 Gene

  • GC04P186693
  • GC04P186554
  • GC04P186317
  • GC04P182071

Summaries for ANKRD37 Gene

GeneCards Summary for ANKRD37 Gene

ANKRD37 (Ankyrin Repeat Domain 37) is a Protein Coding gene. Diseases associated with ANKRD37 include Donnai-Barrow Syndrome. An important paralog of this gene is ANKRD42.

Additional gene information for ANKRD37 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD37 Gene

Genomics for ANKRD37 Gene

GeneHancer (GH) Regulatory Elements for ANKRD37 Gene

Promoters and enhancers for ANKRD37 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J185394 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.3 321 4.1 EP300 FOXK2 ZBTB40 SIN3A NRF1 POLR2G USF1 SP1 NCOR1 GTF2E2 LRP2BP ANKRD37 NONHSAG039516.2 lnc-LRP2BP-1 C4orf47 UFSP2 PRIMPOL CFAP97
GH04J185357 Enhancer 1 Ensembl ENCODE 11.3 -37.3 -37288 3.5 JUND TEAD4 FOS MYC CTBP1 EP300 TAF9B MXI1 NCOR1 RELA LRP2BP ANKRD37 UFSP2 ENSG00000250410 lnc-LRP2BP-3 SNX25
GH04J185343 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.3 -51.0 -51020 2.8 JUND MEF2C POLR2A MXI1 TCF12 GATA3 SRF MEF2B RBM22 BATF LRP2BP UFSP2 ANKRD37 lnc-LRP2BP-3 ENSG00000250410 SNX25
GH04J185383 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.4 -11.3 -11325 3 ZNF217 CTBP1 NCOR1 SIN3A NFIC ARNT POLR2A TRIM24 CEBPG PBX2 UFSP2 LRP2BP ENSG00000250410 ANKRD37
GH04J185398 Enhancer 0.6 ENCODE 0.7 +3.3 3344 1.1 ZBTB40 SIN3A ZNF384 ARNT BATF ELF1 JUNB NFATC1 MXI1 NFIC LRP2BP UFSP2 ANKRD37 NONHSAG039516.2 C4orf47 lnc-LRP2BP-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD37 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD37

Top Transcription factor binding sites by QIAGEN in the ANKRD37 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • YY1

Genomic Locations for ANKRD37 Gene

Genomic Locations for ANKRD37 Gene
chr4:185,396,021-185,400,628
(GRCh38/hg38)
Size:
4,608 bases
Orientation:
Plus strand
chr4:186,317,175-186,321,782
(GRCh37/hg19)
Size:
4,608 bases
Orientation:
Plus strand

Genomic View for ANKRD37 Gene

Genes around ANKRD37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD37 Gene

Proteins for ANKRD37 Gene

  • Protein details for ANKRD37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z713-ANR37_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 37
    Protein Accession:
    Q7Z713

    Protein attributes for ANKRD37 Gene

    Size:
    158 amino acids
    Molecular mass:
    16872 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD37 Gene

Post-translational modifications for ANKRD37 Gene

  • Ubiquitination at Lys120 and Lys126
  • Modification sites at PhosphoSitePlus

Other Protein References for ANKRD37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD37 Gene

Domains & Families for ANKRD37 Gene

Gene Families for ANKRD37 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD37 Gene

Blocks:
  • Ankyrin repeat signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANKRD37 Gene

GenScript: Design optimal peptide antigens:
  • Low-density lipoprotein receptor-related protein 2-binding protein (ANR37_HUMAN)
genes like me logo Genes that share domains with ANKRD37: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD37 Gene

Function for ANKRD37 Gene

genes like me logo Genes that share phenotypes with ANKRD37: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD37 Gene

Localization for ANKRD37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD37 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD37 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 4
extracellular 2
plasma membrane 1
cytoskeleton 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANKRD37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ANKRD37: view

Pathways & Interactions for ANKRD37 Gene

PathCards logo

SuperPathways for ANKRD37 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD37 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD37 Gene

Drugs & Compounds for ANKRD37 Gene

No Compound Related Data Available

Transcripts for ANKRD37 Gene

mRNA/cDNA for ANKRD37 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD37 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6
SP1: -
SP2:
SP3: - - - -
SP4: -
SP5: -

Relevant External Links for ANKRD37 Gene

GeneLoc Exon Structure for
ANKRD37

Expression for ANKRD37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD37 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD37

SOURCE GeneReport for Unigene cluster for ANKRD37 Gene:

Hs.508154

mRNA Expression by UniProt/SwissProt for ANKRD37 Gene:

Q7Z713-ANR37_HUMAN
Tissue specificity: Mainly expressed in testis, small intestine, colon, blood leukocytes and in pancreatic adenocarcinoma cells.

Evidence on tissue expression from TISSUES for ANKRD37 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ANKRD37: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD37 Gene

Orthologs for ANKRD37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD37 31 30
  • 98.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD37 31 30
  • 90.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD37 31 30
  • 87.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd37 30
  • 80.8 (n)
mouse
(Mus musculus)
Mammalia Ankrd37 17 31 30
  • 78.9 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD37 31
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD37 31
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd37 30
  • 64.48 (n)
Str.10884 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8033 30
zebrafish
(Danio rerio)
Actinopterygii ankrd37 31 30
  • 58.13 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
OneToMany
Species where no ortholog for ANKRD37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD37 Gene

ENSEMBL:
Gene Tree for ANKRD37 (if available)
TreeFam:
Gene Tree for ANKRD37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD37: view image

Paralogs for ANKRD37 Gene

Paralogs for ANKRD37 Gene

(1) SIMAP similar genes for ANKRD37 Gene using alignment to 3 proteins:

  • ANR37_HUMAN
  • D6RCL4_HUMAN
  • D6RFF5_HUMAN
genes like me logo Genes that share paralogs with ANKRD37: view

Variants for ANKRD37 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD37 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs4317244 - p.Thr152Ser

Additional dbSNP identifiers (rs#s) for ANKRD37 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD37 Gene

Variant ID Type Subtype PubMed ID
esv2759309 CNV loss 17122850
esv3603492 CNV gain 21293372
esv3603493 CNV gain 21293372
nsv1033523 CNV gain 25217958
nsv428456 CNV gain+loss 18775914

Variation tolerance for ANKRD37 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD37 Gene

Disorders for ANKRD37 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANKRD37 Gene - From: DISEASES

Disorder Aliases PubMed IDs
donnai-barrow syndrome
  • faciooculoacousticorenal syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANKRD37

genes like me logo Genes that share disorders with ANKRD37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD37 Gene

Publications for ANKRD37 Gene

  1. Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains. (PMID: 15809689) Li J … Mao Y (Cellular & molecular biology letters 2005) 3 4 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. (PMID: 19491311) Benita Y … Xavier RJ (Nucleic acids research 2009) 3 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for ANKRD37 Gene

Sources for ANKRD37 Gene