Aliases for ANKRD36C Gene

Aliases for ANKRD36C Gene

  • Ankyrin Repeat Domain 36C 2 3 5
  • Protein Immuno-Reactive With Anti-PTH Polyclonal Antibodies 2 3 4
  • Ankyrin Repeat Domain-Containing Protein 36C 3 4
  • DKFZp667P0924 2
  • ANKRD36C 5

External Ids for ANKRD36C Gene

Previous GeneCards Identifiers for ANKRD36C Gene

  • GC02M096515
  • GC02M095828

Summaries for ANKRD36C Gene

GeneCards Summary for ANKRD36C Gene

ANKRD36C (Ankyrin Repeat Domain 36C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ion channel inhibitor activity. An important paralog of this gene is ANKRD36.

Additional gene information for ANKRD36C Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD36C Gene

Genomics for ANKRD36C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD36C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J095990 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.1 70 3.5 GATAD2A CTCF ZNF629 IKZF1 ZNF692 LARP7 ZNF143 ZIC2 RBFOX2 PKNOX1 ANKRD36C lnc-GPAT2-3 piR-54421 ADRA2B GPAT2 TRIM43
GH02J095855 Promoter 0.3 EPDnew 600.1 +136.4 136416 0.1 piR-39352-001 ANKRD36C piR-49713-007 TRIM43
GH02J096009 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 0.4 -18.7 -18696 2.1 CREB1 CTCF ATF7 ZNF629 ZNF692 BACH1 PKNOX1 MTA1 PATZ1 ZNF501 FAHD2CP lnc-CIAO1-4 GPAT2 ADRA2B DUSP2 ASTL ENSG00000230747 ITPRIPL1 lnc-ANKRD36C-3 ANKRD36C
GH02J095995 Enhancer 0.3 Ensembl 0.7 -4.7 -4670 1.4 MNT ADRA2B ANKRD36C lnc-GPAT2-3 RF00017-3267 RN7SL210P GPAT2
GH02J096023 Enhancer 0.6 Ensembl 0.3 -31.6 -31569 1.6 CTCF ZNF143 REST RAD21 TRIM22 SMARCA5 ZNF444 ZNF217 ELF1 SMC3 GPAT2 SNRNP200 piR-57014-002 lnc-ANKRD36C-4-001 FAHD2CP lnc-CIAO1-4 ANKRD36C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD36C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD36C

Genomic Locations for ANKRD36C Gene

Genomic Locations for ANKRD36C Gene
chr2:95,836,919-95,991,831
(GRCh38/hg38)
Size:
154,913 bases
Orientation:
Minus strand
chr2:96,514,587-96,657,980
(GRCh37/hg19)
Size:
143,394 bases
Orientation:
Minus strand

Genomic View for ANKRD36C Gene

Genes around ANKRD36C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD36C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD36C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD36C Gene

Proteins for ANKRD36C Gene

  • Protein details for ANKRD36C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JPF3-AN36C_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 36C
    Protein Accession:
    Q5JPF3
    Secondary Accessions:
    • C9JZ08
    • Q15694
    • Q53S06
    • Q658V2

    Protein attributes for ANKRD36C Gene

    Size:
    1778 amino acids
    Molecular mass:
    199748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB02177.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAB02177.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAY24080.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH56324.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD36C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD36C Gene

Post-translational modifications for ANKRD36C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD36C Gene

No data available for DME Specific Peptides for ANKRD36C Gene

Domains & Families for ANKRD36C Gene

Gene Families for ANKRD36C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD36C Gene

Graphical View of Domain Structure for InterPro Entry

Q5JPF3

UniProtKB/Swiss-Prot:

AN36C_HUMAN :
  • Belongs to the ANKRD36 family.
Family:
  • Belongs to the ANKRD36 family.
genes like me logo Genes that share domains with ANKRD36C: view

No data available for Suggested Antigen Peptide Sequences for ANKRD36C Gene

Function for ANKRD36C Gene

Phenotypes From GWAS Catalog for ANKRD36C Gene

Gene Ontology (GO) - Molecular Function for ANKRD36C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008200 ion channel inhibitor activity NAS 8608414
genes like me logo Genes that share ontologies with ANKRD36C: view

Phenotypes for ANKRD36C Gene

genes like me logo Genes that share phenotypes with ANKRD36C: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD36C Gene

Localization for ANKRD36C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD36C gene
Compartment Confidence
nucleus 3
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD36C Gene

Pathways & Interactions for ANKRD36C Gene

PathCards logo

SuperPathways for ANKRD36C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD36C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD36C Gene

Drugs & Compounds for ANKRD36C Gene

No Compound Related Data Available

Transcripts for ANKRD36C Gene

mRNA/cDNA for ANKRD36C Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD36C Gene

No ASD Table

Relevant External Links for ANKRD36C Gene

GeneLoc Exon Structure for
ANKRD36C

Expression for ANKRD36C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD36C Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD36C Gene

This gene is overexpressed in Minor Salivary Gland (x5.7).

Protein differential expression in normal tissues from HIPED for ANKRD36C Gene

This gene is overexpressed in Blymphocyte (19.6), CD8 Tcells (17.6), Monocytes (15.5), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD36C Gene



Protein tissue co-expression partners for ANKRD36C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD36C

SOURCE GeneReport for Unigene cluster for ANKRD36C Gene:

Hs.646318

Evidence on tissue expression from TISSUES for ANKRD36C Gene

  • Stomach(4.5)
  • Lymph node(4)
  • Nervous system(2.8)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with ANKRD36C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD36C Gene

Orthologs for ANKRD36C Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD36C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD36 30
  • 97.15 (n)
ANKRD36C 31
  • 20 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 42 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 11 (a)
ManyToMany
-- 31
  • 7 (a)
ManyToMany
-- 31
  • 7 (a)
ManyToMany
-- 31
  • 6 (a)
ManyToMany
-- 31
  • 4 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Gm15319 31
  • 19 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 5 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 5 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 8 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 34 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii ANKRD7 31
  • 5 (a)
OneToMany
Species where no ortholog for ANKRD36C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD36C Gene

ENSEMBL:
Gene Tree for ANKRD36C (if available)
TreeFam:
Gene Tree for ANKRD36C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD36C: view image

Paralogs for ANKRD36C Gene

Paralogs for ANKRD36C Gene

(25) SIMAP similar genes for ANKRD36C Gene using alignment to 7 proteins:

  • AN36C_HUMAN
  • E9PJI0_HUMAN
  • F8WEX4_HUMAN
  • H0YDI7_HUMAN
  • H7BXK8_HUMAN
  • H7C425_HUMAN
  • I1Z9D4_HUMAN
genes like me logo Genes that share paralogs with ANKRD36C: view

Variants for ANKRD36C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD36C Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
691504 Uncertain Significance: Peritoneal Gliomatosis 95,855,406(-) C/G MISSENSE_VARIANT
rs780640771 Not Provided: CIC-DUX Sarcoma 95,938,828(-) C/T SPLICE_DONOR_VARIANT

Additional dbSNP identifiers (rs#s) for ANKRD36C Gene

Variation tolerance for ANKRD36C Gene

Gene Damage Index Score: 9.73; 89.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD36C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD36C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD36C Gene

Disorders for ANKRD36C Gene

No disorders were found for ANKRD36C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD36C Gene

Publications for ANKRD36C Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Inhibitors of renal epithelial phosphate transport in tumor-induced osteomalacia and uremia. (PMID: 8608414) Kumar R … Cai Q (Proceedings of the Association of American Physicians 1995) 3 4
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4

Products for ANKRD36C Gene

Sources for ANKRD36C Gene