Free for academic non-profit institutions. Other users need a Commercial license
Aliases for ANKRD36C Gene
Aliases for ANKRD36C Gene
External Ids for ANKRD36C Gene
- HGNC: 32946
- Entrez Gene: 400986
- Ensembl: ENSG00000174501
- UniProtKB: Q5JPF3
Previous GeneCards Identifiers for ANKRD36C Gene
- GC02M096515
- GC02M095828
Summaries for ANKRD36C Gene
GeneCards Summary for ANKRD36C Gene
ANKRD36C (Ankyrin Repeat Domain 36C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ion channel inhibitor activity. An important paralog of this gene is ANKRD36.
Additional gene information for ANKRD36C Gene
- HGNC(32946)
- Entrez Gene(400986)
- Ensembl(ENSG00000174501)
- UniProtKB(Q5JPF3)
- Open Targets Platform(ENSG00000174501)
- Search for ANKRD36C at DataMed
- Search for ANKRD36C at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD36C Gene
Genomics for ANKRD36C Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ANKRD36C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ANKRD36C on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD36C
Genomic Locations for ANKRD36C Gene
Genomic Locations for ANKRD36C Gene
- chr2:95,836,919-95,991,831
- (GRCh38/hg38)
- Size:
- 154,913 bases
- Orientation:
- Minus strand
- chr2:96,514,587-96,657,980
- (GRCh37/hg19)
- Size:
- 143,394 bases
- Orientation:
- Minus strand
Genomic View for ANKRD36C Gene
Genes around ANKRD36C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.1 by HGNC
- 2q11.1 by Entrez Gene
- 2q11.1 by Ensembl
ANKRD36C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD36C Gene
Proteins for ANKRD36C Gene
-
Protein details for ANKRD36C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5JPF3-AN36C_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 36C
- Protein Accession:
- Q5JPF3
- C9JZ08
- Q15694
- Q53S06
- Q658V2
Protein attributes for ANKRD36C Gene
- Size:
- 1778 amino acids
- Molecular mass:
- 199748 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAB02177.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAB02177.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAY24080.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH56324.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for ANKRD36C Gene
Post-translational modifications for ANKRD36C Gene
Other Protein References for ANKRD36C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ANKRD36C
- Invitrogen Antibodies for ANKRD36C (AFLGC-ANKRD36C)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ANKRD36C
- Origene Custom Protein Services for ANKRD36C
- Novus Biologicals proteins for ANKRD36C
No data available for DME Specific Peptides for ANKRD36C Gene
Domains & Families for ANKRD36C Gene
Gene Families for ANKRD36C Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ANKRD36C Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
Q5JPF3- Family:
-
- Belongs to the ANKRD36 family.
No data available for Suggested Antigen Peptide Sequences for ANKRD36C Gene
Function for ANKRD36C Gene
Phenotypes From GWAS Catalog for ANKRD36C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
| GO:0008200 | ion channel inhibitor activity | NAS | 8608414 |
Phenotypes for ANKRD36C Gene
- GenomeRNAi human phenotypes for ANKRD36C:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ANKRD36C - Select products 50% OFF >
- * ANKRD36C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ANKRD36C
miRNA Products
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for ANKRD36C
- Browse OriGene Inhibitory RNA Products For ANKRD36C
Clone Products
- Applied Biological Materials (abm): Clones for ANKRD36C - Select products 50% OFF >
- * ANKRD36C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD36C Gene
Localization for ANKRD36C Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| extracellular | 1 |
| cytosol | 1 |
- Cytosol (2)
- Nucleoplasm (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD36C Gene
Pathways & Interactions for ANKRD36C Gene
Interacting Proteins for ANKRD36C Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| CDK3 | ||
| ENSG00000272822 | ||
| AAK1 | ||
| ABAT | ||
| ACTN1 |
GPS-Prot Interaction Network for ANKRD36C
No data available for Pathways by source and SIGNOR curated interactions for ANKRD36C Gene
Transcripts for ANKRD36C Gene
mRNA/cDNA for ANKRD36C Gene
- 2 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000456556 5428 nts (view in UCSC)
- ENST00000488721 2740 nts (view in UCSC)
- ENST00000531153 2811 nts (view in UCSC)
- ENST00000534304 2301 nts (view in UCSC)
- ENST00000528268 1907 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ANKRD36C - Select products 50% OFF >
- * ANKRD36C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ANKRD36C
miRNA Products
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for ANKRD36C
- Browse OriGene Inhibitory RNA Products For ANKRD36C
Clone Products
- Applied Biological Materials (abm): Clones for ANKRD36C - Select products 50% OFF >
- * ANKRD36C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for ANKRD36C Gene
- GeneLoc Exon Structure for
- ANKRD36C
Expression for ANKRD36C Gene
mRNA differential expression in normal tissues according to GTEx for ANKRD36C Gene
This gene is overexpressed in Minor Salivary Gland (x5.7).
This gene is overexpressed in Blymphocyte (19.6), CD8 Tcells (17.6), Monocytes (15.5), and Ovary (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD36C Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD36C
SOURCE GeneReport for Unigene cluster for ANKRD36C Gene:
Hs.646318Evidence on tissue expression from TISSUES for ANKRD36C Gene
- Stomach(4.5)
- Lymph node(4)
- Nervous system(2.8)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs for ANKRD36C
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD36C Gene
Orthologs for ANKRD36C Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ANKRD36 30 |
|
||
| ANKRD36C 31 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Mouse (Mus musculus) |
Mammalia | Gm15319 31 |
|
ManyToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | ANKRD7 31 |
|
OneToMany |
- Species where no ortholog for ANKRD36C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ANKRD36C Gene
- ENSEMBL:
- Gene Tree for ANKRD36C (if available)
- TreeFam:
- Gene Tree for ANKRD36C (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ANKRD36C: view image
Paralogs for ANKRD36C Gene
(25) SIMAP similar genes for ANKRD36C Gene using alignment to 7 proteins:
- AN36C_HUMAN
- E9PJI0_HUMAN
- F8WEX4_HUMAN
- H0YDI7_HUMAN
- H7BXK8_HUMAN
- H7C425_HUMAN
- I1Z9D4_HUMAN
Pseudogenes.org Pseudogenes for ANKRD36C Gene
Variants for ANKRD36C Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD36C Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 691504 | Uncertain Significance: Peritoneal Gliomatosis | 95,855,406(-) | C/G | MISSENSE_VARIANT | |
| rs780640771 | Not Provided: CIC-DUX Sarcoma | 95,938,828(-) | C/T | SPLICE_DONOR_VARIANT |
Gene Damage Index Score:
9.73;
89.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ANKRD36C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD36C
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANKRD36C Gene
Disorders for ANKRD36C Gene
Additional Disease Information for ANKRD36C
No disorders were found for ANKRD36C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD36C Gene
Publications for ANKRD36C Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Inhibitors of renal epithelial phosphate transport in tumor-induced osteomalacia and uremia. (PMID: 8608414) Kumar R … Cai Q (Proceedings of the Association of American Physicians 1995) 3 4
- VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4
- The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4
ExternalLinks
Products for ANKRD36C Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ANKRD36C
- Origene Custom Protein Services for ANKRD36C
- Origene shrna and RNAi products in human, mouse, rat for ANKRD36C
- Browse OriGene Inhibitory RNA Products For ANKRD36C
- OriGene qPCR primer pairs for ANKRD36C
- OriGene CRISPR knockouts for ANKRD36C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ANKRD36C
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ANKRD36C
- Novus Biologicals proteins for ANKRD36C
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for ANKRD36C (AFLGC-ANKRD36C)
- VectorBuilder Custom and pre-made DNA vectors for ANKRD36C (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ANKRD36C (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ANKRD36C (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ANKRD36C CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ANKRD36C
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for ANKRD36C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for ANKRD36C
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ANKRD36C
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for ANKRD36C
Sources for ANKRD36C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB