Aliases for ANKRD36 Gene

Aliases for ANKRD36 Gene

  • Ankyrin Repeat Domain 36 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 36A 3 4
  • UNQ2430 2 3
  • Ankyrin Repeat Domain-Containing Protein 36 3
  • Ankyrin-Related 3
  • ANKRD36A 4
  • KIAA1641 4
  • ANKRD36 5

External Ids for ANKRD36 Gene

Previous GeneCards Identifiers for ANKRD36 Gene

  • GC02P097202
  • GC02P097782
  • GC02P091738

Summaries for ANKRD36 Gene

GeneCards Summary for ANKRD36 Gene

ANKRD36 (Ankyrin Repeat Domain 36) is a Protein Coding gene. Diseases associated with ANKRD36 include Giant Axonal Neuropathy. An important paralog of this gene is ANKRD36C.

Additional gene information for ANKRD36 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD36 Gene

Genomics for ANKRD36 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD36 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD36 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD36

Top Transcription factor binding sites by QIAGEN in the ANKRD36 gene promoter:
  • CUTL1
  • MRF-2
  • Pbx1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RSRFC4

Genomic Locations for ANKRD36 Gene

Genomic Locations for ANKRD36 Gene
chr2:97,113,153-97,264,521
(GRCh38/hg38)
Size:
151,369 bases
Orientation:
Plus strand
chr2:97,779,233-97,930,258
(GRCh37/hg19)
Size:
151,026 bases
Orientation:
Plus strand

Genomic View for ANKRD36 Gene

Genes around ANKRD36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD36 Gene

Proteins for ANKRD36 Gene

  • Protein details for ANKRD36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6QL64-AN36A_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 36A
    Protein Accession:
    A6QL64
    Secondary Accessions:
    • A0A494C0M0
    • B4E3I8
    • Q6UX02
    • Q86X62
    • Q9HCD1

    Protein attributes for ANKRD36 Gene

    Size:
    1915 amino acids
    Molecular mass:
    214500 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88934.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB13467.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD36 Gene

neXtProt entry for ANKRD36 Gene

Post-translational modifications for ANKRD36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD36 Gene

Domains & Families for ANKRD36 Gene

Gene Families for ANKRD36 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD36 Gene

Suggested Antigen Peptide Sequences for ANKRD36 Gene

GenScript: Design optimal peptide antigens:
  • ANKRD36 protein (A1A5B0_HUMAN)
  • ANKRD36 protein (A2VCN4_HUMAN)
  • Ankyrin repeat domain-containing protein 36A (AN36A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6QL64

UniProtKB/Swiss-Prot:

AN36A_HUMAN :
  • Belongs to the ANKRD36 family.
Family:
  • Belongs to the ANKRD36 family.
genes like me logo Genes that share domains with ANKRD36: view

Function for ANKRD36 Gene

Phenotypes From GWAS Catalog for ANKRD36 Gene

Gene Ontology (GO) - Molecular Function for ANKRD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD36: view

Phenotypes for ANKRD36 Gene

genes like me logo Genes that share phenotypes with ANKRD36: view

Animal Model Products

CRISPR Products

miRNA for ANKRD36 Gene

miRTarBase miRNAs that target ANKRD36

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD36

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD36 Gene

Localization for ANKRD36 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD36 gene
Compartment Confidence
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD36 Gene

Pathways & Interactions for ANKRD36 Gene

PathCards logo

SuperPathways for ANKRD36 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD36 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD36 Gene

Drugs & Compounds for ANKRD36 Gene

No Compound Related Data Available

Transcripts for ANKRD36 Gene

mRNA/cDNA for ANKRD36 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD36

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD36 Gene

No ASD Table

Relevant External Links for ANKRD36 Gene

GeneLoc Exon Structure for
ANKRD36

Expression for ANKRD36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD36 Gene

Protein differential expression in normal tissues from HIPED for ANKRD36 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD36 Gene



Protein tissue co-expression partners for ANKRD36 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD36

SOURCE GeneReport for Unigene cluster for ANKRD36 Gene:

Hs.541894

Evidence on tissue expression from TISSUES for ANKRD36 Gene

  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with ANKRD36: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD36 Gene

Orthologs for ANKRD36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD36 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD36 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 42 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
-- 31
  • 18 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 41 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gm1758 31
  • 33 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 21 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 16 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 22 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 35 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii ANKRD7 31
  • 13 (a)
OneToMany
Species where no ortholog for ANKRD36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD36 Gene

ENSEMBL:
Gene Tree for ANKRD36 (if available)
TreeFam:
Gene Tree for ANKRD36 (if available)

Paralogs for ANKRD36 Gene

Paralogs for ANKRD36 Gene

(28) SIMAP similar genes for ANKRD36 Gene using alignment to 4 proteins:

  • AN36A_HUMAN
  • A1A5B0_HUMAN
  • A2VCN4_HUMAN
  • B5MDC9_HUMAN

Pseudogenes.org Pseudogenes for ANKRD36 Gene

genes like me logo Genes that share paralogs with ANKRD36: view

Variants for ANKRD36 Gene

Additional dbSNP identifiers (rs#s) for ANKRD36 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD36 Gene

Variant ID Type Subtype PubMed ID
dgv1142e212 CNV loss 25503493
dgv1143e212 CNV loss 25503493
dgv1144e212 CNV loss 25503493
dgv1145e212 CNV gain 25503493
dgv1146e212 CNV loss 25503493
dgv1974n106 CNV deletion 24896259
dgv2199e59 CNV duplication 20981092
dgv4010n100 CNV gain 25217958
dgv4011n100 CNV loss 25217958
dgv4012n100 CNV loss 25217958
dgv4013n100 CNV gain+loss 25217958
dgv4014n100 CNV gain 25217958
dgv4015n100 CNV gain+loss 25217958
dgv4016n100 CNV loss 25217958
dgv4017n100 CNV gain 25217958
dgv4018n100 CNV gain 25217958
dgv4019n100 CNV gain 25217958
dgv4020n100 CNV gain 25217958
dgv4021n100 CNV gain 25217958
dgv4022n100 CNV gain 25217958
dgv4023n100 CNV loss 25217958
dgv4024n100 CNV gain 25217958
dgv4025n100 CNV gain 25217958
dgv607e201 CNV deletion 23290073
dgv6971n54 CNV gain 21841781
dgv6972n54 CNV loss 21841781
dgv720e199 CNV deletion 23128226
esv25103 CNV gain 19812545
esv2598149 CNV deletion 19546169
esv2660796 CNV deletion 23128226
esv2661280 CNV deletion 23128226
esv2671652 CNV deletion 23128226
esv2675758 CNV deletion 23128226
esv27016 CNV gain+loss 19812545
esv2720415 CNV deletion 23290073
esv2720416 CNV deletion 23290073
esv2720418 CNV deletion 23290073
esv2720419 CNV deletion 23290073
esv2720420 CNV deletion 23290073
esv2720421 CNV deletion 23290073
esv2759077 CNV gain+loss 17122850
esv2760609 CNV gain+loss 21179565
esv2763630 CNV gain+loss 21179565
esv3119345 CNV duplication 24192839
esv32762 CNV loss 17666407
esv3357691 CNV duplication 20981092
esv3382408 CNV duplication 20981092
esv3394465 CNV duplication 20981092
esv3413527 CNV duplication 20981092
esv3418578 CNV duplication 20981092
esv3425717 CNV duplication 20981092
esv3559821 CNV deletion 23714750
esv3559822 CNV deletion 23714750
esv3575281 CNV gain 25503493
esv3583944 CNV loss 25503493
esv3583955 CNV loss 25503493
esv3583964 CNV loss 25503493
esv3591697 CNV loss 21293372
esv3591698 CNV gain 21293372
esv3591699 CNV loss 21293372
esv3591701 CNV loss 21293372
esv3591702 CNV loss 21293372
esv3591704 CNV loss 21293372
esv3591706 CNV loss 21293372
esv3591707 CNV loss 21293372
esv3892959 CNV loss 25118596
esv3892971 CNV loss 25118596
esv5003 OTHER complex 18987735
esv5642 CNV loss 19470904
esv5691 CNV loss 19470904
esv992727 CNV gain 20482838
nsv1000203 CNV gain+loss 25217958
nsv1007387 CNV gain+loss 25217958
nsv1008637 CNV loss 25217958
nsv10096 CNV gain+loss 18304495
nsv10097 CNV gain+loss 18304495
nsv1010807 CNV gain 25217958
nsv1011763 CNV gain 25217958
nsv1071246 CNV deletion 25765185
nsv1072009 CNV deletion 25765185
nsv1076490 CNV duplication 25765185
nsv1077364 CNV duplication 25765185
nsv1077365 CNV duplication 25765185
nsv1077887 CNV duplication 25765185
nsv1078465 CNV duplication 25765185
nsv1110349 CNV duplication 24896259
nsv1112767 CNV deletion 24896259
nsv1118640 CNV duplication 24896259
nsv1118869 CNV deletion 24896259
nsv1123359 CNV deletion 24896259
nsv1125311 OTHER inversion 24896259
nsv1128803 CNV duplication 24896259
nsv1131493 CNV deletion 24896259
nsv1132498 CNV duplication 24896259
nsv1135873 CNV deletion 24896259
nsv1136388 CNV deletion 24896259
nsv1138820 CNV deletion 24896259
nsv1139723 CNV duplication 24896259
nsv1141354 CNV duplication 24896259
nsv1146869 CNV duplication 26484159
nsv1148786 OTHER inversion 26484159
nsv1150248 CNV duplication 26484159
nsv1151122 CNV duplication 26484159
nsv1160826 CNV duplication 26073780
nsv1160827 CNV duplication 26073780
nsv1160828 CNV duplication 26073780
nsv213262 CNV deletion 16902084
nsv436306 CNV deletion 17901297
nsv441770 CNV gain+loss 18776908
nsv470477 CNV loss 18288195
nsv511164 CNV loss 21212237
nsv511798 CNV loss 21212237
nsv517613 CNV gain+loss 19592680
nsv522486 CNV gain 19592680
nsv582500 CNV loss 21841781
nsv582502 CNV gain 21841781
nsv7323 OTHER inversion 18451855
nsv818074 CNV loss 17921354
nsv820355 CNV duplication 20802225
nsv821502 CNV duplication 20802225
nsv834308 CNV gain 17160897
nsv953482 CNV duplication 24416366
nsv953483 CNV duplication 24416366
nsv953484 CNV deletion 24416366
nsv954758 CNV deletion 24416366
nsv954787 CNV deletion 24416366
nsv979067 CNV duplication 23825009
nsv997395 CNV loss 25217958
nsv998307 CNV loss 25217958

Variation tolerance for ANKRD36 Gene

Gene Damage Index Score: 13.00; 94.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD36 Gene

Disorders for ANKRD36 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANKRD36 Gene - From: GeneCards

Disorder Aliases PubMed IDs
giant axonal neuropathy
  • gan1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANKRD36

genes like me logo Genes that share disorders with ANKRD36: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD36 Gene

Publications for ANKRD36 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4

Products for ANKRD36 Gene

Sources for ANKRD36 Gene