Aliases for ANKRD35 Gene

Aliases for ANKRD35 Gene

  • Ankyrin Repeat Domain 35 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 35 3 4

External Ids for ANKRD35 Gene

Previous GeneCards Identifiers for ANKRD35 Gene

  • GC01P143039
  • GC01P144260
  • GC01P145549
  • GC01P119512

Summaries for ANKRD35 Gene

GeneCards Summary for ANKRD35 Gene

ANKRD35 (Ankyrin Repeat Domain 35) is a Protein Coding gene. An important paralog of this gene is ZDHHC17.

Additional gene information for ANKRD35 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD35 Gene

Genomics for ANKRD35 Gene

GeneHancer (GH) Regulatory Elements for ANKRD35 Gene

Promoters and enhancers for ANKRD35 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J145885 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 761.1 -0.4 -407 1.9 SP1 MNT ZNF384 PKNOX1 NRF1 PATZ1 SP2 SCRT2 SAP130 TRIM28 ANKRD35 HSALNG0006715 ITGA10 POLR3C ENSG00000244619
GH01J145887 Enhancer 0.6 ENCODE 750.6 -2.0 -1954 0.2 CTBP1 SOX13 RFX1 SAP130 DPF2 ZNF217 CUX1 FOS TEAD3 SMARCE1 ANKRD35 HSALNG0006715 POLR3C ENSG00000244619
GH01J145976 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 22.5 -96.1 -96120 10 PPP1R10 ZBTB40 SP1 CTCF SREBF1 SIX5 SMARCE1 POLR2A NR2F1 NR2F6 POLR3GL NBPF20 GPR89A POLR3C ANKRD35 PIAS3 HJV RBM8A LIX1L-AS1 NUDT17
GH01J145954 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 23.5 -74.6 -74599 11.5 PPP1R10 SIN3A ZBTB40 SP1 ZBTB6 MLX RBPJ POLR2A NR2F6 ATF1 LIX1L ENSG00000278431 POLR3GL POLR3C LIX1L-AS1 ANKRD35 NBPF20 RBM8A TXNIP PEX11B
GH01J145917 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 23.4 -33.0 -33035 3 SIN3A SP1 SREBF1 ZBTB6 POLR2A NR2F6 CREB1 HCFC1 MYC RAD21 GNRHR2 PEX11B lnc-POLR3GL-5 POLR3C ANKRD35 NBPF20 PIAS3 HJV LIX1L-AS1 ITGA10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD35 gene promoter:
  • AML1a
  • Bach1
  • GATA-2
  • HTF
  • NCX
  • NF-1/L
  • Pax-5
  • SEF-1 (1)
  • TBP

Genomic Locations for ANKRD35 Gene

Genomic Locations for ANKRD35 Gene
chr1:145,866,560-145,885,866
(GRCh38/hg38)
Size:
19,307 bases
Orientation:
Minus strand
chr1:145,549,209-145,568,526
(GRCh37/hg19)
Size:
19,318 bases
Orientation:
Plus strand

Genomic View for ANKRD35 Gene

Genes around ANKRD35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD35 Gene

Proteins for ANKRD35 Gene

  • Protein details for ANKRD35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N283-ANR35_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 35
    Protein Accession:
    Q8N283
    Secondary Accessions:
    • A6NEU0
    • B4DL62
    • Q3MJ10
    • Q96LS3

    Protein attributes for ANKRD35 Gene

    Size:
    1001 amino acids
    Molecular mass:
    109966 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71597.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD35 Gene

Post-translational modifications for ANKRD35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD35 Gene

Domains & Families for ANKRD35 Gene

Gene Families for ANKRD35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD35 Gene

Suggested Antigen Peptide Sequences for ANKRD35 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 35 (ANR35_HUMAN)
  • cDNA FLJ57392, highly similar to Ankyrin repeat domain-containing protein 35 (B4DL62_HUMAN)
genes like me logo Genes that share domains with ANKRD35: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD35 Gene

Function for ANKRD35 Gene

Phenotypes From GWAS Catalog for ANKRD35 Gene

genes like me logo Genes that share phenotypes with ANKRD35: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD35 Gene

Localization for ANKRD35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD35 gene
Compartment Confidence
mitochondrion 2
nucleus 2
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKRD35 Gene

Pathways & Interactions for ANKRD35 Gene

PathCards logo

SuperPathways for ANKRD35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD35 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD35 Gene

Drugs & Compounds for ANKRD35 Gene

No Compound Related Data Available

Transcripts for ANKRD35 Gene

mRNA/cDNA for ANKRD35 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD35 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for ANKRD35 Gene

GeneLoc Exon Structure for
ANKRD35
ECgene alternative splicing isoforms for
ANKRD35

Expression for ANKRD35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD35 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD35 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x8.2) and Skin - Not Sun Exposed (Suprapubic) (x6.7).

Protein differential expression in normal tissues from HIPED for ANKRD35 Gene

This gene is overexpressed in Placenta (20.2), Liver (13.4), Cervix (9.6), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD35 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKRD35 Gene:

ANKRD35

SOURCE GeneReport for Unigene cluster for ANKRD35 Gene:

Hs.710624
genes like me logo Genes that share expression patterns with ANKRD35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD35 Gene

Orthologs for ANKRD35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD35 33 32
  • 98.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD35 33 32
  • 86.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD35 33 32
  • 85.4 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd35 32
  • 83.35 (n)
mouse
(Mus musculus)
Mammalia Ankrd35 17 33 32
  • 83.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD35 33
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD35 33
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 65 (a)
OneToMany
-- 33
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii uaca 33
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 28 (a)
OneToMany
Species where no ortholog for ANKRD35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD35 Gene

ENSEMBL:
Gene Tree for ANKRD35 (if available)
TreeFam:
Gene Tree for ANKRD35 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD35: view image

Paralogs for ANKRD35 Gene

Paralogs for ANKRD35 Gene

(8) SIMAP similar genes for ANKRD35 Gene using alignment to 2 proteins:

  • ANR35_HUMAN
  • B4DL62_HUMAN
genes like me logo Genes that share paralogs with ANKRD35: view

Variants for ANKRD35 Gene

Sequence variations from dbSNP and Humsavar for ANKRD35 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000409389 -- 145,883,856(-) A/G intron_variant
rs1000747624 -- 145,882,704(-) C/T intron_variant
rs1000798417 -- 145,881,959(-) T/C intron_variant
rs1001306365 -- 145,883,243(-) C/G/T intron_variant
rs1001359658 -- 145,877,336(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD35 Gene

Variant ID Type Subtype PubMed ID
esv32826 CNV gain 17666407
esv3587420 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv831381 CNV gain 17160897
nsv946265 CNV duplication 23825009

Variation tolerance for ANKRD35 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.45; 92.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD35 Gene

Disorders for ANKRD35 Gene

Additional Disease Information for ANKRD35

No disorders were found for ANKRD35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD35 Gene

Publications for ANKRD35 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. (PMID: 27684187) Rosenbluh J … Hahn WC (Cell systems 2016) 3 56
  5. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. (PMID: 25505242) Fernandez J … Arhel NJ (The Journal of biological chemistry 2015) 3 56

Products for ANKRD35 Gene

Sources for ANKRD35 Gene