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Aliases for ANKRD35 Gene

Aliases for ANKRD35 Gene

  • Ankyrin Repeat Domain 35 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 35 3

External Ids for ANKRD35 Gene

Previous GeneCards Identifiers for ANKRD35 Gene

  • GC01P143039
  • GC01P144260
  • GC01P145549
  • GC01P119512

Summaries for ANKRD35 Gene

GeneCards Summary for ANKRD35 Gene

ANKRD35 (Ankyrin Repeat Domain 35) is a Protein Coding gene. An important paralog of this gene is ANKRD24.

Additional gene information for ANKRD35 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD35 Gene

Genomics for ANKRD35 Gene

GeneHancer (GH) Regulatory Elements for ANKRD35 Gene

Promoters and enhancers for ANKRD35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J145885 Promoter/Enhancer 1.2 Ensembl ENCODE 655.4 -0.1 -107 1.3 KLF1 PKNOX1 SAP130 SUZ12 NEUROD1 SIN3A ZNF384 FEZF1 ZNF335 PATZ1 ANKRD35 ITGA10 POLR3C ENSG00000244619
GH01J145887 Enhancer 0.6 ENCODE 650.7 -2.0 -1954 0.2 SMARCE1 SOX13 SAP130 DPF2 TEAD3 ZNF217 CTBP1 GATA3 CUX1 FOS ANKRD35 POLR3C ENSG00000244619
GH01J145976 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.5 -96.4 -96417 10.6 CLOCK YBX1 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC POLR3GL NBPF20 POLR3C GPR89A PIAS3 ANKRD35 HJV RBM8A LIX1L-AS1 PEX11B
GH01J145917 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 23.4 -33.0 -32956 2.8 HDGF ARNT ZFP64 ARID4B NEUROD1 SIN3A YY1 POLR2B E2F8 ZNF143 GNRHR2 PEX11B ANKRD35 HJV ENSG00000213240 POLR3C LIX1L-AS1 ITGA10 RBM8A
GH01J145890 Enhancer 1.3 Ensembl ENCODE 25.7 -6.4 -6442 3.6 HDGF PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 YY1 ENSG00000244619 ANKRD35 TXNIP POLR3C ITGA10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD35 gene promoter:
  • TBP
  • HTF
  • Pax-5
  • GATA-2
  • SEF-1 (1)
  • Bach1
  • NCX
  • NF-1/L
  • AML1a

Genomic Locations for ANKRD35 Gene

Genomic Locations for ANKRD35 Gene
19,307 bases
Minus strand
19,318 bases
Plus strand

Genomic View for ANKRD35 Gene

Genes around ANKRD35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD35 Gene

Proteins for ANKRD35 Gene

  • Protein details for ANKRD35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 35
    Protein Accession:
    Secondary Accessions:
    • A6NEU0
    • B4DL62
    • Q3MJ10
    • Q96LS3

    Protein attributes for ANKRD35 Gene

    1001 amino acids
    Molecular mass:
    109966 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71597.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD35 Gene


neXtProt entry for ANKRD35 Gene

Post-translational modifications for ANKRD35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD35 Gene

Domains & Families for ANKRD35 Gene

Gene Families for ANKRD35 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD35 Gene

Suggested Antigen Peptide Sequences for ANKRD35 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD35: view

No data available for UniProtKB/Swiss-Prot for ANKRD35 Gene

Function for ANKRD35 Gene

Phenotypes From GWAS Catalog for ANKRD35 Gene

genes like me logo Genes that share phenotypes with ANKRD35: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD35 Gene

Localization for ANKRD35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD35 gene
Compartment Confidence
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKRD35 Gene

Pathways & Interactions for ANKRD35 Gene

SuperPathways for ANKRD35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD35 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD35 Gene

Drugs & Compounds for ANKRD35 Gene

No Compound Related Data Available

Transcripts for ANKRD35 Gene

mRNA/cDNA for ANKRD35 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD35 Gene

Ankyrin repeat domain 35:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD35 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: - -
SP3: -

Relevant External Links for ANKRD35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD35 Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD35 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x8.2) and Skin - Not Sun Exposed (Suprapubic) (x6.7).

Protein differential expression in normal tissues from HIPED for ANKRD35 Gene

This gene is overexpressed in Placenta (20.2), Liver (13.4), Cervix (9.6), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD35 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD35 Gene:


SOURCE GeneReport for Unigene cluster for ANKRD35 Gene:

genes like me logo Genes that share expression patterns with ANKRD35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD35 Gene

Orthologs for ANKRD35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKRD35 34 33
  • 98.85 (n)
(Bos Taurus)
Mammalia ANKRD35 34 33
  • 86.13 (n)
(Canis familiaris)
Mammalia ANKRD35 34 33
  • 85.4 (n)
(Rattus norvegicus)
Mammalia Ankrd35 33
  • 83.35 (n)
(Mus musculus)
Mammalia Ankrd35 16 34 33
  • 83.05 (n)
(Ornithorhynchus anatinus)
Mammalia ANKRD35 34
  • 82 (a)
(Monodelphis domestica)
Mammalia ANKRD35 34
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
-- 34
  • 58 (a)
(Danio rerio)
Actinopterygii uaca 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for ANKRD35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD35 Gene

Gene Tree for ANKRD35 (if available)
Gene Tree for ANKRD35 (if available)
Evolutionary constrained regions (ECRs) for ANKRD35: view image

Paralogs for ANKRD35 Gene

Paralogs for ANKRD35 Gene

(8) SIMAP similar genes for ANKRD35 Gene using alignment to 2 proteins:

  • B4DL62_HUMAN
genes like me logo Genes that share paralogs with ANKRD35: view

Variants for ANKRD35 Gene

Sequence variations from dbSNP and Humsavar for ANKRD35 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000409389 -- 145,883,856(-) A/G intron_variant
rs1000747624 -- 145,882,704(-) C/T intron_variant
rs1000798417 -- 145,881,959(-) T/C intron_variant
rs1001306365 -- 145,883,243(-) C/G/T intron_variant
rs1001359658 -- 145,877,336(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD35 Gene

Variant ID Type Subtype PubMed ID
esv32826 CNV gain 17666407
esv3587420 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv831381 CNV gain 17160897
nsv946265 CNV duplication 23825009

Variation tolerance for ANKRD35 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.45; 92.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD35 Gene

Disorders for ANKRD35 Gene

Additional Disease Information for ANKRD35

No disorders were found for ANKRD35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD35 Gene

Publications for ANKRD35 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 58
  5. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. (PMID: 25505242) Fernandez J … Arhel NJ (The Journal of biological chemistry 2015) 3 58

Products for ANKRD35 Gene

Sources for ANKRD35 Gene

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