Aliases for ANKRD34B Gene

Aliases for ANKRD34B Gene

  • Ankyrin Repeat Domain 34B 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 34B 3 4
  • DP58 2 3
  • Dendritic Phosphoprotein 58 KDa 3
  • Cytosolic Phosphoprotein DP58 3
  • ANKRD34B 5

External Ids for ANKRD34B Gene

Previous GeneCards Identifiers for ANKRD34B Gene

  • GC05M079888
  • GC05M075060

Summaries for ANKRD34B Gene

GeneCards Summary for ANKRD34B Gene

ANKRD34B (Ankyrin Repeat Domain 34B) is a Protein Coding gene. An important paralog of this gene is ANKRD34A.

Additional gene information for ANKRD34B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD34B Gene

Genomics for ANKRD34B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD34B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J080569 Promoter/Enhancer 1.1 Ensembl ENCODE 600.7 +0.4 391 1.8 ZNF629 PRDM10 ZNF692 ZIC2 ZSCAN4 PATZ1 ZNF501 EZH2 ZNF600 ZNF341 ANKRD34B HSALNG0042993 DHFR FAM151B
GH05J080607 Enhancer 0.9 Ensembl ENCODE 11.9 -38.5 -38509 2.8 RXRB IRF2 SP1 EED SOX13 RUNX3 FOXA2 MAFK KDM6A ELF1 DHFR ANKRD34B piR-60990-002 DBIP2 lnc-DHFR-3 LINC01337 MTRNR2L2
GH05J080606 Enhancer 0.2 FANTOM5 11.2 -36.5 -36454 0 ANKRD34B DBIP2 lnc-DHFR-3 piR-60990-002 MTRNR2L2
GH05J080568 Enhancer 0.3 FANTOM5 7.5 +2.1 2081 0.1 EZH2 HSALNG0042993 ANKRD34B lnc-ANKRD34B-3 FAM151B
GH05J080538 Enhancer 0.2 Ensembl 12.4 +31.4 31391 0.2 ANKRD34B lnc-ANKRD34B-3 HSALNG0042993 FAM151B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD34B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD34B

Top Transcription factor binding sites by QIAGEN in the ANKRD34B gene promoter:
  • AML1a
  • ATF6
  • E47
  • Hand1
  • HSF2
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • Pax-4a
  • YY1

Genomic Locations for ANKRD34B Gene

Genomic Locations for ANKRD34B Gene
chr5:80,556,755-80,570,292
(GRCh38/hg38)
Size:
13,538 bases
Orientation:
Minus strand
chr5:79,852,574-79,866,307
(GRCh37/hg19)
Size:
13,734 bases
Orientation:
Minus strand

Genomic View for ANKRD34B Gene

Genes around ANKRD34B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD34B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD34B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD34B Gene

Proteins for ANKRD34B Gene

  • Protein details for ANKRD34B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5PLL1-AN34B_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 34B
    Protein Accession:
    A5PLL1
    Secondary Accessions:
    • B2RPH1
    • Q68D79

    Protein attributes for ANKRD34B Gene

    Size:
    514 amino acids
    Molecular mass:
    56414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD34B Gene

Post-translational modifications for ANKRD34B Gene

Other Protein References for ANKRD34B Gene

No data available for DME Specific Peptides for ANKRD34B Gene

Domains & Families for ANKRD34B Gene

Gene Families for ANKRD34B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD34B Gene

Suggested Antigen Peptide Sequences for ANKRD34B Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 34B (AN34B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A5PLL1

UniProtKB/Swiss-Prot:

AN34B_HUMAN :
  • Belongs to the ANKRD34 family.
Family:
  • Belongs to the ANKRD34 family.
genes like me logo Genes that share domains with ANKRD34B: view

Function for ANKRD34B Gene

Phenotypes From GWAS Catalog for ANKRD34B Gene

Gene Ontology (GO) - Molecular Function for ANKRD34B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD34B: view
genes like me logo Genes that share phenotypes with ANKRD34B: view

Animal Model Products

CRISPR Products

miRNA for ANKRD34B Gene

miRTarBase miRNAs that target ANKRD34B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD34B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD34B Gene

Localization for ANKRD34B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD34B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD34B gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANKRD34B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ANKRD34B: view

Pathways & Interactions for ANKRD34B Gene

PathCards logo

SuperPathways for ANKRD34B Gene

No Data Available

Interacting Proteins for ANKRD34B Gene

Selected Interacting proteins: A5PLL1-AN34B_HUMAN for ANKRD34B Gene via IID

Symbol External ID(s) Details
MPP5

Gene Ontology (GO) - Biological Process for ANKRD34B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD34B Gene

Drugs & Compounds for ANKRD34B Gene

No Compound Related Data Available

Transcripts for ANKRD34B Gene

mRNA/cDNA for ANKRD34B Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD34B

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD34B Gene

No ASD Table

Relevant External Links for ANKRD34B Gene

GeneLoc Exon Structure for
ANKRD34B

Expression for ANKRD34B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD34B Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD34B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x14.9), Brain - Putamen (basal ganglia) (x12.8), and Brain - Caudate (basal ganglia) (x12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD34B Gene



Protein tissue co-expression partners for ANKRD34B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD34B

SOURCE GeneReport for Unigene cluster for ANKRD34B Gene:

Hs.519404

Evidence on tissue expression from TISSUES for ANKRD34B Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ANKRD34B: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD34B Gene

Orthologs for ANKRD34B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD34B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD34B 30 31
  • 99.61 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANKRD34B 30 31
  • 88.87 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANKRD34B 30 31
  • 88.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ankrd34b 30 17 31
  • 81.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ankrd34b 30
  • 81.5 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD34B 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ANKRD34B 31
  • 63 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 67 (a)
OneToMany
-- 31
  • 67 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ankrd34b 30
  • 66.27 (n)
Zebrafish
(Danio rerio)
Actinopterygii ankrd34bb 30 31
  • 56.91 (n)
OneToMany
ankrd34ba 31
  • 44 (a)
OneToMany
Species where no ortholog for ANKRD34B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD34B Gene

ENSEMBL:
Gene Tree for ANKRD34B (if available)
TreeFam:
Gene Tree for ANKRD34B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD34B: view image

Paralogs for ANKRD34B Gene

Paralogs for ANKRD34B Gene

(2) SIMAP similar genes for ANKRD34B Gene using alignment to 2 proteins:

  • AN34B_HUMAN
  • D6RH12_HUMAN
genes like me logo Genes that share paralogs with ANKRD34B: view

Variants for ANKRD34B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD34B Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs32857 - p.Leu156Ser

Additional dbSNP identifiers (rs#s) for ANKRD34B Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD34B Gene

Variant ID Type Subtype PubMed ID
dgv5705n100 CNV gain 25217958
dgv5706n100 CNV gain 25217958
dgv5707n100 CNV gain 25217958
esv3575860 CNV gain 25503493
esv3575862 CNV gain 25503493
esv3605573 CNV loss 21293372
esv3605576 CNV loss 21293372
esv3605577 CNV gain 21293372
nsv483112 CNV loss 15286789

Variation tolerance for ANKRD34B Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD34B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD34B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD34B Gene

Disorders for ANKRD34B Gene

Additional Disease Information for ANKRD34B

No disorders were found for ANKRD34B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD34B Gene

Publications for ANKRD34B Gene

  1. A novel phosphoprotein is induced during bone marrow commitment to dendritic cells. (PMID: 15358210) Al-Shaibi N … Ghosh SK (Biochemical and biophysical research communications 2004) 3 23
  2. WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. (PMID: 30655611) Jeong WJ … Choi KY (Nature communications 2019) 3
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 41
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for ANKRD34B Gene

  • Biorbyt antibodies for ANKRD34B

Sources for ANKRD34B Gene