Aliases for ANKRD34A Gene

Aliases for ANKRD34A Gene

  • Ankyrin Repeat Domain 34A 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 34A 3 4
  • Ankyrin Repeat Domain 34 2 3
  • ANKRD34 3 4
  • ANKRD34A 5

External Ids for ANKRD34A Gene

Previous HGNC Symbols for ANKRD34A Gene

  • ANKRD34

Previous GeneCards Identifiers for ANKRD34A Gene

  • GC01P144182
  • GC01P145470
  • GC01P119434

Summaries for ANKRD34A Gene

GeneCards Summary for ANKRD34A Gene

ANKRD34A (Ankyrin Repeat Domain 34A) is a Protein Coding gene. An important paralog of this gene is ANKRD34B.

Additional gene information for ANKRD34A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD34A Gene

Genomics for ANKRD34A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD34A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J145990 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.1 -30.8 -30767 10.5 ARHGAP35 SP1 CREB1 GATAD2A ZBTB33 PRDM10 REST ZNF629 TFE3 LEF1 TXNIP lnc-HFE2-2 piR-42110 POLR3C NBPF20 GPR89A PIAS3 LIX1L-AS1 HJV RBM8A
GH01J145954 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.7 +4.1 4110 11.5 SP1 HNRNPL CREB1 GATAD2A YBX1 ZNF629 PRDM10 REST RFX1 NFKBIZ LIX1L ENSG00000278431 POLR3GL POLR3C ANKRD35 NBPF20 LIX1L-AS1 RBM8A TXNIP GNRHR2
GH01J145976 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -17.4 -17411 10 CEBPG SP1 CREB1 GATAD2A CTCF ZBTB33 TEAD4 YBX1 PRDM10 REST POLR3GL NBPF20 POLR3C GPR89A PIAS3 ANKRD35 HJV RBM8A LIX1L-AS1 PEX11B
GH01J145972 Enhancer 0.8 Ensembl 0.4 -8.0 -8026 0.8 CEBPG GATAD2A ATF7 REST RCOR2 RXRB IRF2 SP1 CEBPA FOXK2 RF00017-313 POLR3C ANKRD34A MN308980 POLR3GL TXNIP ENSG00000280778
GH01J145988 Promoter/Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 -24.3 -24338 0.7 CREB1 HMBOX1 POLR2A lnc-POLR3GL-4 HJV RBM8A LIX1L-AS1 PEX11B GNRHR2 MN308788 TXNIP ANKRD34A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD34A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD34A

Top Transcription factor binding sites by QIAGEN in the ANKRD34A gene promoter:
  • C/EBPalpha
  • CHOP-10
  • HOXA5
  • LCR-F1
  • NF-1
  • Olf-1
  • RelA
  • Sp1
  • Spz1

Genomic Locations for ANKRD34A Gene

Genomic Locations for ANKRD34A Gene
chr1:145,959,441-145,964,575
(GRCh38/hg38)
Size:
5,135 bases
Orientation:
Minus strand
chr1:145,470,508-145,475,647
(GRCh37/hg19)
Size:
5,140 bases
Orientation:
Plus strand

Genomic View for ANKRD34A Gene

Genes around ANKRD34A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD34A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD34A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD34A Gene

Proteins for ANKRD34A Gene

  • Protein details for ANKRD34A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YU3-AN34A_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 34A
    Protein Accession:
    Q69YU3
    Secondary Accessions:
    • B3KSU3

    Protein attributes for ANKRD34A Gene

    Size:
    496 amino acids
    Molecular mass:
    52636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD34A Gene

Post-translational modifications for ANKRD34A Gene

Other Protein References for ANKRD34A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD34A Gene

Domains & Families for ANKRD34A Gene

Gene Families for ANKRD34A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD34A Gene

Suggested Antigen Peptide Sequences for ANKRD34A Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 34A (AN34A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q69YU3

UniProtKB/Swiss-Prot:

AN34A_HUMAN :
  • Belongs to the ANKRD34 family.
Family:
  • Belongs to the ANKRD34 family.
genes like me logo Genes that share domains with ANKRD34A: view

Function for ANKRD34A Gene

Gene Ontology (GO) - Molecular Function for ANKRD34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD34A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD34A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD34A Gene

Localization for ANKRD34A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD34A gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD34A Gene

Pathways & Interactions for ANKRD34A Gene

PathCards logo

SuperPathways for ANKRD34A Gene

No Data Available

Interacting Proteins for ANKRD34A Gene

Gene Ontology (GO) - Biological Process for ANKRD34A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD34A Gene

Drugs & Compounds for ANKRD34A Gene

No Compound Related Data Available

Transcripts for ANKRD34A Gene

mRNA/cDNA for ANKRD34A Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD34A

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD34A Gene

No ASD Table

Relevant External Links for ANKRD34A Gene

GeneLoc Exon Structure for
ANKRD34A

Expression for ANKRD34A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD34A Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD34A Gene

This gene is overexpressed in Brain - Cortex (x5.0), Brain - Frontal Cortex (BA9) (x4.9), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for ANKRD34A Gene

This gene is overexpressed in Frontal cortex (56.1) and Retina (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD34A Gene



Protein tissue co-expression partners for ANKRD34A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD34A

SOURCE GeneReport for Unigene cluster for ANKRD34A Gene:

Hs.620591

Evidence on tissue expression from TISSUES for ANKRD34A Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with ANKRD34A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD34A Gene

Orthologs for ANKRD34A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD34A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD34A 30
  • 98.56 (n)
Cow
(Bos Taurus)
Mammalia ANKRD34A 30
  • 91.43 (n)
Dog
(Canis familiaris)
Mammalia ANKRD34A 30
  • 90.93 (n)
Rat
(Rattus norvegicus)
Mammalia Ankrd34a 30
  • 89.63 (n)
Mouse
(Mus musculus)
Mammalia Ankrd34a 30 17
  • 89.09 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ankrd34a 30
  • 59.54 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC798097 30
  • 60.57 (n)
Species where no ortholog for ANKRD34A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD34A Gene

ENSEMBL:
Gene Tree for ANKRD34A (if available)
TreeFam:
Gene Tree for ANKRD34A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD34A: view image

Paralogs for ANKRD34A Gene

Paralogs for ANKRD34A Gene

(2) SIMAP similar genes for ANKRD34A Gene using alignment to 1 proteins:

  • AN34A_HUMAN
genes like me logo Genes that share paralogs with ANKRD34A: view

Variants for ANKRD34A Gene

Additional dbSNP identifiers (rs#s) for ANKRD34A Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD34A Gene

Variant ID Type Subtype PubMed ID
esv33401 CNV gain 17666407
nsv1005055 CNV loss 25217958
nsv509457 CNV insertion 20534489
nsv8103 CNV gain 18304495
nsv831381 CNV gain 17160897

Variation tolerance for ANKRD34A Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD34A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD34A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD34A Gene

Disorders for ANKRD34A Gene

No disorders were found for ANKRD34A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD34A Gene

Publications for ANKRD34A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates. (PMID: 26797129) Kusevic D … Jeltsch A (The Journal of biological chemistry 2016) 4
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4

Products for ANKRD34A Gene

Sources for ANKRD34A Gene