Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD33B Gene

Aliases for ANKRD33B Gene

  • Ankyrin Repeat Domain 33B 2 3 5

External Ids for ANKRD33B Gene

Previous GeneCards Identifiers for ANKRD33B Gene

  • GC05P010616

Summaries for ANKRD33B Gene

GeneCards Summary for ANKRD33B Gene

ANKRD33B (Ankyrin Repeat Domain 33B) is a Protein Coding gene. An important paralog of this gene is ANKRD33.

Additional gene information for ANKRD33B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD33B Gene

Genomics for ANKRD33B Gene

GeneHancer (GH) Regulatory Elements for ANKRD33B Gene

Promoters and enhancers for ANKRD33B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I010562 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 554 +1.1 1108 6.3 HDGF PKNOX1 SIN3A IRF4 ZNF121 GLIS2 ELK1 ZNF207 ATF7 KLF7 ANKRD33B ANKRD33B-AS1 ROPN1L ROPN1L-AS1 MARCH6 GC05M010581
GH05I010606 Enhancer 1.4 FANTOM5 Ensembl ENCODE 14.7 +43.4 43442 2.5 HDGF PKNOX1 ARNT FEZF1 ZNF2 IRF4 ZNF766 ZNF213 JUNB REST ANKRD33B ANKRD33B-AS1 LINC02213 ROPN1L ROPN1L-AS1 FAM173B LINC01513 ENSG00000251196 MARCH6 GC05P010606
GH05I010599 Enhancer 1.5 FANTOM5 Ensembl ENCODE 13.6 +37.0 37025 3.3 HDGF PKNOX1 FOXA2 SMAD1 SIN3A FEZF1 ZNF2 ZBTB7B IRF4 YY1 ANKRD33B ANKRD33B-AS1 GC05P010606 GC05P010586
GH05I010626 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 11.7 +63.3 63293 2 HDGF PKNOX1 ARNT ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF213 E2F8 ANKRD33B-AS1 ANKRD33B LINC02213 LINC01513 GC05P010606
GH05I010484 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.2 -78.8 -78843 2.2 PKNOX1 ATF1 FEZF1 BRCA1 TCF12 ZNF766 ZNF213 GATA2 KLF7 ATF7 LINC02213 ANKRD33B-AS1 ANKRD33B RPL30P7 LINC01513
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANKRD33B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD33B gene promoter:

Genomic Locations for ANKRD33B Gene

Genomic Locations for ANKRD33B Gene
93,494 bases
Plus strand

Genomic View for ANKRD33B Gene

Genes around ANKRD33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD33B Gene

Proteins for ANKRD33B Gene

  • Protein details for ANKRD33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 33B
    Protein Accession:

    Protein attributes for ANKRD33B Gene

    494 amino acids
    Molecular mass:
    53975 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD33B Gene

Post-translational modifications for ANKRD33B Gene

No Post-translational modifications

Other Protein References for ANKRD33B Gene

No data available for DME Specific Peptides for ANKRD33B Gene

Domains & Families for ANKRD33B Gene

Gene Families for ANKRD33B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD33B Gene

Suggested Antigen Peptide Sequences for ANKRD33B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD33B: view

No data available for UniProtKB/Swiss-Prot for ANKRD33B Gene

Function for ANKRD33B Gene

Phenotypes From GWAS Catalog for ANKRD33B Gene

Phenotypes for ANKRD33B Gene

GenomeRNAi human phenotypes for ANKRD33B:
genes like me logo Genes that share phenotypes with ANKRD33B: view

Animal Model Products

miRNA for ANKRD33B Gene

miRTarBase miRNAs that target ANKRD33B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD33B Gene

Localization for ANKRD33B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD33B gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD33B Gene

Pathways & Interactions for ANKRD33B Gene

SuperPathways for ANKRD33B Gene

No Data Available

Interacting Proteins for ANKRD33B Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
Selected Interacting proteins: A6NCL7-AN33B_HUMAN ENSP00000296657 for ANKRD33B Gene via IID STRING

Gene Ontology (GO) - Biological Process for ANKRD33B Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD33B Gene

Drugs & Compounds for ANKRD33B Gene

No Compound Related Data Available

Transcripts for ANKRD33B Gene

mRNA/cDNA for ANKRD33B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD33B Gene

Ankyrin repeat domain 33B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD33B Gene

No ASD Table

Relevant External Links for ANKRD33B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD33B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD33B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD33B Gene

This gene is overexpressed in Heart (51.5) and Retina (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD33B Gene

Protein tissue co-expression partners for ANKRD33B Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD33B Gene:


SOURCE GeneReport for Unigene cluster for ANKRD33B Gene:

genes like me logo Genes that share expression patterns with ANKRD33B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD33B Gene

Orthologs for ANKRD33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD33B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKRD33B 33 34
  • 99.19 (n)
(Canis familiaris)
Mammalia ANKRD33B 33 34
  • 83.92 (n)
(Bos Taurus)
Mammalia ANKRD33B 33 34
  • 83.67 (n)
(Mus musculus)
Mammalia Ankrd33b 33 16 34
  • 78.28 (n)
(Rattus norvegicus)
Mammalia Ankrd33b 33
  • 77.48 (n)
(Monodelphis domestica)
Mammalia ANKRD33B 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia ANKRD33B 34
  • 58 (a)
(Gallus gallus)
Aves ANKRD33B 33 34
  • 63.69 (n)
(Anolis carolinensis)
Reptilia ANKRD33B 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494504 33
  • 54.16 (n)
(Danio rerio)
Actinopterygii ankrd33ba 33 34
  • 58.29 (n)
ankrd33bb 34
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for ANKRD33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD33B Gene

Gene Tree for ANKRD33B (if available)
Gene Tree for ANKRD33B (if available)

Paralogs for ANKRD33B Gene

Paralogs for ANKRD33B Gene

(1) SIMAP similar genes for ANKRD33B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD33B: view

Variants for ANKRD33B Gene

Sequence variations from dbSNP and Humsavar for ANKRD33B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000035661 -- 10,616,902(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000133567 -- 10,580,883(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000147850 -- 10,610,078(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000152131 -- 10,650,916(+) A/G 3_prime_UTR_variant
rs1000183204 -- 10,574,627(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD33B Gene

Variant ID Type Subtype PubMed ID
esv25753 CNV loss 19812545
esv2570309 CNV deletion 19546169
esv2429278 CNV deletion 19546169
esv2302807 CNV deletion 18987734
esv1001828 CNV gain 20482838
dgv9581n54 CNV loss 21841781
dgv9580n54 CNV loss 21841781
dgv9579n54 CNV loss 21841781
dgv931e201 CNV deletion 23290073
dgv349e215 CNV deletion 23714750
dgv3036n106 CNV deletion 24896259
nsv968139 CNV duplication 23825009
nsv956440 CNV deletion 24416366
nsv597138 CNV gain 21841781
nsv597137 CNV loss 21841781
nsv597136 CNV loss 21841781
nsv597135 CNV loss 21841781
nsv597127 CNV loss 21841781
nsv597126 CNV loss 21841781
nsv597125 CNV loss 21841781
nsv597124 CNV gain 21841781
nsv597122 CNV gain 21841781
nsv597121 CNV loss 21841781
nsv597119 CNV loss 21841781
nsv513221 CNV loss 21212237
nsv513220 CNV loss 21212237
nsv511306 CNV loss 21212237
nsv507230 OTHER sequence alteration 20534489
nsv472473 CNV novel sequence insertion 20440878
nsv329565 CNV deletion 16902084
nsv329316 CNV deletion 16902084
nsv1140509 CNV deletion 24896259
nsv1074809 CNV deletion 25765185
nsv1073041 CNV deletion 25765185
nsv1021311 CNV loss 25217958
esv5923 CNV loss 19470904
esv5335 CNV loss 18987735
esv3604004 CNV loss 21293372
esv3604003 CNV loss 21293372
esv3565521 CNV deletion 23714750
esv3400859 CNV insertion 20981092
esv3304412 CNV mobile element insertion 20981092
esv29091 CNV gain+loss 19812545
esv27558 CNV loss 19812545
esv2729745 CNV deletion 23290073
esv2729744 CNV deletion 23290073

Variation tolerance for ANKRD33B Gene

Gene Damage Index Score: 3.38; 54.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD33B Gene

Disorders for ANKRD33B Gene

Additional Disease Information for ANKRD33B

No disorders were found for ANKRD33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD33B Gene

Publications for ANKRD33B Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for ANKRD33B Gene

Sources for ANKRD33B Gene

Loading form....