Aliases for ANKRD33B Gene

Aliases for ANKRD33B Gene

  • Ankyrin Repeat Domain 33B 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 33B 3 4
  • Ankyrin Repeat Domain-Containing Protein LOC651746 3
  • ANKRD33B 5

External Ids for ANKRD33B Gene

Previous GeneCards Identifiers for ANKRD33B Gene

  • GC05P010616

Summaries for ANKRD33B Gene

GeneCards Summary for ANKRD33B Gene

ANKRD33B (Ankyrin Repeat Domain 33B) is a Protein Coding gene. An important paralog of this gene is ANKRD33.

Additional gene information for ANKRD33B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD33B Gene

Genomics for ANKRD33B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD33B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD33B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD33B

Top Transcription factor binding sites by QIAGEN in the ANKRD33B gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • CUTL1
  • E47
  • Egr-3
  • Egr-4
  • Evi-1
  • p53

Genomic Locations for ANKRD33B Gene

Genomic Locations for ANKRD33B Gene
chr5:10,564,070-10,657,816
(GRCh38/hg38)
Size:
93,747 bases
Orientation:
Plus strand
chr5:10,564,435-10,657,928
(GRCh37/hg19)
Size:
93,494 bases
Orientation:
Plus strand

Genomic View for ANKRD33B Gene

Genes around ANKRD33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD33B Gene

Proteins for ANKRD33B Gene

  • Protein details for ANKRD33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCL7-AN33B_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 33B
    Protein Accession:
    A6NCL7

    Protein attributes for ANKRD33B Gene

    Size:
    494 amino acids
    Molecular mass:
    53975 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD33B Gene

Post-translational modifications for ANKRD33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD33B Gene

No data available for DME Specific Peptides for ANKRD33B Gene

Domains & Families for ANKRD33B Gene

Gene Families for ANKRD33B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD33B Gene

Suggested Antigen Peptide Sequences for ANKRD33B Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 33B (AN33B_HUMAN)
genes like me logo Genes that share domains with ANKRD33B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD33B Gene

Function for ANKRD33B Gene

Phenotypes From GWAS Catalog for ANKRD33B Gene

Gene Ontology (GO) - Molecular Function for ANKRD33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD33B: view

Phenotypes for ANKRD33B Gene

genes like me logo Genes that share phenotypes with ANKRD33B: view

Animal Model Products

CRISPR Products

miRNA for ANKRD33B Gene

miRTarBase miRNAs that target ANKRD33B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD33B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD33B Gene

Localization for ANKRD33B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD33B gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD33B Gene

Pathways & Interactions for ANKRD33B Gene

PathCards logo

SuperPathways for ANKRD33B Gene

No Data Available

Interacting Proteins for ANKRD33B Gene

Gene Ontology (GO) - Biological Process for ANKRD33B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD33B Gene

Drugs & Compounds for ANKRD33B Gene

No Compound Related Data Available

Transcripts for ANKRD33B Gene

mRNA/cDNA for ANKRD33B Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD33B

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD33B Gene

No ASD Table

Relevant External Links for ANKRD33B Gene

GeneLoc Exon Structure for
ANKRD33B

Expression for ANKRD33B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD33B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD33B Gene

This gene is overexpressed in Heart (51.5) and Retina (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD33B Gene



Protein tissue co-expression partners for ANKRD33B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD33B

SOURCE GeneReport for Unigene cluster for ANKRD33B Gene:

Hs.26039
genes like me logo Genes that share expression patterns with ANKRD33B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD33B Gene

Orthologs for ANKRD33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD33B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD33B 30 31
  • 99.19 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANKRD33B 30 31
  • 83.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANKRD33B 30 31
  • 83.67 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ankrd33b 30 17 31
  • 78.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ankrd33b 30
  • 77.48 (n)
Oppossum
(Monodelphis domestica)
Mammalia ANKRD33B 31
  • 61 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD33B 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ANKRD33B 30 31
  • 63.69 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANKRD33B 31
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100494504 30
  • 54.16 (n)
Zebrafish
(Danio rerio)
Actinopterygii ankrd33ba 30 31
  • 58.29 (n)
OneToMany
ankrd33bb 31
  • 47 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToMany
Species where no ortholog for ANKRD33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD33B Gene

ENSEMBL:
Gene Tree for ANKRD33B (if available)
TreeFam:
Gene Tree for ANKRD33B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD33B: view image

Paralogs for ANKRD33B Gene

Paralogs for ANKRD33B Gene

(1) SIMAP similar genes for ANKRD33B Gene using alignment to 2 proteins:

  • AN33B_HUMAN
  • D6R912_HUMAN
genes like me logo Genes that share paralogs with ANKRD33B: view

Variants for ANKRD33B Gene

Additional dbSNP identifiers (rs#s) for ANKRD33B Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD33B Gene

Variant ID Type Subtype PubMed ID
dgv3036n106 CNV deletion 24896259
dgv349e215 CNV deletion 23714750
dgv931e201 CNV deletion 23290073
dgv9579n54 CNV loss 21841781
dgv9580n54 CNV loss 21841781
dgv9581n54 CNV loss 21841781
esv1001828 CNV gain 20482838
esv2302807 CNV deletion 18987734
esv2429278 CNV deletion 19546169
esv2570309 CNV deletion 19546169
esv25753 CNV loss 19812545
esv2729744 CNV deletion 23290073
esv2729745 CNV deletion 23290073
esv27558 CNV loss 19812545
esv29091 CNV gain+loss 19812545
esv3304412 CNV mobile element insertion 20981092
esv3400859 CNV insertion 20981092
esv3565521 CNV deletion 23714750
esv3604003 CNV loss 21293372
esv3604004 CNV loss 21293372
esv5335 CNV loss 18987735
esv5923 CNV loss 19470904
nsv1021311 CNV loss 25217958
nsv1073041 CNV deletion 25765185
nsv1074809 CNV deletion 25765185
nsv1140509 CNV deletion 24896259
nsv329316 CNV deletion 16902084
nsv329565 CNV deletion 16902084
nsv472473 CNV novel sequence insertion 20440878
nsv507230 OTHER sequence alteration 20534489
nsv511306 CNV loss 21212237
nsv513220 CNV loss 21212237
nsv513221 CNV loss 21212237
nsv597119 CNV loss 21841781
nsv597121 CNV loss 21841781
nsv597122 CNV gain 21841781
nsv597124 CNV gain 21841781
nsv597125 CNV loss 21841781
nsv597126 CNV loss 21841781
nsv597127 CNV loss 21841781
nsv597135 CNV loss 21841781
nsv597136 CNV loss 21841781
nsv597137 CNV loss 21841781
nsv597138 CNV gain 21841781
nsv956440 CNV deletion 24416366
nsv968139 CNV duplication 23825009

Variation tolerance for ANKRD33B Gene

Gene Damage Index Score: 3.38; 54.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD33B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD33B Gene

Disorders for ANKRD33B Gene

Additional Disease Information for ANKRD33B

No disorders were found for ANKRD33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD33B Gene

Publications for ANKRD33B Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3

Products for ANKRD33B Gene

Sources for ANKRD33B Gene