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Aliases for ANKRD29 Gene

Aliases for ANKRD29 Gene

  • Ankyrin Repeat Domain 29 2 3 5

External Ids for ANKRD29 Gene

Previous GeneCards Identifiers for ANKRD29 Gene

  • GC18M019432
  • GC18M019434
  • GC18M021178
  • GC18M018035

Summaries for ANKRD29 Gene

GeneCards Summary for ANKRD29 Gene

ANKRD29 (Ankyrin Repeat Domain 29) is a Protein Coding gene. An important paralog of this gene is ANKRD50.

Additional gene information for ANKRD29 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD29 Gene

Genomics for ANKRD29 Gene

GeneHancer (GH) Regulatory Elements for ANKRD29 Gene

Promoters and enhancers for ANKRD29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I023662 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.2 152 0.9 ZSCAN4 SIN3A BMI1 ZNF2 ZEB1 ZNF335 GLIS2 EGR1 SCRT2 ZNF391 GC18M023644 ANKRD29 RMC1
GH18I023582 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +77.9 77902 5.8 HDGF FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 NPC1 RMC1 ANKRD29 CABLES1 TMEM241 CABYR ENSG00000199366 GC18M023583 GC18P023587
GH18I023625 Enhancer 1.1 Ensembl ENCODE 17.6 +35.7 35738 2.7 PKNOX1 FEZF1 BRCA1 YY1 ZNF213 FOS SP3 TSHZ1 SREBF1 STAT3 ANKRD29 LAMA3 NPC1 GC18P023609 GC18M023644
GH18I023991 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 9.4 -330.6 -330573 3.7 PKNOX1 MZF1 FEZF1 RAD21 RFX5 YY1 ZEB1 ZNF335 ZNF366 ZSCAN5C TTC39C LAMA3 TTC39C-AS1 CABYR ANKRD29 RPL23AP77
GH18I023617 Promoter/Enhancer 1.3 Ensembl ENCODE 11.9 +43.7 43661 3.6 HDGF FOXA2 RB1 DMAP1 RARA YY1 ZNF143 ATF7 IKZF2 RXRA NPC1 LAMA3 ANKRD29 TTC39C-AS1 GC18P023609 GC18M023644
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANKRD29 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD29 gene promoter:

Genomic Locations for ANKRD29 Gene

Genomic Locations for ANKRD29 Gene
chr18:23,598,926-23,662,892
(GRCh38/hg38)
Size:
63,967 bases
Orientation:
Minus strand
chr18:21,178,890-21,242,849
(GRCh37/hg19)

Genomic View for ANKRD29 Gene

Genes around ANKRD29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD29 Gene

Proteins for ANKRD29 Gene

  • Protein details for ANKRD29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6D5-ANR29_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 29
    Protein Accession:
    Q8N6D5
    Secondary Accessions:
    • B2R972
    • Q6ZWE8
    • Q96LU9

    Protein attributes for ANKRD29 Gene

    Size:
    301 amino acids
    Molecular mass:
    32442 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85555.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD29 Gene

Post-translational modifications for ANKRD29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD29 Gene

Domains & Families for ANKRD29 Gene

Gene Families for ANKRD29 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ANKRD29 Gene

Suggested Antigen Peptide Sequences for ANKRD29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD29: view

No data available for UniProtKB/Swiss-Prot for ANKRD29 Gene

Function for ANKRD29 Gene

Phenotypes From GWAS Catalog for ANKRD29 Gene

genes like me logo Genes that share phenotypes with ANKRD29: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD29 Gene

Localization for ANKRD29 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD29 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 2
peroxisome 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANKRD29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANKRD29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKRD29 Gene

Pathways & Interactions for ANKRD29 Gene

SuperPathways for ANKRD29 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD29 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD29 Gene

Drugs & Compounds for ANKRD29 Gene

No Compound Related Data Available

Transcripts for ANKRD29 Gene

Unigene Clusters for ANKRD29 Gene

Ankyrin repeat domain 29:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD29 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7:
SP8:
SP9:

ExUns: 12g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ANKRD29 Gene

GeneLoc Exon Structure for
ANKRD29
ECgene alternative splicing isoforms for
ANKRD29

Expression for ANKRD29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD29 Gene

This gene is overexpressed in Frontal cortex (27.8), Monocytes (13.4), Spinal cord (11.9), Ovary (9.1), and Retina (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD29 Gene



Protein tissue co-expression partners for ANKRD29 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD29 Gene:

ANKRD29

SOURCE GeneReport for Unigene cluster for ANKRD29 Gene:

Hs.374774
genes like me logo Genes that share expression patterns with ANKRD29: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD29 Gene

Orthologs for ANKRD29 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD29 33 34
  • 99.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ANKRD29 33 34
  • 90.18 (n)
mouse
(Mus musculus)
Mammalia Ankrd29 16 34 33
  • 89.48 (n)
cow
(Bos Taurus)
Mammalia ANKRD29 33 34
  • 89 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd29 33
  • 88.04 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD29 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD29 34 33
  • 78.86 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD29 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd29 33
  • 73.98 (n)
zebrafish
(Danio rerio)
Actinopterygii ankrd29 33 34
  • 68.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009428 33
  • 54.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3104 33 34
  • 54.2 (n)
worm
(Caenorhabditis elegans)
Secernentea R11A8.7 34
  • 4 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3733 34
  • 43 (a)
OneToOne
Species where no ortholog for ANKRD29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKRD29 Gene

ENSEMBL:
Gene Tree for ANKRD29 (if available)
TreeFam:
Gene Tree for ANKRD29 (if available)

Paralogs for ANKRD29 Gene

Variants for ANKRD29 Gene

Sequence variations from dbSNP and Humsavar for ANKRD29 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs767831283 A breast cancer sample 23,638,896(-) C/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000011610 -- 23,615,897(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000021902 -- 23,607,501(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000057829 -- 23,609,235(-) T/C genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000104608 -- 23,648,556(-) C/G 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD29 Gene

Variant ID Type Subtype PubMed ID
esv34149 CNV loss 18971310
esv3446599 CNV duplication 20981092
nsv131804 CNV insertion 16902084
nsv131838 CNV insertion 16902084
nsv472602 CNV novel sequence insertion 20440878
nsv509688 CNV insertion 20534489

Variation tolerance for ANKRD29 Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD29 Gene

Disorders for ANKRD29 Gene

Additional Disease Information for ANKRD29

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANKRD29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD29 Gene

Publications for ANKRD29 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis. (PMID: 24256812) Fogh I … SLAGEN Consortium and Collaborators (Human molecular genetics 2014) 3 58

Products for ANKRD29 Gene

Sources for ANKRD29 Gene

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