Aliases for ANKRD29 Gene

Aliases for ANKRD29 Gene

  • Ankyrin Repeat Domain 29 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 29 3 4
  • FLJ25053 2
  • ANKRD29 5

External Ids for ANKRD29 Gene

Previous GeneCards Identifiers for ANKRD29 Gene

  • GC18M019432
  • GC18M019434
  • GC18M021178
  • GC18M018035

Summaries for ANKRD29 Gene

GeneCards Summary for ANKRD29 Gene

ANKRD29 (Ankyrin Repeat Domain 29) is a Protein Coding gene. Diseases associated with ANKRD29 include Transitional Papilloma. An important paralog of this gene is ASB12.

Additional gene information for ANKRD29 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD29 Gene

Genomics for ANKRD29 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J023662 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.2 -186 2.2 RNF2 PRDM10 ZNF692 TARDBP PRDM1 ZSCAN4 PATZ1 ZNF501 EZH2 ZNF600 ANKRD29 LAMA3 RMC1 RPS10P27
GH18J023582 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 +77.9 77874 5.9 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 REST TFE3 SOX13 ZNF692 NPC1 RMC1 ANKRD29 CABLES1 TMEM241 CABYR ENSG00000199366 lnc-RMC1-4
GH18J023625 Enhancer 1.1 Ensembl ENCODE 17.6 +36.0 36013 3.4 PRDM10 ZNF629 KDM1A ZNF692 PRDM1 PATZ1 ZNF501 ZNF600 CEBPA MNT ANKRD29 LAMA3 NPC1 FJ601684-199 lnc-NPC1-2
GH18J023991 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 9.4 -330.6 -330551 3.7 PRDM10 ZNF629 ZNF692 POLR2A FOXA1 PATZ1 SMAD5 PKNOX1 ZNF561 EED TTC39C LAMA3 TTC39C-AS1 CABYR ANKRD29 RPL23AP77 NONHSAG023555.2
GH18J023617 Promoter/Enhancer 1.3 Ensembl ENCODE 11.9 +43.7 43683 3.6 GATAD2A CTCF LARP7 PRDM1 ZNF143 RELA RXRB IKZF2 SP1 TRIM22 NPC1 LAMA3 ANKRD29 TTC39C-AS1 FJ601684-199 lnc-NPC1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD29 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD29

Top Transcription factor binding sites by QIAGEN in the ANKRD29 gene promoter:
  • AP-1
  • c-Myc
  • E4BP4
  • Evi-1
  • HNF-1
  • HNF-1A
  • Max1
  • Olf-1
  • USF-1
  • USF1

Genomic Locations for ANKRD29 Gene

Genomic Locations for ANKRD29 Gene
chr18:23,598,926-23,662,914
(GRCh38/hg38)
Size:
63,989 bases
Orientation:
Minus strand
chr18:21,178,890-21,242,849
(GRCh37/hg19)
Size:
63,960 bases
Orientation:
Minus strand

Genomic View for ANKRD29 Gene

Genes around ANKRD29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD29 Gene

Proteins for ANKRD29 Gene

  • Protein details for ANKRD29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6D5-ANR29_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 29
    Protein Accession:
    Q8N6D5
    Secondary Accessions:
    • B2R972
    • Q6ZWE8
    • Q96LU9

    Protein attributes for ANKRD29 Gene

    Size:
    301 amino acids
    Molecular mass:
    32442 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85555.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD29 Gene

Post-translational modifications for ANKRD29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD29 Gene

Domains & Families for ANKRD29 Gene

Gene Families for ANKRD29 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ANKRD29 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for ANKRD29 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 29 (ANR29_HUMAN)
genes like me logo Genes that share domains with ANKRD29: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD29 Gene

Function for ANKRD29 Gene

Phenotypes From GWAS Catalog for ANKRD29 Gene

Gene Ontology (GO) - Molecular Function for ANKRD29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD29: view
genes like me logo Genes that share phenotypes with ANKRD29: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD29

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD29 Gene

Localization for ANKRD29 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD29 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 2
extracellular 1
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANKRD29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANKRD29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKRD29 Gene

Pathways & Interactions for ANKRD29 Gene

PathCards logo

SuperPathways for ANKRD29 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD29 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD29 Gene

Drugs & Compounds for ANKRD29 Gene

No Compound Related Data Available

Transcripts for ANKRD29 Gene

mRNA/cDNA for ANKRD29 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD29

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD29 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7:
SP8:
SP9:

ExUns: 12g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ANKRD29 Gene

GeneLoc Exon Structure for
ANKRD29

Expression for ANKRD29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD29 Gene

This gene is overexpressed in Frontal cortex (27.8), Monocytes (13.4), Spinal cord (11.9), Ovary (9.1), and Retina (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD29 Gene



Protein tissue co-expression partners for ANKRD29 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD29

SOURCE GeneReport for Unigene cluster for ANKRD29 Gene:

Hs.374774
genes like me logo Genes that share expression patterns with ANKRD29: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD29 Gene

Orthologs for ANKRD29 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD29 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD29 30 31
  • 99.56 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 92 (a)
OneToMany
-- 31
  • 86 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia ANKRD29 30 31
  • 90.18 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ankrd29 30 17 31
  • 89.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANKRD29 30 31
  • 89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ankrd29 30
  • 88.04 (n)
Oppossum
(Monodelphis domestica)
Mammalia ANKRD29 31
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ANKRD29 30 31
  • 78.86 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANKRD29 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ankrd29 30
  • 73.98 (n)
Zebrafish
(Danio rerio)
Actinopterygii ankrd29 30 31
  • 68.16 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009428 30
  • 54.27 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG3104 30 31
  • 54.2 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea R11A8.7 31
  • 4 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3733 31
  • 43 (a)
OneToOne
Species where no ortholog for ANKRD29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ANKRD29 Gene

ENSEMBL:
Gene Tree for ANKRD29 (if available)
TreeFam:
Gene Tree for ANKRD29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD29: view image

Paralogs for ANKRD29 Gene

Paralogs for ANKRD29 Gene

(31) SIMAP similar genes for ANKRD29 Gene using alignment to 5 proteins:

  • ANR29_HUMAN
  • C9IZK0_HUMAN
  • K7EL63_HUMAN
  • K7EQM1_HUMAN
  • V9GYT2_HUMAN
genes like me logo Genes that share paralogs with ANKRD29: view

Variants for ANKRD29 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD29 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs767831283 A breast cancer sample p.Val95Met
rs17855552 - p.Gly112Glu

Additional dbSNP identifiers (rs#s) for ANKRD29 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD29 Gene

Variant ID Type Subtype PubMed ID
esv34149 CNV loss 18971310
esv3446599 CNV duplication 20981092
nsv131804 CNV insertion 16902084
nsv131838 CNV insertion 16902084
nsv472602 CNV novel sequence insertion 20440878
nsv509688 CNV insertion 20534489

Variation tolerance for ANKRD29 Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD29 Gene

Disorders for ANKRD29 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANKRD29 Gene - From: DISEASES

Disorder Aliases PubMed IDs
transitional papilloma
  • transitional cell papilloma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANKRD29

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ANKRD29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD29 Gene

Publications for ANKRD29 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for ANKRD29 Gene

Sources for ANKRD29 Gene