Aliases for ANKRD24 Gene

Aliases for ANKRD24 Gene

  • Ankyrin Repeat Domain 24 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 24 3 4
  • KIAA1981 2 4
  • ANKRD24 5

External Ids for ANKRD24 Gene

Previous GeneCards Identifiers for ANKRD24 Gene

  • GC19P004134
  • GC19P004135
  • GC19P003946

Summaries for ANKRD24 Gene

GeneCards Summary for ANKRD24 Gene

ANKRD24 (Ankyrin Repeat Domain 24) is a Protein Coding gene. An important paralog of this gene is UACA.

Additional gene information for ANKRD24 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD24 Gene

Genomics for ANKRD24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD24

Top Transcription factor binding sites by QIAGEN in the ANKRD24 gene promoter:
  • ARP-1
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HEN1
  • HFH-3
  • LUN-1
  • MIF-1
  • Nkx2-5
  • Olf-1

Genomic Locations for ANKRD24 Gene

Genomic Locations for ANKRD24 Gene
chr19:4,182,618-4,224,814
(GRCh38/hg38)
Size:
42,197 bases
Orientation:
Plus strand
chr19:4,183,351-4,224,811
(GRCh37/hg19)
Size:
41,461 bases
Orientation:
Plus strand

Genomic View for ANKRD24 Gene

Genes around ANKRD24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD24 Gene

Proteins for ANKRD24 Gene

  • Protein details for ANKRD24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF21-ANR24_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 24
    Protein Accession:
    Q8TF21
    Secondary Accessions:
    • O75268
    • O95781

    Protein attributes for ANKRD24 Gene

    Size:
    1146 amino acids
    Molecular mass:
    124187 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC33490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD15479.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD24 Gene

Post-translational modifications for ANKRD24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD24 Gene

Domains & Families for ANKRD24 Gene

Gene Families for ANKRD24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD24 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for ANKRD24 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 24 (ANR24_HUMAN)
genes like me logo Genes that share domains with ANKRD24: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD24 Gene

Function for ANKRD24 Gene

Phenotypes From GWAS Catalog for ANKRD24 Gene

Gene Ontology (GO) - Molecular Function for ANKRD24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD24: view

Phenotypes for ANKRD24 Gene

GenomeRNAi human phenotypes for ANKRD24:
genes like me logo Genes that share phenotypes with ANKRD24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD24

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD24 Gene

Localization for ANKRD24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD24 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Microtubules (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD24 Gene

Pathways & Interactions for ANKRD24 Gene

PathCards logo

SuperPathways for ANKRD24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD24 Gene

Drugs & Compounds for ANKRD24 Gene

No Compound Related Data Available

Transcripts for ANKRD24 Gene

mRNA/cDNA for ANKRD24 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD24

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1: -
SP2:
SP3: -

Relevant External Links for ANKRD24 Gene

GeneLoc Exon Structure for
ANKRD24

Expression for ANKRD24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD24 Gene

This gene is overexpressed in Brain - Cortex (x7.5), Brain - Frontal Cortex (BA9) (x6.4), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for ANKRD24 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.9), Kidney (9.6), and Fetal gut (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD24 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD24

SOURCE GeneReport for Unigene cluster for ANKRD24 Gene:

Hs.197872
genes like me logo Genes that share expression patterns with ANKRD24: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD24 Gene

Orthologs for ANKRD24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD24 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ANKRD24 30 31
  • 83.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANKRD24 30 31
  • 83.58 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANKRD24 31
  • 80 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ankrd24 30 17 31
  • 71.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100909645 30
  • 66.52 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD24 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ANKRD24 31
  • 42 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 18 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii ankrd24 31
  • 33 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 26 (a)
OneToMany
Species where no ortholog for ANKRD24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANKRD24 Gene

ENSEMBL:
Gene Tree for ANKRD24 (if available)
TreeFam:
Gene Tree for ANKRD24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD24: view image

Paralogs for ANKRD24 Gene

Paralogs for ANKRD24 Gene

(10) SIMAP similar genes for ANKRD24 Gene using alignment to 3 proteins:

  • ANR24_HUMAN
  • M0QZ18_HUMAN
  • M0R0N9_HUMAN
genes like me logo Genes that share paralogs with ANKRD24: view

Variants for ANKRD24 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD24 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10413818 - p.Glu585Lys
rs12978469 - p.Arg349Gln
rs2052191 - p.Ala111Thr
rs353693 - p.Ser684Ala

Additional dbSNP identifiers (rs#s) for ANKRD24 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD24 Gene

Variant ID Type Subtype PubMed ID
dgv216e215 CNV deletion 23714750
dgv651e214 CNV gain 21293372
esv1448643 CNV deletion 17803354
esv2717991 CNV deletion 23290073
esv2717992 CNV deletion 23290073
esv2717993 CNV deletion 23290073
esv2717994 CNV deletion 23290073
esv32625 CNV gain 17666407
esv3643490 CNV loss 21293372
nsv1121544 CNV deletion 24896259
nsv833716 CNV loss 17160897
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897

Variation tolerance for ANKRD24 Gene

Gene Damage Index Score: 9.79; 89.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD24 Gene

Disorders for ANKRD24 Gene

No disorders were found for ANKRD24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD24 Gene

Publications for ANKRD24 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4
  2. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  3. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S … Ideker T (Nature methods 2010) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for ANKRD24 Gene

Sources for ANKRD24 Gene