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This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation. [provided by RefSeq, Jul 2008]
ANKRD23 (Ankyrin Repeat Domain 23) is a Protein Coding gene. Diseases associated with ANKRD23 include Glioblastoma Proneural Subtype and Tibial Muscular Dystrophy. Gene Ontology (GO) annotations related to this gene include titin binding.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J096856 | Promoter/Enhancer | 2.4 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | -0.6 | -560 | 3.8 | SP1 HNRNPL CREB1 CTCF PRDM10 IKZF1 NFKBIZ ZNF692 POLR2A BACH1 | ANKRD23 ANKRD39 SNRNP200 KANSL3 ANKRD36 ANKRD36B CNNM3 ACTR1B CIAO1 SEMA4C | |
GH02J096843 | Promoter/Enhancer | 1 | EPDnew Ensembl ENCODE | 600.4 | +14.6 | 14633 | 1.8 | ZIC2 POLR2A PAF1 GLIS1 NBN | lnc-ANKRD23-1 ANKRD23 LMAN2L ANKRD39 CNNM3 | |
GH02J096853 | Promoter | 0.3 | EPDnew | 600.7 | +4.4 | 4383 | 0.1 | ANKRD23 ANKRD39 lnc-ANKRD23-1 CNNM3 | ||
GH02J096905 | Enhancer | 1 | ENCODE CraniofacialAtlas dbSUPER | 13.1 | -49.3 | -49286 | 2.5 | RFX5 ZIC2 SP1 SCRT2 ZFX RNF2 USF1 YY1 ZNF217 NR2F2 | FAM178B SEMA4C ANKRD23 ANKRD39 SNRNP200 ENSG00000286654 HSALNG0017094 | |
GH02J096908 | Enhancer | 0.3 | Ensembl dbSUPER | 12 | -51.8 | -51767 | 0.6 | SEMA4C ANKRD23 ANKRD39 FAM178B SNRNP200 ENSG00000286654 HSALNG0017094 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA | -- |
GO:0031432 | titin binding | IPI | 14583192 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0014704 | intercalated disc | IEA | -- |
GO:0015629 | actin cytoskeleton | IDA | -- |
Symbol | External ID(s) | Details |
---|---|---|
CAPN3 | ||
CDK3 | ||
ENSG00000272822 | ||
FHL2 | ||
GRB2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0009612 | response to mechanical stimulus | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ANKRD23 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ankrd23 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ANKRD23 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Ankrd23 30 |
|
||
Cow (Bos Taurus) |
Mammalia | ANKRD23 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ANKRD23 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ANKRD23 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | gabpb1 31 |
|
ManyToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv607e201 | CNV | deletion | 23290073 |
esv3425717 | CNV | duplication | 20981092 |
esv5003 | OTHER | complex | 18987735 |
nsv1135873 | CNV | deletion | 24896259 |
nsv526313 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
glioblastoma proneural subtype |
|
|
tibial muscular dystrophy |
|
|
total anomalous pulmonary venous return 1 |
|
|
dilated cardiomyopathy |
|
|