Aliases for ANKRD22 Gene

Aliases for ANKRD22 Gene

  • Ankyrin Repeat Domain 22 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 22 3 4

External Ids for ANKRD22 Gene

Previous GeneCards Identifiers for ANKRD22 Gene

  • GC10M090247
  • GC10M090572
  • GC10M084214

Summaries for ANKRD22 Gene

GeneCards Summary for ANKRD22 Gene

ANKRD22 (Ankyrin Repeat Domain 22) is a Protein Coding gene. An important paralog of this gene is PLA2G6.

Additional gene information for ANKRD22 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD22 Gene

Genomics for ANKRD22 Gene

GeneHancer (GH) Regulatory Elements for ANKRD22 Gene

Promoters and enhancers for ANKRD22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J088850 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 505.5 +0.4 433 2.7 ZNF217 POLR2A ATF2 CTBP1 FOS NR3C1 CEBPB JUND SPI1 ELF1 ANKRD22 STAMBPL1 lnc-ACTA2-2
GH10J088853 Enhancer 0.6 FANTOM5 534.1 -1.3 -1336 0.4 SPI1 JUND GABPA REST RXRA POLR2A HNF4A MYC SP1 ANKRD22 IFIT3 IFIT2 PTCD2P2
GH10J088830 Enhancer 1.3 FANTOM5 Ensembl ENCODE 56.3 +15.3 15275 12.2 EP300 CTCF ZIC2 REST RELA RUNX1 RAD21 TRIM22 EZH2 ATF2 ANKRD22 STAMBPL1 FAS ACTA2-AS1 LIPM ENSG00000201548 LIPJ RNLS LIPF LIPN
GH10J088857 Enhancer 0.9 FANTOM5 Ensembl ENCODE 36.6 -7.5 -7526 5 SRF BCL3 FOS ZNF549 SCRT2 ZFP36 STAT3 ANKRD22 ACTA2-AS1 FAS LIPM LIPJ ENSG00000201548 RNLS IFIT3 IFIT2 PTCD2P2
GH10J089241 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -390.5 -390470 2.9 SP1 ZIC2 RFX1 MEF2C BCL11A NR2F2 FOXA2 CEBPB USF1 SAP130 LIPA ANKRD22 ENSG00000232110 IFIT1B CH25H IFIT3 IFIT5 IFIT2 piR-36588-047
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD22 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD22

Top Transcription factor binding sites by QIAGEN in the ANKRD22 gene promoter:
  • C/EBPalpha
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Nkx2-5
  • Nkx3-1
  • Nkx3-1 v1
  • RORalpha2

Genomic Locations for ANKRD22 Gene

Genomic Locations for ANKRD22 Gene
chr10:88,819,896-88,851,975
(GRCh38/hg38)
Size:
32,080 bases
Orientation:
Minus strand
chr10:90,579,656-90,611,732
(GRCh37/hg19)
Size:
32,077 bases
Orientation:
Minus strand

Genomic View for ANKRD22 Gene

Genes around ANKRD22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD22 Gene

Proteins for ANKRD22 Gene

  • Protein details for ANKRD22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYY1-ANR22_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 22
    Protein Accession:
    Q5VYY1
    Secondary Accessions:
    • B2R9Y7
    • Q8WU06

    Protein attributes for ANKRD22 Gene

    Size:
    191 amino acids
    Molecular mass:
    21849 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD22 Gene

Post-translational modifications for ANKRD22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD22 Gene

Domains & Families for ANKRD22 Gene

Gene Families for ANKRD22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD22 Gene

Suggested Antigen Peptide Sequences for ANKRD22 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 22 (ANR22_HUMAN)
genes like me logo Genes that share domains with ANKRD22: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD22 Gene

Function for ANKRD22 Gene

Phenotypes From GWAS Catalog for ANKRD22 Gene

genes like me logo Genes that share phenotypes with ANKRD22: view

Animal Model Products

miRNA for ANKRD22 Gene

miRTarBase miRNAs that target ANKRD22

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD22 Gene

Localization for ANKRD22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD22 gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD22 Gene

Pathways & Interactions for ANKRD22 Gene

PathCards logo

SuperPathways for ANKRD22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD22 Gene

Drugs & Compounds for ANKRD22 Gene

No Compound Related Data Available

Transcripts for ANKRD22 Gene

mRNA/cDNA for ANKRD22 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD22 Gene

No ASD Table

Relevant External Links for ANKRD22 Gene

GeneLoc Exon Structure for
ANKRD22

Expression for ANKRD22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD22 Gene

This gene is overexpressed in Whole Blood (x8.5), Stomach (x8.4), Esophagus - Mucosa (x6.5), Skin - Not Sun Exposed (Suprapubic) (x5.6), and Skin - Sun Exposed (Lower leg) (x5.5).

Protein differential expression in normal tissues from HIPED for ANKRD22 Gene

This gene is overexpressed in Nasal epithelium (42.6) and Plasma (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD22 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD22

SOURCE GeneReport for Unigene cluster for ANKRD22 Gene:

Hs.217484
genes like me logo Genes that share expression patterns with ANKRD22: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD22 Gene

Orthologs for ANKRD22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD22 31 30
  • 99.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD22 31 30
  • 89.3 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd22 17 31 30
  • 85.09 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd22 30
  • 84.39 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD22 31
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD22 31 30
  • 79.82 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD22 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD22 31 30
  • 68.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD22 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd22 30
  • 64.91 (n)
zebrafish
(Danio rerio)
Actinopterygii ankrd22 31 30
  • 57.94 (n)
OneToOne
Species where no ortholog for ANKRD22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD22 Gene

ENSEMBL:
Gene Tree for ANKRD22 (if available)
TreeFam:
Gene Tree for ANKRD22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD22: view image

Paralogs for ANKRD22 Gene

Paralogs for ANKRD22 Gene

genes like me logo Genes that share paralogs with ANKRD22: view

Variants for ANKRD22 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD22 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs17113412 - p.Glu73Gly
rs17851907 - p.Tyr79His
rs2304804 - p.Gln148Pro
rs7912706 - p.Arg177Ile

Additional dbSNP identifiers (rs#s) for ANKRD22 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD22 Gene

Variant ID Type Subtype PubMed ID
esv3624139 CNV gain 21293372
esv3624140 CNV loss 21293372
esv3624141 CNV gain 21293372
nsv1043015 CNV gain 25217958
nsv551840 CNV gain 21841781
nsv7484 CNV insertion 18451855
nsv831941 CNV gain 17160897
nsv831942 CNV gain 17160897
nsv950991 CNV duplication 24416366

Variation tolerance for ANKRD22 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.77; 73.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD22 Gene

Human Gene Mutation Database (HGMD)
ANKRD22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD22 Gene

Disorders for ANKRD22 Gene

Additional Disease Information for ANKRD22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANKRD22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD22 Gene

Publications for ANKRD22 Gene

  1. ANKRD22 promotes progression of non-small cell lung cancer through transcriptional up-regulation of E2F1. (PMID: 28667340) Yin J … Zhao J (Scientific reports 2017) 2 3 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54

Products for ANKRD22 Gene

Sources for ANKRD22 Gene