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Aliases for ANKRD18B Gene

Aliases for ANKRD18B Gene

  • Ankyrin Repeat Domain 18B 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 18B 3
  • BA255A11.3 3
  • BA255A11.5 3

External Ids for ANKRD18B Gene

Previous GeneCards Identifiers for ANKRD18B Gene

  • GC09P033516
  • GC09U900806

Summaries for ANKRD18B Gene

GeneCards Summary for ANKRD18B Gene

ANKRD18B (Ankyrin Repeat Domain 18B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is ANKRD18A.

Additional gene information for ANKRD18B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD18B Gene

Genomics for ANKRD18B Gene

GeneHancer (GH) Regulatory Elements for ANKRD18B Gene

Promoters and enhancers for ANKRD18B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J033523 Promoter/Enhancer 1.4 Ensembl ENCODE 662.7 -0.1 -124 1.9 SIN3A ZNF2 ZNF48 YY1 GLIS2 KLF7 SP3 REST GLIS1 SP7 ANKRD18B GC09P033525 PIR41298 AQP3 NOL6 APTX CYP4F26P ENSG00000228072
GH09J033526 Enhancer 0.3 Ensembl 650.7 +1.7 1748 0.2 PRDM1 GC09P033525 PIR41298 ANKRD18B PIR60351
GH09J033472 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 -50.8 -50796 2.9 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 NOL6 NFX1 TOPORS ASS1P12 SMU1 TCEA1P4 ENSG00000228352 DFFBP1 UBAP2 ENSG00000223440
GH09J033510 Promoter/Enhancer 1.4 Ensembl ENCODE 12.5 -13.3 -13300 1.9 PKNOX1 ATF1 SIN3A FEZF1 ZNF48 YY1 ZNF121 POLR2B GLIS2 ATF7 PIR50034 SUGT1P1 VN1R47P ANKRD18B PRSS3
GH09J033452 Enhancer 1.3 Ensembl ENCODE dbSUPER 8.9 -70.7 -70654 2.6 HDGF ELF3 MLX ZFP64 ARID4B SIN3A ZBTB7B ZNF48 RAD21 RARA GC09P033453 AQP3 NOL6 ANKRD18B CYP4F26P PTENP1 MIR6851
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD18B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD18B gene promoter:
  • ATF
  • Cdc5
  • GATA-6
  • POU2F1a
  • POU2F1
  • GATA-1
  • HFH-3
  • FOXI1
  • E2F-1
  • E2F

Genomic Locations for ANKRD18B Gene

Genomic Locations for ANKRD18B Gene
chr9:33,524,353-33,575,969
(GRCh38/hg38)
Size:
51,617 bases
Orientation:
Plus strand
chr9:33,524,392-33,573,007
(GRCh37/hg19)
Size:
48,616 bases
Orientation:
Plus strand

Genomic View for ANKRD18B Gene

Genes around ANKRD18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD18B Gene

Proteins for ANKRD18B Gene

  • Protein details for ANKRD18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2A2Z9-AN18B_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 18B
    Protein Accession:
    A2A2Z9

    Protein attributes for ANKRD18B Gene

    Size:
    1011 amino acids
    Molecular mass:
    118231 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD18B Gene

Post-translational modifications for ANKRD18B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD18B Gene

No data available for DME Specific Peptides for ANKRD18B Gene

Domains & Families for ANKRD18B Gene

Gene Families for ANKRD18B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD18B Gene

Suggested Antigen Peptide Sequences for ANKRD18B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD18B: view

No data available for UniProtKB/Swiss-Prot for ANKRD18B Gene

Function for ANKRD18B Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD18B Gene

Localization for ANKRD18B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD18B gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD18B Gene

Pathways & Interactions for ANKRD18B Gene

SuperPathways for ANKRD18B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD18B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD18B Gene

Drugs & Compounds for ANKRD18B Gene

No Compound Related Data Available

Transcripts for ANKRD18B Gene

mRNA/cDNA for ANKRD18B Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD18B Gene

Ankyrin repeat domain 18B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD18B Gene

No ASD Table

Relevant External Links for ANKRD18B Gene

GeneLoc Exon Structure for
ANKRD18B
ECgene alternative splicing isoforms for
ANKRD18B

Expression for ANKRD18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD18B Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD18B Gene

This gene is overexpressed in Brain - Cerebellum (x11.2), Brain - Cerebellar Hemisphere (x9.5), and Testis (x5.4).

Protein differential expression in normal tissues from HIPED for ANKRD18B Gene

This gene is overexpressed in Tlymphocyte (37.8) and Plasma (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD18B Gene



Protein tissue co-expression partners for ANKRD18B Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD18B Gene:

ANKRD18B

SOURCE GeneReport for Unigene cluster for ANKRD18B Gene:

Hs.493710
genes like me logo Genes that share expression patterns with ANKRD18B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD18B Gene

Orthologs for ANKRD18B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD18B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC746826 33
  • 98.94 (n)
ANKRD18B 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 45 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
-- 34
  • 20 (a)
ManyToMany
-- 34
  • 13 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm1758 34
  • 37 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 27 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 14 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 18 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 34
  • 12 (a)
OneToMany
Species where no ortholog for ANKRD18B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD18B Gene

ENSEMBL:
Gene Tree for ANKRD18B (if available)
TreeFam:
Gene Tree for ANKRD18B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD18B: view image

Paralogs for ANKRD18B Gene

(17) SIMAP similar genes for ANKRD18B Gene using alignment to 4 proteins:

  • AN18B_HUMAN
  • A2A300_HUMAN
  • R4GNB3_HUMAN
  • S4R3H1_HUMAN
genes like me logo Genes that share paralogs with ANKRD18B: view

Variants for ANKRD18B Gene

Sequence variations from dbSNP and Humsavar for ANKRD18B Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000030004 -- 33,563,190(+) C/A intron_variant
rs1000080755 -- 33,527,458(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000081834 -- 33,562,914(+) G/A intron_variant
rs1000231664 -- 33,557,431(+) A/G intron_variant
rs1000332506 -- 33,550,878(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD18B Gene

Variant ID Type Subtype PubMed ID
esv3576648 CNV gain 25503493
nsv1024207 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv973205 CNV duplication 23825009
nsv973207 CNV duplication 23825009
nsv982208 CNV duplication 23825009

Variation tolerance for ANKRD18B Gene

Gene Damage Index Score: 5.81; 73.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD18B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD18B Gene

Disorders for ANKRD18B Gene

Additional Disease Information for ANKRD18B

No disorders were found for ANKRD18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD18B Gene

Publications for ANKRD18B Gene

  1. Epigenetic regulation of ANKRD18B in lung cancer. (PMID: 24249358) Liu WB … Liu JY (Molecular carcinogenesis 2015) 3 58
  2. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ANKRD18B Gene

  • Biorbyt antibodies for ANKRD18B

Sources for ANKRD18B Gene

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