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The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to t... See more...
Aliases for ANKRD17 Gene
Aliases for ANKRD17 Gene
External Ids for ANKRD17 Gene
- HGNC: 23575
- Entrez Gene: 26057
- Ensembl: ENSG00000132466
- OMIM: 615929
- UniProtKB: O75179
Previous GeneCards Identifiers for ANKRD17 Gene
- GC04M074407
- GC04M074406
- GC04M074305
- GC04M074159
- GC04M073940
- GC04M069746
Summaries for ANKRD17 Gene
-
The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
GeneCards Summary for ANKRD17 Gene
ANKRD17 (Ankyrin Repeat Domain 17) is a Protein Coding gene. Diseases associated with ANKRD17 include Hand, Foot And Mouth Disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ANKHD1.
UniProtKB/Swiss-Prot Summary for ANKRD17 Gene
-
Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).
Additional gene information for ANKRD17 Gene
- HGNC(23575)
- Entrez Gene(26057)
- Ensembl(ENSG00000132466)
- OMIM(615929)
- UniProtKB(O75179)
- Open Targets Platform(ENSG00000132466)
- Monarch Initiative
- Search for ANKRD17 at DataMed
- Search for ANKRD17 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD17 Gene
Genomics for ANKRD17 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ANKRD17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ANKRD17 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD17
- Top Transcription factor binding sites by QIAGEN in the ANKRD17 gene promoter:
-
- AML1a
- COUP
- COUP-TF
- COUP-TF1
- CREB
- FOXL1
- HNF-4alpha1
- HNF-4alpha2
- MAZR
- SEF-1 (1)
Genomic Locations for ANKRD17 Gene
Genomic Locations for ANKRD17 Gene
- chr4:73,073,376-73,259,766
- (GRCh38/hg38)
- Size:
- 186,391 bases
- Orientation:
- Minus strand
- chr4:73,939,093-74,124,515
- (GRCh37/hg19)
- Size:
- 185,423 bases
- Orientation:
- Minus strand
Genomic View for ANKRD17 Gene
Genes around ANKRD17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by HGNC
- 4q13.3 by Entrez Gene
- 4q13.3 by Ensembl
ANKRD17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD17 Gene
Proteins for ANKRD17 Gene
-
Protein details for ANKRD17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75179-ANR17_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 17
- Protein Accession:
- O75179
- E7EUV3
- G5E964
- Q6PJ85
- Q6PK85
- Q6PKA2
- Q86XI3
- Q8NDR5
- Q96I86
- Q9H288
- Q9H6J9
Protein attributes for ANKRD17 Gene
- Size:
- 2603 amino acids
- Molecular mass:
- 274258 Da
- Quaternary structure:
-
- Interacts (via N-terminus) with NOD2. Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA. Interacts with MAVS and IFIH1. Interacts (via the second ankyrin repeat cluster) with DDX58.
- (Microbial infection) Interacts with enterovirus 71/EV71 capsid protein VP1.
- SequenceCaution:
-
- Sequence=AAG48253.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH04173.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for ANKRD17 Gene
Post-translational modifications for ANKRD17 Gene
- Phosphorylated by CDK2.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ANKRD17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-ANKRD17 monoclonal antibody
- Creative Biolabs Mouse Anti-ANKRD17 Recombinant Antibody (1D12)
- Novus Biologicals Antibodies for ANKRD17
-
Abcam antibodies for ANKRD17
- Invitrogen Antibodies for ANKRD17 (AFLGC-ANKRD17)
- antibodies-online: Show 7 available ANKRD17 Antibodies ranked by validation data
- Compare Top ANKRD17 Antibodies
-
Recommended
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 WB Antibody (anti-rat)
- 17 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 1 WB Antibody (anti-mouse)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ANKRD17
- Origene Custom Protein Services for ANKRD17
-
Abcam proteins for ANKRD17
No data available for DME Specific Peptides for ANKRD17 Gene
Domains & Families for ANKRD17 Gene
Gene Families for ANKRD17 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ANKRD17 Gene
- InterPro:
- Blocks:
-
- KH domain
- KH, type 1
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD17 Gene
- GenScript: Design optimal peptide antigens:
-
- Serologically defined breast cancer antigen NY-BR-16 (ANR17_HUMAN)
- cDNA FLJ39199 fis, clone OCBBF2005189, highly similar to Homo sapiens ankyrin repeat domain 17 (ANKRD17), transcript variant 2, mRNA (B3KU50_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD17 Gene
Function for ANKRD17 Gene
Molecular function for ANKRD17 Gene
- UniProtKB/Swiss-Prot Function:
- Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).
Phenotypes From GWAS Catalog for ANKRD17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003682 | chromatin binding | IDA | 19150984 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IEA,IPI | 19150984 |
Phenotypes for ANKRD17 Gene
- MGI mutant phenotypes for ANKRD17:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ANKRD17:
-
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- shRNA abundance <= 25%
- Increased shRNA abundance (Z-score > 2)
- Increased ionizing radiation sensitivity
- Increased nuclear migration distance, increased nuclear migration speed
- Decreased vaccinia virus (VACV-LREV ) gene expression
- High actin ratio cells
Animal Models for ANKRD17 Gene
- MGI Knock Outs for ANKRD17:
-
- Ankrd17 Ankrd17<tm1.1Yty>
Animal Model Products
-
Taconic Biosciences Mouse Models for ANKRD17
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ANKRD17 - Select products 50% OFF >
- * ANKRD17 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ANKRD17
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANKRD17
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD17
miRNA for ANKRD17 Gene
- miRTarBase miRNAs that target ANKRD17
-
- mmu-miR-451a (MIRT008389)
- mmu-miR-223-3p (MIRT009796)
- mmu-miR-17-5p (MIRT010157)
- mmu-miR-30e-5p (MIRT013517)
- hsa-miR-23b-3p (MIRT023473)
- hsa-miR-1-3p (MIRT023980)
- hsa-miR-16-5p (MIRT031910)
- hsa-miR-424-5p (MIRT042449)
- hsa-miR-186-5p (MIRT045049)
- hsa-let-7c-5p (MIRT051812)
- hsa-let-7b-5p (MIRT052283)
- hsa-let-7a-5p (MIRT052463)
- hsa-miR-664b-3p (MIRT449010)
- hsa-miR-579-3p (MIRT449011)
- hsa-miR-549a (MIRT449012)
- hsa-miR-4699-3p (MIRT449013)
- hsa-miR-582-5p (MIRT449014)
- hsa-miR-101-3p (MIRT449015)
- hsa-miR-885-5p (MIRT449016)
- hsa-miR-6504-3p (MIRT449017)
- mmu-miR-1264-3p (MIRT584888)
- mmu-miR-338-5p (MIRT584889)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANKRD17
- Browse OriGene Inhibitory RNA Products For ANKRD17
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD17
Clone Products
- Applied Biological Materials (abm): Clones for ANKRD17 - Select products 50% OFF >
- * ANKRD17 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ANKRD17
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANKRD17
Cell Line Products
-
Horizon Cell Lines for ANKRD17
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD17 Gene
Localization for ANKRD17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANKRD17 Gene
- Cytoplasm. Nucleus. Note=Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner. {ECO:0000269 PubMed:17276651, ECO:0000269 PubMed:19150984}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 3 |
| cytosol | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| peroxisome | 0 |
| endoplasmic reticulum | 0 |
- Nucleoplasm (3)
- Nuclear membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IDA | 19150984 |
| GO:0005634 | nucleus | IBA,IDA | 19150984 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA,IDA | 22328336 |
| GO:0016020 | membrane | HDA | 19946888 |
Pathways & Interactions for ANKRD17 Gene
Interacting Proteins for ANKRD17 Gene
Selected Interacting proteins:
O75179-ANR17_HUMAN
ENSP00000351416
for ANKRD17 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for ANKRD17
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001955 | blood vessel maturation | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006275 | regulation of DNA replication | IMP | 19150984 |
| GO:0016032 | viral process | IEA | -- |
| GO:0042742 | defense response to bacterium | IDA | 23711367 |
No data available for Pathways by source and SIGNOR curated interactions for ANKRD17 Gene
Transcripts for ANKRD17 Gene
mRNA/cDNA for ANKRD17 Gene
- 4 REFSEQ mRNAs :
- 28 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000358602 10797 nts (view in UCSC)
- ENST00000558247 8456 nts (view in UCSC)
- ENST00000509867 8105 nts (view in UCSC)
- ENST00000330838 7734 nts (view in UCSC)
- ENST00000510127 504 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ANKRD17 - Select products 50% OFF >
- * ANKRD17 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ANKRD17
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANKRD17
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD17
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANKRD17
- Browse OriGene Inhibitory RNA Products For ANKRD17
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD17
Clone Products
- Applied Biological Materials (abm): Clones for ANKRD17 - Select products 50% OFF >
- * ANKRD17 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ANKRD17
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANKRD17
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - |
| ExUns: | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35a | · | 35b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - |
Relevant External Links for ANKRD17 Gene
- GeneLoc Exon Structure for
- ANKRD17
Expression for ANKRD17 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
This gene is overexpressed in Lung (18.9), Platelet (15.4), Retina (8.4), and Fetal Brain (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD17 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD17
SOURCE GeneReport for Unigene cluster for ANKRD17 Gene:
Hs.601206mRNA Expression by UniProt/SwissProt for ANKRD17 Gene:
O75179-ANR17_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for ANKRD17 Gene
- Nervous system(4.9)
- Muscle(4.5)
- Liver(4.5)
- Skin(2.4)
- Kidney(2.4)
- Lung(2.3)
- Heart(2.2)
Primer Products
-
OriGene qPCR primer pairs for ANKRD17
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD17 Gene
Orthologs for ANKRD17 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ANKRD17 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ANKRD17 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ANKRD17 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ankrd17 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ankrd17 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | ANKRD17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRD17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ANKRD17 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ANKRD17 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ankrd17 30 |
|
||
| Str.15599 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | mask 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.13317 30 |
|
- Species where no ortholog for ANKRD17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for ANKRD17 Gene
- ENSEMBL:
- Gene Tree for ANKRD17 (if available)
- TreeFam:
- Gene Tree for ANKRD17 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ANKRD17: view image
Paralogs for ANKRD17 Gene
Paralogs for ANKRD17 Gene
(14) SIMAP similar genes for ANKRD17 Gene using alignment to 5 proteins:
- ANR17_HUMAN
- E7EUV3_HUMAN
- H0YLQ3_HUMAN
- H0YM23_HUMAN
- H0YMS3_HUMAN
Variants for ANKRD17 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD17 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 690371 | Uncertain Significance: not provided | 73,139,993(-) | C/A | NONSENSE,INTRON_VARIANT | |
| 691342 | Uncertain Significance: Pyloric stenosis; Esophageal atresia | 73,258,574(-) | G/A | MISSENSE_VARIANT | |
| 816890 | Likely Pathogenic: Intellectual disability | 73,091,871(-) | T/TG | FRAMESHIFT_VARIANT | |
| rs2306058 | Association: Lip and oral cavity carcinoma | 73,076,961(-) | C/T | SYNONYMOUS_VARIANT | |
| rs2306059 | - | p.His2560Tyr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3600984 | CNV | gain | 21293372 |
| esv3600985 | CNV | gain | 21293372 |
| esv3600989 | CNV | loss | 21293372 |
| esv3600990 | CNV | loss | 21293372 |
| esv3600991 | CNV | loss | 21293372 |
| nsv1000509 | CNV | gain | 25217958 |
| nsv523169 | CNV | gain | 19592680 |
| nsv966284 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
0.175% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.36;
41.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ANKRD17 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD17
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD17 Gene
Disorders for ANKRD17 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hand, foot and mouth disease |
|
|
Search ANKRD17 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ANKRD17
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD17 Gene
Publications for ANKRD17 Gene
- Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. (PMID: 19150984) Deng M … Ye X (The Journal of biological chemistry 2009) 3 4 23
- A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses. (PMID: 23711367) Menning M … Kufer TA (FEBS letters 2013) 3 4
- Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. (PMID: 22328336) Wang Y … Ye X (European journal of immunology 2012) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- The VP1 structural protein of enterovirus 71 interacts with human ornithine decarboxylase and gene trap ankyrin repeat. (PMID: 17276651) Yeo WM … Chow VT (Microbial pathogenesis 2007) 3 4
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Products for ANKRD17 Gene
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- antibodies-online: Show 7 available ANKRD17 Antibodies ranked by validation data
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