Aliases for ANKRD17 Gene
Aliases for ANKRD17 Gene
External Ids for ANKRD17 Gene
- HGNC: 23575
- Entrez Gene: 26057
- Ensembl: ENSG00000132466
- OMIM: 615929
- UniProtKB: O75179
Previous GeneCards Identifiers for ANKRD17 Gene
- GC04M074407
- GC04M074406
- GC04M074305
- GC04M074159
- GC04M073940
- GC04M069746
Summaries for ANKRD17 Gene
-
The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
GeneCards Summary for ANKRD17 Gene
ANKRD17 (Ankyrin Repeat Domain 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ANKHD1-EIF4EBP3.
UniProtKB/Swiss-Prot for ANKRD17 Gene
-
Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).
Additional gene information for ANKRD17 Gene
- Monarch Initiative
- Search for ANKRD17 at DataMed
- Search for ANKRD17 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD17 Gene
Genomics for ANKRD17 Gene
GeneHancer (GH) Regulatory Elements for ANKRD17 Gene
Promoters and enhancers for ANKRD17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ANKRD17 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ANKRD17 gene promoter:
-
- MAZR
- FOXL1
- AML1a
- SEF-1 (1)
- COUP-TF1
- HNF-4alpha2
- HNF-4alpha1
- COUP-TF
- COUP
- CREB
Regulatory Element Products
Genomic Locations for ANKRD17 Gene
Genomic Locations for ANKRD17 Gene
- chr4:73,073,376-73,259,142
- (GRCh38/hg38)
- Size:
- 185,767 bases
- Orientation:
- Minus strand
- chr4:73,939,093-74,124,515
- (GRCh37/hg19)
- Size:
- 185,423 bases
- Orientation:
- Minus strand
Genomic View for ANKRD17 Gene
Genes around ANKRD17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by Entrez Gene
- 4q13.3 by HGNC
- 4q13.3 by Ensembl
ANKRD17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD17 Gene
Proteins for ANKRD17 Gene
-
Protein details for ANKRD17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75179-ANR17_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 17
- Protein Accession:
- O75179
- E7EUV3
- G5E964
- Q6PJ85
- Q6PK85
- Q6PKA2
- Q86XI3
- Q8NDR5
- Q96I86
- Q9H288
- Q9H6J9
Protein attributes for ANKRD17 Gene
- Size:
- 2603 amino acids
- Molecular mass:
- 274258 Da
- Quaternary structure:
-
- Interacts with VP1 capsid protein of enterovirus 71 (EV71). Interacts (via N-terminus) with NOD2. Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA. Interacts with MAVS and IFIH1. Interacts (via the second ankyrin repeat cluster) with DDX58.
- SequenceCaution:
-
- Sequence=AAG48253.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAH04173.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for ANKRD17 Gene
Post-translational modifications for ANKRD17 Gene
- Phosphorylated by CDK2.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ANKRD17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ANKRD17
-
Abcam antibodies for ANKRD17
- Invitrogen Antibodies for ANKRD17
- antibodies-online: Search results for 39 available ANKRD17 Antibodies ranked by validation data
- Compare Top ANKRD17 Antibodies
-
Recommended
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 WB Antibody (anti-rat)
- 18 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 1 WB Antibody (anti-mouse)
- Search GeneTex for Antibodies for ANKRD17
-
Biorbyt antibodies for ANKRD17
-
Boster Bio Antibodies for ANKRD17
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ANKRD17
- Origene Custom Protein Services for ANKRD17
- Search GeneTex for Proteins for ANKRD17
-
Abcam proteins for ANKRD17
Assay Products
No data available for DME Specific Peptides for ANKRD17 Gene
Domains & Families for ANKRD17 Gene
Gene Families for ANKRD17 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ANKRD17 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD17 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKRD17 Gene
Function for ANKRD17 Gene
Molecular function for ANKRD17 Gene
- UniProtKB/Swiss-Prot Function:
- Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).
Phenotypes From GWAS Catalog for ANKRD17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003682 | chromatin binding | IDA | 19150984 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IEA,IPI | 19150984 |
Phenotypes for ANKRD17 Gene
- MGI mutant phenotypes for ANKRD17:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ANKRD17:
-
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV-LREV ) gene expression
- shRNA abundance <= 50%
- Lamellipodia cells
Animal Models for ANKRD17 Gene
- MGI Knock Outs for ANKRD17:
-
- Ankrd17 Ankrd17<tm1.1Yty>
Animal Model Products
-
Taconic Biosciences Mouse Models for ANKRD17
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKRD17
-
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD17
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANKRD17
- genomics-online: gRNA clones - Search results for 84 available ANKRD17 gene related products
- Overview of 84 available ANKRD17 gene related products
- Applied Biological Materials CRISPR for ANKRD17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD17
- GenScript: Design CRISPR guide RNA sequences for ANKRD17
miRNA for ANKRD17 Gene
- miRTarBase miRNAs that target ANKRD17
-
- hsa-mir-23b-3p (MIRT023473)
- hsa-mir-1-3p (MIRT023980)
- hsa-mir-16-5p (MIRT031910)
- hsa-mir-424-5p (MIRT042449)
- hsa-mir-186-5p (MIRT045049)
- hsa-let-7c-5p (MIRT051812)
- hsa-let-7b-5p (MIRT052283)
- hsa-let-7a-5p (MIRT052463)
- hsa-mir-664b-3p (MIRT449010)
- hsa-mir-579-3p (MIRT449011)
- hsa-mir-549a (MIRT449012)
- hsa-mir-4699-3p (MIRT449013)
- hsa-mir-582-5p (MIRT449014)
- hsa-mir-101-3p (MIRT449015)
- hsa-mir-885-5p (MIRT449016)
- hsa-mir-6504-3p (MIRT449017)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANKRD17
- Browse OriGene Inhibitory RNA Products For ANKRD17
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD17
- genomics-online: shRNA clones - Search results for 84 available ANKRD17 gene related products
- Overview of 84 available ANKRD17 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ANKRD17
- VectorBuilder custom plasmid, inducible vectors for ANKRD17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANKRD17
- Applied Biological Materials Clones for ANKRD17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ANKRD17
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD17 Gene
Localization for ANKRD17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANKRD17 Gene
- Cytoplasm. Nucleus. Note=Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner. {ECO:0000269 PubMed:17276651, ECO:0000269 PubMed:19150984}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Nucleus (3)
- Nuclear membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IDA | 19150984 |
| GO:0005634 | nucleus | IEA,IDA | 19150984 |
| GO:0005737 | cytoplasm | IDA,IEA | 22328336 |
| GO:0016020 | membrane | HDA | 19946888 |
| GO:0031965 | nuclear membrane | IDA | -- |
Pathways & Interactions for ANKRD17 Gene
No Data Available
Interacting Proteins for ANKRD17 Gene
Selected Interacting proteins:
ENSP00000351416
O75179-ANR17_HUMAN
for ANKRD17 Gene via
STRING
MINT
IID
GPS-Prot Interaction Network for ANKRD17
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001955 | blood vessel maturation | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006275 | regulation of DNA replication | IMP | 19150984 |
| GO:0016032 | viral process | IEA | -- |
| GO:0042742 | defense response to bacterium | IDA | 23711367 |
No data available for Pathways by source and SIGNOR curated interactions for ANKRD17 Gene
Transcripts for ANKRD17 Gene
mRNA/cDNA for ANKRD17 Gene
- (14) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (351) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000358602 10784 bps (uc003hgp.4)
- ENST00000558247 8456 bps (uc062xfe.1)
- ENST00000509867 8105 bps (uc003hgo.5)
- ENST00000330838 7734 bps (uc003hgq.4)
- ENST00000510127 504 bps (uc062xff.1)
Unigene Clusters for ANKRD17 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD17
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANKRD17
- genomics-online: gRNA clones - Search results for 84 available ANKRD17 gene related products
- Overview of 84 available ANKRD17 gene related products
- Applied Biological Materials CRISPR for ANKRD17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD17
- GenScript: Design CRISPR guide RNA sequences for ANKRD17
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANKRD17
- Browse OriGene Inhibitory RNA Products For ANKRD17
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD17
- genomics-online: shRNA clones - Search results for 84 available ANKRD17 gene related products
- Overview of 84 available ANKRD17 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ANKRD17
- VectorBuilder custom plasmid, inducible vectors for ANKRD17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANKRD17
- Applied Biological Materials Clones for ANKRD17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - |
| ExUns: | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35a | · | 35b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - |
Expression for ANKRD17 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
This gene is overexpressed in Lung (18.9), Platelet (15.4), Retina (8.4), and Fetal Brain (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD17 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ANKRD17 Gene:
ANKRD17SOURCE GeneReport for Unigene cluster for ANKRD17 Gene:
Hs.601206mRNA Expression by UniProt/SwissProt for ANKRD17 Gene:
O75179-ANR17_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for ANKRD17 Gene
- Nervous system(4.9)
- Liver(4.3)
- Muscle(4.3)
- Lung(2.3)
Primer Products
-
OriGene qPCR primer pairs for ANKRD17
- genomics-online: primer clones - Search results for 84 available ANKRD17 gene related products
- Overview of 84 available ANKRD17 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD17 Gene
Orthologs for ANKRD17 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRD17 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANKRD17 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ANKRD17 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ankrd17 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankrd17 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKRD17 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRD17 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKRD17 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ANKRD17 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankrd17 33 |
|
||
| Str.15599 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | mask 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| Cin.13317 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.13317 33 |
|
- Species where no ortholog for ANKRD17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for ANKRD17 Gene
- ENSEMBL:
- Gene Tree for ANKRD17 (if available)
- TreeFam:
- Gene Tree for ANKRD17 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ANKRD17: view image
Paralogs for ANKRD17 Gene
Paralogs for ANKRD17 Gene
(14) SIMAP similar genes for ANKRD17 Gene using alignment to 5 proteins:
- ANR17_HUMAN
- E7EUV3_HUMAN
- H0YLQ3_HUMAN
- H0YM23_HUMAN
- H0YMS3_HUMAN
Variants for ANKRD17 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2306058 | association, Lip and oral cavity carcinoma | 73,076,961(-) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant | |
| rs1000023133 | -- | 73,177,997(-) | C/T | intron_variant | |
| rs1000028889 | -- | 73,220,013(-) | T/C | intron_variant | |
| rs1000040193 | -- | 73,110,467(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000050398 | -- | 73,252,783(-) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv966284 | CNV | duplication | 23825009 |
| nsv523169 | CNV | gain | 19592680 |
| nsv1000509 | CNV | gain | 25217958 |
| esv3600991 | CNV | loss | 21293372 |
| esv3600990 | CNV | loss | 21293372 |
| esv3600989 | CNV | loss | 21293372 |
| esv3600985 | CNV | gain | 21293372 |
| esv3600984 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
0.175% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.36;
41.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ANKRD17 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD17
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD17 Gene
Disorders for ANKRD17 Gene
Additional Disease Information for ANKRD17
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ANKRD17 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD17 Gene
Publications for ANKRD17 Gene
- Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. (PMID: 19150984) Deng M … Ye X (The Journal of biological chemistry 2009) 3 4 22 58
- A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses. (PMID: 23711367) Menning M … Kufer TA (FEBS letters 2013) 3 4 58
- Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. (PMID: 22328336) Wang Y … Ye X (European journal of immunology 2012) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- The VP1 structural protein of enterovirus 71 interacts with human ornithine decarboxylase and gene trap ankyrin repeat. (PMID: 17276651) Yeo WM … Chow VT (Microbial pathogenesis 2007) 3 4 58
Products for ANKRD17 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
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- GenScript: Next-day shipping of latest version cDNA ORF clones for ANKRD17 in any vector
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- GenScript: Design CRISPR guide RNA sequences for ANKRD17
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- Taconic Biosciences Mouse Models for ANKRD17
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKRD17
- VectorBuilder custom plasmid, inducible vectors for ANKRD17
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
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- antibodies-online: Search results for 39 available ANKRD17 Antibodies ranked by validation data
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- 12 IF (p) Antibodies (anti-rat)
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- 18 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 1 WB Antibody (anti-mouse)
- antibodies-online: Search results for available ANKRD17 related products ranked by validation data
- antibodies-online: Search results for 2 available ANKRD17 Proteins ranked by validation data
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- Search GeneTex for Antibodies for ANKRD17
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- Horizon Cell Lines for ANKRD17
- genomics-online: cdna clones - Search results for 84 available ANKRD17 gene related products
- Overview of 84 available ANKRD17 gene related products
- orf clones - Search results for 84 available ANKRD17 gene related products
- Overview of 84 available ANKRD17 gene related products
- genomics-online: gRNA clones - Search results for 84 available ANKRD17 gene related products
- Overview of 84 available ANKRD17 gene related products
- genomics-online: primer clones - Search results for 84 available ANKRD17 gene related products
- Overview of 84 available ANKRD17 gene related products
- genomics-online: shRNA clones - Search results for 84 available ANKRD17 gene related products
- Overview of 84 available ANKRD17 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANKRD17
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- Boster Bio Antibodies for ANKRD17
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for ANKRD17
Sources for ANKRD17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (144) ProteoGenix
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- (153) DataMed
- (154) HumanCyc
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- (169) Biorbyt