Aliases for ANKRD16 Gene

Aliases for ANKRD16 Gene

  • Ankyrin Repeat Domain 16 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 16 3 4

External Ids for ANKRD16 Gene

Previous GeneCards Identifiers for ANKRD16 Gene

  • GC10M005907
  • GC10M005942
  • GC10M005905
  • GC10M005906
  • GC10M005830
  • GC10M005909
  • GC10M005911
  • GC10M005912
  • GC10M005914
  • GC10M005916
  • GC10M005918
  • GC10M005920

Summaries for ANKRD16 Gene

GeneCards Summary for ANKRD16 Gene

ANKRD16 (Ankyrin Repeat Domain 16) is a Protein Coding gene. An important paralog of this gene is ASB1.

UniProtKB/Swiss-Prot Summary for ANKRD16 Gene

  • Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides.

Additional gene information for ANKRD16 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD16 Gene

Genomics for ANKRD16 Gene

GeneHancer (GH) Regulatory Elements for ANKRD16 Gene

Promoters and enhancers for ANKRD16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD16 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD16

Top Transcription factor binding sites by QIAGEN in the ANKRD16 gene promoter:
  • Brachyury
  • c-Myb
  • CUTL1
  • ITF-2
  • LCR-F1
  • SEF-1 (1)
  • Sox9
  • SRY
  • Tal-1beta
  • YY1

Genomic Locations for ANKRD16 Gene

Genomic Locations for ANKRD16 Gene
chr10:5,861,616-5,889,906
(GRCh38/hg38)
Size:
28,291 bases
Orientation:
Minus strand
chr10:5,903,580-5,931,869
(GRCh37/hg19)
Size:
28,290 bases
Orientation:
Minus strand

Genomic View for ANKRD16 Gene

Genes around ANKRD16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD16 Gene

Proteins for ANKRD16 Gene

  • Protein details for ANKRD16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P6B7-ANR16_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 16
    Protein Accession:
    Q6P6B7
    Secondary Accessions:
    • A6NEF0
    • F8WEI4
    • Q9NT01

    Protein attributes for ANKRD16 Gene

    Size:
    361 amino acids
    Molecular mass:
    39284 Da
    Quaternary structure:
    • Interacts with AARS; the interaction is direct.

    Alternative splice isoforms for ANKRD16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD16 Gene

Post-translational modifications for ANKRD16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD16 Gene

No data available for DME Specific Peptides for ANKRD16 Gene

Domains & Families for ANKRD16 Gene

Gene Families for ANKRD16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD16 Gene

Blocks:
  • Ankyrin repeat signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANKRD16 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 16 (ANR16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P6B7

UniProtKB/Swiss-Prot:

ANR16_HUMAN :
  • Side chains of Lys-102, Lys-135 and Lys-165 capture Ser that is misactivated by AARS/AlaRS.
Domain:
  • Side chains of Lys-102, Lys-135 and Lys-165 capture Ser that is misactivated by AARS/AlaRS.
genes like me logo Genes that share domains with ANKRD16: view

Function for ANKRD16 Gene

Molecular function for ANKRD16 Gene

UniProtKB/Swiss-Prot Function:
Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides.

Phenotypes From GWAS Catalog for ANKRD16 Gene

genes like me logo Genes that share phenotypes with ANKRD16: view

Animal Models for ANKRD16 Gene

MGI Knock Outs for ANKRD16:

Animal Model Products

CRISPR Products

miRNA for ANKRD16 Gene

miRTarBase miRNAs that target ANKRD16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD16 Gene

Localization for ANKRD16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD16 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD16 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANKRD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with ANKRD16: view

Pathways & Interactions for ANKRD16 Gene

PathCards logo

SuperPathways for ANKRD16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification ISS --
genes like me logo Genes that share ontologies with ANKRD16: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD16 Gene

Drugs & Compounds for ANKRD16 Gene

No Compound Related Data Available

Transcripts for ANKRD16 Gene

mRNA/cDNA for ANKRD16 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD16 Gene

No ASD Table

Relevant External Links for ANKRD16 Gene

GeneLoc Exon Structure for
ANKRD16

Expression for ANKRD16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD16 Gene

This gene is overexpressed in Platelet (42.4) and Bone (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD16 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD16

SOURCE GeneReport for Unigene cluster for ANKRD16 Gene:

Hs.289828
genes like me logo Genes that share expression patterns with ANKRD16: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD16 Gene

Orthologs for ANKRD16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD16 31 30
  • 99.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD16 31 30
  • 82.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd16 17 31 30
  • 82.54 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd16 30
  • 82.44 (n)
dog
(Canis familiaris)
Mammalia ANKRD16 31 30
  • 78.41 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD16 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD16 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD16 31 30
  • 69.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD16 31
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd16 30
  • 64.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14968 30
zebrafish
(Danio rerio)
Actinopterygii ankrd16 31 30
  • 62.36 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pain 31
  • 7 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToOne
Species where no ortholog for ANKRD16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD16 Gene

ENSEMBL:
Gene Tree for ANKRD16 (if available)
TreeFam:
Gene Tree for ANKRD16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD16: view image

Paralogs for ANKRD16 Gene

Paralogs for ANKRD16 Gene

(4) SIMAP similar genes for ANKRD16 Gene using alignment to 1 proteins:

  • ANR16_HUMAN
genes like me logo Genes that share paralogs with ANKRD16: view

Variants for ANKRD16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD16 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs1052420 - p.Gln353Arg
rs2296136 - p.Ala128Gly

Additional dbSNP identifiers (rs#s) for ANKRD16 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD16 Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV loss 18971310
esv2668731 CNV deletion 23128226
esv2676037 CNV deletion 23128226
esv3545829 CNV deletion 23714750
esv3622238 CNV loss 21293372
esv3622239 CNV loss 21293372
nsv1118070 CNV deletion 24896259
nsv437655 CNV loss 16327808
nsv519773 CNV loss 19592680
nsv520941 CNV loss 19592680
nsv549904 CNV loss 21841781
nsv549905 CNV loss 21841781
nsv549906 CNV loss 21841781
nsv5654 CNV deletion 18451855
nsv825229 CNV gain 20364138
nsv831775 CNV loss 17160897

Variation tolerance for ANKRD16 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD16 Gene

Human Gene Mutation Database (HGMD)
ANKRD16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD16 Gene

Disorders for ANKRD16 Gene

Additional Disease Information for ANKRD16

No disorders were found for ANKRD16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD16 Gene

Publications for ANKRD16 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 54
  5. Genome-wide association study identifies five new breast cancer susceptibility loci. (PMID: 20453838) Turnbull C … Easton DF (Nature genetics 2010) 3 54

Products for ANKRD16 Gene

Sources for ANKRD16 Gene